Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q635A7 (DXS_BACCZ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS
Gene names
Name:dxs
Ordered Locus Names:BCE33L3930
OrganismBacillus cereus (strain ZK / E33L) [Complete proteome] [HAMAP]
Taxonomic identifier288681 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length630 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315

Subunit structure

Homodimer By similarity. HAMAP MF_00315

Sequence similarities

Belongs to the transketolase family. DXPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6306301-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
PRO_0000256374

Sequences

Sequence LengthMass (Da)Tools
Q635A7 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 29320ADE58BB6B1D

FASTA63069,427
        10         20         30         40         50         60 
MDLTQIQNPS FLKDMSISEL EGLSEDIRKF LIEELSQTGG HIAPNLGVVE LTIALHKLFD 

        70         80         90        100        110        120 
SPKDKFLWDV GHQSYVHKIL TGRAKEFGTL RQYQGLCGFP KRCESEHDVW ETGHSSTSLS 

       130        140        150        160        170        180 
AAMGMALARD LKKTKEYVIP IIGDGALTGG MALEALNHIG HEKTDMIVIL NDNEMSIAPN 

       190        200        210        220        230        240 
VGALHNVLGR LRTAGKYHWV KDELEYILKK IPAVGGKVAA TAEKIKDSLK YLLVSGVFFE 

       250        260        270        280        290        300 
ELGFTYLGPV DGHDYEKLFE TLQYAKKTKG PVLVHVITKK GKGYKPAESD VIGTWHGTGP 

       310        320        330        340        350        360 
YKIESGDFVK PKEVAPAWSA VVSETVLKLA RTDERIVAIT PAMPVGSKLE KFQKEFPDRM 

       370        380        390        400        410        420 
IDVGIAEQHA TTMAAGMATQ GMKPFLAIYS TFLQRAYDQV VHDICRQNLN VFIGIDRSGL 

       430        440        450        460        470        480 
VGADGETHQG VFDISFLRHL PNMVIMMPKD ENEGQHLVYT AMQYEDGPIA LRYARGNGLG 

       490        500        510        520        530        540 
VHMDEELKAI PIGSWETLKE GTQAAILTFG TTIPMAMEAA ERLEKAGVSV KVVNARFIKP 

       550        560        570        580        590        600 
MDEAYLHDLL GKNIPILTIE EACLIGGFGT GVVEFASENG YHSALVERMG IPDRFIEHGS 

       610        620        630 
VTKLLEEIGL TTDAVVDRIH TMIPSKQKRA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000001 Genomic DNA. Translation: AAU16338.1.
RefSeqYP_085510.1. NC_006274.1.

3D structure databases

ProteinModelPortalQ635A7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ635A7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000045121; EBBACP00000044022; EBBACG00000045112.
GeneID3026378.
GenomeReviewsGene locus BCE33L3930 in contig CP000001_GR.
KEGGbcz:BCZK3930.
PATRIC18891652. VBIBacCer95304_4164.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
GeneTreeEBGT00070000031844.
HOGENOMHBG571647.
OMARFANEHD.
ProtClustDBPRK05444.

Enzyme and pathway databases

BioCycBCER288681:BCE33L3930-MONOMER.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDXS_BACCZ
AccessionPrimary (citable) accession number: Q635A7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 25, 2004
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents