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Q63713

- RASA2_RAT

UniProt

Q63713 - RASA2_RAT

Protein

Ras GTPase-activating protein 2

Gene

Rasa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri706 – 74237Btk-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. Ras GTPase activator activity Source: RGD

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. negative regulation of Ras protein signal transduction Source: RefGenome
    3. positive regulation of Ras GTPase activity Source: RefGenome

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras GTPase-activating protein 2
    Alternative name(s):
    GAP1m
    Gene namesi
    Name:Rasa2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi3538. Rasa2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. intracellular membrane-bounded organelle Source: Ensembl
    3. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 847846Ras GTPase-activating protein 2PRO_0000056640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ63713.

    Expressioni

    Tissue specificityi

    Widely expressed. Higher expression in brain, placenta, and kidney.

    Gene expression databases

    GenevestigatoriQ63713.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016327.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63713.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 12198C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini157 – 272116C2 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini355 – 549195Ras-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini603 – 704102PHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 2120Ala-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
    Contains 2 C2 domains.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri706 – 74237Btk-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG323905.
    GeneTreeiENSGT00600000084336.
    HOGENOMiHOG000007183.
    HOVERGENiHBG055643.
    InParanoidiQ63713.
    KOiK08053.
    OMAiKPCTAGV.
    OrthoDBiEOG7J17Z6.
    PhylomeDBiQ63713.
    TreeFamiTF105302.

    Family and domain databases

    Gene3Di1.10.506.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001562. Znf_Btk_motif.
    [Graphical view]
    PfamiPF00779. BTK. 1 hit.
    PF00168. C2. 2 hits.
    PF00169. PH. 1 hit.
    PF00616. RasGAP. 1 hit.
    [Graphical view]
    PRINTSiPR00402. TECBTKDOMAIN.
    SMARTiSM00107. BTK. 1 hit.
    SM00239. C2. 2 hits.
    SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63713-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAPAAAA LTEAPAVPGT AEPETGDEDS REVRVLQSLR GRIYEAKNLL    50
    PYLGPNKMRD CFCTINLDQE EVYRTQVVEK SLSPYFSEEF YFEIPRTFQY 100
    LSFYVYDKNV LQRDLRIGKV AIKKEDLCSH SGKETWFSLQ PIDSNSEVQG 150
    KVHLELKLNE LITENGTVCQ QLVVHIKACH GLPLINGQSC DPYATVSLVG 200
    PSRNDQKKTK VKKKTSNPQF NEVFYFEVTR SSSYTRKSQF QVEEEDIEKL 250
    EIRIDLWNNE NLVQDVFLGE IKVPVNVLRN DSSHQAWYLL QPRDNGNKSS 300
    KPDDLGSLLL TLCYTEDYVL PSEYYGPLKA LLLKSPDVQP VSASAAYILG 350
    EICRDQKDAV LPLVRLLLHH NKLVPFITAV ADLDLKDTQD ANAIFRGNSL 400
    ATQCLTEMMK IVGGHYLKVT LKPVLDEICE SSKSCEIDPV KLKEGDNVES 450
    NKENLYYYVD KVFSAIVGSS VSCPTVMCDI FYSLRQMAAK RFPNNPHVQY 500
    SAVSSFVFLR FFAVAILSPH AFHLRPHYPD TQTVRTLTLI SKTIQIIGNW 550
    GCQSRRKSRF KKSVMCEFLK MFQEERYFTD VKKFLDEISS TETKESSGTS 600
    EPVHLKEGEM YKRAQGRTRI GKKNFKKRWF CLTSKELTYH KQQGKDAIYT 650
    IPVKNILAVE KLEESSFNKK NMFQVIHTEK TLYIQANNCV EANEWIDMLC 700
    RVSRCNHNRL SSFHPSAYLN GNWLCCQETS EGTPGCKPCT AGIPADIQID 750
    IDEDRETERI YSVFTLSLLK LQKMEEACGS IAVYQGPQKE PGYSKFTIED 800
    SVATFKTIQQ IKSTIEKLDE PHEKYRKKRS SSAKYGSKEN PIVGKIS 847
    Length:847
    Mass (Da):96,374
    Last modified:November 1, 1996 - v1
    Checksum:iA7E88AF2DA74516B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30734 mRNA. Translation: BAA06398.1.
    PIRiA56039.
    RefSeqiNP_001099194.1. NM_001105724.1.
    UniGeneiRn.161946.

    Genome annotation databases

    EnsembliENSRNOT00000016327; ENSRNOP00000016327; ENSRNOG00000011909.
    GeneIDi25597.
    KEGGirno:25597.
    UCSCiRGD:3538. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30734 mRNA. Translation: BAA06398.1 .
    PIRi A56039.
    RefSeqi NP_001099194.1. NM_001105724.1.
    UniGenei Rn.161946.

    3D structure databases

    ProteinModelPortali Q63713.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016327.

    Proteomic databases

    PRIDEi Q63713.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000016327 ; ENSRNOP00000016327 ; ENSRNOG00000011909 .
    GeneIDi 25597.
    KEGGi rno:25597.
    UCSCi RGD:3538. rat.

    Organism-specific databases

    CTDi 5922.
    RGDi 3538. Rasa2.

    Phylogenomic databases

    eggNOGi NOG323905.
    GeneTreei ENSGT00600000084336.
    HOGENOMi HOG000007183.
    HOVERGENi HBG055643.
    InParanoidi Q63713.
    KOi K08053.
    OMAi KPCTAGV.
    OrthoDBi EOG7J17Z6.
    PhylomeDBi Q63713.
    TreeFami TF105302.

    Miscellaneous databases

    NextBioi 607291.
    PROi Q63713.

    Gene expression databases

    Genevestigatori Q63713.

    Family and domain databases

    Gene3Di 1.10.506.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001562. Znf_Btk_motif.
    [Graphical view ]
    Pfami PF00779. BTK. 1 hit.
    PF00168. C2. 2 hits.
    PF00169. PH. 1 hit.
    PF00616. RasGAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00402. TECBTKDOMAIN.
    SMARTi SM00107. BTK. 1 hit.
    SM00239. C2. 2 hits.
    SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions."
      Maekawa M., Li S., Iwamatsu A., Morishita T., Yokota K., Imai Y., Kohsaka S., Nakamura S., Hattori S.
      Mol. Cell. Biol. 14:6879-6885(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRASA2_RAT
    AccessioniPrimary (citable) accession number: Q63713
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3