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Protein

Guanylate-binding protein 1

Gene

Gbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).By similarity

Catalytic activityi

GTP + H2O = GDP + phosphate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 52GTPBy similarity8
Nucleotide bindingi67 – 69GTPBy similarity3
Nucleotide bindingi97 – 101GTPBy similarity5

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate-binding protein 1 (EC:3.6.5.-By similarity)
Alternative name(s):
GTP-binding protein 2
Short name:
GBP-2
Guanine nucleotide-binding protein 2
Interferon-induced guanylate-binding protein 2
p67
Gene namesi
Name:Gbp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621810 Gbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001909671 – 586Guanylate-binding protein 1Add BLAST586
PropeptideiPRO_0000370784587 – 589Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei586Cysteine methyl esterSequence analysis1
Lipidationi586S-geranylgeranyl cysteine1 Publication1

Post-translational modificationi

Isoprenylation is required for proper subcellular location.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ63663
PRIDEiQ63663

PTM databases

iPTMnetiQ63663
PhosphoSitePlusiQ63663

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

By IFNG.

Interactioni

Subunit structurei

Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures. Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5.By similarity

Protein-protein interaction databases

BioGridi251165, 1 interactor
STRINGi10116.ENSRNOP00000061437

Structurei

3D structure databases

ProteinModelPortaliQ63663
SMRiQ63663
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 276GB1/RHD3-type GAdd BLAST242

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 309GTPase domain (Globular)By similarityAdd BLAST309

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2037 Eukaryota
ENOG410XR6Z LUCA
HOVERGENiHBG001979
InParanoidiQ63663
KOiK20897

Family and domain databases

CDDicd16269 GBP_C, 1 hit
InterProiView protein in InterPro
IPR030386 G_GB1_RHD3_dom
IPR037684 GBP_C
IPR003191 Guanylate-bd/ATL_C
IPR036543 Guanylate-bd_C_sf
IPR015894 Guanylate-bd_N
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02263 GBP, 1 hit
PF02841 GBP_C, 1 hit
SUPFAMiSSF48340 SSF48340, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51715 G_GB1_RHD3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEIHMLQP MCLIENTEAH LVINQEALRI LSAINQPVVV VAIVGLYRTG
60 70 80 90 100
KSYLMNKLAG KRTGFSLGST VQSHTKGIWM WCVPHPKKAG QTLVLLDTEG
110 120 130 140 150
LEDVEKGDNQ NDCWIFALAV LLSSTFVYNS MGTINQQAMD QLHYVTELTD
160 170 180 190 200
LIKSKSSPDQ SGIDDSANFV GFFPTFVWAL RDFSLELEVN GKLVTPDEYL
210 220 230 240 250
EHSLTLKKGA DKKTKSFNEP RLCIRKFFPK RKCFIFDRPA LRKQLCKLET
260 270 280 290 300
LGEEELCSEF VEQVAEFTSY IFSYSAVKTL SGGIIVNGPR LKSLVQTYVG
310 320 330 340 350
AISSGSLPCM ESAVLTLAQI ENSAAVQKAI THYEEQMNQK IQMPTETLQE
360 370 380 390 400
LLDLHRLIER EAIEIFLKNS FKDVDQKFQT ELGNLLISKR DAFIKKNSDV
410 420 430 440 450
SSAHCSDLIE DIFGPLEEEV KQGTFSKPGG YFLFLQMRQE LEKKYNQAPG
460 470 480 490 500
KGLEAEAVLK KYFESKEDIV ETLLKTDQSL TEAAKEIEVE RIKAETAEAA
510 520 530 540 550
NRELAEKQEK FELMMQQKEE SYQEHVRQLT EKMKEEQKKL IEEQDNIIAL
560 570 580
KLREQEKFLR EGYENESKKL LREIENMKRR QSPGKCTIL
Length:589
Mass (Da):67,109
Last modified:October 24, 2003 - v2
Checksum:i5E52B79102C2D97F
GO

Sequence cautioni

The sequence AAA19909 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80367 mRNA Translation: AAA19909.1 Different initiation.
PIRiS43506
RefSeqiNP_598308.1, NM_133624.2
UniGeneiRn.25736

Genome annotation databases

GeneIDi171164
KEGGirno:171164

Similar proteinsi

Entry informationi

Entry nameiGBP2_RAT
AccessioniPrimary (citable) accession number: Q63663
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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