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Protein

Striated muscle-specific serine/threonine-protein kinase

Gene

Speg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 2 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1635 – 16351ATPPROSITE-ProRule annotation
Active sitei1724 – 17241Proton acceptorBy similarity
Binding sitei2987 – 29871ATPPROSITE-ProRule annotation
Active sitei3077 – 30771Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1612 – 16209ATPPROSITE-ProRule annotation
Nucleotide bindingi2964 – 29729ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • muscle cell differentiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striated muscle-specific serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
Aortic preferentially expressed protein 1
Short name:
APEG-1
Gene namesi
Name:Speg
Synonyms:Apeg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2124. Speg.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 32593259Striated muscle-specific serine/threonine-protein kinasePRO_0000072668Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei141 – 1411PhosphoserineCombined sources
Modified residuei368 – 3681PhosphoserineCombined sources
Modified residuei375 – 3751PhosphoserineCombined sources
Modified residuei379 – 3791PhosphothreonineCombined sources
Modified residuei382 – 3821PhosphoserineBy similarity
Modified residuei385 – 3851PhosphoserineCombined sources
Modified residuei423 – 4231PhosphoserineCombined sources
Modified residuei453 – 4531PhosphothreonineCombined sources
Modified residuei457 – 4571PhosphoserineCombined sources
Modified residuei463 – 4631PhosphoserineCombined sources
Modified residuei493 – 4931PhosphoserineCombined sources
Modified residuei511 – 5111PhosphoserineCombined sources
Modified residuei531 – 5311PhosphoserineBy similarity
Modified residuei554 – 5541PhosphoserineCombined sources
Disulfide bondi994 ↔ 1046PROSITE-ProRule annotation
Modified residuei1133 – 11331PhosphoserineBy similarity
Modified residuei1177 – 11771PhosphoserineCombined sources
Modified residuei1993 – 19931PhosphoserineBy similarity
Modified residuei2004 – 20041PhosphoserineCombined sources
Modified residuei2019 – 20191PhosphoserineCombined sources
Modified residuei2020 – 20201PhosphoserineCombined sources
Modified residuei2042 – 20421PhosphoserineCombined sources
Modified residuei2114 – 21141PhosphoserineCombined sources
Modified residuei2135 – 21351PhosphoserineCombined sources
Modified residuei2182 – 21821PhosphoserineCombined sources
Modified residuei2207 – 22071PhosphoserineCombined sources
Modified residuei2376 – 23761PhosphoserineBy similarity
Modified residuei2380 – 23801PhosphothreonineBy similarity
Modified residuei2410 – 24101PhosphoserineCombined sources
Modified residuei2414 – 24141PhosphoserineCombined sources
Modified residuei2438 – 24381PhosphoserineCombined sources
Modified residuei2439 – 24391PhosphoserineCombined sources
Modified residuei2444 – 24441PhosphoserineBy similarity
Modified residuei2448 – 24481PhosphoserineCombined sources
Modified residuei2521 – 25211PhosphoserineBy similarity
Modified residuei2524 – 25241PhosphoserineBy similarity
Modified residuei2559 – 25591PhosphoserineCombined sources
Disulfide bondi2605 ↔ 2657PROSITE-ProRule annotation
Modified residuei2771 – 27711PhosphothreonineBy similarity
Modified residuei2774 – 27741PhosphoserineCombined sources
Modified residuei2941 – 29411PhosphoserineBy similarity

Post-translational modificationi

May be autophosphorylated.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ63638.
PRIDEiQ63638.

PTM databases

iPTMnetiQ63638.
PhosphoSiteiQ63638.

Expressioni

Tissue specificityi

Isoform 2 is highly expressed in differentiated arterial smooth muscle cells (ASMC) in the medial layer of the aorta. Weakly detected in brain and testis and to a lesser extent in organs rich in striated muscle or visceral smooth muscle.

Gene expression databases

GenevisibleiQ63638. RN.

Interactioni

Subunit structurei

Interacts with MTM1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026941.

