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Protein

Neuropeptide Y receptor type 5

Gene

Npy5r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

GO - Molecular functioni

  • neuropeptide Y receptor activity Source: RGD
  • pancreatic polypeptide receptor activity Source: RGD
  • peptide YY receptor activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cardiac left ventricle morphogenesis Source: Ensembl
  • cell surface receptor signaling pathway Source: GO_Central
  • eating behavior Source: RGD
  • generation of ovulation cycle rhythm Source: RGD
  • negative regulation of acute inflammatory response to antigenic stimulus Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of glutamate secretion Source: RGD
  • negative regulation of synaptic transmission, GABAergic Source: RGD
  • outflow tract morphogenesis Source: Ensembl
  • positive regulation of acute inflammatory response Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • synaptic transmission Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 5
Short name:
NPY5-R
Alternative name(s):
NPY-Y5 receptor
Short name:
NPYY5-R
Short name:
Y5 receptor
Gene namesi
Name:Npy5r
Synonyms:Npyr5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi3199. Npy5r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence analysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 7714CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini99 – 11719ExtracellularSequence analysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini139 – 15618CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini178 – 20831ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini230 – 368139CytoplasmicSequence analysisAdd
BLAST
Transmembranei369 – 38921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini390 – 40617ExtracellularSequence analysisAdd
BLAST
Transmembranei407 – 42721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini428 – 44518CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • neuron projection Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2548.
GuidetoPHARMACOLOGYi308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Neuropeptide Y receptor type 5PRO_0000069942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 198PROSITE-ProRule annotation
Lipidationi441 – 4411S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ63634.
PRIDEiQ63634.

Expressioni

Tissue specificityi

Brain; hypothalamus.

Gene expression databases

GenevisibleiQ63634. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018976.

Chemistry

BindingDBiQ63634.

Structurei

3D structure databases

ProteinModelPortaliQ63634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000294210.
HOVERGENiHBG052662.
InParanoidiQ63634.
KOiK04207.
OMAiLMRKRNQ.
OrthoDBiEOG7S7SDH.
PhylomeDBiQ63634.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKLEEHFN KTFVTENNTA AARNAAFPAW EDYRGSVDDL QYFLIGLYTF
60 70 80 90 100
VSLLGFMGNL LILMAVMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT
110 120 130 140 150
SVLLDQWMFG KAMCHIMPFL QCVSVLVSTL ILISIAIVRY HMIKHPISNN
160 170 180 190 200
LTANHGYFLI ATVWTLGFAI CSPLPVFHSL VELKETFGSA LLSSKYLCVE
210 220 230 240 250
SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC GLSHKENRLE
260 270 280 290 300
ENEMINLTLQ PSKKSRNQAK TPSTQKWSYS FIRKHRRRYS KKTACVLPAP
310 320 330 340 350
AGPSQGKHLA VPENPASVRS QLSPSSKVIP GVPICFEVKP EESSDAHEMR
360 370 380 390 400
VKRSITRIKK RSRSVFYRLT ILILVFAVSW MPLHVFHVVT DFNDNLISNR
410 420 430 440
HFKLVYCICH LLGMMSCCLN PILYGFLNNG IKADLRALIH CLHMS
Length:445
Mass (Da):50,408
Last modified:November 25, 2008 - v2
Checksum:iD529EC04FF8DF62A
GO

Sequence cautioni

The sequence AAC52677.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66274 mRNA. Translation: AAC52845.1.
U56078 mRNA. Translation: AAC52677.1. Different initiation.
AF044264 mRNA. Translation: AAC15670.1.
RefSeqiNP_037001.1. NM_012869.1.
XP_006253075.1. XM_006253013.2.
XP_006253076.1. XM_006253014.2.
UniGeneiRn.10532.

Genome annotation databases

EnsembliENSRNOT00000018976; ENSRNOP00000018976; ENSRNOG00000014172.
GeneIDi25340.
KEGGirno:25340.
UCSCiRGD:3199. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66274 mRNA. Translation: AAC52845.1.
U56078 mRNA. Translation: AAC52677.1. Different initiation.
AF044264 mRNA. Translation: AAC15670.1.
RefSeqiNP_037001.1. NM_012869.1.
XP_006253075.1. XM_006253013.2.
XP_006253076.1. XM_006253014.2.
UniGeneiRn.10532.

3D structure databases

ProteinModelPortaliQ63634.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018976.

Chemistry

BindingDBiQ63634.
ChEMBLiCHEMBL2548.
GuidetoPHARMACOLOGYi308.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ63634.
PRIDEiQ63634.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018976; ENSRNOP00000018976; ENSRNOG00000014172.
GeneIDi25340.
KEGGirno:25340.
UCSCiRGD:3199. rat.

Organism-specific databases

CTDi4889.
RGDi3199. Npy5r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000294210.
HOVERGENiHBG052662.
InParanoidiQ63634.
KOiK04207.
OMAiLMRKRNQ.
OrthoDBiEOG7S7SDH.
PhylomeDBiQ63634.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ63634.

Gene expression databases

GenevisibleiQ63634. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists."
    Parker E.M., Babij C.K., Balasubramaniam A., Burrier R.E., Guzzi M., Hamud F., Mukhopadhyay G., Rudinski M.S., Tao Z., Tice M., Xia L., Mullins D.E., Salisbury B.G.
    Eur. J. Pharmacol. 349:97-105(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNPY5R_RAT
AccessioniPrimary (citable) accession number: Q63634
Secondary accession number(s): P70586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: July 6, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.