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Q63564

- SV2B_RAT

UniProt

Q63564 - SV2B_RAT

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Protein

Synaptic vesicle glycoprotein 2B

Gene
Sv2b, Sv2bb
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably plays a role in the control of regulated secretion in neural and endocrine cells By similarity.1 Publication
Receptor for the botulinium neurotoxin type A/BOTA.1 Publication

GO - Molecular functioni

  1. transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. neurotransmitter uptake Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2B
Short name:
Synaptic vesicle protein 2B
Gene namesi
Name:Sv2b
Synonyms:Sv2bb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619716. Sv2b.

Subcellular locationi

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesiclesecretory vesicleacrosome
Note: Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 110110Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei111 – 13121Helical; Reviewed predictionAdd
BLAST
Topological domaini132 – 14817Extracellular Reviewed predictionAdd
BLAST
Transmembranei149 – 16921Helical; Reviewed predictionAdd
BLAST
Topological domaini170 – 18213Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei183 – 20321Helical; Reviewed predictionAdd
BLAST
Topological domaini204 – 2052Extracellular Reviewed prediction
Transmembranei206 – 22621Helical; Reviewed predictionAdd
BLAST
Topological domaini227 – 23711Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Reviewed predictionAdd
BLAST
Topological domaini259 – 27719Extracellular Reviewed predictionAdd
BLAST
Transmembranei278 – 29821Helical; Reviewed predictionAdd
BLAST
Topological domaini299 – 39092Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei391 – 41121Helical; Reviewed predictionAdd
BLAST
Topological domaini412 – 535124Extracellular Reviewed predictionAdd
BLAST
Transmembranei536 – 55621Helical; Reviewed predictionAdd
BLAST
Topological domaini557 – 5659Cytoplasmic Reviewed prediction
Transmembranei566 – 58621Helical; Reviewed predictionAdd
BLAST
Topological domaini587 – 5926Extracellular Reviewed prediction
Transmembranei593 – 61321Helical; Reviewed predictionAdd
BLAST
Topological domaini614 – 62613Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei627 – 64923Helical; Reviewed predictionAdd
BLAST
Topological domaini650 – 6534Extracellular Reviewed prediction
Transmembranei654 – 67219Helical; Reviewed predictionAdd
BLAST
Topological domaini673 – 68311Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: UniProtKB-SubCell
  2. cell junction Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: RGD
  5. synaptic vesicle Source: RGD
  6. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 683683Synaptic vesicle glycoprotein 2BPRO_0000239770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei423 – 4231Phosphotyrosine By similarity
Glycosylationi441 – 4411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi491 – 4911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication
The N-terminal cytoplasmic domain is phosphorylated by CK1.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63564.
PRIDEiQ63564.

PTM databases

PhosphoSiteiQ63564.

Expressioni

Tissue specificityi

Widely expressed throughout the brain. Specifically expressed by pinealocytes in the pineal gland. Also detected in testis (at protein level). Specifically expressed in neural tissues. Expressed in the spinal cord and in all brain regions with a stronger expression in hippocampus and cortex.4 Publications

Inductioni

By amyloid beta peptide.1 Publication

Gene expression databases

GenevestigatoriQ63564.

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 By similarity.1 Publication

Protein-protein interaction databases

BioGridi250769. 1 interaction.
IntActiQ63564. 3 interactions.
STRINGi10116.ENSRNOP00000015084.

Structurei

3D structure databases

ProteinModelPortaliQ63564.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni486 – 52338BOTA-binding By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ63564.
KOiK06258.
PhylomeDBiQ63564.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PANTHERiPTHR24065. PTHR24065. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63564-1 [UniParc]FASTAAdd to Basket

« Hide

MDDYRYRDNY EGYAPNDGYY RGNEQNPEED AQSDVTEGHD EEDEIYEGEY    50
QGIPHPDDVK SKQTKMAPSR ADGLRGQADL MAERMEDEEQ LAHQYETIID 100
ECGHGRFQWT LFFVLVLALM ADGVEVFVVS FALPSAEKDM CLSSSKKGML 150
GLIVYLGMMA GAFILGGLAD KLGRKKVLSM SLAINASFAS LSSFVQGYGA 200
FLFCRLISGI GIGGSLPIVF AYFSEFLSRE KRGEHLSWLG IFWMTGGIYA 250
SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPATVS MVALKFMPES 300
PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSHI KTPKQMDEFI 350
EIQSSTGTWY QRWLVRFMTI FKQVWDNALY CVMGPYRMNT LILAVVWFTM 400
ALSYYGLTVW FPDMIRYFQD EEYKSKMKVF FGEHVHGATI NFTMENQIHQ 450
HGKLVNDKFI KMYFKHVLFE DTFFDKCYFE DVTSTDTYFK NCTIESTTFY 500
NTDLYKHKFI DCRFINSTFL EQKEGCHMDF EEDNDFLIYL VSFLGSLSVL 550
PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC 600
GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKLGAIL GNTIFASFVG 650
ITKVVPILLA AASLVGGGLV ALRLPETREQ VLM 683
Length:683
Mass (Da):77,502
Last modified:November 1, 1996 - v1
Checksum:iBF862EFD4B99EA7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10362 mRNA. Translation: AAA42189.1.
AF372834 mRNA. Translation: AAL47714.1.
PIRiS34961.
RefSeqiNP_476555.1. NM_057207.3.
UniGeneiRn.58137.

Genome annotation databases

GeneIDi117556.
KEGGirno:117556.
UCSCiRGD:619716. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10362 mRNA. Translation: AAA42189.1 .
AF372834 mRNA. Translation: AAL47714.1 .
PIRi S34961.
RefSeqi NP_476555.1. NM_057207.3.
UniGenei Rn.58137.

3D structure databases

ProteinModelPortali Q63564.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250769. 1 interaction.
IntActi Q63564. 3 interactions.
STRINGi 10116.ENSRNOP00000015084.

PTM databases

PhosphoSitei Q63564.

Proteomic databases

PaxDbi Q63564.
PRIDEi Q63564.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 117556.
KEGGi rno:117556.
UCSCi RGD:619716. rat.

Organism-specific databases

CTDi 9899.
RGDi 619716. Sv2b.

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000065727.
HOVERGENi HBG053967.
InParanoidi Q63564.
KOi K06258.
PhylomeDBi Q63564.

Miscellaneous databases

NextBioi 620409.

Gene expression databases

Genevestigatori Q63564.

Family and domain databases

InterProi IPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view ]
PANTHERi PTHR24065. PTHR24065. 1 hit.
Pfami PF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR01299. synapt_SV2. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Identification of a new synaptic vesicle protein 2B mRNA transcript which is up-regulated in neurons by amyloid beta peptide fragment (1-42)."
    Heese K., Nagai Y., Sawada T.
    Biochem. Biophys. Res. Commun. 289:924-928(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
  3. "Synaptic vesicle protein SV2B, but not SV2A, is predominantly expressed and associated with microvesicles in rat pinealocytes."
    Hayashi M., Yamamoto A., Yatsushiro S., Yamada H., Futai M., Yamaguchi A., Moriyama Y.
    J. Neurochem. 71:356-365(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles."
    Janz R., Hofmann K., Suedhof T.C.
    J. Neurosci. 18:9269-9281(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION.
  5. "SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family."
    Janz R., Suedhof T.C.
    Neuroscience 94:1279-1290(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Phosphorylation of synaptic vesicle protein 2 modulates binding to synaptotagmin."
    Pyle R.A., Schivell A.E., Hidaka H., Bajjalieh S.M.
    J. Biol. Chem. 275:17195-17200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY CK1.
  7. "Brain synaptic junctional proteins at the acrosome of rat testicular germ cells."
    Redecker P., Kreutz M.R., Bockmann J., Gundelfinger E.D., Boeckers T.M.
    J. Histochem. Cytochem. 51:809-819(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment."
    Iezzi M., Theander S., Janz R., Loze C., Wollheim C.B.
    J. Cell Sci. 118:5647-5660(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. Cited for: INTERACTION WITH SYT1.
  10. "SV2 is the protein receptor for botulinum neurotoxin A."
    Dong M., Yeh F., Tepp W.H., Dean C., Johnson E.A., Janz R., Chapman E.R.
    Science 312:592-596(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A BOTA RECEPTOR.

Entry informationi

Entry nameiSV2B_RAT
AccessioniPrimary (citable) accession number: Q63564
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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