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Protein

Synaptic vesicle glycoprotein 2B

Gene

Sv2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably plays a role in the control of regulated secretion in neural and endocrine cells.By similarity
Receptor for the botulinium neurotoxin type A/BOTA.1 Publication

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: InterPro
  • neurotransmitter uptake Source: RGD

Keywordsi

Molecular functionReceptor
Biological processNeurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2B
Short name:
Synaptic vesicle protein 2B
Gene namesi
Name:Sv2b
Synonyms:Sv2bb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619716 Sv2b

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 110CytoplasmicSequence analysisAdd BLAST110
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 148ExtracellularSequence analysisAdd BLAST17
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 182CytoplasmicSequence analysisAdd BLAST13
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 205ExtracellularSequence analysis2
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 237CytoplasmicSequence analysisAdd BLAST11
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 277ExtracellularSequence analysisAdd BLAST19
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 390CytoplasmicSequence analysisAdd BLAST92
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 535ExtracellularSequence analysisAdd BLAST124
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 565CytoplasmicSequence analysis9
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 592ExtracellularSequence analysis6
Transmembranei593 – 613HelicalSequence analysisAdd BLAST21
Topological domaini614 – 626CytoplasmicSequence analysisAdd BLAST13
Transmembranei627 – 649HelicalSequence analysisAdd BLAST23
Topological domaini650 – 653ExtracellularSequence analysis4
Transmembranei654 – 672HelicalSequence analysisAdd BLAST19
Topological domaini673 – 683CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397701 – 683Synaptic vesicle glycoprotein 2BAdd BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineCombined sources1
Modified residuei36PhosphothreonineCombined sources1
Modified residuei423PhosphotyrosineBy similarity1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi516N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication
The N-terminal cytoplasmic domain is phosphorylated by CK1.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63564
PRIDEiQ63564

PTM databases

iPTMnetiQ63564
PhosphoSitePlusiQ63564

Expressioni

Tissue specificityi

Widely expressed throughout the brain. Specifically expressed by pinealocytes in the pineal gland. Also detected in testis (at protein level). Specifically expressed in neural tissues. Expressed in the spinal cord and in all brain regions with a stronger expression in hippocampus and cortex.4 Publications

Inductioni

By amyloid beta peptide.1 Publication

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 (By similarity).By similarity

Protein-protein interaction databases

BioGridi250769, 1 interactor
IntActiQ63564, 3 interactors
MINTiQ63564
STRINGi10116.ENSRNOP00000015084

Structurei

3D structure databases

ProteinModelPortaliQ63564
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni486 – 523BOTA-bindingBy similarityAdd BLAST38

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
HOGENOMiHOG000065727
HOVERGENiHBG053967
InParanoidiQ63564
KOiK06258
PhylomeDBiQ63564

Family and domain databases

CDDicd06174 MFS, 2 hits
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
IPR022308 SV2
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR01299 synapt_SV2, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q63564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDYRYRDNY EGYAPNDGYY RGNEQNPEED AQSDVTEGHD EEDEIYEGEY
60 70 80 90 100
QGIPHPDDVK SKQTKMAPSR ADGLRGQADL MAERMEDEEQ LAHQYETIID
110 120 130 140 150
ECGHGRFQWT LFFVLVLALM ADGVEVFVVS FALPSAEKDM CLSSSKKGML
160 170 180 190 200
GLIVYLGMMA GAFILGGLAD KLGRKKVLSM SLAINASFAS LSSFVQGYGA
210 220 230 240 250
FLFCRLISGI GIGGSLPIVF AYFSEFLSRE KRGEHLSWLG IFWMTGGIYA
260 270 280 290 300
SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPATVS MVALKFMPES
310 320 330 340 350
PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSHI KTPKQMDEFI
360 370 380 390 400
EIQSSTGTWY QRWLVRFMTI FKQVWDNALY CVMGPYRMNT LILAVVWFTM
410 420 430 440 450
ALSYYGLTVW FPDMIRYFQD EEYKSKMKVF FGEHVHGATI NFTMENQIHQ
460 470 480 490 500
HGKLVNDKFI KMYFKHVLFE DTFFDKCYFE DVTSTDTYFK NCTIESTTFY
510 520 530 540 550
NTDLYKHKFI DCRFINSTFL EQKEGCHMDF EEDNDFLIYL VSFLGSLSVL
560 570 580 590 600
PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC
610 620 630 640 650
GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKLGAIL GNTIFASFVG
660 670 680
ITKVVPILLA AASLVGGGLV ALRLPETREQ VLM
Length:683
Mass (Da):77,502
Last modified:November 1, 1996 - v1
Checksum:iBF862EFD4B99EA7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10362 mRNA Translation: AAA42189.1
AF372834 mRNA Translation: AAL47714.1
PIRiS34961
RefSeqiNP_476555.1, NM_057207.3
UniGeneiRn.58137

Genome annotation databases

GeneIDi117556
KEGGirno:117556
UCSCiRGD:619716 rat

Similar proteinsi

Entry informationi

Entry nameiSV2B_RAT
AccessioniPrimary (citable) accession number: Q63564
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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