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Protein

Beta-synuclein

Gene

Sncb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal plasticity.

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-synuclein
Alternative name(s):
Phosphoneuroprotein 14
Short name:
PNP 14
Gene namesi
Name:Sncb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70992. Sncb.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • cytoplasm Source: UniProtKB-SubCell
  • growth cone Source: RGD
  • neuronal cell body Source: RGD
  • terminal bouton Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840361 – 137Beta-synucleinAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118Phosphoserine; by BARK1, CK2 and GRK5By similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63754.
PRIDEiQ63754.

2D gel databases

World-2DPAGE0004:Q63754.

PTM databases

iPTMnetiQ63754.
PhosphoSitePlusiQ63754.
SwissPalmiQ63754.

Expressioni

Tissue specificityi

Expressed specifically in brain.

Gene expression databases

BgeeiENSRNOG00000018039.

Interactioni

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD

Protein-protein interaction databases

BioGridi250205. 2 interactors.
IntActiQ63754. 1 interactor.
STRINGi10116.ENSRNOP00000024357.

Structurei

3D structure databases

ProteinModelPortaliQ63754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 674 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZ8U. Eukaryota.
ENOG4111Y4R. LUCA.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ63754.
PhylomeDBiQ63754.
TreeFamiTF332776.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002461. Synuclein_beta.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

Q63754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTKEGVVQ
60 70 80 90 100
GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKKEEFP TDLKPEEVAQ
110 120 130
EAAEEPLIEP LMEPEGESYE DSPQEEYQEY EPEAKGP
Length:137
Mass (Da):14,504
Last modified:November 1, 1996 - v1
Checksum:i678C6CB84FA01A03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17764 mRNA. Translation: BAA04610.1.
BC087579 mRNA. Translation: AAH87579.1.
RefSeqiNP_542955.2. NM_080777.2.
XP_006253656.1. XM_006253594.2.
UniGeneiRn.20352.

Genome annotation databases

GeneIDi113893.
KEGGirno:113893.
UCSCiRGD:70992. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17764 mRNA. Translation: BAA04610.1.
BC087579 mRNA. Translation: AAH87579.1.
RefSeqiNP_542955.2. NM_080777.2.
XP_006253656.1. XM_006253594.2.
UniGeneiRn.20352.

3D structure databases

ProteinModelPortaliQ63754.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250205. 2 interactors.
IntActiQ63754. 1 interactor.
STRINGi10116.ENSRNOP00000024357.

PTM databases

iPTMnetiQ63754.
PhosphoSitePlusiQ63754.
SwissPalmiQ63754.

2D gel databases

World-2DPAGE0004:Q63754.

Proteomic databases

PaxDbiQ63754.
PRIDEiQ63754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi113893.
KEGGirno:113893.
UCSCiRGD:70992. rat.

Organism-specific databases

CTDi6620.
RGDi70992. Sncb.

Phylogenomic databases

eggNOGiENOG410IZ8U. Eukaryota.
ENOG4111Y4R. LUCA.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ63754.
PhylomeDBiQ63754.
TreeFamiTF332776.

Miscellaneous databases

PROiQ63754.

Gene expression databases

BgeeiENSRNOG00000018039.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002461. Synuclein_beta.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01213. BSYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetiSearch...

Entry informationi

Entry nameiSYUB_RAT
AccessioniPrimary (citable) accession number: Q63754
Secondary accession number(s): Q5PPN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.