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Q63624

- SFR19_RAT

UniProt

Q63624 - SFR19_RAT

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Protein

Splicing factor, arginine/serine-rich 19

Gene

Scaf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May function in pre-mRNA splicing.1 Publication

GO - Molecular functioni

  1. protein domain specific binding Source: RGD
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: RGD
  2. RNA splicing Source: UniProtKB-KW
  3. transcription from RNA polymerase II promoter Source: RGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor, arginine/serine-rich 19
Alternative name(s):
CTD-binding SR-like protein rA1
SR-related and CTD-associated factor 1
Gene namesi
Name:Scaf1
Synonyms:Sfrs19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi708405. Scaf1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12581258Splicing factor, arginine/serine-rich 19PRO_0000299408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei241 – 2411PhosphoserineBy similarity
Modified residuei444 – 4441PhosphoserineBy similarity
Modified residuei449 – 4491PhosphoserineBy similarity
Modified residuei493 – 4931PhosphoserineBy similarity
Modified residuei495 – 4951PhosphoserineBy similarity
Modified residuei512 – 5121PhosphoserineBy similarity
Modified residuei579 – 5791PhosphoserineBy similarity
Modified residuei581 – 5811PhosphoserineBy similarity
Modified residuei693 – 6931PhosphoserineBy similarity
Modified residuei697 – 6971PhosphoserineBy similarity
Modified residuei823 – 8231PhosphoserineBy similarity
Modified residuei878 – 8781PhosphoserineBy similarity
Modified residuei885 – 8851PhosphoserineBy similarity
Modified residuei914 – 9141PhosphoserineBy similarity
Modified residuei925 – 9251PhosphothreonineBy similarity
Modified residuei938 – 9381PhosphothreonineBy similarity
Modified residuei950 – 9501PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63624.
PRIDEiQ63624.

PTM databases

PhosphoSiteiQ63624.

Expressioni

Gene expression databases

GenevestigatoriQ63624.

Interactioni

Subunit structurei

Interacts with POLR2A.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027801.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1133 – 1258126Necessary for interaction with the CTD domain of POLR2ABy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi186 – 26984Pro-richAdd
BLAST
Compositional biasi193 – 20917Ser-richAdd
BLAST
Compositional biasi270 – 28213Glu-richAdd
BLAST
Compositional biasi478 – 642165Arg-richAdd
BLAST
Compositional biasi712 – 823112Ser-richAdd
BLAST
Compositional biasi845 – 87531Lys-richAdd
BLAST
Compositional biasi958 – 98528Glu-richAdd
BLAST
Compositional biasi1230 – 125728Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG291550.
GeneTreeiENSGT00530000063661.
HOGENOMiHOG000154300.
HOVERGENiHBG097942.
InParanoidiQ63624.
OMAiADTRWGG.
OrthoDBiEOG7F24SX.
PhylomeDBiQ63624.
TreeFamiTF332183.

Sequencei

Sequence statusi: Complete.

Q63624-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEEDESRGK TEESGEDRGD GPPDRDPALS PSAFILRAIQ QAVGSSLQGD
60 70 80 90 100
LPNDKDGSRC CGLQWRRCCR SPRSEPRSQE SGGADMATVL DTAADSFLVE
110 120 130 140 150
LVSILDPPDT WVPSHLDLQP GESEDVLELV AEVRIGDRDP MPLPVPSLLP
160 170 180 190 200
RLRAWRTGKT VSPQSHASRP ACSRHLLTLG TGDGGPAPPP APSSASSSPS
210 220 230 240 250
PSPSSSSPSP PPPPPPPPPP ALPAPRFDIY DPFHPTDEAY SPPPAPEQKY
260 270 280 290 300
DPFEPTGSNP SSSAGTPSPE EEEEEEEEEE EEGLSQSISR ISETLAGIYD
310 320 330 340 350
DNSLSQDFPG DDSPHREPPP PQTLGAPGTP PQADSTRAEG APRRRVFVVG
360 370 380 390 400
PEAEACLEGK VSVEVVTTAG GPALPLPPLP PTDPEIEEGE IVQPEEEPRV
410 420 430 440 450
AVSLFRAARP RQPPASVATL ASVAAPAAPP ASAPRAPEGD DFLSLHADSD
460 470 480 490 500
GEGALQVDLG EPPAPPAADA RWGGLDLRRK ILTQRRERYR QRSASPGPPP
510 520 530 540 550
ARKKARRERQ RSGDPAPPDS PTWEAKKHRS RERKLGSHST ARRRSRSRSR
560 570 580 590 600
RRSRSRSADR RRGSHRSRSR EKRRRRRRSA SPPPAASSSS SSRRERHRGK
610 620 630 640 650
RREGGKKKKK RSRSRAEKRS GDLEKLPAPV PPSGSDRDSR RRGAVPPSIQ
660 670 680 690 700
DLTDHDLFAI KRTITVGRPD KTEPRAPSPA PAVSPKREVL YDSEGLSADE
710 720 730 740 750
RGAKGDKDRR RSGAASSSSS SREKASRRKA LDGDRGRDRD RSSKKTRPPK
760 770 780 790 800
DSAPGSGALP KAPPSSGSSS SSSSCSSRKV KLQSKVAVLI REGVSSTTPA
810 820 830 840 850
KDSSSSGLGS IGVKFSRDRE SRSPFLKPDE RAPAEGVKVA PGSTKPKKTK
860 870 880 890 900
AKAKAGAKKA KGTKGKTKPS KTRKKVRSGG SSTASGGPGS LKKSKADSCS
910 920 930 940 950
QAASAKGTEE TSWSGEERTT KAPSTPPPKV APPPPALTPD SQTVDSSCKT
960 970 980 990 1000
PEVSFLPEEA SEDTGVRVGA EEEEEEEEEE EEEEEQQPAT TTATSTAAAA
1010 1020 1030 1040 1050
PSTAPSAGST AGDSGAEDGP AARASQLPTL PPPMPWNLPA GVDCTTSGVL
1060 1070 1080 1090 1100
ALTALLFKME EANLASRAKA QELIQATNQI LSHRKPPSTL GVTPAPVPTS
1110 1120 1130 1140 1150
LGLPPGPSSY LLPGSLPIGG CGSTPPTPTG LVPASDKREG SSSSEGRGDT
1160 1170 1180 1190 1200
DKYLKKLHTQ ERAVEEVKLA IKPYYQKKDI TKEEYKDILR KAVHKICHSK
1210 1220 1230 1240 1250
SGEINPVKVS NLVRAYVQRY RYFRKHGRKP GDPPGPPRPP KEPGPPDKGG

