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Q63691

- CD14_RAT

UniProt

Q63691 - CD14_RAT

Protein

Monocyte differentiation antigen CD14

Gene

Cd14

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules By similarity.By similarity

    GO - Molecular functioni

    1. lipopolysaccharide binding Source: Ensembl
    2. lipoteichoic acid binding Source: Ensembl
    3. protein binding Source: RGD

    GO - Biological processi

    1. cellular response to lipopolysaccharide Source: RGD
    2. cellular response to lipoteichoic acid Source: Ensembl
    3. inflammatory response Source: RGD
    4. innate immune response Source: UniProtKB-KW
    5. positive regulation of cytokine secretion Source: RGD
    6. positive regulation of endocytosis Source: Ensembl
    7. positive regulation of tumor necrosis factor production Source: Ensembl
    8. response to electrical stimulus Source: RGD
    9. response to ethanol Source: RGD
    10. response to heat Source: RGD
    11. response to lipopolysaccharide Source: RGD
    12. response to magnesium ion Source: RGD
    13. response to tumor necrosis factor Source: RGD

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_194376. IKK complex recruitment mediated by RIP1.
    REACT_198288. TRIF-mediated programmed cell death.
    REACT_198983. TRAF6 mediated induction of TAK1 complex.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocyte differentiation antigen CD14
    Alternative name(s):
    Myeloid cell-specific leucine-rich glycoprotein
    CD_antigen: CD14
    Gene namesi
    Name:Cd14
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi620588. Cd14.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. cell surface Source: RGD
    3. extracellular space Source: RGD
    4. lipopolysaccharide receptor complex Source: RGD
    5. membrane raft Source: Ensembl
    6. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 342325Monocyte differentiation antigen CD14PRO_0000020891Add
    BLAST
    Propeptidei343 – 37230Removed in mature formSequence AnalysisPRO_0000020892Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 38By similarity
    Disulfide bondi36 ↔ 53By similarity
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi189 ↔ 219By similarity
    Disulfide bondi243 ↔ 272By similarity
    Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis
    Lipidationi342 – 3421GPI-anchor amidated asparagineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ63691.
    PRIDEiQ63691.

    Expressioni

    Gene expression databases

    GenevestigatoriQ63691.

    Interactioni

    Subunit structurei

    Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000023977.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63691.
    SMRiQ63691. Positions 20-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati57 – 8428LRR 1Add
    BLAST
    Repeati85 – 12036LRR 2Add
    BLAST
    Repeati121 – 14626LRR 3Add
    BLAST
    Repeati147 – 17428LRR 4Add
    BLAST
    Repeati175 – 19824LRR 5Add
    BLAST
    Repeati199 – 22628LRR 6Add
    BLAST
    Repeati227 – 25327LRR 7Add
    BLAST
    Repeati254 – 27825LRR 8Add
    BLAST
    Repeati279 – 29921LRR 9Add
    BLAST
    Repeati300 – 32122LRR 10Add
    BLAST
    Repeati322 – 34625LRR 11Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni44 – 9148Ligand-binding pocket rimBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 11 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG86091.
    GeneTreeiENSGT00390000005689.
    HOGENOMiHOG000237268.
    HOVERGENiHBG005269.
    InParanoidiQ63691.
    KOiK04391.
    OMAiWATGGAW.
    OrthoDBiEOG751NFQ.
    PhylomeDBiQ63691.
    TreeFamiTF338550.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR016337. Monocyte_diff_Ag_CD14.
    [Graphical view]
    PIRSFiPIRSF002017. CD14. 1 hit.
    PROSITEiPS51450. LRR. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63691-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLMLGLLLL PLTLVHASPA TPEPCELDQD EESVRCYCNF SDPQPNWSSA    50
    FLCAGAEDVE FYGGGRSLEY LLKRVDTEAN LGQYTDIIRS LPLKRLTVRS 100
    ARVPTQILFG TLRVLGYSGL RELTLENLEV TGTALSPLLD ATGPDLNTLS 150
    LRNVSWATTD TWLAELQQWL KPGLKVLSIA QAHSLNFSCK QVGVFPALAT 200
    LDLSDNPELG EKGLISALCP HKFPTLQVLA LRNAGMETTS GVCSALAAAR 250
    VPLQALDLSH NSLRDTAGTP SCDWPSQLNS LNLSFTGLEH VPKGLPAKLS 300
    VLDLSYNRLD RKPRPEELPE VGSLSLTGNP FLHSESQSEA YNSGVVIATA 350
    LSPGSAGLSG TLALLLGHRL FV 372
    Length:372
    Mass (Da):40,054
    Last modified:May 1, 2007 - v2
    Checksum:iE99DD2C551DBBE69
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561Missing in AAB01154. (PubMed:8598386)Curated
    Sequence conflicti220 – 2201P → S in AAB01154. (PubMed:8598386)Curated
    Sequence conflicti269 – 2691T → A in AAB01154. (PubMed:8598386)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51804 mRNA. Translation: AAB01154.1.
    AF087943 mRNA. Translation: AAC35371.1.
    BC061733 mRNA. Translation: AAH61733.1.
    RefSeqiNP_068512.1. NM_021744.1.
    UniGeneiRn.42942.

