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Protein

Growth arrest-specific protein 6

Gene

Gas6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi326 – 3261CalciumBy similarity
Metal bindingi328 – 3281Calcium; via carbonyl oxygenBy similarity
Metal bindingi437 – 4371Calcium; via carbonyl oxygenBy similarity
Metal bindingi652 – 6521CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.
R-RNO-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-RNO-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
R-RNO-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 6
Short name:
GAS-6
Alternative name(s):
AXL receptor tyrosine kinase ligand
Growth-potentiating factor
Short name:
GPF
Gene namesi
Name:Gas6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi61913. Gas6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: Ensembl
  • extracellular space Source: UniProtKB
  • intracellular Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 674647Growth arrest-specific protein 6PRO_0000007591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 67By similarity
Modified residuei68 – 681PhosphoserineBy similarity
Disulfide bondi117 ↔ 130By similarity
Disulfide bondi122 ↔ 139By similarity
Disulfide bondi141 ↔ 150By similarity
Disulfide bondi157 ↔ 168By similarity
Disulfide bondi164 ↔ 177By similarity
Disulfide bondi179 ↔ 192By similarity
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi198 ↔ 209By similarity
Disulfide bondi204 ↔ 218By similarity
Disulfide bondi220 ↔ 233By similarity
Disulfide bondi239 ↔ 248By similarity
Disulfide bondi244 ↔ 257By similarity
Disulfide bondi259 ↔ 274By similarity
Disulfide bondi280 ↔ 566By similarity
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi441 ↔ 467By similarity
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence analysis
Modified residuei609 – 6091PhosphothreonineCombined sources
Modified residuei614 – 6141PhosphoserineCombined sources
Modified residuei617 – 6171PhosphothreonineCombined sources
Modified residuei633 – 6331PhosphothreonineCombined sources
Modified residuei636 – 6361PhosphotyrosineCombined sources
Disulfide bondi639 ↔ 666By similarity

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium (Probable).1 Publication

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63772.
PRIDEiQ63772.

PTM databases

iPTMnetiQ63772.
PhosphoSiteiQ63772.

Expressioni

Tissue specificityi

Plasma.1 Publication

Gene expression databases

BgeeiENSRNOG00000018233.
ExpressionAtlasiQ63772. baseline and differential.
GenevisibleiQ63772. RN.

Interactioni

Subunit structurei

Heterodimer and heterotetramer with AXL.

GO - Molecular functioni

  • growth factor activity Source: RGD
  • receptor binding Source: UniProtKB
  • receptor tyrosine kinase binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024677.

Structurei

3D structure databases

ProteinModelPortaliQ63772.
SMRiQ63772. Positions 50-89, 276-670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 9142GlaPROSITE-ProRule annotationAdd
BLAST
Domaini113 – 15139EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini153 – 19341EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini194 – 23441EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini235 – 27541EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini295 – 467173Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini474 – 666193Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EGF-like domains.PROSITE-ProRule annotation
Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IGK1. Eukaryota.
ENOG410ZPM2. LUCA.
GeneTreeiENSGT00530000063339.
HOGENOMiHOG000065758.
HOVERGENiHBG051702.
InParanoidiQ63772.
OMAiPVIRLRF.
OrthoDBiEOG091G034Z.
PhylomeDBiQ63772.
TreeFamiTF352157.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPPGPTAA LGTALLLLLL ASESSHTVLL RAREAAQFLR PRQRRAYQVF
60 70 80 90 100
EEAKQGHLER ECVEEVCSKE EAREVFENDP ETDYFYPRYQ ECMRKYGRPE
110 120 130 140 150
DKNPNFATCV KNLPDQCTPN PCDKKGTQLC QDLMGNFFCL CKDGWGGRLC
160 170 180 190 200
DKDVNECSQK NGGCSQVCHN KPGSFQCACH SGFSLQSDNK SCQDIDECTD
210 220 230 240 250
SDTCGDARCK NLPGSYSCLC DKGYTYSSKE KTCQDVDECQ QDRCEQTCVN
260 270 280 290 300
SPGSYTCHCN GRGGLKLSPD MDTCEDILPC VPFSMAKSVK SLYLGRMFSG
310 320 330 340 350
TPVIRLRFKR LQPTRLLAEF DFRTFDPEGV LFFAGGRSDS TWIVLGLRAG
360 370 380 390 400
RLELQLRYNG VGRITSSGPT INHGMWQTIS VEELDRNLVI KVNKDAVMKI
410 420 430 440 450
AVAGGLFQLE RGLYHLNLTV GGIPFKESDL VQPINPRLDG CMRSWNWLNG
460 470 480 490 500
EDSAIQETVK ANTKMQCFSV TERGSFFPGN GFAFYSLNYT RTSLDVGTET
510 520 530 540 550
TWEVEVVARI RPATDTGVLM ALVGDKDVVL LSVALVDYHS TKKLKKQLVV
560 570 580 590 600
LAVENVALAL MEIKVCDSQE HTVTVSLRDG EATLEVDGTK GQSEVSTAQL
610 620 630 640 650
QERLDLLKTR LQGSVLTFVG GLPDVQVTST PVTAFYRGCM TLEVNGKTLD
660 670
LDTASYKHSD ITSHSCPPVE HVTA
Length:674
Mass (Da):74,638
Last modified:November 1, 1996 - v1
Checksum:iFBF8F6B8664D6F2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42148 mRNA. Translation: BAA07719.1.
PIRiI55476.
UniGeneiRn.52228.

Genome annotation databases

EnsembliENSRNOT00000024677; ENSRNOP00000024677; ENSRNOG00000018233.
UCSCiRGD:61913. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42148 mRNA. Translation: BAA07719.1.
PIRiI55476.
UniGeneiRn.52228.

3D structure databases

ProteinModelPortaliQ63772.
SMRiQ63772. Positions 50-89, 276-670.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024677.

PTM databases

iPTMnetiQ63772.
PhosphoSiteiQ63772.

Proteomic databases

PaxDbiQ63772.
PRIDEiQ63772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024677; ENSRNOP00000024677; ENSRNOG00000018233.
UCSCiRGD:61913. rat.

Organism-specific databases

RGDi61913. Gas6.

Phylogenomic databases

eggNOGiENOG410IGK1. Eukaryota.
ENOG410ZPM2. LUCA.
GeneTreeiENSGT00530000063339.
HOGENOMiHOG000065758.
HOVERGENiHBG051702.
InParanoidiQ63772.
OMAiPVIRLRF.
OrthoDBiEOG091G034Z.
PhylomeDBiQ63772.
TreeFamiTF352157.

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.
R-RNO-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-RNO-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
R-RNO-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

PROiQ63772.

Gene expression databases

BgeeiENSRNOG00000018233.
ExpressionAtlasiQ63772. baseline and differential.
GenevisibleiQ63772. RN.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAS6_RAT
AccessioniPrimary (citable) accession number: Q63772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.