SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q63713

- RASA2_RAT

UniProt

Q63713 - RASA2_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ras GTPase-activating protein 2
Gene
Rasa2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri706 – 74237Btk-type
Add
BLAST

GO - Molecular functioni

  1. Ras GTPase activator activity Source: RGD
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. negative regulation of Ras protein signal transduction Source: RefGenome
  3. positive regulation of Ras GTPase activity Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 2
Alternative name(s):
GAP1m
Gene namesi
Name:Rasa2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi3538. Rasa2.

Subcellular locationi

Cell membrane Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. intracellular membrane-bounded organelle Source: Ensembl
  3. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 847846Ras GTPase-activating protein 2
PRO_0000056640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ63713.

Expressioni

Tissue specificityi

Widely expressed. Higher expression in brain, placenta, and kidney.

Gene expression databases

GenevestigatoriQ63713.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016327.

Structurei

3D structure databases

ProteinModelPortaliQ63713.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 12198C2 1
Add
BLAST
Domaini157 – 272116C2 2
Add
BLAST
Domaini355 – 549195Ras-GAP
Add
BLAST
Domaini603 – 704102PH
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 2120Ala-rich
Add
BLAST

Sequence similaritiesi

Contains 2 C2 domains.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG323905.
GeneTreeiENSGT00600000084336.
HOGENOMiHOG000007183.
HOVERGENiHBG055643.
InParanoidiQ63713.
KOiK08053.
OMAiKPCTAGV.
OrthoDBiEOG7J17Z6.
PhylomeDBiQ63713.
TreeFamiTF105302.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
PRINTSiPR00402. TECBTKDOMAIN.
SMARTiSM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63713-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAAPAAAA LTEAPAVPGT AEPETGDEDS REVRVLQSLR GRIYEAKNLL    50
PYLGPNKMRD CFCTINLDQE EVYRTQVVEK SLSPYFSEEF YFEIPRTFQY 100
LSFYVYDKNV LQRDLRIGKV AIKKEDLCSH SGKETWFSLQ PIDSNSEVQG 150
KVHLELKLNE LITENGTVCQ QLVVHIKACH GLPLINGQSC DPYATVSLVG 200
PSRNDQKKTK VKKKTSNPQF NEVFYFEVTR SSSYTRKSQF QVEEEDIEKL 250
EIRIDLWNNE NLVQDVFLGE IKVPVNVLRN DSSHQAWYLL QPRDNGNKSS 300
KPDDLGSLLL TLCYTEDYVL PSEYYGPLKA LLLKSPDVQP VSASAAYILG 350
EICRDQKDAV LPLVRLLLHH NKLVPFITAV ADLDLKDTQD ANAIFRGNSL 400
ATQCLTEMMK IVGGHYLKVT LKPVLDEICE SSKSCEIDPV KLKEGDNVES 450
NKENLYYYVD KVFSAIVGSS VSCPTVMCDI FYSLRQMAAK RFPNNPHVQY 500
SAVSSFVFLR FFAVAILSPH AFHLRPHYPD TQTVRTLTLI SKTIQIIGNW 550
GCQSRRKSRF KKSVMCEFLK MFQEERYFTD VKKFLDEISS TETKESSGTS 600
EPVHLKEGEM YKRAQGRTRI GKKNFKKRWF CLTSKELTYH KQQGKDAIYT 650
IPVKNILAVE KLEESSFNKK NMFQVIHTEK TLYIQANNCV EANEWIDMLC 700
RVSRCNHNRL SSFHPSAYLN GNWLCCQETS EGTPGCKPCT AGIPADIQID 750
IDEDRETERI YSVFTLSLLK LQKMEEACGS IAVYQGPQKE PGYSKFTIED 800
SVATFKTIQQ IKSTIEKLDE PHEKYRKKRS SSAKYGSKEN PIVGKIS 847
Length:847
Mass (Da):96,374
Last modified:November 1, 1996 - v1
Checksum:iA7E88AF2DA74516B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30734 mRNA. Translation: BAA06398.1.
PIRiA56039.
RefSeqiNP_001099194.1. NM_001105724.1.
UniGeneiRn.161946.

Genome annotation databases

EnsembliENSRNOT00000016327; ENSRNOP00000016327; ENSRNOG00000011909.
GeneIDi25597.
KEGGirno:25597.
UCSCiRGD:3538. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30734 mRNA. Translation: BAA06398.1 .
PIRi A56039.
RefSeqi NP_001099194.1. NM_001105724.1.
UniGenei Rn.161946.

3D structure databases

ProteinModelPortali Q63713.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016327.

Proteomic databases

PRIDEi Q63713.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016327 ; ENSRNOP00000016327 ; ENSRNOG00000011909 .
GeneIDi 25597.
KEGGi rno:25597.
UCSCi RGD:3538. rat.

Organism-specific databases

CTDi 5922.
RGDi 3538. Rasa2.

Phylogenomic databases

eggNOGi NOG323905.
GeneTreei ENSGT00600000084336.
HOGENOMi HOG000007183.
HOVERGENi HBG055643.
InParanoidi Q63713.
KOi K08053.
OMAi KPCTAGV.
OrthoDBi EOG7J17Z6.
PhylomeDBi Q63713.
TreeFami TF105302.

Miscellaneous databases

NextBioi 607291.
PROi Q63713.

Gene expression databases

Genevestigatori Q63713.

Family and domain databases

Gene3Di 1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view ]
Pfami PF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view ]
PRINTSi PR00402. TECBTKDOMAIN.
SMARTi SM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions."
    Maekawa M., Li S., Iwamatsu A., Morishita T., Yokota K., Imai Y., Kohsaka S., Nakamura S., Hattori S.
    Mol. Cell. Biol. 14:6879-6885(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRASA2_RAT
AccessioniPrimary (citable) accession number: Q63713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi