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Protein

Phosducin-like protein

Gene

Pdcl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function.By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processCilium biogenesis/degradation, Sensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-RNO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein
Short name:
PHLP
Gene namesi
Name:Pdcl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi621135 Pdcl

Subcellular locationi

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001637572 – 301Phosducin-like proteinAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei20PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei226PhosphoserineBy similarity1
Modified residuei293PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63737
PRIDEiQ63737

PTM databases

iPTMnetiQ63737
PhosphoSitePlusiQ63737

Expressioni

Gene expression databases

BgeeiENSRNOG00000008484
GenevisibleiQ63737 RN

Interactioni

Subunit structurei

Interacts with the CCT chaperonin complex (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

Protein-protein interaction databases

BioGridi248932, 1 interactor
STRINGi10116.ENSRNOP00000012160

Structurei

3D structure databases

ProteinModelPortaliQ63737
SMRiQ63737
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni158 – 301Thioredoxin foldBy similarityAdd BLAST144

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171 Eukaryota
ENOG4110DRD LUCA
GeneTreeiENSGT00910000144170
HOGENOMiHOG000232010
HOVERGENiHBG003456
InParanoidiQ63737
OMAiPSIKFAK
OrthoDBiEOG091G0ISM
PhylomeDBiQ63737
TreeFamiTF315179

Family and domain databases

CDDicd02987 Phd_like_Phd, 1 hit
Gene3Di1.10.168.10, 1 hit
InterProiView protein in InterPro
IPR001200 Phosducin
IPR023196 Phosducin_N_dom_sf
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
PRINTSiPR00677 PHOSDUCIN
SUPFAMiSSF52833 SSF52833, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Long (identifier: Q63737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTLDDKLLG EKLQYYYSTS EDEDSDHEDK DRGRGAPASS STPAEAELAG
60 70 80 90 100
EGISVNTGPK GVINDWRRFK QLETEQREEQ CREMERLIKK LSMSCRSHLD
110 120 130 140 150
EEEEQQKQKD LQEKISGKMT LKECGMMDKN LDDEEFLQQY RKQRMDEMRQ
160 170 180 190 200
QLHKGPQFKQ VLEIPSGEGF LDMIDKEQKS TLIMVHIYED GVPGTEAMNG
210 220 230 240 250
CMICLAAEYP TVKFCRVRSS VIGASSRFTR NALPALLIYK AGELIGNFVR
260 270 280 290 300
VTDQLGEDFF AVDLEAFLQE FGLLPEKEVL VLTSVRNSAT CHSEDSDLEI

D
Length:301
Mass (Da):34,274
Last modified:November 1, 1996 - v1
Checksum:iF32C776373354AD8
GO
Isoform Short (identifier: Q63737-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:218
Mass (Da):24,925
Checksum:iCFBC4307AE43634F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0047041 – 83Missing in isoform Short. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15354 mRNA Translation: AAB00333.1
L15355 mRNA Translation: AAB00334.1
AF080435, AF080433, AF080434 Genomic DNA Translation: AAC77925.1
BC097322 mRNA Translation: AAH97322.1
PIRiA58928
RefSeqiNP_071583.1, NM_022247.1 [Q63737-1]
UniGeneiRn.51153

Genome annotation databases

EnsembliENSRNOT00000012160; ENSRNOP00000012160; ENSRNOG00000008484 [Q63737-1]
GeneIDi64013
KEGGirno:64013
UCSCiRGD:621135 rat [Q63737-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPHLP_RAT
AccessioniPrimary (citable) accession number: Q63737
Secondary accession number(s): Q4V8L9, Q63738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health