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Q63799 (TCEA2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Transcription elongation factor A protein 2
Alternative name(s):
Protein S-II-T1
Testis-specific S-II
Transcription elongation factor S-II protein 2
Transcription elongation factor TFIIS.l
Gene names
Name:Tcea2
Synonyms:Siit1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. Ref.1

Subunit structure

Interacts with the basal transcription factor GTF2B. Interacts with REXO1 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Testis specific. Ref.1

Sequence similarities

Belongs to the TFS-II family.

Contains 1 TFIIS central domain.

Contains 1 TFIIS N-terminal domain.

Contains 1 TFIIS-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Transcription elongation factor A protein 2
PRO_0000121451

Regions

Domain5 – 8278TFIIS N-terminal
Domain138 – 254117TFIIS central
Zinc finger257 – 29741TFIIS-type

Amino acid modifications

Cross-link57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63799 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 24BF8D56ECE3BB3F

FASTA29933,528
        10         20         30         40         50         60 
MGKEEEIARI ARRLDKMVTR KNAEGAMDLL RELKNMPITL HLLQSTRVGM SVNALRKQSS 

        70         80         90        100        110        120 
DEELIALAKS LIKSWKKLLD VSDGKSRDQG RGTPLPTSSS KDASGTTDLS CKKPDPPRTS 

       130        140        150        160        170        180 
STPRITTFPQ VPITCDAVRN KCREMLTLAL QTDHDHVAVG VSCEHLSSQI EECIFLDVGN 

       190        200        210        220        230        240 
TDMKYKNRVR SRISNLKDAK NPGLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK 

       250        260        270        280        290 
EAIREHQMAR TGGTQTDLFT CNKCRKKNCT YTQVQTRSSD EPMTTYVVCN ECGNRWKFC 

« Hide

References

[1]"Cloning and identification of testis-specific transcription elongation factor S-II."
Xu Q., Nakanishi T., Sekimizu K., Natori S.
J. Biol. Chem. 269:3100-3103(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D12927 mRNA. Translation: BAA02310.1.
PIRA53004.
RefSeqNP_476439.1. NM_057098.1.
UniGeneRn.78891.

3D structure databases

ProteinModelPortalQ63799.
SMRQ63799. Positions 1-83, 250-299.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000059673.

Proteomic databases

PaxDbQ63799.
PRIDEQ63799.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000022073; ENSRNOP00000022073; ENSRNOG00000016288.
GeneID29575.
KEGGrno:29575.
UCSCRGD:61825. rat.

Organism-specific databases

CTD6919.
RGD61825. Tcea2.

Phylogenomic databases

eggNOGCOG1594.
GeneTreeENSGT00390000017794.
HOGENOMHOG000195015.
HOVERGENHBG055022.
InParanoidQ63799.
KOK03145.
OMARITTFPQ.
OrthoDBEOG7GQXWQ.
PhylomeDBQ63799.

Gene expression databases

GenevestigatorQ63799.

Family and domain databases

Gene3D1.10.472.30. 1 hit.
1.20.930.10. 1 hit.
InterProIPR016492. TF_IIS-rel.
IPR003617. TFIIS/CRSP70_N_sub.
IPR003618. TFIIS_cen_dom.
IPR017923. TFIIS_N.
IPR017890. TFS2M.
IPR006289. TFSII.
IPR001222. Znf_TFIIS.
[Graphical view]
PfamPF08711. Med26. 1 hit.
PF01096. TFIIS_C. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view]
PIRSFPIRSF006704. TF_IIS. 1 hit.
SMARTSM00510. TFS2M. 1 hit.
SM00509. TFS2N. 1 hit.
SM00440. ZnF_C2C2. 1 hit.
[Graphical view]
SUPFAMSSF46942. SSF46942. 1 hit.
SSF47676. SSF47676. 1 hit.
TIGRFAMsTIGR01385. TFSII. 1 hit.
PROSITEPS51321. TFIIS_CENTRAL. 1 hit.
PS51319. TFIIS_N. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609666.

Entry information

Entry nameTCEA2_RAT
AccessionPrimary (citable) accession number: Q63799
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families