Structurei

3D structure databases

ProteinModelPortaliQ63638.
SMRiQ63638. Positions 871-966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 12682Ig-like 1Add
BLAST
Domaini727 – 81791Ig-like 2Add
BLAST
Domaini874 – 96390Ig-like 3Add
BLAST
Domaini968 – 105689Ig-like 4Add
BLAST
Domaini1069 – 115789Ig-like 5Add
BLAST
Domaini1193 – 128391Ig-like 6Add
BLAST
Domaini1290 – 138798Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini1490 – 157889Ig-like 7Add
BLAST
Domaini1606 – 1859254Protein kinase 1PROSITE-ProRule annotationAdd
BLAST
Domaini2583 – 267391Ig-like 8Add
BLAST
Domaini2680 – 277495Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini2859 – 2965107Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini2958 – 3210253Protein kinase 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi277 – 34872Pro-richAdd
BLAST
Compositional biasi560 – 5634Poly-Pro
Compositional biasi1924 – 19296Poly-Ser
Compositional biasi1930 – 19367Poly-Glu
Compositional biasi2180 – 2317138Pro-richAdd
BLAST
Compositional biasi2782 – 2957176Pro-richAdd
BLAST
Compositional biasi3238 – 32414Poly-Arg

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 protein kinase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
KOG0613. Eukaryota.
ENOG410XQFD. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000154379.
HOVERGENiHBG083339.
InParanoidiQ63638.
KOiK08809.
OMAiQYRDVHR.
OrthoDBiEOG7QC7V5.
PhylomeDBiQ63638.
TreeFamiTF331962.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR015726. Ser/Thr_kin_striated_muscle-sp.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR10489:SF728. PTHR10489:SF728. 6 hits.
PfamiPF07679. I-set. 8 hits.
PF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 9 hits.
SM00408. IGc2. 8 hits.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 9 hits.
SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 8 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q63638-1) [UniParc]FASTAAdd to basket

