Ras GTPase-activating protein 2 - Rattus norvegicus (Rat)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Ras GTPase-activating protein 2

Alternative name(s):
GAP1m

Gene names

Name:

Rasa2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	847 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids.
Subcellular location	Cell membrane Potential.
Tissue specificity	Widely expressed. Higher expression in brain, placenta, and kidney.
Sequence similarities	Contains 1 Btk-type zinc finger. Contains 2 C2 domains. Contains 1 PH domain. Contains 1 Ras-GAP domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro negative regulation of Ras protein signal transduction Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome intracellular membrane-bounded organelle Inferred from electronic annotation. Source: Compara intrinsic to internal side of plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	Ras GTPase activator activity Inferred from direct assay Ref.1. Source: RGD metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 847

847

Ras GTPase-activating protein 2

PRO_0000056640

Regions

Domain

24 – 121

98

C2 1

Domain

157 – 272

116

C2 2

Domain

355 – 549

195

Ras-GAP

Domain

603 – 704

102

PH

Zinc finger

706 – 742

37

Btk-type

Compositional bias

2 – 21

20

Ala-rich

Sequences

Sequence

Length

Mass (Da)

Tools

Q63713 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A7E88AF2DA74516B
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FASTA

847

96,374

        10         20         30         40         50         60 
MAAAAPAAAA LTEAPAVPGT AEPETGDEDS REVRVLQSLR GRIYEAKNLL PYLGPNKMRD 

        70         80         90        100        110        120 
CFCTINLDQE EVYRTQVVEK SLSPYFSEEF YFEIPRTFQY LSFYVYDKNV LQRDLRIGKV 

       130        140        150        160        170        180 
AIKKEDLCSH SGKETWFSLQ PIDSNSEVQG KVHLELKLNE LITENGTVCQ QLVVHIKACH 

       190        200        210        220        230        240 
GLPLINGQSC DPYATVSLVG PSRNDQKKTK VKKKTSNPQF NEVFYFEVTR SSSYTRKSQF 

       250        260        270        280        290        300 
QVEEEDIEKL EIRIDLWNNE NLVQDVFLGE IKVPVNVLRN DSSHQAWYLL QPRDNGNKSS 

       310        320        330        340        350        360 
KPDDLGSLLL TLCYTEDYVL PSEYYGPLKA LLLKSPDVQP VSASAAYILG EICRDQKDAV 

       370        380        390        400        410        420 
LPLVRLLLHH NKLVPFITAV ADLDLKDTQD ANAIFRGNSL ATQCLTEMMK IVGGHYLKVT 

       430        440        450        460        470        480 
LKPVLDEICE SSKSCEIDPV KLKEGDNVES NKENLYYYVD KVFSAIVGSS VSCPTVMCDI 

       490        500        510        520        530        540 
FYSLRQMAAK RFPNNPHVQY SAVSSFVFLR FFAVAILSPH AFHLRPHYPD TQTVRTLTLI 

       550        560        570        580        590        600 
SKTIQIIGNW GCQSRRKSRF KKSVMCEFLK MFQEERYFTD VKKFLDEISS TETKESSGTS 

       610        620        630        640        650        660 
EPVHLKEGEM YKRAQGRTRI GKKNFKKRWF CLTSKELTYH KQQGKDAIYT IPVKNILAVE 

       670        680        690        700        710        720 
KLEESSFNKK NMFQVIHTEK TLYIQANNCV EANEWIDMLC RVSRCNHNRL SSFHPSAYLN 

       730        740        750        760        770        780 
GNWLCCQETS EGTPGCKPCT AGIPADIQID IDEDRETERI YSVFTLSLLK LQKMEEACGS 

       790        800        810        820        830        840 
IAVYQGPQKE PGYSKFTIED SVATFKTIQQ IKSTIEKLDE PHEKYRKKRS SSAKYGSKEN 


PIVGKIS

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References

[1]	"A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions." Maekawa M., Li S., Iwamatsu A., Morishita T., Yokota K., Imai Y., Kohsaka S., Nakamura S., Hattori S. Mol. Cell. Biol. 14:6879-6885(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D30734 mRNA. Translation: BAA06398.1.
IPI	IPI00211775.
PIR	A56039.
RefSeq	NP_001099194.1. NM_001105724.1.
UniGene	Rn.161946.
3D structure databases
ProteinModelPortal	Q63713.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000016327.
Proteomic databases
PRIDE	Q63713.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000016327; ENSRNOP00000016327; ENSRNOG00000011909.
GeneID	25597.
KEGG	rno:25597.
UCSC	RGD:3538. rat.
Organism-specific databases
CTD	5922.
RGD	3538. Rasa2.
Phylogenomic databases
eggNOG	NOG323905.
GeneTree	ENSGT00600000084336.
HOGENOM	HOG000007183.
HOVERGEN	HBG055643.
InParanoid	Q63713.
KO	K08053.
OMA	KICEAKN.
OrthoDB	EOG4MSCXJ.
Gene expression databases
Genevestigator	Q63713.
GermOnline	ENSRNOG00000011909. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.506.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR001936. RasGAP. IPR023152. RasGAP_CS. IPR008936. Rho_GTPase_activation_prot. IPR001562. Znf_Btk_motif. [Graphical view]
Pfam	PF00779. BTK. 1 hit. PF00168. C2. 2 hits. PF00169. PH. 1 hit. PF00616. RasGAP. 1 hit. [Graphical view]
PRINTS	PR00402. TECBTKDOMAIN.
SMART	SM00107. BTK. 1 hit. SM00239. C2. 2 hits. SM00233. PH. 1 hit. SM00323. RasGAP. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 2 hits. SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50004. C2. 2 hits. PS50003. PH_DOMAIN. 1 hit. PS00509. RAS_GTPASE_ACTIV_1. 1 hit. PS50018. RAS_GTPASE_ACTIV_2. 1 hit. PS51113. ZF_BTK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	607291.

Entry information

Entry name

RASA2_RAT

Accession

Primary (citable) accession number: Q63713

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents