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Q63799

- TCEA2_RAT

UniProt

Q63799 - TCEA2_RAT

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Protein
Transcription elongation factor A protein 2
Gene
Tcea2, Siit1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri257 – 29741TFIIS-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: RGD
  2. regulation of DNA-templated transcription, elongation Source: InterPro
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein 2
Alternative name(s):
Protein S-II-T1
Testis-specific S-II
Transcription elongation factor S-II protein 2
Transcription elongation factor TFIIS.l
Gene namesi
Name:Tcea2
Synonyms:Siit1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi61825. Tcea2.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Transcription elongation factor A protein 2
PRO_0000121451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki57 – 57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ63799.
PRIDEiQ63799.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

GenevestigatoriQ63799.

Interactioni

Subunit structurei

Interacts with the basal transcription factor GTF2B. Interacts with REXO1 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059673.

Structurei

3D structure databases

ProteinModelPortaliQ63799.
SMRiQ63799. Positions 1-83, 250-299.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8278TFIIS N-terminal
Add
BLAST
Domaini138 – 254117TFIIS central
Add
BLAST

Sequence similaritiesi

Belongs to the TFS-II family.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1594.
GeneTreeiENSGT00390000017794.
HOGENOMiHOG000195015.
HOVERGENiHBG055022.
InParanoidiQ63799.
KOiK03145.
OMAiRITTFPQ.
OrthoDBiEOG7GQXWQ.
PhylomeDBiQ63799.

Family and domain databases

Gene3Di1.10.472.30. 1 hit.
1.20.930.10. 1 hit.
InterProiIPR016492. TF_IIS-rel.
IPR003617. TFIIS/CRSP70_N_sub.
IPR003618. TFIIS_cen_dom.
IPR017923. TFIIS_N.
IPR017890. TFS2M.
IPR006289. TFSII.
IPR001222. Znf_TFIIS.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
PF01096. TFIIS_C. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view]
PIRSFiPIRSF006704. TF_IIS. 1 hit.
SMARTiSM00510. TFS2M. 1 hit.
SM00509. TFS2N. 1 hit.
SM00440. ZnF_C2C2. 1 hit.
[Graphical view]
SUPFAMiSSF46942. SSF46942. 1 hit.
SSF47676. SSF47676. 1 hit.
TIGRFAMsiTIGR01385. TFSII. 1 hit.
PROSITEiPS51321. TFIIS_CENTRAL. 1 hit.
PS51319. TFIIS_N. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63799-1 [UniParc]FASTAAdd to Basket

« Hide

MGKEEEIARI ARRLDKMVTR KNAEGAMDLL RELKNMPITL HLLQSTRVGM    50
SVNALRKQSS DEELIALAKS LIKSWKKLLD VSDGKSRDQG RGTPLPTSSS 100
KDASGTTDLS CKKPDPPRTS STPRITTFPQ VPITCDAVRN KCREMLTLAL 150
QTDHDHVAVG VSCEHLSSQI EECIFLDVGN TDMKYKNRVR SRISNLKDAK 200
NPGLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK EAIREHQMAR 250
TGGTQTDLFT CNKCRKKNCT YTQVQTRSSD EPMTTYVVCN ECGNRWKFC 299
Length:299
Mass (Da):33,528
Last modified:November 1, 1996 - v1
Checksum:i24BF8D56ECE3BB3F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D12927 mRNA. Translation: BAA02310.1.
PIRiA53004.
RefSeqiNP_476439.1. NM_057098.1.
UniGeneiRn.78891.

Genome annotation databases

EnsembliENSRNOT00000022073; ENSRNOP00000022073; ENSRNOG00000016288.
GeneIDi29575.
KEGGirno:29575.
UCSCiRGD:61825. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D12927 mRNA. Translation: BAA02310.1 .
PIRi A53004.
RefSeqi NP_476439.1. NM_057098.1.
UniGenei Rn.78891.

3D structure databases

ProteinModelPortali Q63799.
SMRi Q63799. Positions 1-83, 250-299.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000059673.

Proteomic databases

PaxDbi Q63799.
PRIDEi Q63799.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022073 ; ENSRNOP00000022073 ; ENSRNOG00000016288 .
GeneIDi 29575.
KEGGi rno:29575.
UCSCi RGD:61825. rat.

Organism-specific databases

CTDi 6919.
RGDi 61825. Tcea2.

Phylogenomic databases

eggNOGi COG1594.
GeneTreei ENSGT00390000017794.
HOGENOMi HOG000195015.
HOVERGENi HBG055022.
InParanoidi Q63799.
KOi K03145.
OMAi RITTFPQ.
OrthoDBi EOG7GQXWQ.
PhylomeDBi Q63799.

Miscellaneous databases

NextBioi 609666.

Gene expression databases

Genevestigatori Q63799.

Family and domain databases

Gene3Di 1.10.472.30. 1 hit.
1.20.930.10. 1 hit.
InterProi IPR016492. TF_IIS-rel.
IPR003617. TFIIS/CRSP70_N_sub.
IPR003618. TFIIS_cen_dom.
IPR017923. TFIIS_N.
IPR017890. TFS2M.
IPR006289. TFSII.
IPR001222. Znf_TFIIS.
[Graphical view ]
Pfami PF08711. Med26. 1 hit.
PF01096. TFIIS_C. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view ]
PIRSFi PIRSF006704. TF_IIS. 1 hit.
SMARTi SM00510. TFS2M. 1 hit.
SM00509. TFS2N. 1 hit.
SM00440. ZnF_C2C2. 1 hit.
[Graphical view ]
SUPFAMi SSF46942. SSF46942. 1 hit.
SSF47676. SSF47676. 1 hit.
TIGRFAMsi TIGR01385. TFSII. 1 hit.
PROSITEi PS51321. TFIIS_CENTRAL. 1 hit.
PS51319. TFIIS_N. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and identification of testis-specific transcription elongation factor S-II."
    Xu Q., Nakanishi T., Sekimizu K., Natori S.
    J. Biol. Chem. 269:3100-3103(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Testis.

Entry informationi

Entry nameiTCEA2_RAT
AccessioniPrimary (citable) accession number: Q63799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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