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Q63788

- P85B_RAT

UniProt

Q63788 - P85B_RAT

Protein

Phosphatidylinositol 3-kinase regulatory subunit beta

Gene

Pik3r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

    GO - Molecular functioni

    1. phosphatidylinositol 3-kinase regulator activity Source: InterPro

    GO - Biological processi

    1. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    2. signal transduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase regulatory subunit beta
    Short name:
    PI3-kinase regulatory subunit beta
    Short name:
    PI3K regulatory subunit beta
    Short name:
    PtdIns-3-kinase regulatory subunit beta
    Alternative name(s):
    Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
    Short name:
    PI3-kinase subunit p85-beta
    Short name:
    PtdIns-3-kinase regulatory subunit p85-beta
    Gene namesi
    Name:Pik3r2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi68341. Pik3r2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. phosphatidylinositol 3-kinase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 722722Phosphatidylinositol 3-kinase regulatory subunit betaPRO_0000080765Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei458 – 4581PhosphotyrosineBy similarity
    Modified residuei599 – 5991PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated in response to signaling from activated receptor-type protein kinases. Dephosphorylated by PTPRJ By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ63788.
    PRIDEiQ63788.

    PTM databases

    PhosphoSiteiQ63788.

    Expressioni

    Gene expression databases

    GenevestigatoriQ63788.

    Interactioni

    Subunit structurei

    Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated). Interacts with NYAP1, NYAP2 and MYO16 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ63788.
    SMRiQ63788. Positions 4-86, 318-590, 608-712.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 8077SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini112 – 289178Rho-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini324 – 41996SH2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini616 – 71095SH2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3K p85 subunit family.Curated
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 2 SH2 domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiNOG263689.
    HOGENOMiHOG000008438.
    HOVERGENiHBG082100.
    InParanoidiQ63788.
    PhylomeDBiQ63788.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    3.30.505.10. 2 hits.
    InterProiIPR001720. PI3kinase_P85.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR10155. PTHR10155. 1 hit.
    PfamiPF00620. RhoGAP. 1 hit.
    PF00017. SH2. 2 hits.
    [Graphical view]
    PRINTSiPR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTiSM00324. RhoGAP. 1 hit.
    SM00252. SH2. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEiPS50238. RHOGAP. 1 hit.
    PS50001. SH2. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63788-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGAEGFQYR AVYPFRRERP EDLELLPGDL LVVSRVALQA LGVADGGERC    50
    PHNVGWMPGF NERTRQRGDF PGTYVEFLGP VALARPGPRP RGPRPLPARP 100
    LDGPSESGHT LASLAEQFSP PESAPPILVK LIEAIEQAEL DSEFYSRPEL 150
    PAPRTDWSLS DLEQWDRTTL YDAVKGFLLA LPAAVVTPEA ASEAYRAMRE 200
    VTGPVGLVLE PPTLPLHQAL TLRFLLQHLG RVARRAPSPA TAVHALASAF 250
    GPLLLRAPPP GGEGDGSEPA PDFPVLLLER LVQEHVDEQD TAPPALPPKP 300
    SKVKPAPTAL ANGGSTPSLQ DAEWYWGDIS REEVNERLRD TPDGTFLVRD 350
    ASSKIQGEYT LTLRKGGNNK LIKVFHRDGH YGFSEPLTFC SVVELISHYR 400
    HESLAQYNAK LDTRLLYPVS KYQQDQVVKE DSVEAVGAQL KVYHQQYQDK 450
    SREYDQLYEE YTRTSQELQM KRTAIEAFNE TILIFEEQGQ TQEKCSKEYL 500
    ERFRREGNEK EMQRILLNSE RLKSRIAEIH ESRTKLEQDL RAQASDNREI 550
    DKRMNSLKPD LMQLRKIRDQ YLVWLTQKGA RQRKINEWLG IKNETEDQYS 600
    LMEDEDALPH HEERTWYVGK INRTQAEEML SAKRDGTFLI RESSQRGCYA 650
    CSVVVDGDTK HCVIYRTATG FGFAEPYNLY GSLKELVLHY QHASLVQHND 700
    ALTVTLAHPV RAPGPGPPPA AR 722
    Length:722
    Mass (Da):81,329
    Last modified:November 1, 1996 - v1
    Checksum:i1208368B9F6F0C95
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D64046 mRNA. Translation: BAA10926.1.
    UniGeneiRn.22497.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D64046 mRNA. Translation: BAA10926.1 .
    UniGenei Rn.22497.

    3D structure databases

    ProteinModelPortali Q63788.
    SMRi Q63788. Positions 4-86, 318-590, 608-712.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q63788.

    Proteomic databases

    PaxDbi Q63788.
    PRIDEi Q63788.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 68341. Pik3r2.

    Phylogenomic databases

    eggNOGi NOG263689.
    HOGENOMi HOG000008438.
    HOVERGENi HBG082100.
    InParanoidi Q63788.
    PhylomeDBi Q63788.

    Miscellaneous databases

    PROi Q63788.

    Gene expression databases

    Genevestigatori Q63788.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    3.30.505.10. 2 hits.
    InterProi IPR001720. PI3kinase_P85.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR10155. PTHR10155. 1 hit.
    Pfami PF00620. RhoGAP. 1 hit.
    PF00017. SH2. 2 hits.
    [Graphical view ]
    PRINTSi PR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTi SM00324. RhoGAP. 1 hit.
    SM00252. SH2. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEi PS50238. RHOGAP. 1 hit.
    PS50001. SH2. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK is generated by alternative splicing of the p85alpha gene."
      Inukai K., Anai M., van Breda E., Hosaka T., Katagiri H., Funaki M., Fukushima Y., Ogihara T., Yazaki Y., Kikuchi M., Oka Y., Asano T.
      J. Biol. Chem. 271:5317-5320(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.

    Entry informationi

    Entry nameiP85B_RAT
    AccessioniPrimary (citable) accession number: Q63788
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3