Also known as: SPEG

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGRGVLVTGA GAGAPVFLRP
60 70 80 90 100
LKNAAVCAGS DVRLRVVVSG TPEPSLSWFR DGQLLPTPVP EPSCLWLRNC
110 120 130 140 150
GAQDAGVYSC SAQNERGKAS CEAVLTVLEV RDSETAEDDI SDVPGTQRLE
160 170 180 190 200
LRDDRAFSTP TGGSDTLVGT SLDTPPTSVT GTSEEQVSWW GSGQTVLEQE
210 220 230 240 250
AGSGGGTRPL PGSPRQAQTT GAGPRHLGVE PLVRASRANL VGASWGSEDS
260 270 280 290 300
LSVASDLYGS AFSLYRGRAL SIHVSIPPSG LRREEPDLQP QPASDALRPR
310 320 330 340 350
PALPPPSKSA LLPPPSPRVG KRALPGSSAQ PPATPTSPHR CTQEPSLPED
360 370 380 390 400
ITTTEEKRGK KPKSSGPSLA GTVESRPQTP LSEASGRLSA LGRSPRLVRA
410 420 430 440 450
GSRILDKLQF FEERRRSLER SDSPPAPLRP WVPLRKARSL EQPKSEGGAA
460 470 480 490 500
WDTPGASQEE LRSPRGSVAE RRRLFQQKAA SLDERTRQRS ATSDLELRFA
510 520 530 540 550
QELGRIRRST SREELVRSHE SLRATLQRAP SPREPGEPPL FSRPSIPKTS
560 570 580 590 600
RAVSPAATQP PPPSGAGKSG DETGRPRSRG PVGRTEPGEG PQQEIKRRDQ
610 620 630 640 650
FPLTRSRAIQ ECRSPVPPFT ADPPESRTKA PSARKREPPA QAVRFLPWAT
660 670 680 690 700
PGVEDSVLPQ TLEKNRAGPE AEKRLRRGPE EDGPWGAWDR RGTRSQGKGR
710 720 730 740 750
RARPTSPELE SSDDSYVSAG EEPLEAPVFE IPLQNMVVAP GADVLLKCII
760 770 780 790 800
TANPPPQVSW KKDGSVLHSE GRLLIRAEGE RHTLLLREAQ AADAGSYTAT
810 820 830 840 850
ATNELGQASC ASSLAVRPGA STSPFSSPIT SDEEYLSPPE EFPEPGETWS
860 870 880 890 900
RTPTMKPSPS QDRDSSDSSS KAPPTFKVSL MDQSVREGQD VIMSIRVQGE
910 920 930 940 950
PKPVVSWLRN RQPVRPDQRR FAEEAEGGLC RLRILAAERG DAGFYTCKAV
960 970 980 990 1000
NEYGARQCEA RLEVRAHPES RSLAVLAPLQ DVDVGAGEMA LFECLVAGPA
1010 1020 1030 1040 1050
DVEVDWLCRG RLLQPALLKC KMHFDGRKCK LLLTSVHEDD SGVYTCKLST
1060 1070 1080 1090 1100
VKDELTCSAR LTVRPSLAPL FTRLLEDVEV LEGRAARLDC KISGTPPPSV
1110 1120 1130 1140 1150
TWTHFGHPVN ESENLRLRQD GGLHSLHIAR VGSEDEGLYE VSATNTHGQA
1160 1170 1180 1190 1200
HCSAQLYVEE PRTAASGPSS KLEKMPSIPE EPEHGDLERL SIPDFLRPLQ
1210 1220 1230 1240 1250
DLEVGLAKEA MLECQVTGLP YPTISWFHNG HRIQSSDDRR MTQYRDIHRL
1260 1270 1280 1290 1300
VFPAVGPQHA GVYKSVIANK LGKAACYAHL YVTDVVPGPP DGAPQVVAVT
1310 1320 1330 1340 1350
GRMVTLSWNP PRSLDMAIDP DSLTYTVQHQ VLGSDQWTAL VTGLREPEWA
1360 1370 1380 1390 1400
ATGLKKGLHH IFRVLSSSGK SSSKPSAPSE PVQLLEHGPP LEEAPAVLDK
1410 1420 1430 1440 1450
QDIVYVVEGQ PACVTVTFNH VEAQVVWRSC RGALLEPRTG VYELSQPDDD
1460 1470 1480 1490 1500
QYCLRICRVS RRDLGPLTCS ARNRHGTKAC SITLELAEAP RFESIMEDVE
1510 1520 1530 1540 1550
VGPGETARFA VVVEGKPLPD IMWYKDEVLL AESNHVSFVY EENECSLVVL
1560 1570 1580 1590 1600
SAGSQDGGVY TCTARNLAGE VSCKAELSVH SAQTAMEVEG VGEDEEHRGR
1610 1620 1630 1640 1650
RLSDYYDIHQ EIGRGAFSYL RRVVERSSGL EFAAKFIPSQ AKPKASARRE
