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Protein

Potassium voltage-gated channel subfamily C member 4

Gene

Kcnc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

GO - Biological processi

  • forebrain development Source: RGD
  • negative regulation of neuronal action potential Source: RGD
  • negative regulation of sensory perception of pain Source: RGD
  • potassium ion transmembrane transport Source: GO_Central
  • protein homooligomerization Source: InterPro
  • regulation of ion transmembrane transport Source: UniProtKB-KW

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily C member 4
Alternative name(s):
Raw3
Voltage-gated potassium channel subunit Kv3.4
Gene namesi
Name:Kcnc4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1589169 Kcnc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 227CytoplasmicSequence analysisAdd BLAST227
Transmembranei228 – 248Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei279 – 299Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini300 – 313CytoplasmicSequence analysisAdd BLAST14
Transmembranei314 – 334Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei346 – 365Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST20
Topological domaini366 – 381CytoplasmicSequence analysisAdd BLAST16
Transmembranei382 – 402Helical; Name=Segment S5Sequence analysisAdd BLAST21
Transmembranei453 – 473Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini474 – 625CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi551

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540601 – 625Potassium voltage-gated channel subfamily C member 4Add BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63734
PRIDEiQ63734

PTM databases

PhosphoSitePlusiQ63734

Interactioni

Subunit structurei

Homotetramer (Probable). Heterotetramer of potassium channel proteins (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065398

Structurei

3D structure databases

ProteinModelPortaliQ63734
SMRiQ63734
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28Inactivation gateAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi437 – 442Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
HOVERGENiHBG105862
InParanoidiQ63734
KOiK04890
PhylomeDBiQ63734

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003974 K_chnl_volt-dep_Kv3
IPR005405 K_chnl_volt-dep_Kv3.4
IPR021105 K_chnl_volt-dep_Kv3_ID
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PF11404 Potassium_chann, 1 hit
PRINTSiPR00169 KCHANNEL
PR01583 KV34CHANNEL
PR01491 KVCHANNEL
PR01498 SHAWCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q63734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY
60 70 80 90 100
RSTLRTLPGT RLAWLADPDG GGRPESDGGG AGSSGSSGGG GGCEFFFDRH
110 120 130 140 150
PGVFAYVLNY YRTGKLHCPA DVCGPLFEEE LTFWGIDETD VEPCCWMTYR
160 170 180 190 200
QHRDAEEALD IFESPDGGGG GAGPGDEAGD DERELALQRL GPHEGGSGPG
210 220 230 240 250
AGSGGCRGWQ PRMWALFEDP YSSRAARVVA FASLFFILVS ITTFCLETHE
260 270 280 290 300
AFNIDRNVTE IHRVGNITSV RFRREVETEP ILTYIEGVCV MWFTLEFLVR
310 320 330 340 350
IVCCPDTLDF VKNLLNIIDF VAILPFYLEV GLSGLSSKAA RDVLGFLRVV
360 370 380 390 400
RFVRILRIFK LTRHFVGLRV LGHTLRASTN EFLLLIIFLA LGVLIFATMI
410 420 430 440 450
YYAERIGARP SDPRGNDHTD FKNIPIGFWW AVVTMTTLGY GDMYPKTWSG
460 470 480 490 500
MLVGALCALA GVLTIAMPVP VIVNNFGMYY SLAMAKQKLP KKRKKHVPRP
510 520 530 540 550
PQLESPIYCK SEETSPRDST YSDTSPPARE EGMVERKRAD SKQNGDANAV
560 570 580 590 600
LSDEEGAGLT QPLASAPTPE ERRALRRSGT RDRNKKAAAC FLLSAGDYAC
610 620
ADGSVQKEGS VEPKACVPVS HTCAL
Length:625
Mass (Da):68,435
Last modified:November 1, 1996 - v1
Checksum:iC3A86BC88231FB04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62841 mRNA Translation: CAA44645.1
PIRiS13919
RefSeqiNP_001116248.1, NM_001122776.1
UniGeneiRn.216718

Genome annotation databases

GeneIDi684516
KEGGirno:684516

Similar proteinsi

Entry informationi

Entry nameiKCNC4_RAT
AccessioniPrimary (citable) accession number: Q63734
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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