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Q63789

- P55G_RAT

UniProt

Q63789 - P55G_RAT

Protein

Phosphatidylinositol 3-kinase regulatory subunit gamma

Gene

Pik3r3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase regulator activity Source: RGD

    GO - Biological processi

    1. regulation of phosphatidylinositol 3-kinase activity Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase regulatory subunit gamma
    Short name:
    PI3-kinase regulatory subunit gamma
    Short name:
    PI3K regulatory subunit gamma
    Short name:
    PtdIns-3-kinase regulatory subunit gamma
    Alternative name(s):
    Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
    Short name:
    PI3-kinase subunit p55-gamma
    Short name:
    PtdIns-3-kinase regulatory subunit p55-gamma
    p55PIK
    Gene namesi
    Name:Pik3r3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621042. Pik3r3.

    Subcellular locationi

    GO - Cellular componenti

    1. phosphatidylinositol 3-kinase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Phosphatidylinositol 3-kinase regulatory subunit gammaPRO_0000080769Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei341 – 3411PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ63789.
    PRIDEiQ63789.

    PTM databases

    PhosphoSiteiQ63789.

    Expressioni

    Tissue specificityi

    Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen.

    Gene expression databases

    GenevestigatoriQ63789.

    Interactioni

    Subunit structurei

    Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000157.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63789.
    SMRiQ63789. Positions 58-331, 348-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 16399SH2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini358 – 45598SH2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3K p85 subunit family.Curated
    Contains 2 SH2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain

    Phylogenomic databases

    eggNOGiNOG249532.
    HOGENOMiHOG000008438.
    HOVERGENiHBG082100.
    InParanoidiQ63789.
    KOiK02649.
    PhylomeDBiQ63789.

    Family and domain databases

    Gene3Di3.30.505.10. 2 hits.
    InterProiIPR001720. PI3kinase_P85.
    IPR000980. SH2.
    [Graphical view]
    PANTHERiPTHR10155. PTHR10155. 1 hit.
    PfamiPF00017. SH2. 2 hits.
    [Graphical view]
    PRINTSiPR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTiSM00252. SH2. 2 hits.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 2 hits.
    PROSITEiPS50001. SH2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63789-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPVTSAVT    50
    NGMKDCFVSL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY 100
    TLTLRKGGNN KLIKIYHRDG NYGFSEPLTF NSVVELINHY HHESLAQYNP 150
    KLDVKLMYPV SRYQQDQLVK EDNIDAVGKN LQEFHSQYQE KSKEYDRLYE 200
    EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKDY IERFRREGNE 250
    KEIERIMMNY DKLKSRLGEI HDSKVRLEQD LKKQALDNRE IDKKMNSIKP 300
    DLIQLRKIRD QHLVWLNHRG VRQRRLNAWL GIKSEDTDES YFINEDDESL 350
    PHYDEKTWFV EDVNRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE 400
    VKPCVIYSPA RGYGFAEPYN LYGSLKELVL HYQQTSLVQH NDSLNVTLAY 450
    PVHAQMPSLC R 461
    Length:461
    Mass (Da):54,254
    Last modified:November 1, 1996 - v1
    Checksum:i6467D88447CC562B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D64047 mRNA. Translation: BAA10927.1.
    RefSeqiNP_071549.1. NM_022213.1.
    UniGeneiRn.44448.

    Genome annotation databases

    GeneIDi60664.
    KEGGirno:60664.
    UCSCiRGD:621042. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D64047 mRNA. Translation: BAA10927.1 .
    RefSeqi NP_071549.1. NM_022213.1.
    UniGenei Rn.44448.

    3D structure databases

    ProteinModelPortali Q63789.
    SMRi Q63789. Positions 58-331, 348-455.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000157.

    PTM databases

    PhosphoSitei Q63789.

    Proteomic databases

    PaxDbi Q63789.
    PRIDEi Q63789.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 60664.
    KEGGi rno:60664.
    UCSCi RGD:621042. rat.

    Organism-specific databases

    CTDi 8503.
    RGDi 621042. Pik3r3.

    Phylogenomic databases

    eggNOGi NOG249532.
    HOGENOMi HOG000008438.
    HOVERGENi HBG082100.
    InParanoidi Q63789.
    KOi K02649.
    PhylomeDBi Q63789.

    Miscellaneous databases

    NextBioi 612373.
    PROi Q63789.

    Gene expression databases

    Genevestigatori Q63789.

    Family and domain databases

    Gene3Di 3.30.505.10. 2 hits.
    InterProi IPR001720. PI3kinase_P85.
    IPR000980. SH2.
    [Graphical view ]
    PANTHERi PTHR10155. PTHR10155. 1 hit.
    Pfami PF00017. SH2. 2 hits.
    [Graphical view ]
    PRINTSi PR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTi SM00252. SH2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 2 hits.
    PROSITEi PS50001. SH2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK is generated by alternative splicing of the p85alpha gene."
      Inukai K., Anai M., van Breda E., Hosaka T., Katagiri H., Funaki M., Fukushima Y., Ogihara T., Yazaki Y., Kikuchi M., Oka Y., Asano T.
      J. Biol. Chem. 271:5317-5320(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.

    Entry informationi

    Entry nameiP55G_RAT
    AccessioniPrimary (citable) accession number: Q63789
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3