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Protein

Beta-synuclein

Gene

Sncb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal plasticity.

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-synuclein
Alternative name(s):
Phosphoneuroprotein 14
Short name:
PNP 14
Gene namesi
Name:Sncb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70992. Sncb.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • cytoplasm Source: UniProtKB-SubCell
  • growth cone Source: RGD
  • neuronal cell body Source: RGD
  • terminal bouton Source: ParkinsonsUK-UCL

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840361 – 137Beta-synucleinAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118Phosphoserine; by BARK1, CK2 and GRK5By similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63754.
PRIDEiQ63754.

2D gel databases

World-2DPAGEi0004:Q63754.

PTM databases

iPTMnetiQ63754.
PhosphoSitePlusiQ63754.
SwissPalmiQ63754.

Expressioni

Tissue specificityi

Expressed specifically in brain.

Gene expression databases

BgeeiENSRNOG00000018039.

Interactioni

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD

Protein-protein interaction databases

BioGridi250205. 2 interactors.
IntActiQ63754. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ63754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 674 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZ8U. Eukaryota.
ENOG4111Y4R. LUCA.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ63754.
PhylomeDBiQ63754.
TreeFamiTF332776.

Family and domain databases

InterProiView protein in InterPro
IPR001058. Synuclein.
IPR002461. Synuclein_beta.
PANTHERiPTHR13820. PTHR13820. 1 hit.
PTHR13820:SF13. PTHR13820:SF13. 1 hit.
PfamiView protein in Pfam
PF01387. Synuclein. 1 hit.
PRINTSiPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

Q63754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTKEGVVQ
60 70 80 90 100
GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKKEEFP TDLKPEEVAQ
110 120 130
EAAEEPLIEP LMEPEGESYE DSPQEEYQEY EPEAKGP
Length:137
Mass (Da):14,504
Last modified:November 1, 1996 - v1
Checksum:i678C6CB84FA01A03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17764 mRNA. Translation: BAA04610.1.
BC087579 mRNA. Translation: AAH87579.1.
RefSeqiNP_542955.2. NM_080777.2.
XP_006253656.1. XM_006253594.2.
UniGeneiRn.20352.

Genome annotation databases

GeneIDi113893.
KEGGirno:113893.
UCSCiRGD:70992. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSYUB_RAT
AccessioniPrimary (citable) accession number: Q63754
Secondary accession number(s): Q5PPN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families