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Q63713 (RASA2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras GTPase-activating protein 2
Alternative name(s):
GAP1m
Gene names
Name:Rasa2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length847 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids.

Subcellular location

Cell membrane Potential.

Tissue specificity

Widely expressed. Higher expression in brain, placenta, and kidney.

Sequence similarities

Contains 1 Btk-type zinc finger.

Contains 2 C2 domains.

Contains 1 PH domain.

Contains 1 Ras-GAP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 847846Ras GTPase-activating protein 2
PRO_0000056640

Regions

Domain24 – 12198C2 1
Domain157 – 272116C2 2
Domain355 – 549195Ras-GAP
Domain603 – 704102PH
Zinc finger706 – 74237Btk-type
Compositional bias2 – 2120Ala-rich

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63713 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A7E88AF2DA74516B

FASTA84796,374
        10         20         30         40         50         60 
MAAAAPAAAA LTEAPAVPGT AEPETGDEDS REVRVLQSLR GRIYEAKNLL PYLGPNKMRD 

        70         80         90        100        110        120 
CFCTINLDQE EVYRTQVVEK SLSPYFSEEF YFEIPRTFQY LSFYVYDKNV LQRDLRIGKV 

       130        140        150        160        170        180 
AIKKEDLCSH SGKETWFSLQ PIDSNSEVQG KVHLELKLNE LITENGTVCQ QLVVHIKACH 

       190        200        210        220        230        240 
GLPLINGQSC DPYATVSLVG PSRNDQKKTK VKKKTSNPQF NEVFYFEVTR SSSYTRKSQF 

       250        260        270        280        290        300 
QVEEEDIEKL EIRIDLWNNE NLVQDVFLGE IKVPVNVLRN DSSHQAWYLL QPRDNGNKSS 

       310        320        330        340        350        360 
KPDDLGSLLL TLCYTEDYVL PSEYYGPLKA LLLKSPDVQP VSASAAYILG EICRDQKDAV 

       370        380        390        400        410        420 
LPLVRLLLHH NKLVPFITAV ADLDLKDTQD ANAIFRGNSL ATQCLTEMMK IVGGHYLKVT 

       430        440        450        460        470        480 
LKPVLDEICE SSKSCEIDPV KLKEGDNVES NKENLYYYVD KVFSAIVGSS VSCPTVMCDI 

       490        500        510        520        530        540 
FYSLRQMAAK RFPNNPHVQY SAVSSFVFLR FFAVAILSPH AFHLRPHYPD TQTVRTLTLI 

       550        560        570        580        590        600 
SKTIQIIGNW GCQSRRKSRF KKSVMCEFLK MFQEERYFTD VKKFLDEISS TETKESSGTS 

       610        620        630        640        650        660 
EPVHLKEGEM YKRAQGRTRI GKKNFKKRWF CLTSKELTYH KQQGKDAIYT IPVKNILAVE 

       670        680        690        700        710        720 
KLEESSFNKK NMFQVIHTEK TLYIQANNCV EANEWIDMLC RVSRCNHNRL SSFHPSAYLN 

       730        740        750        760        770        780 
GNWLCCQETS EGTPGCKPCT AGIPADIQID IDEDRETERI YSVFTLSLLK LQKMEEACGS 

       790        800        810        820        830        840 
IAVYQGPQKE PGYSKFTIED SVATFKTIQQ IKSTIEKLDE PHEKYRKKRS SSAKYGSKEN 


PIVGKIS 

« Hide

References

[1]"A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions."
Maekawa M., Li S., Iwamatsu A., Morishita T., Yokota K., Imai Y., Kohsaka S., Nakamura S., Hattori S.
Mol. Cell. Biol. 14:6879-6885(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D30734 mRNA. Translation: BAA06398.1.
PIRA56039.
RefSeqNP_001099194.1. NM_001105724.1.
UniGeneRn.161946.

3D structure databases

ProteinModelPortalQ63713.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016327.

Proteomic databases

PRIDEQ63713.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000016327; ENSRNOP00000016327; ENSRNOG00000011909.
GeneID25597.
KEGGrno:25597.
UCSCRGD:3538. rat.

Organism-specific databases

CTD5922.
RGD3538. Rasa2.

Phylogenomic databases

eggNOGNOG323905.
GeneTreeENSGT00600000084336.
HOGENOMHOG000007183.
HOVERGENHBG055643.
InParanoidQ63713.
KOK08053.
OMAKPCTAGV.
OrthoDBEOG7J17Z6.
PhylomeDBQ63713.
TreeFamTF105302.

Gene expression databases

GenevestigatorQ63713.

Family and domain databases

Gene3D1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
InterProIPR000008. C2_dom.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamPF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
PRINTSPR00402. TECBTKDOMAIN.
SMARTSM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
PROSITEPS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607291.
PROQ63713.

Entry information

Entry nameRASA2_RAT
AccessionPrimary (citable) accession number: Q63713
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families