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Protein

Beta-synuclein

Gene

Sncb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal plasticity.

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-synuclein
Alternative name(s):
Phosphoneuroprotein 14
Short name:
PNP 14
Gene namesi
Name:Sncb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70992. Sncb.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • cytoplasm Source: UniProtKB-SubCell
  • growth cone Source: RGD
  • neuronal cell body Source: RGD
  • terminal bouton Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Beta-synucleinPRO_0000184036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei118 – 1181Phosphoserine; by BARK1, CK2 and GRK5By similarity
Modified residuei119 – 1191PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63754.
PRIDEiQ63754.

2D gel databases

World-2DPAGE0004:Q63754.

PTM databases

iPTMnetiQ63754.
PhosphoSiteiQ63754.
SwissPalmiQ63754.

Expressioni

Tissue specificityi

Expressed specifically in brain.

Interactioni

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD

Protein-protein interaction databases

BioGridi250205. 2 interactions.
IntActiQ63754. 1 interaction.
STRINGi10116.ENSRNOP00000024357.

Structurei

3D structure databases

ProteinModelPortaliQ63754.
SMRiQ63754. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 30111Add
BLAST
Repeati31 – 41112Add
BLAST
Repeati42 – 56153; approximateAdd
BLAST
Repeati57 – 67114Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 67484 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add
BLAST

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZ8U. Eukaryota.
ENOG4111Y4R. LUCA.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ63754.
OrthoDBiEOG7034KG.
PhylomeDBiQ63754.
TreeFamiTF332776.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002461. Synuclein_beta.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

Q63754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTKEGVVQ
60 70 80 90 100
GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKKEEFP TDLKPEEVAQ
110 120 130
EAAEEPLIEP LMEPEGESYE DSPQEEYQEY EPEAKGP
Length:137
Mass (Da):14,504
Last modified:November 1, 1996 - v1
Checksum:i678C6CB84FA01A03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17764 mRNA. Translation: BAA04610.1.
BC087579 mRNA. Translation: AAH87579.1.
RefSeqiNP_542955.2. NM_080777.2.
XP_006253656.1. XM_006253594.2.
UniGeneiRn.20352.

Genome annotation databases

GeneIDi113893.
KEGGirno:113893.
UCSCiRGD:70992. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17764 mRNA. Translation: BAA04610.1.
BC087579 mRNA. Translation: AAH87579.1.
RefSeqiNP_542955.2. NM_080777.2.
XP_006253656.1. XM_006253594.2.
UniGeneiRn.20352.

3D structure databases

ProteinModelPortaliQ63754.
SMRiQ63754. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250205. 2 interactions.
IntActiQ63754. 1 interaction.
STRINGi10116.ENSRNOP00000024357.

PTM databases

iPTMnetiQ63754.
PhosphoSiteiQ63754.
SwissPalmiQ63754.

2D gel databases

World-2DPAGE0004:Q63754.

Proteomic databases

PaxDbiQ63754.
PRIDEiQ63754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi113893.
KEGGirno:113893.
UCSCiRGD:70992. rat.

Organism-specific databases

CTDi6620.
RGDi70992. Sncb.

Phylogenomic databases

eggNOGiENOG410IZ8U. Eukaryota.
ENOG4111Y4R. LUCA.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ63754.
OrthoDBiEOG7034KG.
PhylomeDBiQ63754.
TreeFamiTF332776.

Miscellaneous databases

NextBioi617964.
PROiQ63754.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002461. Synuclein_beta.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the cDNA encoding a novel brain-specific 14-kDa protein."
    Tobe T., Nakajo S., Tanaka A., Mitoya A., Omata K., Nakaya K., Tomita M., Nakamura Y.
    J. Neurochem. 59:1624-1629(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-134.
    Tissue: Brain.
  3. Lubec G., Afjehi-Sadat L., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 33-43 AND 46-85, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.
  4. "A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation."
    Nakajo S., Tsukada K., Omata K., Nakamura Y., Nakaya K.
    Eur. J. Biochem. 217:1057-1063(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY CAM-KINASE II.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYUB_RAT
AccessioniPrimary (citable) accession number: Q63754
Secondary accession number(s): Q5PPN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 17, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.