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Q63755 (PRDM2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
PR domain zinc finger protein 2
EC=2.1.1.43
Alternative name(s):
PR domain-containing protein 2
Retinoblastoma protein-interacting zinc finger protein
Zinc finger protein RIZ
Gene names
Name:Prdm2
Synonyms:Riz
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length1706 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subunit structure

Binds to the retinoblastoma protein (RB). Interacts with GATA3 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 8 C2H2-type zinc fingers.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17061706PR domain zinc finger protein 2
PRO_0000047759

Regions

Domain26 – 144119SET
Zinc finger355 – 37723C2H2-type 1
Zinc finger385 – 40723C2H2-type 2
Zinc finger476 – 49924C2H2-type 3
Zinc finger1123 – 114523C2H2-type 4
Zinc finger1151 – 117424C2H2-type 5
Zinc finger1180 – 120324C2H2-type 6
Zinc finger1321 – 134323C2H2-type 7; atypical
Zinc finger1443 – 146523C2H2-type 8; atypical
Compositional bias246 – 32782Glu-rich
Compositional bias893 – 1067175Pro-rich
Compositional bias1472 – 156594Ser-rich

Amino acid modifications

Modified residue6371Phosphoserine By similarity
Modified residue7341Phosphoserine By similarity
Modified residue7381Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63755 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 55EA419491D2D68C

FASTA1,706187,555
        10         20         30         40         50         60 
MHQNTESVAA TETLAEVPEH VLRGLPEEVR LFPSAVDKTR IGVWATKPIL KGKKFGPFVG 

        70         80         90        100        110        120 
DKKKRSQVRN NVYMWEVYYP NLGWMCIDAT DPEKGNWLRY VNWACSGEEQ NLFPLEINRA 

       130        140        150        160        170        180 
IYYKTLKPIA PGEELLVWYN GEDNPEIAAA IEEERASARS KRSSPKSRRG KKKSHENKNK 

       190        200        210        220        230        240 
GIRTHPTQLK ASELDSTFAN MRGSAEGPKE EDERPLASAP EQPAPLPEVG NQDAVPQVAI 

       250        260        270        280        290        300 
PLPACEPQPE VDGKQEVTDC EVNDVEEEEL EEEEELEEEE EEELGEDGVE EADMPNESSA 

       310        320        330        340        350        360 
KEPEIRCEEK PEDLLEEPQS MSNEAREDSP DVTPPPHTPR AREEANGDVL ETFMFPCQHC 

       370        380        390        400        410        420 
ERKFATKQGL ERHMHIHIST INHAFKCKYC GKRFGTQINR RRHERRHETG LKRRPSMTLQ 

       430        440        450        460        470        480 
SSEDPDDGKG ENVTSKDESS PPQLGQDCLI LNSEKTSQEV LNSSFVEENG EVKELHPCKY 

       490        500        510        520        530        540 
CKKVFGTHTN MRRHQRRVHE RHLIPKGVRR KGGLLEEPQP PAEQAPPSQN VYVPSTEPEE 

       550        560        570        580        590        600 
EGETDDVYIM DISSNISENL NYYIDGKIQT NSSTSNCDVI EMESNSAHLY GIDCLLTPVT 

       610        620        630        640        650        660 
VEITQNIKST QVSVTDDLLK DSPSSTNCES KKRRTASPPV LPKIKTETES DSTAPSCSLS 

       670        680        690        700        710        720 
LPLSISTAEV VSFHKEKGVY LSSKLKQLLQ TQDKLTLPAG FSAAEIPKLG PVCASAPASM 

       730        740        750        760        770        780 
LPVTSSRFKR RTSSPPSSPQ HSPALRDFGK PNDGKAAWTD TVLTSKKPKL ESRSDSPAWS 

       790        800        810        820        830        840 
LSGRDERETG SPPCFDEYKI SKEWAASSTF SSVCNQQPLD LSSGVKQKSE GTGKTPVPWE 

       850        860        870        880        890        900 
SVLDLSVHKK PCDSEGKEFK ENHLAQPAAK KKKPTTCMLQ KVLLNEYNGV SLPTETTPEV 

       910        920        930        940        950        960 
TRSPSPCKSP DTQPDPELGP DSSCSVPTAE SPPEVVGPSS PPLQTASLSS GQLPPLLTPT 

