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Protein

26S protease regulatory subunit 6A

Gene

Psmc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi227 – 2348ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
26S protease regulatory subunit 6A
Alternative name(s):
26S proteasome AAA-ATPase subunit RPT5
Proteasome 26S subunit ATPase 3
Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA
Tat-binding protein 1
Short name:
TBP-1
Gene namesi
Name:Psmc3
Synonyms:Tbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61905. Psmc3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 43943926S protease regulatory subunit 6APRO_0000084700Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei376 – 3761PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ63569.
PeptideAtlasiQ63569.
PRIDEiQ63569.

PTM databases

iPTMnetiQ63569.
PhosphoSiteiQ63569.

Interactioni

Subunit structurei

May form a heterodimer with a related family member. Interacts with PAAF1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248298. 7 interactions.
IntActiQ63569. 2 interactions.
MINTiMINT-4575508.
STRINGi10116.ENSRNOP00000015757.

Structurei

3D structure databases

ProteinModelPortaliQ63569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0652. Eukaryota.
COG1222. LUCA.
HOVERGENiHBG000109.
InParanoidiQ63569.
KOiK03065.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLPTPESP VTRQEKMATV WDEAEQDGIG EEVLKMSTEE IVQRTRLLDS
60 70 80 90 100
EIKIMKSEVL RVTHELQAMK DKIKENSEKI KVNKTLPYLV SNVIELLDVD
110 120 130 140 150
PNDQEEDGAN IDLDSQRKGK CAVIKTSTRQ TYFLPVIGLV DAEKLKPGDL
160 170 180 190 200
VGVNKDSYLI LETLPTEYDS RVKAMEVDER PTEQYSDIGG LDKQIQELVE
210 220 230 240 250
AIVLPMNHKE KFENLGIQPP KGVLMYGPPG TGKTLLARAC AAQTKATFLK
260 270 280 290 300
LAGPQLVQMF IGDGAKLVRD AFALAKEKAP SIIFIDELDA IGTKRFDSEK
310 320 330 340 350
AGDREVQRTM LELLNQLDGF QPNTQVKVIA ATNRVDILDP ALLRSGRLDR
360 370 380 390 400
KIEFPMPNEE ARARIMQIHS RKMNVSPDVN YEELARCTDD FNGAQCKAVC
410 420 430
VEAGMIALRR GATELTHEDY MEGILEVQAK KKANLQYYA
Length:439
Mass (Da):49,160
Last modified:November 1, 1997 - v1
Checksum:i292E780AEBD19BAE
GO

Sequence cautioni

The sequence AAB70882.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841K → N in AAB70882 (PubMed:9266764).Curated
Sequence conflicti317 – 3171L → M in AAB70882 (PubMed:9266764).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83522 mRNA. Translation: BAA11939.1.
U77918 mRNA. Translation: AAB70882.1. Different initiation.
RefSeqiNP_113783.1. NM_031595.1.
UniGeneiRn.11173.

Genome annotation databases

GeneIDi29677.
KEGGirno:29677.
UCSCiRGD:61905. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83522 mRNA. Translation: BAA11939.1.
U77918 mRNA. Translation: AAB70882.1. Different initiation.
RefSeqiNP_113783.1. NM_031595.1.
UniGeneiRn.11173.

3D structure databases

ProteinModelPortaliQ63569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248298. 7 interactions.
IntActiQ63569. 2 interactions.
MINTiMINT-4575508.
STRINGi10116.ENSRNOP00000015757.

PTM databases

iPTMnetiQ63569.
PhosphoSiteiQ63569.

Proteomic databases

PaxDbiQ63569.
PeptideAtlasiQ63569.
PRIDEiQ63569.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29677.
KEGGirno:29677.
UCSCiRGD:61905. rat.

Organism-specific databases

CTDi5702.
RGDi61905. Psmc3.

Phylogenomic databases

eggNOGiKOG0652. Eukaryota.
COG1222. LUCA.
HOVERGENiHBG000109.
InParanoidiQ63569.
KOiK03065.

Miscellaneous databases

PROiQ63569.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing."
    Makino Y., Yogosawa S., Kanemaki M., Yoshida T., Yamano K., Kishimoto T., Moncollin V., Egly J.-M., Muramatsu M., Tamura T.
    Biochem. Biophys. Res. Commun. 220:1049-1054(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "A protein associated with the manchette during rat spermiogenesis is encoded by a gene of the TBP-1-like subfamily with highly conserved ATPase and protease domains."
    Rivkin E., Cullinan E.B., Tres L.L., Kierszenbaum A.L.
    Mol. Reprod. Dev. 48:77-89(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiPRS6A_RAT
AccessioniPrimary (citable) accession number: Q63569
Secondary accession number(s): P97638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.