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Protein

Antizyme inhibitor 1

Gene

Azin1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity. Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Polyamine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Antizyme inhibitor 1
Short name:
AZI
Alternative name(s):
Ornithine decarboxylase antizyme inhibitor
Gene namesi
Name:Azin1
Synonyms:Oazi, Oazin
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61934. Azin1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Antizyme inhibitor 1PRO_0000149994Add
BLAST

Post-translational modificationi

Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei69 – 691Not modifiedBy similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ63764.

Expressioni

Tissue specificityi

Expressed in various tissues including liver, heart and kidney.

Interactioni

Subunit structurei

Interacts with OAZ1 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation (By similarity). Monomer.By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007999.

Structurei

3D structure databases

ProteinModelPortaliQ63764.
SMRiQ63764. Positions 8-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiQ63764.
PhylomeDBiQ63764.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR031178. Azin1.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF7. PTHR11482:SF7. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK
60 70 80 90 100
KHSQWQNVVA QIKPFYMVKC NSTPAVLEIL AALGTGFACS TKNEMALVQE
110 120 130 140 150
LGVSPENIIY TSPCKQASQI KYAAKVGVNI MTCDNEVELK KIARNHPNAK
160 170 180 190 200
VLLHIATEDN IGGEDGNMKF GTTLKNCRHL LECAKELDVQ IIGVKFHISS
210 220 230 240 250
ACKEYQVYVH ALSDARCVFD MAGEFGFTMN MLDIGGGFTG TEIQLEEVNH
260 270 280 290 300
VISPLLDIYF PEGSGIQIIS EPGSYYVSSA FTLAVNIIAK KVVENDKLSS
310 320 330 340 350
GVEKNGSDEP AFVYYMNDGV YGSFASKLSE DLNTVPEVHK KYKEDEPLFT
360 370 380 390 400
SSLWGPSCDE LDQIVESCLL PELSVGDWLI FDNMGADSLH GPSAFSDTQR
410 420 430 440
PAIYFMMSLS DWYEMQDAGI TSDAMMKNFF FAPSCIQLSQ EDNFSTEA
Length:448
Mass (Da):49,333
Last modified:November 1, 1996 - v1
Checksum:iB9A630098ECBA5DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50734 mRNA. Translation: BAA09365.1.
D89983 mRNA. Translation: BAA23594.1.
UniGeneiRn.6290.

Genome annotation databases

UCSCiRGD:61934. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50734 mRNA. Translation: BAA09365.1.
D89983 mRNA. Translation: BAA23594.1.
UniGeneiRn.6290.

3D structure databases

ProteinModelPortaliQ63764.
SMRiQ63764. Positions 8-435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007999.

Proteomic databases

PaxDbiQ63764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:61934. rat.

Organism-specific databases

RGDi61934. Azin1.

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiQ63764.
PhylomeDBiQ63764.

Miscellaneous databases

NextBioi611600.
PROiQ63764.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR031178. Azin1.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF7. PTHR11482:SF7. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of antizyme inhibitor, a highly homologous protein to ornithine decarboxylase."
    Murakami Y., Ichiba T., Matsufuji S., Hayashi S.
    J. Biol. Chem. 271:3340-3342(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Heart.
  2. "Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor."
    Koguchi K., Kobayashi S., Hayashi T., Matsufuji S., Murakami Y., Hayashi S.
    Biochim. Biophys. Acta 1353:209-216(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  3. "Purification and characterization of antizyme inhibitor of ornithine decarboxylase from rat liver."
    Kitani T., Fujisawa H.
    Biochim. Biophys. Acta 991:44-49(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.

Entry informationi

Entry nameiAZIN1_RAT
AccessioniPrimary (citable) accession number: Q63764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.