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Q635S6 (METE_BACCZ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:BCE33L3760
OrganismBacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]
Taxonomic identifier288681 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length762 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7627625-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_1000017221

Sites

Metal binding6451Zinc By similarity
Metal binding6471Zinc By similarity
Metal binding7301Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q635S6 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 5A454805A069110E

FASTA76287,193
        10         20         30         40         50         60 
MAIQTSNLGY PRIGLQREWK KTLEAFWSNK INEEQFLTTM KEIRLQHVKV QQEKGIELIP 

        70         80         90        100        110        120 
IGDFTYYDHV LDTAYMLGFI PSRFSEFTSY LDVYFAMARG SKDHVASEMT KWFNTNYHYI 

       130        140        150        160        170        180 
VPEYEEGLQI SLKDNRPLRL YEEAKQELGV DGKPVILGPY TFLKLAKGYT QEQFATILKQ 

       190        200        210        220        230        240 
LVAPYVQLLS ELHAAGAQII QVDEPIFASL TKEEVQQAKE IYEAIRKEVP NATLLLQTYF 

       250        260        270        280        290        300 
DSVEENYENI ITFPVSSIGL DFVHGKEGNL NAISKYGFPA DKTLAVGCID GRNIWRADLD 

       310        320        330        340        350        360 
EVLTLFTKLQ TQVQTKDFIV QPSCSLLHTP IDKTEETHLS TELFDALAFA NQKLEELVLI 

       370        380        390        400        410        420 
HSALTQGTES ISNELETYRN VHHTIRSSAA RNREDVKAAR TALKEEDFSR PLPFEKRYKL 

       430        440        450        460        470        480 
QQVALKLPLL PTTTIGSFPQ TTEVRQTRKE WRTGVISNKQ YEQFIEKETE KWIRYQEEIG 

       490        500        510        520        530        540 
LDVLVHGEFE RTDMVEYFGE RLAGFSFTKN GWVQSYGSRC VKPPVIYGDV AFINGMTIKE 

       550        560        570        580        590        600 
TVYAQSLTEK VVKGMLTGPV TILNWSFVRN DIPRKEVSYQ IALALRHEIE LLESSGIRVI 

       610        620        630        640        650        660 
QVDEPALREG MPLKEKDWDA YITWAVQSFL LATSSVANVT QIHTHMCYSN FEDIVDAIRA 

       670        680        690        700        710        720 
LDADVISIET SRSHGEFIDT LKHTTYEKGI GLGVYDIHSP RVPSKDEMYK IVEQSLEVCD 

       730        740        750        760 
PKYFWINPDC GLKTRRTEEV IPALEHMVQA AKDARSLLKT NA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000001 Genomic DNA. Translation: AAU16507.1.
RefSeqYP_085341.1. NC_006274.1.

3D structure databases

HSSPHSSP built from PDB template 1XR2 based on UniProtKB Q9X112.
ProteinModelPortalQ635S6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ635S6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000045003; EBBACP00000043904; EBBACG00000044994.
GeneID3023856.
GenomeReviewsGene locus BCE33L3760 in contig CP000001_GR.
KEGGbcz:BCZK3760.
PATRIC18891284. VBIBacCer95304_3980.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0620.
GeneTreeEBGT00050000001686.
HOGENOMHBG287495.
OMARNIWRAN.
PhylomeDBQ635S6.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycBCER288681:BCE33L3760-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_BACCZ
AccessionPrimary (citable) accession number: Q635S6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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