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Protein

Tyrosine-protein phosphatase

Gene

Ptpn12

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei231Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  • tissue regeneration Source: RGD

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-1250196 SHC1 events in ERBB2 signaling
R-RNO-182971 EGFR downregulation
R-RNO-186797 Signaling by PDGF
R-RNO-8863795 Downregulation of ERBB2 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:Ptpn12Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620894 Ptpn12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ63745

Expressioni

Gene expression databases

BgeeiENSRNOG00000013135
ExpressionAtlasiQ63745 baseline and differential
GenevisibleiQ63745 RN

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 293Tyrosine-protein phosphataseInterPro annotationAdd BLAST266
Domaini207 – 284TYR_PHOSPHATASE_2InterPro annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00900000140785
HOGENOMiHOG000252955
KOiK18024

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q63745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQVEILRRF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT
60 70 80 90 100
ATGEKEENVK KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP
110 120 130 140 150
RAYVATQGPL ANTVIDFWRM IWEYNVVIIV MACREFEMGR KKCERYWPLY
160 170 180 190 200
GEDPITFAPF KISCENEQAR TDYFIRTLLL EFQNESRRLY QFHYVNWPDH
210 220 230 240 250
DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA ICAIDYTWNL
260 270 280 290 300
LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL
310 320 330 340 350
YEIHGAQKIT DGNEISTGNM VSSIDSEKQD SPPPKPPRTR SCLVEGDAKE
360 370 380
EILQPPEPHP VPPILTPSPP SAFPTLHCVA RQ
Length:382
Mass (Da):44,439
Last modified:November 1, 1996 - v1
Checksum:i25A517FDEBB7C344
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07059239 Genomic DNA No translation available.
AABR07059240 Genomic DNA No translation available.
D38072 mRNA Translation: BAA07266.1
PIRiS48748
RefSeqiNP_476456.2, NM_057115.2
UniGeneiRn.10707

Genome annotation databases

EnsembliENSRNOT00000081939; ENSRNOP00000075346; ENSRNOG00000013135
GeneIDi117255
KEGGirno:117255

Similar proteinsi

Entry informationi

Entry nameiQ63745_RAT
AccessioniPrimary (citable) accession number: Q63745
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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