SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q63624

- SFR19_RAT

UniProt

Q63624 - SFR19_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Splicing factor, arginine/serine-rich 19

Gene
Scaf1, Sfrs19
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May function in pre-mRNA splicing.1 Publication

GO - Molecular functioni

  1. protein domain specific binding Source: RGD
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: RGD
  2. RNA splicing Source: UniProtKB-KW
  3. transcription from RNA polymerase II promoter Source: RGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor, arginine/serine-rich 19
Alternative name(s):
CTD-binding SR-like protein rA1
SR-related and CTD-associated factor 1
Gene namesi
Name:Scaf1
Synonyms:Sfrs19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi708405. Scaf1.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12581258Splicing factor, arginine/serine-rich 19PRO_0000299408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei241 – 2411Phosphoserine By similarity
Modified residuei444 – 4441Phosphoserine By similarity
Modified residuei449 – 4491Phosphoserine By similarity
Modified residuei493 – 4931Phosphoserine By similarity
Modified residuei495 – 4951Phosphoserine By similarity
Modified residuei512 – 5121Phosphoserine By similarity
Modified residuei579 – 5791Phosphoserine By similarity
Modified residuei581 – 5811Phosphoserine By similarity
Modified residuei693 – 6931Phosphoserine By similarity
Modified residuei697 – 6971Phosphoserine By similarity
Modified residuei823 – 8231Phosphoserine By similarity
Modified residuei878 – 8781Phosphoserine By similarity
Modified residuei885 – 8851Phosphoserine By similarity
Modified residuei914 – 9141Phosphoserine By similarity
Modified residuei925 – 9251Phosphothreonine By similarity
Modified residuei938 – 9381Phosphothreonine By similarity
Modified residuei950 – 9501Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63624.
PRIDEiQ63624.

PTM databases

PhosphoSiteiQ63624.

Expressioni

Gene expression databases

GenevestigatoriQ63624.

Interactioni

Subunit structurei

Interacts with POLR2A.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027801.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1133 – 1258126Necessary for interaction with the CTD domain of POLR2A By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi186 – 26984Pro-richAdd
BLAST
Compositional biasi193 – 20917Ser-richAdd
BLAST
Compositional biasi270 – 28213Glu-richAdd
BLAST
Compositional biasi478 – 642165Arg-richAdd
BLAST
Compositional biasi712 – 823112Ser-richAdd
BLAST
Compositional biasi845 – 87531Lys-richAdd
BLAST
Compositional biasi958 – 98528Glu-richAdd
BLAST
Compositional biasi1230 – 125728Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG291550.
GeneTreeiENSGT00530000063661.
HOGENOMiHOG000154300.
HOVERGENiHBG097942.
InParanoidiQ63624.
OMAiADTRWGG.
OrthoDBiEOG7F24SX.
PhylomeDBiQ63624.
TreeFamiTF332183.

Sequencei

Sequence statusi: Complete.

Q63624-1 [UniParc]FASTAAdd to Basket

« Hide

MEEEDESRGK TEESGEDRGD GPPDRDPALS PSAFILRAIQ QAVGSSLQGD     50
LPNDKDGSRC CGLQWRRCCR SPRSEPRSQE SGGADMATVL DTAADSFLVE 100
LVSILDPPDT WVPSHLDLQP GESEDVLELV AEVRIGDRDP MPLPVPSLLP 150
RLRAWRTGKT VSPQSHASRP ACSRHLLTLG TGDGGPAPPP APSSASSSPS 200
PSPSSSSPSP PPPPPPPPPP ALPAPRFDIY DPFHPTDEAY SPPPAPEQKY 250
DPFEPTGSNP SSSAGTPSPE EEEEEEEEEE EEGLSQSISR ISETLAGIYD 300
DNSLSQDFPG DDSPHREPPP PQTLGAPGTP PQADSTRAEG APRRRVFVVG 350
PEAEACLEGK VSVEVVTTAG GPALPLPPLP PTDPEIEEGE IVQPEEEPRV 400
AVSLFRAARP RQPPASVATL ASVAAPAAPP ASAPRAPEGD DFLSLHADSD 450
GEGALQVDLG EPPAPPAADA RWGGLDLRRK ILTQRRERYR QRSASPGPPP 500
ARKKARRERQ RSGDPAPPDS PTWEAKKHRS RERKLGSHST ARRRSRSRSR 550
RRSRSRSADR RRGSHRSRSR EKRRRRRRSA SPPPAASSSS SSRRERHRGK 600
RREGGKKKKK RSRSRAEKRS GDLEKLPAPV PPSGSDRDSR RRGAVPPSIQ 650
DLTDHDLFAI KRTITVGRPD KTEPRAPSPA PAVSPKREVL YDSEGLSADE 700
RGAKGDKDRR RSGAASSSSS SREKASRRKA LDGDRGRDRD RSSKKTRPPK 750
DSAPGSGALP KAPPSSGSSS SSSSCSSRKV KLQSKVAVLI REGVSSTTPA 800
KDSSSSGLGS IGVKFSRDRE SRSPFLKPDE RAPAEGVKVA PGSTKPKKTK 850
AKAKAGAKKA KGTKGKTKPS KTRKKVRSGG SSTASGGPGS LKKSKADSCS 900
QAASAKGTEE TSWSGEERTT KAPSTPPPKV APPPPALTPD SQTVDSSCKT 950
PEVSFLPEEA SEDTGVRVGA EEEEEEEEEE EEEEEQQPAT TTATSTAAAA 1000
PSTAPSAGST AGDSGAEDGP AARASQLPTL PPPMPWNLPA GVDCTTSGVL 1050
ALTALLFKME EANLASRAKA QELIQATNQI LSHRKPPSTL GVTPAPVPTS 1100
LGLPPGPSSY LLPGSLPIGG CGSTPPTPTG LVPASDKREG SSSSEGRGDT 1150
DKYLKKLHTQ ERAVEEVKLA IKPYYQKKDI TKEEYKDILR KAVHKICHSK 1200
SGEINPVKVS NLVRAYVQRY RYFRKHGRKP GDPPGPPRPP KEPGPPDKGG 1250
PGLPLPPL 1258
Length:1,258
Mass (Da):133,856
Last modified:September 11, 2007 - v2
Checksum:iBBEC7D4027E2F179
GO

Sequence cautioni

The sequence AAC52657.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011L → V in AAC52657. 1 Publication
Sequence conflicti195 – 1951A → G in AAC52657. 1 Publication
Sequence conflicti255 – 2551P → A in AAC52657. 1 Publication
Sequence conflicti264 – 2641A → G in AAC52657. 1 Publication
Sequence conflicti289 – 2891S → R in AAC52657. 1 Publication
Sequence conflicti687 – 6871R → G in AAC52657. 1 Publication
Sequence conflicti746 – 7483TRP → PRT in AAC52657. 1 Publication
Sequence conflicti765 – 7651S → R in AAC52657. 1 Publication
Sequence conflicti832 – 8321A → S in AAC52657. 1 Publication
Sequence conflicti952 – 9521E → D in AAC52657. 1 Publication
Sequence conflicti957 – 9571P → A in AAC52657. 1 Publication
Sequence conflicti1076 – 10761A → D in AAC52657. 1 Publication
Sequence conflicti1082 – 10821S → R in AAC52657. 1 Publication
Sequence conflicti1101 – 11011L → F in AAC52657. 1 Publication
Sequence conflicti1106 – 11061G → A in AAC52657. 1 Publication
Sequence conflicti1170 – 11701A → S in AAC52657. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03002356 Genomic DNA. No translation available.
U49056 mRNA. Translation: AAC52657.1. Different initiation.
PIRiT31421.
RefSeqiNP_062257.1. NM_019384.1.
XP_006229190.1. XM_006229128.1.
UniGeneiRn.93.

Genome annotation databases

EnsembliENSRNOT00000027801; ENSRNOP00000027801; ENSRNOG00000020499.
GeneIDi56081.
KEGGirno:56081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03002356 Genomic DNA. No translation available.
U49056 mRNA. Translation: AAC52657.1 . Different initiation.
PIRi T31421.
RefSeqi NP_062257.1. NM_019384.1.
XP_006229190.1. XM_006229128.1.
UniGenei Rn.93.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000027801.

PTM databases

PhosphoSitei Q63624.

Proteomic databases

PaxDbi Q63624.
PRIDEi Q63624.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027801 ; ENSRNOP00000027801 ; ENSRNOG00000020499 .
GeneIDi 56081.
KEGGi rno:56081.

Organism-specific databases

CTDi 58506.
RGDi 708405. Scaf1.

Phylogenomic databases

eggNOGi NOG291550.
GeneTreei ENSGT00530000063661.
HOGENOMi HOG000154300.
HOVERGENi HBG097942.
InParanoidi Q63624.
OMAi ADTRWGG.
OrthoDBi EOG7F24SX.
PhylomeDBi Q63624.
TreeFami TF332183.

Miscellaneous databases

NextBioi 611095.
PROi Q63624.

Gene expression databases

Genevestigatori Q63624.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins."
    Yuryev A., Patturajan M., Litingtung Y., Joshi R.V., Gentile C., Gebara M., Corden J.L.
    Proc. Natl. Acad. Sci. U.S.A. 93:6975-6980(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-1258, FUNCTION, INTERACTION WITH POLR2A.
    Tissue: Hippocampus.

Entry informationi

Entry nameiSFR19_RAT
AccessioniPrimary (citable) accession number: Q63624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi