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Protein

Syntaxin-6

Gene

Stx6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in intracellular vesicle trafficking.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-6811438 Intra-Golgi traffic
R-RNO-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-6
Gene namesi
Name:Stx6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi61915 Stx6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 234CytoplasmicSequence analysisAdd BLAST233
Transmembranei235 – 255Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002102112 – 255Syntaxin-6Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei129PhosphoserineBy similarity1
Modified residuei152PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63635
PRIDEiQ63635

PTM databases

iPTMnetiQ63635
PhosphoSitePlusiQ63635
SwissPalmiQ63635

Expressioni

Tissue specificityi

Widely expressed, with relatively higher expression in brain, lung and kidney.

Gene expression databases

BgeeiENSRNOG00000003402
GenevisibleiQ63635 RN

Interactioni

Subunit structurei

Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Binds EEA1 (PubMed:10506127). Interacts with VPS45A and GOPC (By similarity). Interacts with MARCH2 and MARCH3 (PubMed:15689499, PubMed:16428329). Interacts with UHRF1BP1L (via C-terminal coiled-coil domain) (PubMed:20163565).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EEA1Q150754EBI-398854,EBI-298113From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248852, 3 interactors
CORUMiQ63635
IntActiQ63635, 9 interactors
MINTiQ63635
STRINGi10116.ENSRNOP00000037536

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 31Combined sources26
Helixi40 – 72Combined sources33
Helixi75 – 78Combined sources4
Helixi82 – 108Combined sources27

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LVFX-ray2.10A/B1-110[»]
ProteinModelPortaliQ63635
SMRiQ63635
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63635

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 225t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 112Interaction with UHRF1BP1L1 PublicationAdd BLAST111

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 74Sequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202 Eukaryota
ENOG410ZZA3 LUCA
GeneTreeiENSGT00390000008991
HOGENOMiHOG000237350
HOVERGENiHBG007194
InParanoidiQ63635
KOiK08498
OMAiWARNELK
OrthoDBiEOG091G0KE5
PhylomeDBiQ63635
TreeFamiTF313254

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR015260 Syntaxin-6_N
IPR006012 Syntaxin/epimorphin_CS
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF09177 Syntaxin-6_N, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQGPSAATR EEIDWTTNEL
60 70 80 90 100
RNNLRSIEWD LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQIVR
110 120 130 140 150
DMKDQMSASS VQALAERKNR QALLGDSSSQ NWDAGVTDRY GRLDRELQLA
160 170 180 190 200
NSHFIEEQQA QQQLIVEQQD EQLELVSGSI GVLKNMSQRI GGELEEQAVM
210 220 230 240 250
LDDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI LFAVLLVVLT

LFLVL
Length:255
Mass (Da):29,057
Last modified:November 1, 1996 - v1
Checksum:iD725FB12C1DCCA74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56815 mRNA Translation: AAC52709.1
BC081769 mRNA Translation: AAH81769.1
RefSeqiNP_113853.1, NM_031665.2
UniGeneiRn.100217

Genome annotation databases

EnsembliENSRNOT00000035145; ENSRNOP00000037536; ENSRNOG00000003402
GeneIDi60562
KEGGirno:60562

Similar proteinsi

Entry informationi

Entry nameiSTX6_RAT
AccessioniPrimary (citable) accession number: Q63635
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health