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Protein
Submitted name:

Protein Ptpn12

Gene

Ptpn12

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  • tissue regeneration Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-1250196. SHC1 events in ERBB2 signaling.
R-RNO-182971. EGFR downregulation.
R-RNO-186797. Signaling by PDGF.
R-RNO-8863795. Downregulation of ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Ptpn12Imported
Submitted name:
Protein tyrosine phosphataseImported
Gene namesi
Name:Ptpn12Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620894. Ptpn12.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ63745. baseline and differential.
GenevisibleiQ63745. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017907.

Structurei

3D structure databases

ProteinModelPortaliQ63745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 293Tyrosine-protein phosphataseInterPro annotationAdd BLAST266
Domaini207 – 284TYR_PHOSPHATASE_2InterPro annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000252955.
KOiK18024.
PhylomeDBiQ63745.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQVEILRRF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT
60 70 80 90 100
ATGEKEENVK KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP
110 120 130 140 150
RAYVATQGPL ANTVIDFWRM IWEYNVVIIV MACREFEMGR KKCERYWPLY
160 170 180 190 200
GEDPITFAPF KISCENEQAR TDYFIRTLLL EFQNESRRLY QFHYVNWPDH
210 220 230 240 250
DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA ICAIDYTWNL
260 270 280 290 300
LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL
310 320 330 340 350
YEIHGAQKIT DGNEISTGNM VSSIDSEKQD SPPPKPPRTR SCLVEGDAKE
360 370 380
EILQPPEPHP VPPILTPSPP SAFPTLHCVA RQ
Length:382
Mass (Da):44,439
Last modified:November 1, 1996 - v1
Checksum:i25A517FDEBB7C344
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07059239 Genomic DNA. No translation available.
AABR07059240 Genomic DNA. No translation available.
D38072 mRNA. Translation: BAA07266.1.
PIRiS48748.
RefSeqiNP_476456.2. NM_057115.2.
UniGeneiRn.10707.

Genome annotation databases

EnsembliENSRNOT00000081939; ENSRNOP00000075346; ENSRNOG00000013135.
GeneIDi117255.
KEGGirno:117255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07059239 Genomic DNA. No translation available.
AABR07059240 Genomic DNA. No translation available.
D38072 mRNA. Translation: BAA07266.1.
PIRiS48748.
RefSeqiNP_476456.2. NM_057115.2.
UniGeneiRn.10707.

3D structure databases

ProteinModelPortaliQ63745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017907.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000081939; ENSRNOP00000075346; ENSRNOG00000013135.
GeneIDi117255.
KEGGirno:117255.

Organism-specific databases

CTDi5782.
RGDi620894. Ptpn12.

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000252955.
KOiK18024.
PhylomeDBiQ63745.

Enzyme and pathway databases

ReactomeiR-RNO-1250196. SHC1 events in ERBB2 signaling.
R-RNO-182971. EGFR downregulation.
R-RNO-186797. Signaling by PDGF.
R-RNO-8863795. Downregulation of ERBB2 signaling.

Gene expression databases

ExpressionAtlasiQ63745. baseline and differential.
GenevisibleiQ63745. RN.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ63745_RAT
AccessioniPrimary (citable) accession number: Q63745
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.