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Protein

Interleukin-1 receptor accessory protein

Gene

Il1rap

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity).By similarity

GO - Molecular functioni

  • interleukin-1 binding Source: RGD
  • interleukin-1 receptor activity Source: InterPro
  • interleukin-1 receptor binding Source: RGD
  • protein binding, bridging Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor accessory protein
Short name:
IL-1 receptor accessory protein
Short name:
IL-1RAcP
Gene namesi
Name:Il1rap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2893. Il1rap.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 367347ExtracellularSequence analysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence analysisAdd
BLAST
Topological domaini389 – 570182CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 570550Interleukin-1 receptor accessory proteinPRO_0000015453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122PROSITE-ProRule annotation
Disulfide bondi47 ↔ 114PROSITE-ProRule annotation
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi137 ↔ 181PROSITE-ProRule annotation
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi160 ↔ 212PROSITE-ProRule annotation
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis
Disulfide bondi266 ↔ 332PROSITE-ProRule annotation
Modified residuei557 – 5571PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ63621.

Expressioni

Tissue specificityi

Highly expressed in hypothalamus, in the dentate gyrus of hippocampus, cerebral cortex, cerebellum, liver and lung.1 Publication

Interactioni

Subunit structurei

The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex (By similarity). Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoechiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).By similarity

GO - Molecular functioni

  • interleukin-1 binding Source: RGD
  • interleukin-1 receptor binding Source: RGD
  • protein binding, bridging Source: RGD

Protein-protein interaction databases

BioGridi247499. 2 interactions.
IntActiQ63621. 1 interaction.
MINTiMINT-7138533.

Structurei

3D structure databases

ProteinModelPortaliQ63621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 128108Ig-like C2-type 1Add
BLAST
Domaini141 – 23090Ig-like C2-type 2Add
BLAST
Domaini243 – 348106Ig-like C2-type 3Add
BLAST
Domaini403 – 549147TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000092977.
HOVERGENiHBG104298.
InParanoidiQ63621.
KOiK04723.
PhylomeDBiQ63621.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPWCLMSL FFCGILQSHA SERCDDWGLD TMRQIQVFED EPARIKCPLF
60 70 80 90 100
EHFLKYNYST AHSSGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW
110 120 130 140 150
FRPTLLNDTG NYTCMLRNTT YCSKVAFPLE VVQKDSCFNS PMRLPVHRLY
160 170 180 190 200
IEQGIHNITC PNVDGYFPSS VKPSVTWYKG CTEIVNFHNV QPKGMNLSFF
210 220 230 240 250
IPLVSNNGNY TCVVTYLENG RLFHLTRTMT VKVVGSPKDA VPPHIYSPND
260 270 280 290 300
RVVYEKEPGE ELVIPCKVYF SFIMDSHNEI WWTIDGKKPD DVPVDITIIE
310 320 330 340 350
SVSYSSTEDE TRTQILSIKK VTPEDLKRNY VCHARNAEGE AEQAAKVKQK
360 370 380 390 400
VIPPRYTVEL ACGFGATVFL VVVLIVVYHV YWLEMVLFYR AHFGTDETIL
410 420 430 440 450
DGKEYDIYVS YARNAEEEEF VLLTLRGVLE NEFGYKLCIF DRDSFPGGIV
460 470 480 490 500
TDETLSFIQK SRRLLVVLSP NYVLQGTQAL LELKAGLENM ASRGNINVIL
510 520 530 540 550
VQYKAVKDLK VKELKRAKSV LTVIKWKGEK SKYPQGRFWK QLQVAMPVKK
560 570
SPRWSSSDKQ GLSYSSLKNV
Length:570
Mass (Da):65,599
Last modified:November 1, 1996 - v1
Checksum:i20C3A5478127AABE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48592 mRNA. Translation: AAB03502.1.
RefSeqiNP_037100.1. NM_012968.1.
UniGeneiRn.10511.

Genome annotation databases

GeneIDi25466.
KEGGirno:25466.
UCSCiRGD:2893. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48592 mRNA. Translation: AAB03502.1.
RefSeqiNP_037100.1. NM_012968.1.
UniGeneiRn.10511.

3D structure databases

ProteinModelPortaliQ63621.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247499. 2 interactions.
IntActiQ63621. 1 interaction.
MINTiMINT-7138533.

Proteomic databases

PRIDEiQ63621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25466.
KEGGirno:25466.
UCSCiRGD:2893. rat.

Organism-specific databases

CTDi3556.
RGDi2893. Il1rap.

Phylogenomic databases

HOGENOMiHOG000092977.
HOVERGENiHBG104298.
InParanoidiQ63621.
KOiK04723.
PhylomeDBiQ63621.

Miscellaneous databases

PROiQ63621.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL1AP_RAT
AccessioniPrimary (citable) accession number: Q63621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.