       970        980        990       1000       1010       1020 
EPSSPPPCPP VLTVATPPPP LLPTVPLSHP SSDASPQQCP SPFSNTTAQS PLPILSPTVS 

      1030       1040       1050       1060       1070       1080 
PSPSPIPPVE PLMSAASPGP PTLSSSSSSS SSFPSSSCSS TSPSPPPLSA VSSVVSSGDN 

      1090       1100       1110       1120       1130       1140 
LEASLPAVTF KQEESESEGL KPKEEAPPAG GQSVVQETFS KNFICNVCES PFLSIKDLTK 

      1150       1160       1170       1180       1190       1200 
HLSVHAEEWP FKCEFCVQLF KVKTDLSEHR FLLHGVGNIF VCSVCKKEFA FLCNLQQHQR 

      1210       1220       1230       1240       1250       1260 
DLHPDEVCTH HEFESGTLRP QNFTDPSKAN VEHMPSLPEE PLETSREEEL NDSSEELYTT 

      1270       1280       1290       1300       1310       1320 
IKIMASGIKT KDPDVRLGLN QHYPSFKPPP FQYHHRNPMG IGVTATNFTT HNIPQTFTTA 

      1330       1340       1350       1360       1370       1380 
IRCTKCGKGV DNMPELHKHI LACASASDKK RYTPKKNPVP LKQTVQPKNG VVVLDNSGKN 

      1390       1400       1410       1420       1430       1440 
AFRRMGQPKR LSFNVELGKM SPNKLKLSAL KKKNQLVQKA ILQKNRAAKQ KADLRDTSEA 

      1450       1460       1470       1480       1490       1500 
SSHICPYCDR EFTYIGSLNK HAAFSCPKKP LSPSKRKVSH SSKKGGHASS SSSDRNSSCH 

      1510       1520       1530       1540       1550       1560 
PRRRTADTEI KMQSTQAPLG KTRARSTGPA QASLPSSSFR SRQNVKFAAS VKSKKASSSS 

      1570       1580       1590       1600       1610       1620 
LRNSSPIRMA KITHVEGKKP KAVAKSHSAQ LSSKSSRGLH VRVQKSKAVI QSKTALASKR 

      1630       1640       1650       1660       1670       1680 
RTDRFIVKSR ERSGGPITRS LQLAAAADLS ESRREDSSAR HELKDFSYSL RLASRCGSST 

      1690       1700 
ASYITRQCRK VKAAAATPFQ GPFLKE

« Hide

References

[1]"The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein."
Buyse I.M., Shao G., Huang S.
Proc. Natl. Acad. Sci. U.S.A. 92:4467-4471(1995) [PubMed: 7538672] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U17837 mRNA. Translation: AAA74468.1.
IPIIPI00327589.
RefSeqNP_001071116.1. NM_001077648.1.
UniGeneRn.202632.

3D structure databases

ProteinModelPortalQ63755.
SMRQ63755. Positions 1-160.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-473N.
STRINGQ63755.

PTM databases

PhosphoSiteQ63755.

Proteomic databases

PRIDEQ63755.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID313678.
KEGGrno:313678.
UCSCU17837. rat.

Organism-specific databases

CTD7799.
RGD1594531. Prdm2.

Phylogenomic databases

eggNOGroNOG04288.
GeneTreeENSGT00530000063182.
HOVERGENHBG053671.
InParanoidQ63755.
OrthoDBEOG48D0TG.

Gene expression databases

ArrayExpressQ63755.
GenevestigatorQ63755.
GermOnlineENSRNOG00000033522. Rattus norvegicus.

Family and domain databases

InterProIPR009170. RIZ_retinblastoma-bd_prot.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
KOK11432.
PANTHERPTHR24402:SF91. PTHR24402:SF91. 1 hit.
PfamPF00856. SET. 1 hit.
PF00096. zf-C2H2. 4 hits.
[Graphical view]
PIRSFPIRSF002395. RIZ_SET. 1 hit.
SMARTSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio666643.

Entry information

Entry namePRDM2_RAT
AccessionPrimary (citable) accession number: Q63755
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: November 1, 1996
Last modified: November 16, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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