PGLPLPPL
Length:1,258
Mass (Da):133,856
Last modified:September 11, 2007 - v2
Checksum:iBBEC7D4027E2F179
GO

Sequence cautioni

The sequence AAC52657.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011L → V in AAC52657. (PubMed:8692929)Curated
Sequence conflicti195 – 1951A → G in AAC52657. (PubMed:8692929)Curated
Sequence conflicti255 – 2551P → A in AAC52657. (PubMed:8692929)Curated
Sequence conflicti264 – 2641A → G in AAC52657. (PubMed:8692929)Curated
Sequence conflicti289 – 2891S → R in AAC52657. (PubMed:8692929)Curated
Sequence conflicti687 – 6871R → G in AAC52657. (PubMed:8692929)Curated
Sequence conflicti746 – 7483TRP → PRT in AAC52657. (PubMed:8692929)Curated
Sequence conflicti765 – 7651S → R in AAC52657. (PubMed:8692929)Curated
Sequence conflicti832 – 8321A → S in AAC52657. (PubMed:8692929)Curated
Sequence conflicti952 – 9521E → D in AAC52657. (PubMed:8692929)Curated
Sequence conflicti957 – 9571P → A in AAC52657. (PubMed:8692929)Curated
Sequence conflicti1076 – 10761A → D in AAC52657. (PubMed:8692929)Curated
Sequence conflicti1082 – 10821S → R in AAC52657. (PubMed:8692929)Curated
Sequence conflicti1101 – 11011L → F in AAC52657. (PubMed:8692929)Curated
Sequence conflicti1106 – 11061G → A in AAC52657. (PubMed:8692929)Curated
Sequence conflicti1170 – 11701A → S in AAC52657. (PubMed:8692929)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03002356 Genomic DNA. No translation available.
U49056 mRNA. Translation: AAC52657.1. Different initiation.
PIRiT31421.
RefSeqiNP_062257.1. NM_019384.1.
UniGeneiRn.93.

Genome annotation databases

EnsembliENSRNOT00000027801; ENSRNOP00000027801; ENSRNOG00000020499.
GeneIDi56081.
KEGGirno:56081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03002356 Genomic DNA. No translation available.
U49056 mRNA. Translation: AAC52657.1 . Different initiation.
PIRi T31421.
RefSeqi NP_062257.1. NM_019384.1.
UniGenei Rn.93.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000027801.

PTM databases

PhosphoSitei Q63624.

Proteomic databases

PaxDbi Q63624.
PRIDEi Q63624.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027801 ; ENSRNOP00000027801 ; ENSRNOG00000020499 .
GeneIDi 56081.
KEGGi rno:56081.

Organism-specific databases

CTDi 58506.
RGDi 708405. Scaf1.

Phylogenomic databases

eggNOGi NOG291550.
GeneTreei ENSGT00530000063661.
HOGENOMi HOG000154300.
HOVERGENi HBG097942.
InParanoidi Q63624.
OMAi ADTRWGG.
OrthoDBi EOG7F24SX.
PhylomeDBi Q63624.
TreeFami TF332183.

Miscellaneous databases

NextBioi 611095.
PROi Q63624.

Gene expression databases

Genevestigatori Q63624.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins."
    Yuryev A., Patturajan M., Litingtung Y., Joshi R.V., Gentile C., Gebara M., Corden J.L.
    Proc. Natl. Acad. Sci. U.S.A. 93:6975-6980(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-1258, FUNCTION, INTERACTION WITH POLR2A.
    Tissue: Hippocampus.

Entry informationi

Entry nameiSFR19_RAT
AccessioniPrimary (citable) accession number: Q63624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3