Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras GTPase-activating protein 2

Gene

Rasa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri706 – 74237Btk-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. Ras GTPase activator activity Source: RGD

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. negative regulation of Ras protein signal transduction Source: GO_Central
  3. positive regulation of Ras GTPase activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 2
Alternative name(s):
GAP1m
Gene namesi
Name:Rasa2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi3538. Rasa2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. intrinsic component of the cytoplasmic side of the plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 847846Ras GTPase-activating protein 2PRO_0000056640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ63713.

Expressioni

Tissue specificityi

Widely expressed. Higher expression in brain, placenta, and kidney.

Gene expression databases

GenevestigatoriQ63713.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016327.

Structurei

3D structure databases

ProteinModelPortaliQ63713.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 12198C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini157 – 272116C2 2PROSITE-ProRule annotationAdd
BLAST
Domaini355 – 549195Ras-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini603 – 704102PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 2120Ala-richAdd
BLAST

Sequence similaritiesi

Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri706 – 74237Btk-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG323905.
GeneTreeiENSGT00760000119092.
HOGENOMiHOG000007183.
HOVERGENiHBG055643.
InParanoidiQ63713.
KOiK08053.
OMAiVMCDIFY.
OrthoDBiEOG7J17Z6.
PhylomeDBiQ63713.
TreeFamiTF105302.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
PRINTSiPR00402. TECBTKDOMAIN.
SMARTiSM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAPAAAA LTEAPAVPGT AEPETGDEDS REVRVLQSLR GRIYEAKNLL
60 70 80 90 100
PYLGPNKMRD CFCTINLDQE EVYRTQVVEK SLSPYFSEEF YFEIPRTFQY
110 120 130 140 150
LSFYVYDKNV LQRDLRIGKV AIKKEDLCSH SGKETWFSLQ PIDSNSEVQG
160 170 180 190 200
KVHLELKLNE LITENGTVCQ QLVVHIKACH GLPLINGQSC DPYATVSLVG
210 220 230 240 250
PSRNDQKKTK VKKKTSNPQF NEVFYFEVTR SSSYTRKSQF QVEEEDIEKL
260 270 280 290 300
EIRIDLWNNE NLVQDVFLGE IKVPVNVLRN DSSHQAWYLL QPRDNGNKSS
310 320 330 340 350
KPDDLGSLLL TLCYTEDYVL PSEYYGPLKA LLLKSPDVQP VSASAAYILG
360 370 380 390 400
EICRDQKDAV LPLVRLLLHH NKLVPFITAV ADLDLKDTQD ANAIFRGNSL
410 420 430 440 450
ATQCLTEMMK IVGGHYLKVT LKPVLDEICE SSKSCEIDPV KLKEGDNVES
460 470 480 490 500
NKENLYYYVD KVFSAIVGSS VSCPTVMCDI FYSLRQMAAK RFPNNPHVQY
510 520 530 540 550
SAVSSFVFLR FFAVAILSPH AFHLRPHYPD TQTVRTLTLI SKTIQIIGNW
560 570 580 590 600
GCQSRRKSRF KKSVMCEFLK MFQEERYFTD VKKFLDEISS TETKESSGTS
610 620 630 640 650
EPVHLKEGEM YKRAQGRTRI GKKNFKKRWF CLTSKELTYH KQQGKDAIYT
660 670 680 690 700
IPVKNILAVE KLEESSFNKK NMFQVIHTEK TLYIQANNCV EANEWIDMLC
710 720 730 740 750
RVSRCNHNRL SSFHPSAYLN GNWLCCQETS EGTPGCKPCT AGIPADIQID
760 770 780 790 800
IDEDRETERI YSVFTLSLLK LQKMEEACGS IAVYQGPQKE PGYSKFTIED
810 820 830 840
SVATFKTIQQ IKSTIEKLDE PHEKYRKKRS SSAKYGSKEN PIVGKIS
Length:847
Mass (Da):96,374
Last modified:November 1, 1996 - v1
Checksum:iA7E88AF2DA74516B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30734 mRNA. Translation: BAA06398.1.
PIRiA56039.
RefSeqiNP_001099194.1. NM_001105724.1.
UniGeneiRn.161946.

Genome annotation databases

EnsembliENSRNOT00000016327; ENSRNOP00000016327; ENSRNOG00000011909.
GeneIDi25597.
KEGGirno:25597.
UCSCiRGD:3538. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30734 mRNA. Translation: BAA06398.1.
PIRiA56039.
RefSeqiNP_001099194.1. NM_001105724.1.
UniGeneiRn.161946.

3D structure databases

ProteinModelPortaliQ63713.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016327.

Proteomic databases

PRIDEiQ63713.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016327; ENSRNOP00000016327; ENSRNOG00000011909.
GeneIDi25597.
KEGGirno:25597.
UCSCiRGD:3538. rat.

Organism-specific databases

CTDi5922.
RGDi3538. Rasa2.

Phylogenomic databases

eggNOGiNOG323905.
GeneTreeiENSGT00760000119092.
HOGENOMiHOG000007183.
HOVERGENiHBG055643.
InParanoidiQ63713.
KOiK08053.
OMAiVMCDIFY.
OrthoDBiEOG7J17Z6.
PhylomeDBiQ63713.
TreeFamiTF105302.

Miscellaneous databases

NextBioi607291.
PROiQ63713.

Gene expression databases

GenevestigatoriQ63713.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
PRINTSiPR00402. TECBTKDOMAIN.
SMARTiSM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions."
    Maekawa M., Li S., Iwamatsu A., Morishita T., Yokota K., Imai Y., Kohsaka S., Nakamura S., Hattori S.
    Mol. Cell. Biol. 14:6879-6885(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRASA2_RAT
AccessioniPrimary (citable) accession number: Q63713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.