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Protein

PR domain zinc finger protein 2

Gene

Prdm2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri355 – 377C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 499C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1123 – 1145C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1151 – 1174C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1180 – 1203C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1321 – 1343C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1443 – 1465C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 2 (EC:2.1.1.43)
Alternative name(s):
PR domain-containing protein 2
Retinoblastoma protein-interacting zinc finger protein
Zinc finger protein RIZ
Gene namesi
Name:Prdm2
Synonyms:Riz
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1594531. Prdm2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477591 – 1706PR domain zinc finger protein 2Add BLAST1706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei416PhosphoserineBy similarity1
Modified residuei637PhosphoserineCombined sources1
Cross-linki645Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei738PhosphoserineBy similarity1
Cross-linki769Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei776PhosphoserineCombined sources1
Modified residuei780PhosphoserineCombined sources1
Modified residuei791PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ63755.
PRIDEiQ63755.

PTM databases

iPTMnetiQ63755.
PhosphoSitePlusiQ63755.

Interactioni

Subunit structurei

Binds to the retinoblastoma protein (RB). Interacts with GATA3 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-473N.
STRINGi10116.ENSRNOP00000046011.

Structurei

3D structure databases

ProteinModelPortaliQ63755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 140SETPROSITE-ProRule annotationAdd BLAST114

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi246 – 327Glu-richAdd BLAST82
Compositional biasi893 – 1067Pro-richAdd BLAST175
Compositional biasi1472 – 1565Ser-richAdd BLAST94

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri355 – 377C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 499C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1123 – 1145C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1151 – 1174C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1180 – 1203C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1321 – 1343C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1443 – 1465C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2461. Eukaryota.
ENOG410ZFVU. LUCA.
HOGENOMiHOG000231078.
HOVERGENiHBG053671.
InParanoidiQ63755.
KOiK11432.
PhylomeDBiQ63755.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR009170. RIZ_retinblastoma-bd_prot.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
PIRSFiPIRSF002395. RIZ_SET. 1 hit.
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHQNTESVAA TETLAEVPEH VLRGLPEEVR LFPSAVDKTR IGVWATKPIL
60 70 80 90 100
KGKKFGPFVG DKKKRSQVRN NVYMWEVYYP NLGWMCIDAT DPEKGNWLRY
110 120 130 140 150
VNWACSGEEQ NLFPLEINRA IYYKTLKPIA PGEELLVWYN GEDNPEIAAA
160 170 180 190 200
IEEERASARS KRSSPKSRRG KKKSHENKNK GIRTHPTQLK ASELDSTFAN
210 220 230 240 250
MRGSAEGPKE EDERPLASAP EQPAPLPEVG NQDAVPQVAI PLPACEPQPE
260 270 280 290 300
VDGKQEVTDC EVNDVEEEEL EEEEELEEEE EEELGEDGVE EADMPNESSA
310 320 330 340 350
KEPEIRCEEK PEDLLEEPQS MSNEAREDSP DVTPPPHTPR AREEANGDVL
360 370 380 390 400
ETFMFPCQHC ERKFATKQGL ERHMHIHIST INHAFKCKYC GKRFGTQINR
410 420 430 440 450
RRHERRHETG LKRRPSMTLQ SSEDPDDGKG ENVTSKDESS PPQLGQDCLI
460 470 480 490 500
LNSEKTSQEV LNSSFVEENG EVKELHPCKY CKKVFGTHTN MRRHQRRVHE
510 520 530 540 550
RHLIPKGVRR KGGLLEEPQP PAEQAPPSQN VYVPSTEPEE EGETDDVYIM
560 570 580 590 600
DISSNISENL NYYIDGKIQT NSSTSNCDVI EMESNSAHLY GIDCLLTPVT
610 620 630 640 650
VEITQNIKST QVSVTDDLLK DSPSSTNCES KKRRTASPPV LPKIKTETES
660 670 680 690 700
DSTAPSCSLS LPLSISTAEV VSFHKEKGVY LSSKLKQLLQ TQDKLTLPAG
710 720 730 740 750
FSAAEIPKLG PVCASAPASM LPVTSSRFKR RTSSPPSSPQ HSPALRDFGK
760 770 780 790 800
PNDGKAAWTD TVLTSKKPKL ESRSDSPAWS LSGRDERETG SPPCFDEYKI
810 820 830 840 850
SKEWAASSTF SSVCNQQPLD LSSGVKQKSE GTGKTPVPWE SVLDLSVHKK
860 870 880 890 900
PCDSEGKEFK ENHLAQPAAK KKKPTTCMLQ KVLLNEYNGV SLPTETTPEV
910 920 930 940 950
TRSPSPCKSP DTQPDPELGP DSSCSVPTAE SPPEVVGPSS PPLQTASLSS
960 970 980 990 1000
GQLPPLLTPT EPSSPPPCPP VLTVATPPPP LLPTVPLSHP SSDASPQQCP
1010 1020 1030 1040 1050
SPFSNTTAQS PLPILSPTVS PSPSPIPPVE PLMSAASPGP PTLSSSSSSS
1060 1070 1080 1090 1100
SSFPSSSCSS TSPSPPPLSA VSSVVSSGDN LEASLPAVTF KQEESESEGL
1110 1120 1130 1140 1150
KPKEEAPPAG GQSVVQETFS KNFICNVCES PFLSIKDLTK HLSVHAEEWP
1160 1170 1180 1190 1200
FKCEFCVQLF KVKTDLSEHR FLLHGVGNIF VCSVCKKEFA FLCNLQQHQR
1210 1220 1230 1240 1250
DLHPDEVCTH HEFESGTLRP QNFTDPSKAN VEHMPSLPEE PLETSREEEL
1260 1270 1280 1290 1300
NDSSEELYTT IKIMASGIKT KDPDVRLGLN QHYPSFKPPP FQYHHRNPMG
1310 1320 1330 1340 1350
IGVTATNFTT HNIPQTFTTA IRCTKCGKGV DNMPELHKHI LACASASDKK
1360 1370 1380 1390 1400
RYTPKKNPVP LKQTVQPKNG VVVLDNSGKN AFRRMGQPKR LSFNVELGKM
1410 1420 1430 1440 1450
SPNKLKLSAL KKKNQLVQKA ILQKNRAAKQ KADLRDTSEA SSHICPYCDR
1460 1470 1480 1490 1500
EFTYIGSLNK HAAFSCPKKP LSPSKRKVSH SSKKGGHASS SSSDRNSSCH
1510 1520 1530 1540 1550
PRRRTADTEI KMQSTQAPLG KTRARSTGPA QASLPSSSFR SRQNVKFAAS
1560 1570 1580 1590 1600
VKSKKASSSS LRNSSPIRMA KITHVEGKKP KAVAKSHSAQ LSSKSSRGLH
1610 1620 1630 1640 1650
VRVQKSKAVI QSKTALASKR RTDRFIVKSR ERSGGPITRS LQLAAAADLS
1660 1670 1680 1690 1700
ESRREDSSAR HELKDFSYSL RLASRCGSST ASYITRQCRK VKAAAATPFQ

