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Protein

Splicing factor, arginine/serine-rich 19

Gene

Scaf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function in pre-mRNA splicing.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • mRNA processing Source: RGD
  • RNA splicing Source: UniProtKB-KW
  • transcription from RNA polymerase II promoter Source: RGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor, arginine/serine-rich 19
Alternative name(s):
CTD-binding SR-like protein rA1
SR-related and CTD-associated factor 1
Gene namesi
Name:Scaf1
Synonyms:Sfrs19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi708405. Scaf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994081 – 1258Splicing factor, arginine/serine-rich 19Add BLAST1258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei241PhosphoserineCombined sources1
Modified residuei329PhosphothreonineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei449PhosphoserineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei495PhosphoserineBy similarity1
Modified residuei512PhosphoserineCombined sources1
Modified residuei520PhosphoserineCombined sources1
Modified residuei579PhosphoserineBy similarity1
Modified residuei581PhosphoserineBy similarity1
Modified residuei665PhosphothreonineBy similarity1
Modified residuei678PhosphoserineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei691PhosphotyrosineBy similarity1
Modified residuei693PhosphoserineCombined sources1
Modified residuei697PhosphoserineCombined sources1
Modified residuei821PhosphoserineBy similarity1
Modified residuei823PhosphoserineBy similarity1
Modified residuei878PhosphoserineBy similarity1
Modified residuei885PhosphoserineBy similarity1
Modified residuei912PhosphoserineBy similarity1
Modified residuei914PhosphoserineCombined sources1
Modified residuei925PhosphothreonineBy similarity1
Modified residuei938PhosphothreonineBy similarity1
Modified residuei941PhosphoserineBy similarity1
Modified residuei950PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63624.
PRIDEiQ63624.

PTM databases

iPTMnetiQ63624.
PhosphoSitePlusiQ63624.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020499.
GenevisibleiQ63624. RN.

Interactioni

Subunit structurei

Interacts with POLR2A.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027801.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1133 – 1258Necessary for interaction with the CTD domain of POLR2ABy similarityAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi186 – 269Pro-richAdd BLAST84
Compositional biasi193 – 209Ser-richAdd BLAST17
Compositional biasi270 – 282Glu-richAdd BLAST13
Compositional biasi478 – 642Arg-richAdd BLAST165
Compositional biasi712 – 823Ser-richAdd BLAST112
Compositional biasi845 – 875Lys-richAdd BLAST31
Compositional biasi958 – 985Glu-richAdd BLAST28
Compositional biasi1230 – 1257Pro-richAdd BLAST28

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0825. Eukaryota.
ENOG4111F4U. LUCA.
GeneTreeiENSGT00530000063661.
HOGENOMiHOG000154300.
HOVERGENiHBG097942.
InParanoidiQ63624.
OMAiRPDKPDP.
OrthoDBiEOG091G05JH.
PhylomeDBiQ63624.
TreeFamiTF332183.

Sequencei

Sequence statusi: Complete.

