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Protein

Sushi repeat-containing protein SRPX

Gene

Srpx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi repeat-containing protein SRPX
Alternative name(s):
Down-regulated by v-SRC
Short name:
DRS
Gene namesi
Name:Srpx
Synonyms:Drs
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi70950. Srpx.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 464436Sushi repeat-containing protein SRPXPRO_0000022418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 85PROSITE-ProRule annotation
Disulfide bondi69 ↔ 103PROSITE-ProRule annotation
Disulfide bondi89 ↔ 115PROSITE-ProRule annotation
Disulfide bondi120 ↔ 161PROSITE-ProRule annotation
Disulfide bondi147 ↔ 174PROSITE-ProRule annotation
Disulfide bondi262 ↔ 304PROSITE-ProRule annotation
Disulfide bondi290 ↔ 317PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ63769.
PRIDEiQ63769.

Expressioni

Tissue specificityi

Normal cells and cells transformed by human papillomavirus type 16 E6E7 and polyomavirus large T. Suppressed in cells transformed by oncogenes such as V-SRC, V-ABL, V-FPS, V-MOS, V-SIS, V-K-RAS, and polyomavirus middle T.

Gene expression databases

GenevisibleiQ63769. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048924.

Structurei

3D structure databases

ProteinModelPortaliQ63769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 11761Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini118 – 17659Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini177 – 25983HYRPROSITE-ProRule annotationAdd
BLAST
Domaini260 – 31960Sushi 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HYR domain.PROSITE-ProRule annotation
Contains 3 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IEWW. Eukaryota.
ENOG410XP80. LUCA.
GeneTreeiENSGT00730000110685.
HOGENOMiHOG000232093.
HOVERGENiHBG007217.
InParanoidiQ63769.
OMAiRVRRCGK.
OrthoDBiEOG7GN2MN.
PhylomeDBiQ63769.
TreeFamiTF336515.

Family and domain databases

InterProiIPR025232. DUF4174.
IPR003410. HYR_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF13778. DUF4174. 1 hit.
PF02494. HYR. 1 hit.
PF00084. Sushi. 3 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50825. HYR. 1 hit.
PS50923. SUSHI. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q63769-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSPGLRPTL LLPQVLLLLL ALLHVPPSQG FPGSGDSPLE DDGVWSSHSL
60 70 80 90 100
YKDTPWCSPI KVKYGDVYCR APPGGYYKTA LGTRCDIRCR KGYELHGSSQ
110 120 130 140 150
LVCQSNRRWS DKVICKQKRC PTLTMPANGG FKCVDGAYFN SRCEYYCSPG
160 170 180 190 200
YTLKGERTVT CMDNKAWSGR PASCVDMEPP RIKCPSVKER IAEPNKLTVR
210 220 230 240 250
VSWETPEGRD TADGILTDVI LRGLPPGSNF PEGDHKIEYT VYDRAENKGT
260 270 280 290 300
CKFRVKVRVR RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP
310 320 330 340 350
ARVCQSNLAW SGTEPSCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA
360 370 380 390 400
RNLLYRLQLG MLQQAQCGLD LRHITVVELV GVFPTLIGRI RAKIMPPALA
410 420 430 440 450
LQLRLLLRIP LYSFSMVLVD KHGMDKERYV SLVTPMALFN LIDTFPLRKE
460
EMILQAEMGQ SCNT
Length:464
Mass (Da):51,560
Last modified:November 1, 1996 - v1
Checksum:iB27C5B163090A97E
GO
Isoform 2 (identifier: Q63769-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-52: Missing.

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):49,442
Checksum:i63D593577F7CEBDC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei33 – 5220Missing in isoform 2. 1 PublicationVSP_014017Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78359 mRNA. Translation: BAA11371.1.
BC087639 mRNA. Translation: AAH87639.1.
RefSeqiNP_071969.1. NM_022524.1. [Q63769-1]
XP_006256745.1. XM_006256683.2. [Q63769-2]
UniGeneiRn.1489.

Genome annotation databases

EnsembliENSRNOT00000045753; ENSRNOP00000048924; ENSRNOG00000039666. [Q63769-1]
GeneIDi64316.
KEGGirno:64316.
UCSCiRGD:70950. rat. [Q63769-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78359 mRNA. Translation: BAA11371.1.
BC087639 mRNA. Translation: AAH87639.1.
RefSeqiNP_071969.1. NM_022524.1. [Q63769-1]
XP_006256745.1. XM_006256683.2. [Q63769-2]
UniGeneiRn.1489.

3D structure databases

ProteinModelPortaliQ63769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048924.

Proteomic databases

PaxDbiQ63769.
PRIDEiQ63769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045753; ENSRNOP00000048924; ENSRNOG00000039666. [Q63769-1]
GeneIDi64316.
KEGGirno:64316.
UCSCiRGD:70950. rat. [Q63769-1]

Organism-specific databases

CTDi8406.
RGDi70950. Srpx.

Phylogenomic databases

eggNOGiENOG410IEWW. Eukaryota.
ENOG410XP80. LUCA.
GeneTreeiENSGT00730000110685.
HOGENOMiHOG000232093.
HOVERGENiHBG007217.
InParanoidiQ63769.
OMAiRVRRCGK.
OrthoDBiEOG7GN2MN.
PhylomeDBiQ63769.
TreeFamiTF336515.

Miscellaneous databases

NextBioi612996.
PROiQ63769.

Gene expression databases

GenevisibleiQ63769. RN.

Family and domain databases

InterProiIPR025232. DUF4174.
IPR003410. HYR_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF13778. DUF4174. 1 hit.
PF02494. HYR. 1 hit.
PF00084. Sushi. 3 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50825. HYR. 1 hit.
PS50923. SUSHI. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Fischer.
    Tissue: Embryonic fibroblast.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Ovary.

Entry informationi

Entry nameiSRPX_RAT
AccessioniPrimary (citable) accession number: Q63769
Secondary accession number(s): Q5PPK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.