GPFLKE
Length:1,706
Mass (Da):187,555
Last modified:November 1, 1996 - v1
Checksum:i55EA419491D2D68C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17837 mRNA. Translation: AAA74468.1.
RefSeqiNP_001071116.1. NM_001077648.1.
UniGeneiRn.202632.

Genome annotation databases

GeneIDi313678.
KEGGirno:313678.
UCSCiRGD:1594531. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17837 mRNA. Translation: AAA74468.1.
RefSeqiNP_001071116.1. NM_001077648.1.
UniGeneiRn.202632.

3D structure databases

ProteinModelPortaliQ63755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-473N.
STRINGi10116.ENSRNOP00000046011.

PTM databases

iPTMnetiQ63755.
PhosphoSitePlusiQ63755.

Proteomic databases

PaxDbiQ63755.
PRIDEiQ63755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi313678.
KEGGirno:313678.
UCSCiRGD:1594531. rat.

Organism-specific databases

CTDi7799.
RGDi1594531. Prdm2.

Phylogenomic databases

eggNOGiKOG2461. Eukaryota.
ENOG410ZFVU. LUCA.
HOGENOMiHOG000231078.
HOVERGENiHBG053671.
InParanoidiQ63755.
KOiK11432.
PhylomeDBiQ63755.

Miscellaneous databases

PROiQ63755.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR009170. RIZ_retinblastoma-bd_prot.
IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
PIRSFiPIRSF002395. RIZ_SET. 1 hit.
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRDM2_RAT
AccessioniPrimary (citable) accession number: Q63755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.