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Protein

Protein jagged-1

Gene

Jag1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor-induced angiogenesis.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Notch binding Source: RGD

GO - Biological processi

  • auditory receptor cell differentiation Source: RGD
  • cell fate determination Source: UniProtKB
  • glomerular visceral epithelial cell development Source: UniProtKB
  • negative regulation of cell differentiation Source: RGD
  • nephron development Source: UniProtKB
  • Notch signaling pathway Source: RGD
  • organ regeneration Source: RGD
  • positive regulation of Notch signaling pathway Source: UniProtKB
  • regulation of cell proliferation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-1
Short name:
Jagged1
Alternative name(s):
CD_antigen: CD339
Gene namesi
Name:Jag1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2937. Jag1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 10671034ExtracellularSequence analysisAdd
BLAST
Transmembranei1068 – 109326HelicalSequence analysisAdd
BLAST
Topological domaini1094 – 1219126CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 12191186Protein jagged-1PRO_0000007627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi187 ↔ 196By similarity
Disulfide bondi200 ↔ 212By similarity
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi220 ↔ 229By similarity
Disulfide bondi234 ↔ 245By similarity
Disulfide bondi238 ↔ 251By similarity
Disulfide bondi253 ↔ 262By similarity
Disulfide bondi265 ↔ 276By similarity
Disulfide bondi271 ↔ 282By similarity
Disulfide bondi284 ↔ 293By similarity
Disulfide bondi300 ↔ 312By similarity
Disulfide bondi306 ↔ 322By similarity
Disulfide bondi324 ↔ 333By similarity
Disulfide bondi340 ↔ 351By similarity
Disulfide bondi345 ↔ 360By similarity
Disulfide bondi362 ↔ 371By similarity
Disulfide bondi378 ↔ 389By similarity
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi383 ↔ 398By similarity
Disulfide bondi400 ↔ 409By similarity
Disulfide bondi416 ↔ 427By similarity
Disulfide bondi421 ↔ 436By similarity
Disulfide bondi438 ↔ 447By similarity
Disulfide bondi454 ↔ 464By similarity
Disulfide bondi458 ↔ 473By similarity
Disulfide bondi475 ↔ 484By similarity
Disulfide bondi491 ↔ 502By similarity
Disulfide bondi496 ↔ 511By similarity
Disulfide bondi513 ↔ 522By similarity
Disulfide bondi529 ↔ 540By similarity
Disulfide bondi534 ↔ 549By similarity
Disulfide bondi551 ↔ 560By similarity
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi578 ↔ 605By similarity
Disulfide bondi599 ↔ 615By similarity
Disulfide bondi617 ↔ 626By similarity
Disulfide bondi633 ↔ 644By similarity
Disulfide bondi638 ↔ 653By similarity
Disulfide bondi655 ↔ 664By similarity
Disulfide bondi671 ↔ 682By similarity
Disulfide bondi676 ↔ 691By similarity
Disulfide bondi693 ↔ 702By similarity
Disulfide bondi709 ↔ 720By similarity
Disulfide bondi714 ↔ 729By similarity
Disulfide bondi731 ↔ 740By similarity
Glycosylationi745 – 7451N-linked (GlcNAc...)Sequence analysis
Disulfide bondi748 ↔ 759By similarity
Disulfide bondi753 ↔ 768By similarity
Disulfide bondi770 ↔ 779By similarity
Disulfide bondi786 ↔ 797By similarity
Disulfide bondi791 ↔ 806By similarity
Disulfide bondi808 ↔ 817By similarity
Disulfide bondi824 ↔ 835By similarity
Disulfide bondi829 ↔ 844By similarity
Disulfide bondi846 ↔ 855By similarity
Disulfide bondi925 ↔ 936By similarity
Disulfide bondi948 ↔ 958By similarity
Glycosylationi960 – 9601N-linked (GlcNAc...)Sequence analysis
Glycosylationi991 – 9911N-linked (GlcNAc...)Sequence analysis
Glycosylationi1045 – 10451N-linked (GlcNAc...)Sequence analysis
Glycosylationi1064 – 10641N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63722.
PRIDEiQ63722.

Expressioni

Tissue specificityi

Widely expressed in a variety of tissues.

Developmental stagei

Expression is seen in E11.5-E14.5 embryos in four distinct regions of the ventricular zone in the developing spinal cord.

Interactioni

Subunit structurei

Interacts with NOTCH1, NOTCH2 and NOTCH3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LRP1Q079544EBI-4567800,EBI-1046087From a different organism.
Thbs2Q033502EBI-4567800,EBI-4567830From a different organism.

GO - Molecular functioni

  • Notch binding Source: RGD

Protein-protein interaction databases

BioGridi247829. 3 interactions.
IntActiQ63722. 5 interactions.
MINTiMINT-1538167.
STRINGi10116.ENSRNOP00000010638.

