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Protein

Potassium voltage-gated channel subfamily C member 4

Gene

Kcnc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

GO - Biological processi

  • forebrain development Source: RGD
  • negative regulation of neuronal action potential Source: RGD
  • negative regulation of sensory perception of pain Source: RGD
  • protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 4
Alternative name(s):
Raw3
Voltage-gated potassium channel subunit Kv3.4
Gene namesi
Name:Kcnc4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1589169. Kcnc4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 227CytoplasmicSequence analysisAdd BLAST227
Transmembranei228 – 248Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei279 – 299Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini300 – 313CytoplasmicSequence analysisAdd BLAST14
Transmembranei314 – 334Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei346 – 365Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST20
Topological domaini366 – 381CytoplasmicSequence analysisAdd BLAST16
Transmembranei382 – 402Helical; Name=Segment S5Sequence analysisAdd BLAST21
Transmembranei453 – 473Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini474 – 625CytoplasmicSequence analysisAdd BLAST152

GO - Cellular componenti

  • axon Source: RGD
  • dendrite Source: RGD
  • integral component of membrane Source: GO_Central
  • neuronal cell body Source: RGD
  • plasma membrane Source: RGD
  • postsynapse Source: RGD
  • voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540601 – 625Potassium voltage-gated channel subfamily C member 4Add BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63734.
PRIDEiQ63734.

PTM databases

PhosphoSitePlusiQ63734.

Interactioni

Subunit structurei

Homotetramer (Probable). Heterotetramer of potassium channel proteins (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065398.

Structurei

3D structure databases

ProteinModelPortaliQ63734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28Inactivation gateAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi437 – 442Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
HOVERGENiHBG105862.
InParanoidiQ63734.
KOiK04890.
PhylomeDBiQ63734.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005405. K_chnl_volt-dep_Kv3.4.
IPR021105. K_chnl_volt-dep_Kv3_ID.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 3 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11404. Potassium_chann. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01583. KV34CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY
60 70 80 90 100
RSTLRTLPGT RLAWLADPDG GGRPESDGGG AGSSGSSGGG GGCEFFFDRH
110 120 130 140 150
PGVFAYVLNY YRTGKLHCPA DVCGPLFEEE LTFWGIDETD VEPCCWMTYR
160 170 180 190 200
QHRDAEEALD IFESPDGGGG GAGPGDEAGD DERELALQRL GPHEGGSGPG
210 220 230 240 250
AGSGGCRGWQ PRMWALFEDP YSSRAARVVA FASLFFILVS ITTFCLETHE
260 270 280 290 300
AFNIDRNVTE IHRVGNITSV RFRREVETEP ILTYIEGVCV MWFTLEFLVR
310 320 330 340 350
IVCCPDTLDF VKNLLNIIDF VAILPFYLEV GLSGLSSKAA RDVLGFLRVV
360 370 380 390 400
RFVRILRIFK LTRHFVGLRV LGHTLRASTN EFLLLIIFLA LGVLIFATMI
410 420 430 440 450
YYAERIGARP SDPRGNDHTD FKNIPIGFWW AVVTMTTLGY GDMYPKTWSG
460 470 480 490 500
MLVGALCALA GVLTIAMPVP VIVNNFGMYY SLAMAKQKLP KKRKKHVPRP
510 520 530 540 550
PQLESPIYCK SEETSPRDST YSDTSPPARE EGMVERKRAD SKQNGDANAV
560 570 580 590 600
LSDEEGAGLT QPLASAPTPE ERRALRRSGT RDRNKKAAAC FLLSAGDYAC
610 620
ADGSVQKEGS VEPKACVPVS HTCAL
Length:625
Mass (Da):68,435
Last modified:November 1, 1996 - v1
Checksum:iC3A86BC88231FB04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62841 mRNA. Translation: CAA44645.1.
PIRiS13919.
RefSeqiNP_001116248.1. NM_001122776.1.
UniGeneiRn.216718.

Genome annotation databases

GeneIDi684516.
KEGGirno:684516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62841 mRNA. Translation: CAA44645.1.
PIRiS13919.
RefSeqiNP_001116248.1. NM_001122776.1.
UniGeneiRn.216718.

3D structure databases

ProteinModelPortaliQ63734.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065398.

Chemistry databases

GuidetoPHARMACOLOGYi551.

PTM databases

PhosphoSitePlusiQ63734.

Proteomic databases

PaxDbiQ63734.
PRIDEiQ63734.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi684516.
KEGGirno:684516.

Organism-specific databases

CTDi3749.
RGDi1589169. Kcnc4.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
HOVERGENiHBG105862.
InParanoidiQ63734.
KOiK04890.
PhylomeDBiQ63734.

Miscellaneous databases

PROiQ63734.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003974. K_chnl_volt-dep_Kv3.
IPR005405. K_chnl_volt-dep_Kv3.4.
IPR021105. K_chnl_volt-dep_Kv3_ID.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 3 hits.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11404. Potassium_chann. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01583. KV34CHANNEL.
PR01491. KVCHANNEL.
PR01498. SHAWCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNC4_RAT
AccessioniPrimary (citable) accession number: Q63734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.