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Q63789

- P55G_RAT

UniProt

Q63789 - P55G_RAT

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Protein

Phosphatidylinositol 3-kinase regulatory subunit gamma

Gene

Pik3r3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase regulator activity Source: RGD

GO - Biological processi

  1. regulation of phosphatidylinositol 3-kinase activity Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase regulatory subunit gamma
Short name:
PI3-kinase regulatory subunit gamma
Short name:
PI3K regulatory subunit gamma
Short name:
PtdIns-3-kinase regulatory subunit gamma
Alternative name(s):
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
Short name:
PI3-kinase subunit p55-gamma
Short name:
PtdIns-3-kinase regulatory subunit p55-gamma
p55PIK
Gene namesi
Name:Pik3r3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621042. Pik3r3.

Subcellular locationi

GO - Cellular componenti

  1. phosphatidylinositol 3-kinase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Phosphatidylinositol 3-kinase regulatory subunit gammaPRO_0000080769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63789.
PRIDEiQ63789.

PTM databases

PhosphoSiteiQ63789.

Expressioni

Tissue specificityi

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen.

Gene expression databases

GenevestigatoriQ63789.

Interactioni

Subunit structurei

Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000157.

Structurei

3D structure databases

ProteinModelPortaliQ63789.
SMRiQ63789. Positions 58-331, 348-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 16399SH2 1PROSITE-ProRule annotationAdd
BLAST
Domaini358 – 45598SH2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3K p85 subunit family.Curated
Contains 2 SH2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiNOG249532.
HOGENOMiHOG000008438.
HOVERGENiHBG082100.
InParanoidiQ63789.
KOiK02649.
PhylomeDBiQ63789.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63789-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPVTSAVT
60 70 80 90 100
NGMKDCFVSL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY
110 120 130 140 150
TLTLRKGGNN KLIKIYHRDG NYGFSEPLTF NSVVELINHY HHESLAQYNP
160 170 180 190 200
KLDVKLMYPV SRYQQDQLVK EDNIDAVGKN LQEFHSQYQE KSKEYDRLYE
210 220 230 240 250
EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKDY IERFRREGNE
260 270 280 290 300
KEIERIMMNY DKLKSRLGEI HDSKVRLEQD LKKQALDNRE IDKKMNSIKP
310 320 330 340 350
DLIQLRKIRD QHLVWLNHRG VRQRRLNAWL GIKSEDTDES YFINEDDESL
360 370 380 390 400
PHYDEKTWFV EDVNRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE
410 420 430 440 450
VKPCVIYSPA RGYGFAEPYN LYGSLKELVL HYQQTSLVQH NDSLNVTLAY
460
PVHAQMPSLC R
Length:461
Mass (Da):54,254
Last modified:November 1, 1996 - v1
Checksum:i6467D88447CC562B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64047 mRNA. Translation: BAA10927.1.
RefSeqiNP_071549.1. NM_022213.1.
UniGeneiRn.44448.

Genome annotation databases

GeneIDi60664.
KEGGirno:60664.
UCSCiRGD:621042. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64047 mRNA. Translation: BAA10927.1 .
RefSeqi NP_071549.1. NM_022213.1.
UniGenei Rn.44448.

3D structure databases

ProteinModelPortali Q63789.
SMRi Q63789. Positions 58-331, 348-455.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000157.

PTM databases

PhosphoSitei Q63789.

Proteomic databases

PaxDbi Q63789.
PRIDEi Q63789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 60664.
KEGGi rno:60664.
UCSCi RGD:621042. rat.

Organism-specific databases

CTDi 8503.
RGDi 621042. Pik3r3.

Phylogenomic databases

eggNOGi NOG249532.
HOGENOMi HOG000008438.
HOVERGENi HBG082100.
InParanoidi Q63789.
KOi K02649.
PhylomeDBi Q63789.

Miscellaneous databases

NextBioi 612373.
PROi Q63789.

Gene expression databases

Genevestigatori Q63789.

Family and domain databases

Gene3Di 3.30.505.10. 2 hits.
InterProi IPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view ]
PANTHERi PTHR10155. PTHR10155. 1 hit.
Pfami PF00017. SH2. 2 hits.
[Graphical view ]
PRINTSi PR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTi SM00252. SH2. 2 hits.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 2 hits.
PROSITEi PS50001. SH2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK is generated by alternative splicing of the p85alpha gene."
    Inukai K., Anai M., van Breda E., Hosaka T., Katagiri H., Funaki M., Fukushima Y., Ogihara T., Yazaki Y., Kikuchi M., Oka Y., Asano T.
    J. Biol. Chem. 271:5317-5320(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiP55G_RAT
AccessioniPrimary (citable) accession number: Q63789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3