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Q63739

- TP4A1_MOUSE

UniProt

Q63739 - TP4A1_MOUSE

Protein

Protein tyrosine phosphatase type IVA 1

Gene

Ptp4a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Enzyme regulationi

    Inhibited by sodium orthovanadate and pentamidine.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei72 – 721Proton donorBy similarity
    Active sitei104 – 1041Phosphocysteine intermediateBy similarity
    Binding sitei110 – 1101SubstrateBy similarity

    GO - Molecular functioni

    1. prenylated protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. peptidyl-tyrosine dephosphorylation Source: GOC
    4. positive regulation of cell migration Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein tyrosine phosphatase type IVA 1 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase 4a1
    Protein-tyrosine phosphatase of regenerating liver 1
    Short name:
    PRL-1
    Gene namesi
    Name:Ptp4a1
    Synonyms:Prl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1277096. Ptp4a1.

    Subcellular locationi

    Cell membrane 1 Publication. Early endosome 1 Publication. Endoplasmic reticulum 1 Publication. Cytoplasm 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication
    Note: And mitotic spindle.

    GO - Cellular componenti

    1. cytoplasmic side of plasma membrane Source: Ensembl
    2. early endosome Source: UniProtKB-SubCell
    3. endoplasmic reticulum Source: UniProtKB-SubCell
    4. endosome Source: UniProtKB
    5. plasma membrane Source: UniProtKB
    6. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Endosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi104 – 1041C → S: Abolishes activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 170170Protein tyrosine phosphatase type IVA 1PRO_0000094782Add
    BLAST
    Propeptidei171 – 1733Removed in mature formCuratedPRO_0000396728

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 104By similarity
    Modified residuei170 – 1701Cysteine methyl esterCurated
    Lipidationi170 – 1701S-farnesyl cysteine1 Publication

    Post-translational modificationi

    Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ63739.
    PRIDEiQ63739.

    PTM databases

    PhosphoSiteiQ63739.

    Expressioni

    Developmental stagei

    Expressed in all tissues except heart and skeletal muscle, from E10.5 to E18.5.1 Publication

    Gene expression databases

    ArrayExpressiQ63739.
    BgeeiQ63739.
    CleanExiMM_PTP4A1.
    GenevestigatoriQ63739.

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with tubulin By similarity. Interacts with ATF5.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ63739.
    SMRiQ63739. Positions 9-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 14867Tyrosine-protein phosphataseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni97 – 13236Interaction with ATF5Add
    BLAST
    Regioni105 – 1106Phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG265664.
    GeneTreeiENSGT00390000009788.
    HOGENOMiHOG000231265.
    HOVERGENiHBG071295.
    InParanoidiQ63739.
    KOiK18041.
    OMAiDKSIAVH.
    OrthoDBiEOG7C8GJD.
    PhylomeDBiQ63739.
    TreeFamiTF313384.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE    50
    ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI 100
    AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE 150
    KYRPKMRLRF KDSNGHRNNC CIQ 173
    Length:173
    Mass (Da):19,815
    Last modified:November 1, 1996 - v1
    Checksum:i702008013D3F3835
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U84411 mRNA. Translation: AAB58913.1.
    AK081491 mRNA. Translation: BAC38233.1.
    AK148288 mRNA. Translation: BAE28460.1.
    AK150506 mRNA. Translation: BAE29619.1.
    AK151533 mRNA. Translation: BAE30480.1.
    BC055039 mRNA. Translation: AAH55039.1.
    BC086787 mRNA. Translation: AAH86787.1.
    BC094447 mRNA. Translation: AAH94447.1.
    AF064943 mRNA. No translation available.
    CCDSiCCDS14858.1.
    RefSeqiNP_035330.1. NM_011200.2.
    XP_006495861.1. XM_006495798.1.
    XP_006495862.1. XM_006495799.1.
    XP_006544159.1. XM_006544096.1.
    UniGeneiMm.491181.

    Genome annotation databases

    EnsembliENSMUST00000027232; ENSMUSP00000027232; ENSMUSG00000026064.
    ENSMUST00000076587; ENSMUSP00000110861; ENSMUSG00000026064.
    GeneIDi102643131.
    19243.
    KEGGimmu:102643131.
    mmu:19243.
    UCSCiuc007anh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U84411 mRNA. Translation: AAB58913.1 .
    AK081491 mRNA. Translation: BAC38233.1 .
    AK148288 mRNA. Translation: BAE28460.1 .
    AK150506 mRNA. Translation: BAE29619.1 .
    AK151533 mRNA. Translation: BAE30480.1 .
    BC055039 mRNA. Translation: AAH55039.1 .
    BC086787 mRNA. Translation: AAH86787.1 .
    BC094447 mRNA. Translation: AAH94447.1 .
    AF064943 mRNA. No translation available.
    CCDSi CCDS14858.1.
    RefSeqi NP_035330.1. NM_011200.2.
    XP_006495861.1. XM_006495798.1.
    XP_006495862.1. XM_006495799.1.
    XP_006544159.1. XM_006544096.1.
    UniGenei Mm.491181.

    3D structure databases

    ProteinModelPortali Q63739.
    SMRi Q63739. Positions 9-160.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q63739.

    PTM databases

    PhosphoSitei Q63739.

    Proteomic databases

    PaxDbi Q63739.
    PRIDEi Q63739.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027232 ; ENSMUSP00000027232 ; ENSMUSG00000026064 .
    ENSMUST00000076587 ; ENSMUSP00000110861 ; ENSMUSG00000026064 .
    GeneIDi 102643131.
    19243.
    KEGGi mmu:102643131.
    mmu:19243.
    UCSCi uc007anh.1. mouse.

    Organism-specific databases

    CTDi 7803.
    MGIi MGI:1277096. Ptp4a1.

    Phylogenomic databases

    eggNOGi NOG265664.
    GeneTreei ENSGT00390000009788.
    HOGENOMi HOG000231265.
    HOVERGENi HBG071295.
    InParanoidi Q63739.
    KOi K18041.
    OMAi DKSIAVH.
    OrthoDBi EOG7C8GJD.
    PhylomeDBi Q63739.
    TreeFami TF313384.

    Miscellaneous databases

    NextBioi 296058.
    PROi Q63739.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q63739.
    Bgeei Q63739.
    CleanExi MM_PTP4A1.
    Genevestigatori Q63739.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Oh B., Hwang S.-Y., Knowles B.B.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Head.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon and Eye.
    4. "Developmental expression of the murine Prl-1 protein tyrosine phosphatase gene."
      Rundle C.H., Kappen C.
      J. Exp. Zool. 283:612-617(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-23, DEVELOPMENTAL STAGE.
    5. "Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome."
      Zeng Q., Si X., Horstmann H., Xu Y., Hong W., Pallen C.J.
      J. Biol. Chem. 275:21444-21452(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ISOPRENYLATION AT CYS-170, SUBCELLULAR LOCATION.
    6. "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase."
      Peters C.S., Liang X., Li S., Kannan S., Peng Y., Taub R., Diamond R.H.
      J. Biol. Chem. 276:13718-13726(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATF5, MUTAGENESIS OF CYS-104.

    Entry informationi

    Entry nameiTP4A1_MOUSE
    AccessioniPrimary (citable) accession number: Q63739
    Secondary accession number(s): O09097, O09154, Q3UFU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3