1660 1670 1680 1690 1700
ARLLARLQHD CVLYFHEAFE RRRGLVIVTE LCTEELLERM ARKPTVCESE
1710 1720 1730 1740 1750
TRTYMRQVLE GIGYLHQSHV LHLDVKPENL LVWDGAGGEE QVRICDFGNA
1760 1770 1780 1790 1800
QELTPGEPQY CQFGTPEFVA PEIVNQSPVS GVTDIWPVGV VAFLCLTGIS
1810 1820 1830 1840 1850
PFVGENDRTT LMNIRNYNVA FEETTFLSLS REARGFLIKV LVQDRLRPTA
1860 1870 1880 1890 1900
EETLEHPWFK TEAKGAEVST DHLKLFLSRR RWQRSQISYK CHLVLRPIPE
1910 1920 1930 1940 1950
LLRAPPERVW VAMPRRQPPS GGLSSSSDSE EEELEELPSV PRPLQPEFSG
1960 1970 1980 1990 2000
SRVSLTDIPT EDEALGTPEA GAATPMDWQE QGRAPSKDQE APSPEALPSP
2010 2020 2030 2040 2050
GQESPDGPSP RRPELRRGSS AESALPRVGS REPGRSLHKA ASVELPQRRS
2060 2070 2080 2090 2100
PSPGATRLTR GGLGEGEYAQ RLQALRQRLL RGGPEDGKVS GLRGPLLESL
2110 2120 2130 2140 2150
GGRARDPRMA RAASSEAAPH HQPPPESRGL QKSSSFSQGE AEPRGRHRRA
2160 2170 2180 2190 2200
GAPLEIPVAR LGARRLQESP SLSALSETQP PSPALPSAPK PSITKSPEPS
2210 2220 2230 2240 2250
AATSRDSPQP PAPQPVPEKI PEPKPEPVRA AKPAQPPLAL QMPAQSLTPY
2260 2270 2280 2290 2300
AQIMQSLQLS SPTLSPQVPP SEPKPHAAVF ARVASPPPGA SEKRVPSARI
2310 2320 2330 2340 2350
PPVLAEKVRV PTVPPRPGSS LSGSIENLES EAVFEAKFKR SRESPLSRGL
2360 2370 2380 2390 2400
RLLSRSRSEE RGPFRGAEDD GIYRPSPAGT PLELVRRPER SRSVQDLRVA
2410 2420 2430 2440 2450
GEPGLVRRLS LSLSQKLRRT PPGQRHPAWE SRSGDGESSE GGSSARGSPV
2460 2470 2480 2490 2500
LAVRRRLSST LERLSSRLQR SGSSEDSGGA SGRSTPLFGR LRRATSEGES
2510 2520 2530 2540 2550
LRRLGVPHNQ LASQTGATTP SAESLGSEAS GTSGSSAPGE SRSRHRWGLS
2560 2570 2580 2590 2600
RLRKDKGLSQ PNLSASVQED LGHQYVPSES DFPPVFHIKL KDQVLLEGEA
2610 2620 2630 2640 2650
ATLLCLPAAC PTPRISWMKD KQSLRSEPSV VIVSCKDGRQ LLSIPRASKR
2660 2670 2680 2690 2700
HAGLYECSAT NVLGSITSSC TVAVARTPGK LAPPEVPQTY CDTALVLWKP
2710 2720 2730 2740 2750
GDSRAPCTYT LERRVDGESV WHPVSSGIPD CYYNVTQLPV GVTVRFRVAC
2760 2770 2780 2790 2800
SNRAGQGPFS NPSEKVFIRG TQDSPAQSAA APRDAPVTSG PTRAPPPDSP
2810 2820 2830 2840 2850
TSLVPTPPLA PQVSQASTLS PSTSSMSANQ ALSSLKAVGP PPATPPRKHR
2860 2870 2880 2890 2900
GLLATQQAEP SPPSILVTPS EHKSFVPDTG TLTPTSSPQG VKPAPSSSSL
2910 2920 2930 2940 2950
YMVTSFVSAP PDPQPPAPEP PPEPTKVTVR SLSPAKEVVS SPTPESTTLR
2960 2970 2980 2990 3000
QGPPQKPYTF LEEKARGRFG VVRSCRENAT GRTFVAKIVP YAAEGKRRVL
3010 3020 3030 3040 3050
QEYEVLRTLH HERLMSLHEA YITPRYLVLI AESCGNRELL CGLSDRFRYS
3060 3070 3080 3090 3100
EDDVATYVVQ LLQGLDYLHG RHVLHLDIKP DNLLLAADNA LKIVDFGSAQ
3110 3120 3130 3140 3150
PYNPQALKPL GHRTGTLEFM APEMVRGDPI GSATDIWGAG VLTYIMLSGY
3160 3170 3180 3190 3200
SPFYEPDPQE TEARIVGGRF DAFQLYPNTS QSATLFLRKV LSVHPWSRPS
3210 3220 3230 3240 3250
LQDCLAHPWL QDAYLMKLRR QTLTFTTNRL KEFLGEQRRR RAEAATRHKV

