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Protein

Ras GTPase-activating protein 2

Gene

Rasa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri706 – 742Btk-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

  • GTPase activator activity Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • phospholipid binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5658442 Regulation of RAS by GAPs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 2
Alternative name(s):
GAP1m
Gene namesi
Name:Rasa2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3538 Rasa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000566402 – 847Ras GTPase-activating protein 2Add BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei554PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63713
PRIDEiQ63713

Expressioni

Tissue specificityi

Widely expressed. Higher expression in brain, placenta, and kidney.

Gene expression databases

BgeeiENSRNOG00000011909
GenevisibleiQ63713 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016327

Structurei

3D structure databases

ProteinModelPortaliQ63713
SMRiQ63713
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 121C2 1PROSITE-ProRule annotationAdd BLAST98
Domaini157 – 272C2 2PROSITE-ProRule annotationAdd BLAST116
Domaini355 – 549Ras-GAPPROSITE-ProRule annotationAdd BLAST195
Domaini603 – 704PHPROSITE-ProRule annotationAdd BLAST102

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 21Ala-richAdd BLAST20

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri706 – 742Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2059 Eukaryota
ENOG410Y128 LUCA
GeneTreeiENSGT00760000119092
HOGENOMiHOG000007183
HOVERGENiHBG055643
InParanoidiQ63713
KOiK08053
OMAiKPCTAGV
OrthoDBiEOG091G04T8
PhylomeDBiQ63713
TreeFamiTF105302

Family and domain databases

CDDicd13370 PH_GAP1m_mammal-like, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037773 RASA2_PH
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif
PfamiView protein in Pfam
PF00779 BTK, 1 hit
PF00168 C2, 2 hits
PF00169 PH, 1 hit
PF00616 RasGAP, 2 hits
PRINTSiPR00402 TECBTKDOMAIN
SMARTiView protein in SMART
SM00107 BTK, 1 hit
SM00239 C2, 2 hits
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51113 ZF_BTK, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAPAAAA LTEAPAVPGT AEPETGDEDS REVRVLQSLR GRIYEAKNLL
60 70 80 90 100
PYLGPNKMRD CFCTINLDQE EVYRTQVVEK SLSPYFSEEF YFEIPRTFQY
110 120 130 140 150
LSFYVYDKNV LQRDLRIGKV AIKKEDLCSH SGKETWFSLQ PIDSNSEVQG
160 170 180 190 200
KVHLELKLNE LITENGTVCQ QLVVHIKACH GLPLINGQSC DPYATVSLVG
210 220 230 240 250
PSRNDQKKTK VKKKTSNPQF NEVFYFEVTR SSSYTRKSQF QVEEEDIEKL
260 270 280 290 300
EIRIDLWNNE NLVQDVFLGE IKVPVNVLRN DSSHQAWYLL QPRDNGNKSS
310 320 330 340 350
KPDDLGSLLL TLCYTEDYVL PSEYYGPLKA LLLKSPDVQP VSASAAYILG
360 370 380 390 400
EICRDQKDAV LPLVRLLLHH NKLVPFITAV ADLDLKDTQD ANAIFRGNSL
410 420 430 440 450
ATQCLTEMMK IVGGHYLKVT LKPVLDEICE SSKSCEIDPV KLKEGDNVES
460 470 480 490 500
NKENLYYYVD KVFSAIVGSS VSCPTVMCDI FYSLRQMAAK RFPNNPHVQY
510 520 530 540 550
SAVSSFVFLR FFAVAILSPH AFHLRPHYPD TQTVRTLTLI SKTIQIIGNW
560 570 580 590 600
GCQSRRKSRF KKSVMCEFLK MFQEERYFTD VKKFLDEISS TETKESSGTS
610 620 630 640 650
EPVHLKEGEM YKRAQGRTRI GKKNFKKRWF CLTSKELTYH KQQGKDAIYT
660 670 680 690 700
IPVKNILAVE KLEESSFNKK NMFQVIHTEK TLYIQANNCV EANEWIDMLC
710 720 730 740 750
RVSRCNHNRL SSFHPSAYLN GNWLCCQETS EGTPGCKPCT AGIPADIQID
760 770 780 790 800
IDEDRETERI YSVFTLSLLK LQKMEEACGS IAVYQGPQKE PGYSKFTIED
810 820 830 840
SVATFKTIQQ IKSTIEKLDE PHEKYRKKRS SSAKYGSKEN PIVGKIS
Length:847
Mass (Da):96,374
Last modified:November 1, 1996 - v1
Checksum:iA7E88AF2DA74516B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30734 mRNA Translation: BAA06398.1
PIRiA56039
RefSeqiNP_001099194.1, NM_001105724.1
UniGeneiRn.161946

Genome annotation databases

EnsembliENSRNOT00000016327; ENSRNOP00000016327; ENSRNOG00000011909
GeneIDi25597
KEGGirno:25597
UCSCiRGD:3538 rat

Similar proteinsi

Entry informationi

Entry nameiRASA2_RAT
AccessioniPrimary (citable) accession number: Q63713
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health