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Protein

L-selectin

Gene

Sell

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesionUniRule annotation

Keywords - Ligandi

LectinImported

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectinUniRule annotation
Gene namesi
Name:SellImported
ORF Names:rCG_45999Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3655. Sell.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei334 – 35522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 372344L-selectinSequence analysisPRO_5007707465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 155UniRule annotation
Disulfide bondi128 ↔ 147UniRule annotation
Disulfide bondi160 ↔ 171UniRule annotation
Disulfide bondi165 ↔ 180UniRule annotation
Disulfide bondi182 ↔ 191UniRule annotation
Disulfide bondi197 ↔ 241UniRule annotation
Disulfide bondi227 ↔ 254UniRule annotation
Disulfide bondi259 ↔ 303UniRule annotation
Disulfide bondi289 ↔ 316UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003733.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 156123C-type lectinInterPro annotationAdd
BLAST
Domaini156 – 19237EGF-likeInterPro annotationAdd
BLAST
Domaini195 – 25662Sushi (CCP/SCR)InterPro annotationAdd
BLAST
Domaini257 – 31862Sushi (CCP/SCR)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the selectin/LECAM family.UniRule annotation
Contains C-type lectin domain.SAAS annotation

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, SushiSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IS3T. Eukaryota.
ENOG410YB82. LUCA.
HOVERGENiHBG052375.
KOiK06495.
OMAiEAENWGD.
OrthoDBiEOG7DZ8J9.
TreeFamiTF326910.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFPWRCQSA QRGSWSFLKL WIWTLLCCDL LPHHGTHCWT YHYSERSMNW
60 70 80 90 100
ENARKFCKHN YTDLVAIQNK REIEYLEKTL PKNPTYYWIG IRKIGKTWTW
110 120 130 140 150
VGTNKTLTKE AENWGTGEPN NKKSKEDCVE IYIKRERDSG KWNDDACHKR
160 170 180 190 200
KAALCYTASC QPESCNRHGE CVETINNNTC ICDPGYYGPQ CQYVIQCEPL
210 220 230 240 250
KAPELGTMNC IHPLGDFSFQ SQCAFNCSEG SELLGNAKTE CGASGNWTYL
260 270 280 290 300
EPICQVIQCM PLAAPDLGTM ECSHPLANFS FTSACTFTCS EETDLIGERK
310 320 330 340 350
TVCRSSGSWS SPSPICQKTK RSFSKIKEGD YNPLFIPVAV MVTAFSGLAF
360 370
IIWLARRLKK GKKSQERMDD PY
Length:372
Mass (Da):42,471
Last modified:November 1, 1996 - v1
Checksum:i7DFD125610DD6E4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79523 mRNA. Translation: AAC60710.2.
CH473958 Genomic DNA. Translation: EDM09363.1.
RefSeqiNP_062050.3. NM_019177.3.
UniGeneiRn.10461.

Genome annotation databases

GeneIDi29259.
KEGGirno:29259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79523 mRNA. Translation: AAC60710.2.
CH473958 Genomic DNA. Translation: EDM09363.1.
RefSeqiNP_062050.3. NM_019177.3.
UniGeneiRn.10461.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29259.
KEGGirno:29259.

Organism-specific databases

CTDi6402.
RGDi3655. Sell.

Phylogenomic databases

eggNOGiENOG410IS3T. Eukaryota.
ENOG410YB82. LUCA.
HOVERGENiHBG052375.
KOiK06495.
OMAiEAENWGD.
OrthoDBiEOG7DZ8J9.
TreeFamiTF326910.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evidence of post-transcriptional regulation of L-selectin gene expression in rat lymphoid cells."
    Sackstein R., Meng L., Xu X.M., Chin Y.H.
    Immunology 85:198-204(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.

Entry informationi

Entry nameiQ63762_RAT
AccessioniPrimary (citable) accession number: Q63762
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.