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Protein

Neuropeptide Y receptor type 5

Gene

Npy5r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

GO - Molecular functioni

  • neuropeptide Y receptor activity Source: RGD
  • pancreatic polypeptide receptor activity Source: RGD
  • peptide YY receptor activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • blood circulation Source: GO_Central
  • cardiac left ventricle morphogenesis Source: RGD
  • chemical synaptic transmission Source: RGD
  • eating behavior Source: RGD
  • generation of ovulation cycle rhythm Source: RGD
  • negative regulation of acute inflammatory response to antigenic stimulus Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of glutamate secretion Source: RGD
  • negative regulation of synaptic transmission, GABAergic Source: RGD
  • outflow tract morphogenesis Source: RGD
  • positive regulation of acute inflammatory response Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 5
Short name:
NPY5-R
Alternative name(s):
NPY-Y5 receptor
Short name:
NPYY5-R
Short name:
Y5 receptor
Gene namesi
Name:Npy5r
Synonyms:Npyr5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi3199. Npy5r.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 117ExtracellularSequence analysisAdd BLAST19
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini139 – 156CytoplasmicSequence analysisAdd BLAST18
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 208ExtracellularSequence analysisAdd BLAST31
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 368CytoplasmicSequence analysisAdd BLAST139
Transmembranei369 – 389Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini390 – 406ExtracellularSequence analysisAdd BLAST17
Transmembranei407 – 427Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini428 – 445CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2548.
GuidetoPHARMACOLOGYi308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699421 – 445Neuropeptide Y receptor type 5Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 198PROSITE-ProRule annotation
Lipidationi441S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ63634.
PRIDEiQ63634.

PTM databases

PhosphoSitePlusiQ63634.

Expressioni

Tissue specificityi

Brain; hypothalamus.

Gene expression databases

BgeeiENSRNOG00000014172.
GenevisibleiQ63634. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018976.

Chemistry databases

BindingDBiQ63634.

Structurei

3D structure databases

ProteinModelPortaliQ63634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00900000140797.
HOGENOMiHOG000294210.
HOVERGENiHBG052662.
InParanoidiQ63634.
KOiK04207.
OMAiIKADLMS.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ63634.
TreeFamiTF315303.

Family and domain databases

CDDicd15398. 7tmA_NPY5R. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000393. NPY5_rcpt.
IPR000611. NPY_rcpt.
PANTHERiPTHR45422. PTHR45422. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01016. NRPEPTIDEY5R.
PR01012. NRPEPTIDEYR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKLEEHFN KTFVTENNTA AARNAAFPAW EDYRGSVDDL QYFLIGLYTF
60 70 80 90 100
VSLLGFMGNL LILMAVMKKR NQKTTVNFLI GNLAFSDILV VLFCSPFTLT
110 120 130 140 150
SVLLDQWMFG KAMCHIMPFL QCVSVLVSTL ILISIAIVRY HMIKHPISNN
160 170 180 190 200
LTANHGYFLI ATVWTLGFAI CSPLPVFHSL VELKETFGSA LLSSKYLCVE
210 220 230 240 250
SWPSDSYRIA FTISLLLVQY ILPLVCLTVS HTSVCRSISC GLSHKENRLE
260 270 280 290 300
ENEMINLTLQ PSKKSRNQAK TPSTQKWSYS FIRKHRRRYS KKTACVLPAP
310 320 330 340 350
AGPSQGKHLA VPENPASVRS QLSPSSKVIP GVPICFEVKP EESSDAHEMR
360 370 380 390 400
VKRSITRIKK RSRSVFYRLT ILILVFAVSW MPLHVFHVVT DFNDNLISNR
410 420 430 440
HFKLVYCICH LLGMMSCCLN PILYGFLNNG IKADLRALIH CLHMS
Length:445
Mass (Da):50,408
Last modified:November 25, 2008 - v2
Checksum:iD529EC04FF8DF62A
GO

Sequence cautioni

The sequence AAC52677 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66274 mRNA. Translation: AAC52845.1.
U56078 mRNA. Translation: AAC52677.1. Different initiation.
AF044264 mRNA. Translation: AAC15670.1.
RefSeqiNP_037001.1. NM_012869.1.
XP_006253075.1. XM_006253013.3.
XP_006253076.1. XM_006253014.3.
XP_017455484.1. XM_017599995.1.
XP_017455485.1. XM_017599996.1.
XP_017455486.1. XM_017599997.1.
XP_017455487.1. XM_017599998.1.
UniGeneiRn.10532.

Genome annotation databases

EnsembliENSRNOT00000018976; ENSRNOP00000018976; ENSRNOG00000014172.
GeneIDi25340.
KEGGirno:25340.
UCSCiRGD:3199. rat.

Similar proteinsi

Entry informationi

Entry nameiNPY5R_RAT
AccessioniPrimary (citable) accession number: Q63634
Secondary accession number(s): P70586
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: November 22, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families