    Genome annotation databases

    EnsembliENSRNOT00000023977; ENSRNOP00000023977; ENSRNOG00000017819.
    GeneIDi60350.
    KEGGirno:60350.
    UCSCiRGD:620588. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51804 mRNA. Translation: AAB01154.1 .
    AF087943 mRNA. Translation: AAC35371.1 .
    BC061733 mRNA. Translation: AAH61733.1 .
    RefSeqi NP_068512.1. NM_021744.1.
    UniGenei Rn.42942.

    3D structure databases

    ProteinModelPortali Q63691.
    SMRi Q63691. Positions 20-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000023977.

    Proteomic databases

    PaxDbi Q63691.
    PRIDEi Q63691.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000023977 ; ENSRNOP00000023977 ; ENSRNOG00000017819 .
    GeneIDi 60350.
    KEGGi rno:60350.
    UCSCi RGD:620588. rat.

    Organism-specific databases

    CTDi 929.
    RGDi 620588. Cd14.

    Phylogenomic databases

    eggNOGi NOG86091.
    GeneTreei ENSGT00390000005689.
    HOGENOMi HOG000237268.
    HOVERGENi HBG005269.
    InParanoidi Q63691.
    KOi K04391.
    OMAi WATGGAW.
    OrthoDBi EOG751NFQ.
    PhylomeDBi Q63691.
    TreeFami TF338550.

    Enzyme and pathway databases

    Reactomei REACT_194376. IKK complex recruitment mediated by RIP1.
    REACT_198288. TRIF-mediated programmed cell death.
    REACT_198983. TRAF6 mediated induction of TAK1 complex.

    Miscellaneous databases

    NextBioi 612011.
    PROi Q63691.

    Gene expression databases

    Genevestigatori Q63691.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR016337. Monocyte_diff_Ag_CD14.
    [Graphical view ]
    PIRSFi PIRSF002017. CD14. 1 hit.
    PROSITEi PS51450. LRR. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CD14 mediate endotoxin induction of nitric oxide synthase in cultured brain glial cells."
      Galea E., Reis D.J., Fox E.S., Xu H., Feinstein D.L.
      J. Neuroimmunol. 64:19-28(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    2. "Primary structure of rat CD14 and characteristics of rat CD14, cytokine, and NO synthase mRNA expression in mononuclear phagocyte system cells in response to LPS."
      Takai N., Kataoka M., Higuchi Y., Matsuura K., Yamamoto S.
      J. Leukoc. Biol. 61:736-744(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Expression of CD14 by hepatocytes: upregulation by cytokines during endotoxemia."
      Liu S., Khemlani L.S., Shapiro R.A., Johnson M.L., Liu K., Geller D.A., Watkins S.C., Goyert S.M., Billiar T.R.
      Infect. Immun. 66:5089-5098(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiCD14_RAT
    AccessioniPrimary (citable) accession number: Q63691
    Secondary accession number(s): Q6GT04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3