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Protein

Syntaxin-6

Gene

Stx6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in intracellular vesicle trafficking.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-6811438. Intra-Golgi traffic.
R-RNO-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-6
Gene namesi
Name:Stx6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi61915. Stx6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 234233CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25521Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: GOC
  • early endosome Source: Ensembl
  • Golgi apparatus Source: RGD
  • integral component of membrane Source: RGD
  • perinuclear region of cytoplasm Source: Ensembl
  • phagocytic vesicle Source: Ensembl
  • SNARE complex Source: Ensembl
  • terminal bouton Source: ParkinsonsUK-UCL
  • trans-Golgi network membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 255254Syntaxin-6PRO_0000210211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineCombined sources
Modified residuei152 – 1521PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63635.
PRIDEiQ63635.

PTM databases

iPTMnetiQ63635.
SwissPalmiQ63635.

Expressioni

Tissue specificityi

Widely expressed, with relatively higher expression in brain, lung and kidney.

Gene expression databases

GenevisibleiQ63635. RN.

Interactioni

Subunit structurei

Interacts with VPS45A and GOPC (By similarity). Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Binds EEA1. Interacts with MARCH2 and MARCH3.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EEA1Q150754EBI-398854,EBI-298113From a different organism.

Protein-protein interaction databases

BioGridi248852. 3 interactions.
IntActiQ63635. 8 interactions.
MINTiMINT-1542524.
STRINGi10116.ENSRNOP00000037536.

Structurei

Secondary structure

1
255
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 3126Combined sources
Helixi40 – 7233Combined sources
Helixi75 – 784Combined sources
Helixi82 – 10827Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LVFX-ray2.10A/B1-110[»]
ProteinModelPortaliQ63635.
SMRiQ63635. Positions 4-109, 170-232.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63635.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini163 – 22563t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 7434Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202. Eukaryota.
ENOG410ZZA3. LUCA.
GeneTreeiENSGT00390000008991.
HOGENOMiHOG000237350.
HOVERGENiHBG007194.
InParanoidiQ63635.
KOiK08498.
OMAiQVVREMK.
OrthoDBiEOG7JHM7F.
PhylomeDBiQ63635.
TreeFamiTF313254.

Family and domain databases

InterProiIPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQGPSAATR EEIDWTTNEL
60 70 80 90 100
RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQIVR
110 120 130 140 150
DMKDQMSASS VQALAERKNR QALLGDSSSQ NWDAGVTDRY GRLDRELQLA
160 170 180 190 200
NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM
210 220 230 240 250
LDDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLLVVLT

LFLVL
Length:255
Mass (Da):29,057
Last modified:November 1, 1996 - v1
Checksum:iD725FB12C1DCCA74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56815 mRNA. Translation: AAC52709.1.
BC081769 mRNA. Translation: AAH81769.1.
RefSeqiNP_113853.1. NM_031665.2.
UniGeneiRn.100217.

Genome annotation databases

EnsembliENSRNOT00000035145; ENSRNOP00000037536; ENSRNOG00000003402.
GeneIDi60562.
KEGGirno:60562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56815 mRNA. Translation: AAC52709.1.
BC081769 mRNA. Translation: AAH81769.1.
RefSeqiNP_113853.1. NM_031665.2.
UniGeneiRn.100217.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LVFX-ray2.10A/B1-110[»]
ProteinModelPortaliQ63635.
SMRiQ63635. Positions 4-109, 170-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248852. 3 interactions.
IntActiQ63635. 8 interactions.
MINTiMINT-1542524.
STRINGi10116.ENSRNOP00000037536.

PTM databases

iPTMnetiQ63635.
SwissPalmiQ63635.

Proteomic databases

PaxDbiQ63635.
PRIDEiQ63635.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035145; ENSRNOP00000037536; ENSRNOG00000003402.
GeneIDi60562.
KEGGirno:60562.

Organism-specific databases

CTDi10228.
RGDi61915. Stx6.

Phylogenomic databases

eggNOGiKOG3202. Eukaryota.
ENOG410ZZA3. LUCA.
GeneTreeiENSGT00390000008991.
HOGENOMiHOG000237350.
HOVERGENiHBG007194.
InParanoidiQ63635.
KOiK08498.
OMAiQVVREMK.
OrthoDBiEOG7JHM7F.
PhylomeDBiQ63635.
TreeFamiTF313254.

Enzyme and pathway databases

ReactomeiR-RNO-6811438. Intra-Golgi traffic.
R-RNO-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

EvolutionaryTraceiQ63635.
PROiQ63635.

Gene expression databases

GenevisibleiQ63635. RN.

Family and domain databases

InterProiIPR015260. Syntaxin-6_N.
IPR006012. Syntaxin/epimorphin_CS.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
PF09177. Syntaxin-6_N. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new syntaxin family member implicated in targeting of intracellular transport vesicles."
    Bock J.B., Lin R.C., Scheller R.H.
    J. Biol. Chem. 271:17961-17965(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The Rab5 effector EEA1 interacts directly with syntaxin-6."
    Simonsen A., Gaullier J.-M., D'Arrigo A., Stenmark H.
    J. Biol. Chem. 274:28857-28860(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EEA1.
  4. "MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking."
    Nakamura N., Fukuda H., Kato A., Hirose S.
    Mol. Biol. Cell 16:1696-1710(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MARCH2.
  5. "MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II."
    Fukuda H., Nakamura N., Hirose S.
    J. Biochem. 139:137-145(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MARCH3.
  6. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog."
    Misura K.M., Bock J.B., Gonzalez L.C. Jr., Scheller R.H., Weis W.I.
    Proc. Natl. Acad. Sci. U.S.A. 99:9184-9189(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-110.

Entry informationi

Entry nameiSTX6_RAT
AccessioniPrimary (citable) accession number: Q63635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.