LLRSYPGSP
Note: No experimental confirmation available.
Length:3,259
Mass (Da):354,166
Last modified:May 16, 2006 - v2
Checksum:i59915197FF5DADCC
GO
Isoform 2 (identifier: Q63638-2) [UniParc]FASTAAdd to basket

Also known as: APEG1

The sequence of this isoform differs from the canonical sequence as follows:
     1-854: Missing.
     966-967: AH → GE
     968-3259: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:113
Mass (Da):12,668
Checksum:iB213C366A759A363
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 854854Missing in isoform 2. 1 PublicationVSP_018269Add
BLAST
Alternative sequencei966 – 9672AH → GE in isoform 2. 1 PublicationVSP_018270
Alternative sequencei968 – 32592292Missing in isoform 2. 1 PublicationVSP_018271Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03067996 Genomic DNA. No translation available.
U57097 mRNA. Translation: AAC52667.1.
RefSeqiNP_001102272.1. NM_001108802.1. [Q63638-1]
NP_037037.1. NM_012905.2. [Q63638-2]
UniGeneiRn.11313.

Genome annotation databases

EnsembliENSRNOT00000026941; ENSRNOP00000026941; ENSRNOG00000019850. [Q63638-1]
ENSRNOT00000065076; ENSRNOP00000063082; ENSRNOG00000019850. [Q63638-2]
GeneIDi363256.
KEGGirno:363256.
UCSCiRGD:2124. rat. [Q63638-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03067996 Genomic DNA. No translation available.
U57097 mRNA. Translation: AAC52667.1.
RefSeqiNP_001102272.1. NM_001108802.1. [Q63638-1]
NP_037037.1. NM_012905.2. [Q63638-2]
UniGeneiRn.11313.

3D structure databases

ProteinModelPortaliQ63638.
SMRiQ63638. Positions 871-966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026941.

PTM databases

iPTMnetiQ63638.
PhosphoSiteiQ63638.

Proteomic databases

PaxDbiQ63638.
PRIDEiQ63638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026941; ENSRNOP00000026941; ENSRNOG00000019850. [Q63638-1]
ENSRNOT00000065076; ENSRNOP00000063082; ENSRNOG00000019850. [Q63638-2]
GeneIDi363256.
KEGGirno:363256.
UCSCiRGD:2124. rat. [Q63638-1]

Organism-specific databases

CTDi10290.
RGDi2124. Speg.

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
KOG0613. Eukaryota.
ENOG410XQFD. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000154379.
HOVERGENiHBG083339.
InParanoidiQ63638.
KOiK08809.
OMAiQYRDVHR.
OrthoDBiEOG7QC7V5.
PhylomeDBiQ63638.
TreeFamiTF331962.

Miscellaneous databases

PROiQ63638.

Gene expression databases

GenevisibleiQ63638. RN.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR015726. Ser/Thr_kin_striated_muscle-sp.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR10489:SF728. PTHR10489:SF728. 6 hits.
PfamiPF07679. I-set. 8 hits.
PF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 9 hits.
SM00408. IGc2. 8 hits.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 9 hits.
SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 8 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury."
    Hsieh C.-M., Yoshizumi M., Endege W.O., Kho C.-J., Jain M.K., Kashiki S., de Los Santos R., Lee W.-S., Perrella M.A., Lee M.-E.
    J. Biol. Chem. 271:17354-17359(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: Sprague-Dawley.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141; SER-368; SER-375; THR-379; SER-385; SER-423; THR-453; SER-457; SER-463; SER-493; SER-511; SER-554; SER-1177; SER-2004; SER-2019; SER-2020; SER-2042; SER-2114; SER-2135; SER-2182; SER-2207; SER-2410; SER-2414; SER-2438; SER-2439; SER-2448; SER-2559 AND SER-2774, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPEG_RAT
AccessioniPrimary (citable) accession number: Q63638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 16, 2006
Last modified: June 8, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Expression is under the tight control of the locus control region (LCRs).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.