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Reviewed, UniProtKB/Swiss-Prot Q63651 (RK_RAT)

Last modified February 9, 2010. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Rhodopsin kinase
      Short name=RK
    EC=2.7.11.14
Alternative name(s):
    G protein-coupled receptor kinase 1
Gene names
Name: Grk1
Synonyms: Rhok
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Phosphorylates rhodopsin thereby initiating its deactivation.

Catalytic activity

ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.

Subcellular location

Membrane; Lipid-anchor.

Post-translational modification

Autophosphorylated By similarity.

Farnesylation is required for full activity By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Rhodopsin kinase
PRO_0000024379
Propeptide562 – 5643Removed in mature form By similarity
PRO_0000024380

Regions

Domain58 – 175118RGS
Domain190 – 455266Protein kinase
Domain456 – 52166AGC-kinase C-terminal
Nucleotide binding196 – 2049ATP By similarity
Region1 – 189189N-terminal
Region456 – 564109C-terminal

Sites

Active site3171Proton acceptor By similarity
Binding site2191ATP By similarity

Amino acid modifications

Modified residue211Phosphoserine; by autocatalysis By similarity
Modified residue4911Phosphoserine; by autocatalysis By similarity
Modified residue4921Phosphothreonine; by autocatalysis By similarity
Modified residue5611Cysteine methyl ester By similarity
Lipidation5611S-farnesyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63651-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 17E05784E6D1ED00

FASTA56463,769
        10         20         30         40         50         60 
MDFGSLETVV ANSAFIAARG SFDGSSTPSS RDKKYLAKLR LPPLSKCEGL RDSISLEFDN 

        70         80         90        100        110        120 
LCSEQPIGKR LFQQFLKTDE RHVPALELWK DIEDYDTADD DLRPQKAQAI LAEYLDPQGT 

       130        140        150        160        170        180 
LFCNFLDQGM VARVKEGPTG SQDGLFQPLL QATLEHLSQG PFQEYLGSLY FLRFLQWKWL 

       190        200        210        220        230        240 
EAQPIGEDWF LDFRVLGKGG FGEVSACQMK ATGKMYACKK LNKKRLKKRK GYQGAIVEKR 

       250        260        270        280        290        300 
ILAKVHSRFI VSLAYAFETK TDLCLVMTIM NGGDVRYHIY NVDEENPGFP EPRAIYYTAQ 

       310        320        330        340        350        360 
IISGLEHLHQ RRIVYRDLKP ENVLLDNDGN IRISDLGLAV ELKEGQNKTK GYAGTPGFMA 

       370        380        390        400        410        420 
PELLRGEEYD FSVDYFALGV TLYEMIAARG PFRARGEKVE NKELKQRIIS EPVKYPEKFS 

       430        440        450        460        470        480 
QASKDFCEQL LEKDPEKRLG FRDGTCDALR ANVLFKDISW RQLEAGMLIP PFIPDSRTVY 

       490        500        510        520        530        540 
AKNIQDVGAF STVKGVVFDK ADTEFFQEFA SGNCSIPWQE EMIETGFFGD LNVWRPDGQM 

       550        560 
PDDMKGITVE EAAPTAKSGM CLIS 

« Hide

References

[1]"Molecular cloning and localization of rhodopsin kinase in the mammalian pineal."
Zhao X., Haeseleer F., Fariss R.N., Huang J., Baehr W., Milam A.H., Palczewski K.
Vis. Neurosci. 14:225-232(1997) [PubMed: 9147475] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U63971 mRNA. Translation: AAB05930.1.
IPIIPI00211058.
RefSeqNP_112358.1.
UniGeneRn.10548

3D structure databases

SMRQ63651. Positions 30-536.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ63651.

PTM databases

PhosphoSiteQ63651.

Proteomic databases

PRIDEQ63651.

Genome annotation databases

EnsemblENSRNOT00000024999; ENSRNOP00000024999; ENSRNOG00000018430; Rattus norvegicus. [Genome view]
GeneID81760.
KEGGrno:81760.
UCSCNM_031096. rat.

Organism-specific databases

CTD81760.
RGD619712. Grk1.

Phylogenomic databases

eggNOGroNOG15472.
HOVERGENQ63651.
InParanoidQ63651.

Enzyme and pathway databases

BRENDA2.7.11.14. 248.

Gene expression databases

GenevestigatorQ63651.
GermOnlineENSRNOG00000018430. Rattus norvegicus.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000342. Regulat_G_prot_signal.
IPR016137. Regulat_G_prot_signal_superfam.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR00717. GPCRKINASE.
SMARTSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio615542.

Entry information

Entry nameRK_RAT
AccessionPrimary (citable) accession number: Q63651
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 9, 2010
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents