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Protein

Phosducin-like protein

Gene

Pdcl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Sensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-RNO-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein
Short name:
PHLP
Gene namesi
Name:Pdcl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi621135. Pdcl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 301300Phosducin-like proteinPRO_0000163757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei20 – 201PhosphoserineCombined sources
Modified residuei25 – 251PhosphoserineCombined sources
Modified residuei226 – 2261PhosphoserineBy similarity
Modified residuei293 – 2931PhosphoserineCombined sources
Modified residuei296 – 2961PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63737.
PRIDEiQ63737.

PTM databases

iPTMnetiQ63737.
PhosphoSiteiQ63737.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008484.
GenevisibleiQ63737. RN.

Interactioni

Subunit structurei

Interacts with the CCT chaperonin complex (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi248932. 1 interaction.
STRINGi10116.ENSRNOP00000012160.

Structurei

3D structure databases

ProteinModelPortaliQ63737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni158 – 301144Thioredoxin foldBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171. Eukaryota.
ENOG4110DRD. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiQ63737.
OMAiMQEYNML.
OrthoDBiEOG091G0ISM.
PhylomeDBiQ63737.
TreeFamiTF315179.

Family and domain databases

Gene3Di1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Long (identifier: Q63737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTLDDKLLG EKLQYYYSTS EDEDSDHEDK DRGRGAPASS STPAEAELAG
60 70 80 90 100
EGISVNTGPK GVINDWRRFK QLETEQREEQ CREMERLIKK LSMSCRSHLD
110 120 130 140 150
EEEEQQKQKD LQEKISGKMT LKECGMMDKN LDDEEFLQQY RKQRMDEMRQ
160 170 180 190 200
QLHKGPQFKQ VLEIPSGEGF LDMIDKEQKS TLIMVHIYED GVPGTEAMNG
210 220 230 240 250
CMICLAAEYP TVKFCRVRSS VIGASSRFTR NALPALLIYK AGELIGNFVR
260 270 280 290 300
VTDQLGEDFF AVDLEAFLQE FGLLPEKEVL VLTSVRNSAT CHSEDSDLEI

D
Length:301
Mass (Da):34,274
Last modified:November 1, 1996 - v1
Checksum:iF32C776373354AD8
GO
Isoform Short (identifier: Q63737-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:218
Mass (Da):24,925
Checksum:iCFBC4307AE43634F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383Missing in isoform Short. 1 PublicationVSP_004704Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15354 mRNA. Translation: AAB00333.1.
L15355 mRNA. Translation: AAB00334.1.
AF080435, AF080433, AF080434 Genomic DNA. Translation: AAC77925.1.
BC097322 mRNA. Translation: AAH97322.1.
PIRiA58928.
RefSeqiNP_071583.1. NM_022247.1. [Q63737-1]
UniGeneiRn.51153.

Genome annotation databases

EnsembliENSRNOT00000012160; ENSRNOP00000012160; ENSRNOG00000008484. [Q63737-1]
GeneIDi64013.
KEGGirno:64013.
UCSCiRGD:621135. rat. [Q63737-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15354 mRNA. Translation: AAB00333.1.
L15355 mRNA. Translation: AAB00334.1.
AF080435, AF080433, AF080434 Genomic DNA. Translation: AAC77925.1.
BC097322 mRNA. Translation: AAH97322.1.
PIRiA58928.
RefSeqiNP_071583.1. NM_022247.1. [Q63737-1]
UniGeneiRn.51153.

3D structure databases

ProteinModelPortaliQ63737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248932. 1 interaction.
STRINGi10116.ENSRNOP00000012160.

PTM databases

iPTMnetiQ63737.
PhosphoSiteiQ63737.

Proteomic databases

PaxDbiQ63737.
PRIDEiQ63737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012160; ENSRNOP00000012160; ENSRNOG00000008484. [Q63737-1]
GeneIDi64013.
KEGGirno:64013.
UCSCiRGD:621135. rat. [Q63737-1]

Organism-specific databases

CTDi5082.
RGDi621135. Pdcl.

Phylogenomic databases

eggNOGiKOG3171. Eukaryota.
ENOG4110DRD. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiQ63737.
OMAiMQEYNML.
OrthoDBiEOG091G0ISM.
PhylomeDBiQ63737.
TreeFamiTF315179.

Enzyme and pathway databases

ReactomeiR-RNO-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiQ63737.

Gene expression databases

BgeeiENSRNOG00000008484.
GenevisibleiQ63737. RN.

Family and domain databases

Gene3Di1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHLP_RAT
AccessioniPrimary (citable) accession number: Q63737
Secondary accession number(s): Q4V8L9, Q63738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.