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Protein

Tyrosine-protein phosphatase

Gene

Ptpn12

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei231Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  • tissue regeneration Source: RGD

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-1250196. SHC1 events in ERBB2 signaling.
R-RNO-182971. EGFR downregulation.
R-RNO-186797. Signaling by PDGF.
R-RNO-8863795. Downregulation of ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:Ptpn12Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620894. Ptpn12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000013135.
GenevisibleiQ63745. RN.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 293Tyrosine-protein phosphataseInterPro annotationAdd BLAST266
Domaini207 – 284TYR_PHOSPHATASE_2InterPro annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00880000137849.
HOGENOMiHOG000252955.
KOiK18024.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQVEILRRF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT
60 70 80 90 100
ATGEKEENVK KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP
110 120 130 140 150
RAYVATQGPL ANTVIDFWRM IWEYNVVIIV MACREFEMGR KKCERYWPLY
160 170 180 190 200
GEDPITFAPF KISCENEQAR TDYFIRTLLL EFQNESRRLY QFHYVNWPDH
210 220 230 240 250
DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA ICAIDYTWNL
260 270 280 290 300
LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL
310 320 330 340 350
YEIHGAQKIT DGNEISTGNM VSSIDSEKQD SPPPKPPRTR SCLVEGDAKE
360 370 380
EILQPPEPHP VPPILTPSPP SAFPTLHCVA RQ
Length:382
Mass (Da):44,439
Last modified:November 1, 1996 - v1
Checksum:i25A517FDEBB7C344
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07059239 Genomic DNA. No translation available.
AABR07059240 Genomic DNA. No translation available.
D38072 mRNA. Translation: BAA07266.1.
PIRiS48748.
RefSeqiNP_476456.2. NM_057115.2.
UniGeneiRn.10707.

Genome annotation databases

EnsembliENSRNOT00000081939; ENSRNOP00000075346; ENSRNOG00000013135.
GeneIDi117255.
KEGGirno:117255.

Similar proteinsi

Entry informationi

Entry nameiQ63745_RAT
AccessioniPrimary (citable) accession number: Q63745
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported