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Q63739

- TP4A1_MOUSE

UniProt

Q63739 - TP4A1_MOUSE

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Protein

Protein tyrosine phosphatase type IVA 1

Gene

Ptp4a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulationi

Inhibited by sodium orthovanadate and pentamidine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Proton donorBy similarity
Active sitei104 – 1041Phosphocysteine intermediateBy similarity
Binding sitei110 – 1101SubstrateBy similarity

GO - Molecular functioni

  1. prenylated protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. positive regulation of cell migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase type IVA 1 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 4a1
Protein-tyrosine phosphatase of regenerating liver 1
Short name:
PRL-1
Gene namesi
Name:Ptp4a1
Synonyms:Prl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1277096. Ptp4a1.

Subcellular locationi

Cell membrane 1 Publication. Early endosome 1 Publication. Endoplasmic reticulum 1 Publication. Cytoplasm 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication
Note: And mitotic spindle.

GO - Cellular componenti

  1. cytoplasmic side of plasma membrane Source: Ensembl
  2. cytoskeleton Source: UniProtKB-KW
  3. endoplasmic reticulum Source: UniProtKB-KW
  4. endosome Source: UniProtKB
  5. extracellular vesicular exosome Source: Ensembl
  6. nucleus Source: Ensembl
  7. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi104 – 1041C → S: Abolishes activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Protein tyrosine phosphatase type IVA 1PRO_0000094782Add
BLAST
Propeptidei171 – 1733Removed in mature formCuratedPRO_0000396728

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 104By similarity
Modified residuei170 – 1701Cysteine methyl esterCurated
Lipidationi170 – 1701S-farnesyl cysteine1 Publication

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ63739.
PaxDbiQ63739.
PRIDEiQ63739.

PTM databases

PhosphoSiteiQ63739.

Expressioni

Developmental stagei

Expressed in all tissues except heart and skeletal muscle, from E10.5 to E18.5.1 Publication

Gene expression databases

BgeeiQ63739.
CleanExiMM_PTP4A1.
ExpressionAtlasiQ63739. baseline and differential.
GenevestigatoriQ63739.

Interactioni

Subunit structurei

Homotrimer. Interacts with tubulin (By similarity). Interacts with ATF5.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ63739.
SMRiQ63739. Positions 9-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 14867Tyrosine-protein phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 13236Interaction with ATF5Add
BLAST
Regioni105 – 1106Phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG265664.
GeneTreeiENSGT00390000009788.
HOGENOMiHOG000231265.
HOVERGENiHBG071295.
InParanoidiQ63739.
KOiK18041.
OMAiDKSIAVH.
OrthoDBiEOG7C8GJD.
PhylomeDBiQ63739.
TreeFamiTF313384.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63739-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE
60 70 80 90 100
ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI
110 120 130 140 150
AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE
160 170
KYRPKMRLRF KDSNGHRNNC CIQ
Length:173
Mass (Da):19,815
Last modified:November 1, 1996 - v1
Checksum:i702008013D3F3835
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U84411 mRNA. Translation: AAB58913.1.
AK081491 mRNA. Translation: BAC38233.1.
AK148288 mRNA. Translation: BAE28460.1.
AK150506 mRNA. Translation: BAE29619.1.
AK151533 mRNA. Translation: BAE30480.1.
BC055039 mRNA. Translation: AAH55039.1.
BC086787 mRNA. Translation: AAH86787.1.
BC094447 mRNA. Translation: AAH94447.1.
AF064943 mRNA. No translation available.
CCDSiCCDS14858.1.
RefSeqiNP_035330.1. NM_011200.2.
XP_006495861.1. XM_006495798.1.
XP_006495862.1. XM_006495799.1.
XP_006544159.1. XM_006544096.1.
UniGeneiMm.491181.

Genome annotation databases

EnsembliENSMUST00000027232; ENSMUSP00000027232; ENSMUSG00000026064.
ENSMUST00000076587; ENSMUSP00000110861; ENSMUSG00000026064.
GeneIDi102643131.
19243.
KEGGimmu:102643131.
mmu:19243.
UCSCiuc007anh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U84411 mRNA. Translation: AAB58913.1 .
AK081491 mRNA. Translation: BAC38233.1 .
AK148288 mRNA. Translation: BAE28460.1 .
AK150506 mRNA. Translation: BAE29619.1 .
AK151533 mRNA. Translation: BAE30480.1 .
BC055039 mRNA. Translation: AAH55039.1 .
BC086787 mRNA. Translation: AAH86787.1 .
BC094447 mRNA. Translation: AAH94447.1 .
AF064943 mRNA. No translation available.
CCDSi CCDS14858.1.
RefSeqi NP_035330.1. NM_011200.2.
XP_006495861.1. XM_006495798.1.
XP_006495862.1. XM_006495799.1.
XP_006544159.1. XM_006544096.1.
UniGenei Mm.491181.

3D structure databases

ProteinModelPortali Q63739.
SMRi Q63739. Positions 9-160.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q63739.

PTM databases

PhosphoSitei Q63739.

Proteomic databases

MaxQBi Q63739.
PaxDbi Q63739.
PRIDEi Q63739.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027232 ; ENSMUSP00000027232 ; ENSMUSG00000026064 .
ENSMUST00000076587 ; ENSMUSP00000110861 ; ENSMUSG00000026064 .
GeneIDi 102643131.
19243.
KEGGi mmu:102643131.
mmu:19243.
UCSCi uc007anh.1. mouse.

Organism-specific databases

CTDi 7803.
MGIi MGI:1277096. Ptp4a1.

Phylogenomic databases

eggNOGi NOG265664.
GeneTreei ENSGT00390000009788.
HOGENOMi HOG000231265.
HOVERGENi HBG071295.
InParanoidi Q63739.
KOi K18041.
OMAi DKSIAVH.
OrthoDBi EOG7C8GJD.
PhylomeDBi Q63739.
TreeFami TF313384.

Miscellaneous databases

NextBioi 296058.
PROi Q63739.
SOURCEi Search...

Gene expression databases

Bgeei Q63739.
CleanExi MM_PTP4A1.
ExpressionAtlasi Q63739. baseline and differential.
Genevestigatori Q63739.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Oh B., Hwang S.-Y., Knowles B.B.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Eye.
  4. "Developmental expression of the murine Prl-1 protein tyrosine phosphatase gene."
    Rundle C.H., Kappen C.
    J. Exp. Zool. 283:612-617(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-23, DEVELOPMENTAL STAGE.
  5. "Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome."
    Zeng Q., Si X., Horstmann H., Xu Y., Hong W., Pallen C.J.
    J. Biol. Chem. 275:21444-21452(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: ISOPRENYLATION AT CYS-170, SUBCELLULAR LOCATION.
  6. "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase."
    Peters C.S., Liang X., Li S., Kannan S., Peng Y., Taub R., Diamond R.H.
    J. Biol. Chem. 276:13718-13726(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATF5, MUTAGENESIS OF CYS-104.

Entry informationi

Entry nameiTP4A1_MOUSE
AccessioniPrimary (citable) accession number: Q63739
Secondary accession number(s): O09097, O09154, Q3UFU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3