Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Short-wave-sensitive opsin 1

Gene

Opn1sw

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Short-wave-sensitive opsin 1
Short name:
S opsin
Alternative name(s):
Blue cone photoreceptor pigment
Blue-sensitive opsin
Short name:
BOP
Short wavelength-sensitive cone opsin
Gene namesi
Name:Opn1sw
Synonyms:Bcp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621033. Opn1sw.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularAdd
BLAST
Transmembranei32 – 5625Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini57 – 6812CytoplasmicAdd
BLAST
Transmembranei69 – 9426Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini95 – 10814ExtracellularAdd
BLAST
Transmembranei109 – 12820Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini129 – 14719CytoplasmicAdd
BLAST
Transmembranei148 – 17124Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini172 – 19726ExtracellularAdd
BLAST
Transmembranei198 – 22528Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini226 – 24722CytoplasmicAdd
BLAST
Transmembranei248 – 27124Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini272 – 2798Extracellular
Transmembranei280 – 30425Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini305 – 34642CytoplasmicAdd
BLAST

GO - Cellular componenti

  • cell body Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • photoreceptor outer segment Source: RGD
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Short-wave-sensitive opsin 1PRO_0000197767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Curated
Disulfide bondi105 ↔ 182PROSITE-ProRule annotation
Modified residuei291 – 2911N6-(retinylidene)lysine

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63652.
PRIDEiQ63652.

Expressioni

Tissue specificityi

Expressed in cone photoreceptor cells.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009278.

Structurei

3D structure databases

ProteinModelPortaliQ63652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000253932.
HOVERGENiHBG107442.
InParanoidiQ63652.
KOiK04252.
PhylomeDBiQ63652.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR001521. Opsin_blue.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00574. OPSINBLUE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEDEFYLF QNISSVGPWD GPQYHIAPVW AFHLQAAFMG FVFFAGTPLN
60 70 80 90 100
ATVLVATLHY KKLRQPLNYI LVNVSLGGFL FCIFSVFTVF IASCHGYFLF
110 120 130 140 150
GRHVCALEAF LGSVAGLVTG WSLAFLAFER YLVICKPFGN IRFNSKHALT
160 170 180 190 200
VVLITWTIGI GVSIPPFFGW SRFIPEGLQC SCGPDWYTVG TKYRSEHYTW
210 220 230 240 250
FLFIFCFIIP LSLICFSYFQ LLRTLRAVAA QQQESATTQK AEREVSHMVV
260 270 280 290 300
VMVGSFCLCY VPYAALAMYM VNNRNHGLYL RLVTIPAFFS KSSCVYNPII
310 320 330 340
YCFMNKQFRA CILEMVCRKP MTDESDMSGS QKTEVSTVSS SKVGPH
Length:346
Mass (Da):39,062
Last modified:May 30, 2006 - v2
Checksum:i6DE181761AD4F296
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701I → V in AAC05294 (Ref. 2) Curated
Sequence conflicti173 – 1731F → L in AAC05294 (Ref. 2) Curated
Sequence conflicti279 – 2791Y → D in AAC05294 (Ref. 2) Curated
Sequence conflicti329 – 3291G → S in AAC05294 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63972 mRNA. Translation: AAB05931.1.
AF051163 mRNA. Translation: AAC05294.1.
RefSeqiNP_112277.1. NM_031015.1.
UniGeneiRn.10549.

Genome annotation databases

GeneIDi81644.
KEGGirno:81644.
UCSCiRGD:621033. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63972 mRNA. Translation: AAB05931.1.
AF051163 mRNA. Translation: AAC05294.1.
RefSeqiNP_112277.1. NM_031015.1.
UniGeneiRn.10549.

3D structure databases

ProteinModelPortaliQ63652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009278.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ63652.
PRIDEiQ63652.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81644.
KEGGirno:81644.
UCSCiRGD:621033. rat.

Organism-specific databases

CTDi611.
RGDi621033. Opn1sw.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000253932.
HOVERGENiHBG107442.
InParanoidiQ63652.
KOiK04252.
PhylomeDBiQ63652.

Miscellaneous databases

PROiQ63652.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR001521. Opsin_blue.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00574. OPSINBLUE.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and localization of rhodopsin kinase in the mammalian pineal."
    Zhao X., Haeseleer F., Fariss R.N., Huang J., Baehr W., Milam A.H., Palczewski K.
    Vis. Neurosci. 14:225-232(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Pineal gland.
  2. Delahaye-Brown A.-M.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Retina.

Entry informationi

Entry nameiOPSB_RAT
AccessioniPrimary (citable) accession number: Q63652
Secondary accession number(s): O70363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2006
Last modified: July 6, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.