Q635F2 (ARGB_BACCZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	BCE33L3885

Organism

Bacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]

Taxonomic identifier

288681 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000112580
Regions
	Region	40 – 41	2	Substrate binding By similarity
Sites
	Binding site	62	1	Substrate By similarity
	Binding site	153	1	Substrate By similarity
	Site	8	1	Transition state stabilizer By similarity
	Site	212	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q635F2 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 768692331799F3DC	FASTA	255	27,462
	10 20 30 40 50 60 MSDYVVVKCG GSMLDQLNDV FFDCIKKLQQ KYKVVIVHGG GPEIDAQLKD CNINVEKRDG 70 80 90 100 110 120 LRVTPKEVMD VVQMVLCGST NKKLVMNLQK HNLRAVGCSG CDGNLLQVQP VSEEIGYVGE 130 140 150 160 170 180 VRYVETALLK GLINMNYIPV IAPVGINDNE IYNINADTAA AGIAAALSAK ELIFITDVDG 190 200 210 220 230 240 VLHEGKLVKK TDEFEIVNFI ENGVITGGMI PKVQAAIASL KMGVQKVSIV NGMKDFTEVT 250 GECIGTTVTR GVSIA

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ZK / E33L.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000001 Genomic DNA. Translation: AAU16383.1.
RefSeq	YP_085465.1. NC_006274.1.
3D structure databases
ProteinModelPortal	Q635F2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q635F2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000042955; EBBACP00000041856; EBBACG00000042946.
GeneID	3024333.
GenomeReviews	Gene locus BCE33L3885 in contig CP000001_GR.
KEGG	bcz:BCZK3885.
PATRIC	18891550. VBIBacCer95304_4113.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
GeneTree	EBGT00050000001971.
HOGENOM	HBG497643.
OMA	CNINVEK.
PhylomeDB	Q635F2.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	BCER288681:BCE33L3885-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BACCZ

Accession

Primary (citable) accession number: Q635F2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program