Q63624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEDESRGK TEESGEDRGD GPPDRDPALS PSAFILRAIQ QAVGSSLQGD
60 70 80 90 100
LPNDKDGSRC CGLQWRRCCR SPRSEPRSQE SGGADMATVL DTAADSFLVE
110 120 130 140 150
LVSILDPPDT WVPSHLDLQP GESEDVLELV AEVRIGDRDP MPLPVPSLLP
160 170 180 190 200
RLRAWRTGKT VSPQSHASRP ACSRHLLTLG TGDGGPAPPP APSSASSSPS
210 220 230 240 250
PSPSSSSPSP PPPPPPPPPP ALPAPRFDIY DPFHPTDEAY SPPPAPEQKY
260 270 280 290 300
DPFEPTGSNP SSSAGTPSPE EEEEEEEEEE EEGLSQSISR ISETLAGIYD
310 320 330 340 350
DNSLSQDFPG DDSPHREPPP PQTLGAPGTP PQADSTRAEG APRRRVFVVG
360 370 380 390 400
PEAEACLEGK VSVEVVTTAG GPALPLPPLP PTDPEIEEGE IVQPEEEPRV
410 420 430 440 450
AVSLFRAARP RQPPASVATL ASVAAPAAPP ASAPRAPEGD DFLSLHADSD
460 470 480 490 500
GEGALQVDLG EPPAPPAADA RWGGLDLRRK ILTQRRERYR QRSASPGPPP
510 520 530 540 550
ARKKARRERQ RSGDPAPPDS PTWEAKKHRS RERKLGSHST ARRRSRSRSR
560 570 580 590 600
RRSRSRSADR RRGSHRSRSR EKRRRRRRSA SPPPAASSSS SSRRERHRGK
610 620 630 640 650
RREGGKKKKK RSRSRAEKRS GDLEKLPAPV PPSGSDRDSR RRGAVPPSIQ
660 670 680 690 700
DLTDHDLFAI KRTITVGRPD KTEPRAPSPA PAVSPKREVL YDSEGLSADE
710 720 730 740 750
RGAKGDKDRR RSGAASSSSS SREKASRRKA LDGDRGRDRD RSSKKTRPPK
760 770 780 790 800
DSAPGSGALP KAPPSSGSSS SSSSCSSRKV KLQSKVAVLI REGVSSTTPA
810 820 830 840 850
KDSSSSGLGS IGVKFSRDRE SRSPFLKPDE RAPAEGVKVA PGSTKPKKTK
860 870 880 890 900
AKAKAGAKKA KGTKGKTKPS KTRKKVRSGG SSTASGGPGS LKKSKADSCS
910 920 930 940 950
QAASAKGTEE TSWSGEERTT KAPSTPPPKV APPPPALTPD SQTVDSSCKT
960 970 980 990 1000
PEVSFLPEEA SEDTGVRVGA EEEEEEEEEE EEEEEQQPAT TTATSTAAAA
1010 1020 1030 1040 1050
PSTAPSAGST AGDSGAEDGP AARASQLPTL PPPMPWNLPA GVDCTTSGVL
1060 1070 1080 1090 1100
ALTALLFKME EANLASRAKA QELIQATNQI LSHRKPPSTL GVTPAPVPTS
1110 1120 1130 1140 1150
LGLPPGPSSY LLPGSLPIGG CGSTPPTPTG LVPASDKREG SSSSEGRGDT
1160 1170 1180 1190 1200
DKYLKKLHTQ ERAVEEVKLA IKPYYQKKDI TKEEYKDILR KAVHKICHSK
1210 1220 1230 1240 1250
SGEINPVKVS NLVRAYVQRY RYFRKHGRKP GDPPGPPRPP KEPGPPDKGG

PGLPLPPL
Length:1,258
Mass (Da):133,856
Last modified:September 11, 2007 - v2
Checksum:iBBEC7D4027E2F179
GO

Sequence cautioni

The sequence AAC52657 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101L → V in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti195A → G in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti255P → A in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti264A → G in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti289S → R in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti687R → G in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti746 – 748TRP → PRT in AAC52657 (PubMed:8692929).Curated3
Sequence conflicti765S → R in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti832A → S in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti952E → D in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti957P → A in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti1076A → D in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti1082S → R in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti1101L → F in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti1106G → A in AAC52657 (PubMed:8692929).Curated1
Sequence conflicti1170A → S in AAC52657 (PubMed:8692929).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03002356 Genomic DNA. No translation available.
U49056 mRNA. Translation: AAC52657.1. Different initiation.
PIRiT31421.
RefSeqiNP_062257.1. NM_019384.1.
XP_008757631.2. XM_008759409.2.
XP_008757632.1. XM_008759410.2.
XP_017445105.1. XM_017589616.1.
UniGeneiRn.93.

Genome annotation databases

EnsembliENSRNOT00000081430; ENSRNOP00000072566; ENSRNOG00000056946.
GeneIDi56081.
KEGGirno:56081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03002356 Genomic DNA. No translation available.
U49056 mRNA. Translation: AAC52657.1. Different initiation.
PIRiT31421.
RefSeqiNP_062257.1. NM_019384.1.
XP_008757631.2. XM_008759409.2.
XP_008757632.1. XM_008759410.2.
XP_017445105.1. XM_017589616.1.
UniGeneiRn.93.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027801.

PTM databases

iPTMnetiQ63624.
PhosphoSitePlusiQ63624.

Proteomic databases

PaxDbiQ63624.
PRIDEiQ63624.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000081430; ENSRNOP00000072566; ENSRNOG00000056946.
GeneIDi56081.
KEGGirno:56081.

Organism-specific databases

CTDi58506.
RGDi708405. Scaf1.

Phylogenomic databases

eggNOGiKOG0825. Eukaryota.
ENOG4111F4U. LUCA.
GeneTreeiENSGT00530000063661.
HOGENOMiHOG000154300.
HOVERGENiHBG097942.
InParanoidiQ63624.
OMAiRPDKPDP.
OrthoDBiEOG091G05JH.
PhylomeDBiQ63624.
TreeFamiTF332183.

Miscellaneous databases

PROiQ63624.

Gene expression databases

BgeeiENSRNOG00000020499.
GenevisibleiQ63624. RN.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSFR19_RAT
AccessioniPrimary (citable) accession number: Q63624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.