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Q63789 (P55G_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 3-kinase regulatory subunit gamma

Short name=PI3-kinase regulatory subunit gamma
Short name=PI3K regulatory subunit gamma
Short name=PtdIns-3-kinase regulatory subunit gamma
Alternative name(s):
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
Short name=PI3-kinase subunit p55-gamma
Short name=PtdIns-3-kinase regulatory subunit p55-gamma
p55PIK
Gene names
Name:Pik3r3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Subunit structure

Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL By similarity.

Tissue specificity

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen.

Sequence similarities

Belongs to the PI3K p85 subunit family.

Contains 2 SH2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Phosphatidylinositol 3-kinase regulatory subunit gamma
PRO_0000080769

Regions

Domain65 – 16399SH2 1
Domain358 – 45598SH2 2

Amino acid modifications

Modified residue3411Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63789 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6467D88447CC562B

FASTA46154,254
        10         20         30         40         50         60 
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPVTSAVT NGMKDCFVSL 

        70         80         90        100        110        120 
QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY TLTLRKGGNN KLIKIYHRDG 

       130        140        150        160        170        180 
NYGFSEPLTF NSVVELINHY HHESLAQYNP KLDVKLMYPV SRYQQDQLVK EDNIDAVGKN 

       190        200        210        220        230        240 
LQEFHSQYQE KSKEYDRLYE EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKDY 

       250        260        270        280        290        300 
IERFRREGNE KEIERIMMNY DKLKSRLGEI HDSKVRLEQD LKKQALDNRE IDKKMNSIKP 

       310        320        330        340        350        360 
DLIQLRKIRD QHLVWLNHRG VRQRRLNAWL GIKSEDTDES YFINEDDESL PHYDEKTWFV 

       370        380        390        400        410        420 
EDVNRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE VKPCVIYSPA RGYGFAEPYN 

       430        440        450        460 
LYGSLKELVL HYQQTSLVQH NDSLNVTLAY PVHAQMPSLC R 

« Hide

References

[1]"A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK is generated by alternative splicing of the p85alpha gene."
Inukai K., Anai M., van Breda E., Hosaka T., Katagiri H., Funaki M., Fukushima Y., Ogihara T., Yazaki Y., Kikuchi M., Oka Y., Asano T.
J. Biol. Chem. 271:5317-5320(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D64047 mRNA. Translation: BAA10927.1.
RefSeqNP_071549.1. NM_022213.1.
UniGeneRn.44448.

3D structure databases

ProteinModelPortalQ63789.
SMRQ63789. Positions 58-331, 348-455.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000000157.

PTM databases

PhosphoSiteQ63789.

Proteomic databases

PaxDbQ63789.
PRIDEQ63789.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID60664.
KEGGrno:60664.
UCSCRGD:621042. rat.

Organism-specific databases

CTD8503.
RGD621042. Pik3r3.

Phylogenomic databases

eggNOGNOG249532.
HOGENOMHOG000008438.
HOVERGENHBG082100.
InParanoidQ63789.
KOK02649.
PhylomeDBQ63789.

Gene expression databases

GenevestigatorQ63789.

Family and domain databases

Gene3D3.30.505.10. 2 hits.
InterProIPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERPTHR10155. PTHR10155. 1 hit.
PfamPF00017. SH2. 2 hits.
[Graphical view]
PRINTSPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMSSF55550. SSF55550. 2 hits.
PROSITEPS50001. SH2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio612373.
PROQ63789.

Entry information

Entry nameP55G_RAT
AccessionPrimary (citable) accession number: Q63789
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families