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Protein

Guanylate-binding protein 1

Gene

Gbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).By similarity

Catalytic activityi

GTP + H2O = GDP + phosphate.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 528GTPBy similarity
Nucleotide bindingi67 – 693GTPBy similarity
Nucleotide bindingi97 – 1015GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate-binding protein 1 (EC:3.6.5.-By similarity)
Alternative name(s):
GTP-binding protein 2
Short name:
GBP-2
Guanine nucleotide-binding protein 2
Interferon-induced guanylate-binding protein 2
p67
Gene namesi
Name:Gbp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621810. Gbp2.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmperinuclear region By similarity
  • Golgi apparatus membrane By similarity
  • Membrane By similarity; Lipid-anchor By similarity

  • Note: GBP2-GBP5 dimers localize to the Golgi apparatus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Guanylate-binding protein 1PRO_0000190967Add
BLAST
Propeptidei587 – 5893Removed in mature formSequence analysisPRO_0000370784

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei586 – 5861Cysteine methyl esterSequence analysis
Lipidationi586 – 5861S-geranylgeranyl cysteine1 Publication

Post-translational modificationi

Isoprenylation is required for proper subcellular location.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ63663.
PRIDEiQ63663.

PTM databases

iPTMnetiQ63663.
PhosphoSiteiQ63663.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

By IFNG.

Gene expression databases

BgeeiENSRNOG00000031743.

Interactioni

Subunit structurei

Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures. Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5.By similarity

Protein-protein interaction databases

BioGridi251165. 1 interaction.
STRINGi10116.ENSRNOP00000061437.

Structurei

3D structure databases

ProteinModelPortaliQ63663.
SMRiQ63663. Positions 7-580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 276242GB1/RHD3-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 309309GTPase domain (Globular)By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
HOVERGENiHBG001979.
InParanoidiQ63663.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF02841. GBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEIHMLQP MCLIENTEAH LVINQEALRI LSAINQPVVV VAIVGLYRTG
60 70 80 90 100
KSYLMNKLAG KRTGFSLGST VQSHTKGIWM WCVPHPKKAG QTLVLLDTEG
110 120 130 140 150
LEDVEKGDNQ NDCWIFALAV LLSSTFVYNS MGTINQQAMD QLHYVTELTD
160 170 180 190 200
LIKSKSSPDQ SGIDDSANFV GFFPTFVWAL RDFSLELEVN GKLVTPDEYL
210 220 230 240 250
EHSLTLKKGA DKKTKSFNEP RLCIRKFFPK RKCFIFDRPA LRKQLCKLET
260 270 280 290 300
LGEEELCSEF VEQVAEFTSY IFSYSAVKTL SGGIIVNGPR LKSLVQTYVG
310 320 330 340 350
AISSGSLPCM ESAVLTLAQI ENSAAVQKAI THYEEQMNQK IQMPTETLQE
360 370 380 390 400
LLDLHRLIER EAIEIFLKNS FKDVDQKFQT ELGNLLISKR DAFIKKNSDV
410 420 430 440 450
SSAHCSDLIE DIFGPLEEEV KQGTFSKPGG YFLFLQMRQE LEKKYNQAPG
460 470 480 490 500
KGLEAEAVLK KYFESKEDIV ETLLKTDQSL TEAAKEIEVE RIKAETAEAA
510 520 530 540 550
NRELAEKQEK FELMMQQKEE SYQEHVRQLT EKMKEEQKKL IEEQDNIIAL
560 570 580
KLREQEKFLR EGYENESKKL LREIENMKRR QSPGKCTIL
Length:589
Mass (Da):67,109
Last modified:October 24, 2003 - v2
Checksum:i5E52B79102C2D97F
GO

Sequence cautioni

The sequence AAA19909 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80367 mRNA. Translation: AAA19909.1. Different initiation.
PIRiS43506.
RefSeqiNP_598308.1. NM_133624.2.
UniGeneiRn.25736.

Genome annotation databases

GeneIDi171164.
KEGGirno:171164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80367 mRNA. Translation: AAA19909.1. Different initiation.
PIRiS43506.
RefSeqiNP_598308.1. NM_133624.2.
UniGeneiRn.25736.

3D structure databases

ProteinModelPortaliQ63663.
SMRiQ63663. Positions 7-580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251165. 1 interaction.
STRINGi10116.ENSRNOP00000061437.

PTM databases

iPTMnetiQ63663.
PhosphoSiteiQ63663.

Proteomic databases

PaxDbiQ63663.
PRIDEiQ63663.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171164.
KEGGirno:171164.

Organism-specific databases

CTDi2634.
RGDi621810. Gbp2.

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
HOVERGENiHBG001979.
InParanoidiQ63663.

Miscellaneous databases

PROiQ63663.

Gene expression databases

BgeeiENSRNOG00000031743.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF02841. GBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBP2_RAT
AccessioniPrimary (citable) accession number: Q63663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.