Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q63799

- TCEA2_RAT

UniProt

Q63799 - TCEA2_RAT

Protein

Transcription elongation factor A protein 2

Gene

Tcea2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri257 – 29741TFIIS-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: RGD
    2. regulation of DNA-templated transcription, elongation Source: InterPro
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription elongation factor A protein 2
    Alternative name(s):
    Protein S-II-T1
    Testis-specific S-II
    Transcription elongation factor S-II protein 2
    Transcription elongation factor TFIIS.l
    Gene namesi
    Name:Tcea2
    Synonyms:Siit1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi61825. Tcea2.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. nucleus Source: RGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Transcription elongation factor A protein 2PRO_0000121451Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki57 – 57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ63799.
    PRIDEiQ63799.

    Expressioni

    Tissue specificityi

    Testis specific.1 Publication

    Gene expression databases

    GenevestigatoriQ63799.

    Interactioni

    Subunit structurei

    Interacts with the basal transcription factor GTF2B. Interacts with REXO1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000059673.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63799.
    SMRiQ63799. Positions 1-83, 250-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 8278TFIIS N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 254117TFIIS centralPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TFS-II family.Curated
    Contains 1 TFIIS central domain.PROSITE-ProRule annotation
    Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TFIIS-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri257 – 29741TFIIS-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1594.
    GeneTreeiENSGT00390000017794.
    HOGENOMiHOG000195015.
    HOVERGENiHBG055022.
    InParanoidiQ63799.
    KOiK03145.
    OMAiRITTFPQ.
    OrthoDBiEOG7GQXWQ.
    PhylomeDBiQ63799.

    Family and domain databases

    Gene3Di1.10.472.30. 1 hit.
    1.20.930.10. 1 hit.
    InterProiIPR016492. TF_IIS-rel.
    IPR003617. TFIIS/CRSP70_N_sub.
    IPR003618. TFIIS_cen_dom.
    IPR017923. TFIIS_N.
    IPR017890. TFS2M.
    IPR006289. TFSII.
    IPR001222. Znf_TFIIS.
    [Graphical view]
    PfamiPF08711. Med26. 1 hit.
    PF01096. TFIIS_C. 1 hit.
    PF07500. TFIIS_M. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006704. TF_IIS. 1 hit.
    SMARTiSM00510. TFS2M. 1 hit.
    SM00509. TFS2N. 1 hit.
    SM00440. ZnF_C2C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF46942. SSF46942. 1 hit.
    SSF47676. SSF47676. 1 hit.
    TIGRFAMsiTIGR01385. TFSII. 1 hit.
    PROSITEiPS51321. TFIIS_CENTRAL. 1 hit.
    PS51319. TFIIS_N. 1 hit.
    PS00466. ZF_TFIIS_1. 1 hit.
    PS51133. ZF_TFIIS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63799-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKEEEIARI ARRLDKMVTR KNAEGAMDLL RELKNMPITL HLLQSTRVGM    50
    SVNALRKQSS DEELIALAKS LIKSWKKLLD VSDGKSRDQG RGTPLPTSSS 100
    KDASGTTDLS CKKPDPPRTS STPRITTFPQ VPITCDAVRN KCREMLTLAL 150
    QTDHDHVAVG VSCEHLSSQI EECIFLDVGN TDMKYKNRVR SRISNLKDAK 200
    NPGLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK EAIREHQMAR 250
    TGGTQTDLFT CNKCRKKNCT YTQVQTRSSD EPMTTYVVCN ECGNRWKFC 299
    Length:299
    Mass (Da):33,528
    Last modified:November 1, 1996 - v1
    Checksum:i24BF8D56ECE3BB3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12927 mRNA. Translation: BAA02310.1.
    PIRiA53004.
    RefSeqiNP_476439.1. NM_057098.1.
    UniGeneiRn.78891.

    Genome annotation databases

    EnsembliENSRNOT00000022073; ENSRNOP00000022073; ENSRNOG00000016288.
    GeneIDi29575.
    KEGGirno:29575.
    UCSCiRGD:61825. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12927 mRNA. Translation: BAA02310.1 .
    PIRi A53004.
    RefSeqi NP_476439.1. NM_057098.1.
    UniGenei Rn.78891.

    3D structure databases

    ProteinModelPortali Q63799.
    SMRi Q63799. Positions 1-83, 250-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000059673.

    Proteomic databases

    PaxDbi Q63799.
    PRIDEi Q63799.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022073 ; ENSRNOP00000022073 ; ENSRNOG00000016288 .
    GeneIDi 29575.
    KEGGi rno:29575.
    UCSCi RGD:61825. rat.

    Organism-specific databases

    CTDi 6919.
    RGDi 61825. Tcea2.

    Phylogenomic databases

    eggNOGi COG1594.
    GeneTreei ENSGT00390000017794.
    HOGENOMi HOG000195015.
    HOVERGENi HBG055022.
    InParanoidi Q63799.
    KOi K03145.
    OMAi RITTFPQ.
    OrthoDBi EOG7GQXWQ.
    PhylomeDBi Q63799.

    Miscellaneous databases

    NextBioi 609666.

    Gene expression databases

    Genevestigatori Q63799.

    Family and domain databases

    Gene3Di 1.10.472.30. 1 hit.
    1.20.930.10. 1 hit.
    InterProi IPR016492. TF_IIS-rel.
    IPR003617. TFIIS/CRSP70_N_sub.
    IPR003618. TFIIS_cen_dom.
    IPR017923. TFIIS_N.
    IPR017890. TFS2M.
    IPR006289. TFSII.
    IPR001222. Znf_TFIIS.
    [Graphical view ]
    Pfami PF08711. Med26. 1 hit.
    PF01096. TFIIS_C. 1 hit.
    PF07500. TFIIS_M. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006704. TF_IIS. 1 hit.
    SMARTi SM00510. TFS2M. 1 hit.
    SM00509. TFS2N. 1 hit.
    SM00440. ZnF_C2C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46942. SSF46942. 1 hit.
    SSF47676. SSF47676. 1 hit.
    TIGRFAMsi TIGR01385. TFSII. 1 hit.
    PROSITEi PS51321. TFIIS_CENTRAL. 1 hit.
    PS51319. TFIIS_N. 1 hit.
    PS00466. ZF_TFIIS_1. 1 hit.
    PS51133. ZF_TFIIS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and identification of testis-specific transcription elongation factor S-II."
      Xu Q., Nakanishi T., Sekimizu K., Natori S.
      J. Biol. Chem. 269:3100-3103(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Testis.

    Entry informationi

    Entry nameiTCEA2_RAT
    AccessioniPrimary (citable) accession number: Q63799
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3