Structurei

3D structure databases

ProteinModelPortaliQ63722.
SMRiQ63722. Positions 186-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini185 – 22945DSLPROSITE-ProRule annotationAdd
BLAST
Domaini230 – 26334EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini264 – 29431EGF-like 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Domaini296 – 33439EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini336 – 37237EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini374 – 41037EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini412 – 44837EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini450 – 48536EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini487 – 52337EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini525 – 56137EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini586 – 62742EGF-like 10PROSITE-ProRule annotationAdd
BLAST
Domaini629 – 66537EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini667 – 70337EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini705 – 74137EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini744 – 78037EGF-like 14PROSITE-ProRule annotationAdd
BLAST
Domaini782 – 81837EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini820 – 85637EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2079Important for interaction with NOTCH1By similarity

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 16 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ63722.
KOiK06052.
PhylomeDBiQ63722.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 11 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 16 hits.
SM00179. EGF_CA. 14 hits.
SM00214. VWC. 1 hit.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 16 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSPRTRGRP GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ
60 70 80 90 100
NGNCCGGARN PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP
110 120 130 140 150
VIGGNTFNLK ASRGNDRNRI VLPFSFAWPR SYTLLVEAWD SSNDTIQPDS
160 170 180 190 200
IIEKASHSGM INPSRQWQTL KQNTGIAHFE YQIRVTCDDH YYGFGCNKFC
210 220 230 240 250
RPRDDFFGHY ACDQNGNKTC MEGWMGPECN KAICRQGCSP KHGSCKLPGD
260 270 280 290 300
CRCQYGWQGL YCDKCIPHPG CVHGTCNEPW QCLCETNWGG QLCDKDLNYC
310 320 330 340 350
GTHQPCLNRG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS
360 370 380 390 400
CKETSSGFEC ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC
410 420 430 440 450
PPQWTGKTCQ LDANECEAKP CVNARSCKNL IASYYCDCLP GWMGQNCDIN
460 470 480 490 500
INDCLGQCQN DASCRDLVNG YRCICPPGYA GDHCERDIDE CASNPCLNGG
510 520 530 540 550
HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK
560 570 580 590 600
CPEDYEGKNC SHLKDHCRTT PCEVIDSCTV AMASNDTPEG VRYISSNVCG
610 620 630 640 650
PHGKCKSESG GKFTCDCNKG FTGTYCHENI NDCEGNPCTN GGTCIDGVNS
660 670 680 690 700
YKCICSDGWE GAHCENNIND CSQNPCHYGG TCRDLVNDFY CDCKNGWKGK
710 720 730 740 750
TCHSRDSQCD EATCNNGGTC YDEVDTFKCM CPGGWEGTTC NIARNSSCLP
760 770 780 790 800
NPCHNGGTCV VNGDSFTCVC KEGWEGPICT QNTNDCSPHP CYNSGTCVDG
810 820 830 840 850
DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN GYQCICPPGH
860 870 880 890 900
SGAKCHEVSG RSCITMGRVI LDGAKWDDDC NTCQCLNGRV ACSKVWCGPR
910 920 930 940 950
PCRLHKGHGE CPNGQSCIPV LDDQCFVRPC TGAGECRSSS LQPVKTKCTS
960 970 980 990 1000
DSYYQDNCAN ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI
1010 1020 1030 1040 1050
ACEPSLSANN EIHVAISAED IRDDGNPVKE ITDKIIDLVS KRDGNSSLIA
1060 1070 1080 1090 1100
AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA WVCCLVTAFY WCVRKRRRKP
1110 1120 1130 1140 1150
SSHTHSAPED NTTNNVREQL NQIKNPIEKH GANTVPIKDY ENKNSKMSKI
1160 1170 1180 1190 1200
RTHNSEVEED DMDKHQQKVR FAKQPVYTLV DREEKVPQRT PTKHPNWTNK
1210
QDNRDLESAQ SLNRMEYIV
Length:1,219
Mass (Da):134,326
Last modified:January 1, 1998 - v2
Checksum:i65D4CFC238A0E204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38483 mRNA. Translation: AAB06509.1.
PIRiA56136.
RefSeqiNP_062020.1. NM_019147.1.
UniGeneiRn.88804.

Genome annotation databases

GeneIDi29146.
KEGGirno:29146.
UCSCiRGD:2937. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38483 mRNA. Translation: AAB06509.1.
PIRiA56136.
RefSeqiNP_062020.1. NM_019147.1.
UniGeneiRn.88804.

3D structure databases

ProteinModelPortaliQ63722.
SMRiQ63722. Positions 186-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247829. 3 interactions.
IntActiQ63722. 5 interactions.
MINTiMINT-1538167.
STRINGi10116.ENSRNOP00000010638.

Proteomic databases

PaxDbiQ63722.
PRIDEiQ63722.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29146.
KEGGirno:29146.
UCSCiRGD:2937. rat.

Organism-specific databases

CTDi182.
RGDi2937. Jag1.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ63722.
KOiK06052.
PhylomeDBiQ63722.

Miscellaneous databases

PROiQ63722.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 11 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 16 hits.
SM00179. EGF_CA. 14 hits.
SM00214. VWC. 1 hit.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 16 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Jagged: a mammalian ligand that activates Notch1."
    Lindsell C.E., Shawber C.J., Boulter J., Weinmaster G.
    Cell 80:909-917(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Sciatic nerve.

Entry informationi

Entry nameiJAG1_RAT
AccessioniPrimary (citable) accession number: Q63722
Secondary accession number(s): P70640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.