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Q63563

- ABCC9_RAT

UniProt

Q63563 - ABCC9_RAT

Protein

ATP-binding cassette sub-family C member 9

Gene

Abcc9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi701 – 7088ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1342 – 13498ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. drug binding Source: RGD
    4. identical protein binding Source: IntAct
    5. potassium channel activity Source: RGD
    6. potassium channel regulator activity Source: BHF-UCL
    7. sulfonylurea receptor activity Source: BHF-UCL
    8. syntaxin binding Source: RGD

    GO - Biological processi

    1. potassium ion import Source: BHF-UCL
    2. response to drug Source: RGD
    3. signal transduction Source: GOC
    4. substrate-dependent cell migration, cell contraction Source: RGD

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family C member 9
    Alternative name(s):
    Sulfonylurea receptor 2
    Gene namesi
    Name:Abcc9
    Synonyms:Sur2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3787. Abcc9.

    Subcellular locationi

    Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

    GO - Cellular componenti

    1. ATP-sensitive potassium channel complex Source: BHF-UCL
    2. mitochondrion Source: RGD
    3. plasma membrane Source: RGD
    4. T-tubule Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15451545ATP-binding cassette sub-family C member 9PRO_0000093405Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ63563.

    Expressioni

    Tissue specificityi

    Expressed at high levels in heart, skeletal muscle and ovary. Moderate levels are found in brain, tongue and pancreatic islets. Low levels are found in lung, testis and adrenal gland. Expressed at very low levels in stomach, colon, thyroid and pituitary.

    Gene expression databases

    GenevestigatoriQ63563.

    Interactioni

    Subunit structurei

    Interacts with KCNJ11.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000063326.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63563.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 7221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini94 – 1018ExtracellularSequence Analysis
    Topological domaini123 – 13210CytoplasmicSequence Analysis
    Topological domaini154 – 16714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini189 – 301113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini323 – 34725ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini369 – 42052CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini442 – 45211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini474 – 52855CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini550 – 56819ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini590 – 986397CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1008 – 103023ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1052 – 112372CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1145 – 124197ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1263 – 1545283CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121Helical; Name=1PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei73 – 9321Helical; Name=2PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei133 – 15321Helical; Name=4PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=5PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei302 – 32221Helical; Name=6PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei348 – 36821Helical; Name=7PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei421 – 44121Helical; Name=8PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei453 – 47321Helical; Name=9PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei529 – 54921Helical; Name=10PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei569 – 58921Helical; Name=11PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei987 – 100721Helical; Name=12PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1031 – 105121Helical; Name=13PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1124 – 114421Helical; Name=14PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1242 – 126221Helical; Name=15PROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini297 – 594298ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini668 – 908241ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini990 – 1270281ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1308 – 1542235ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    HOGENOMiHOG000168680.
    HOVERGENiHBG101342.
    InParanoidiQ63563.
    KOiK05033.
    PhylomeDBiQ63563.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    IPR001475. Sulphonylurea_rcpt-2.
    IPR000388. Sulphorea_rcpt.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    PRINTSiPR01094. SULFNYLUR2.
    PR01092. SULFNYLUREAR.
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform SUR2A (identifier: Q63563-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLSFCGNNI SSYNIYHGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG     50
    SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSQRASR 100
    HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI 150
    KLVKYWQLGW GMSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ 200
    KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK 250
    LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS 300
    STFRYLADLL GFAGPLCISG IVQRVNEPKN NTTRFSETLS SKEFLENAHV 350
    LAVLLFLALI LQRTFLQASY YVTIETGINL RGALLAMIYN KILRLSTSNL 400
    SMGEMTLGQI NNLVAIETNQ LMWFLFLCPN LWAMPVQIIM GVILLYNLLG 450
    SSALVGAAVI VLLAPIQYFI ATKLAEAQKS TLDYSTERLK KTNEILKGIK 500
    LLKLYAWEHI FCKSVEETRM KELSSLKTFA LYTSLSIFMN AAIPIAAVLA 550
    TFVTHAYASG NNLKPAEAFA SLSLFHILVT PLFLLSTVVR FAVKAIISVQ 600
    KLNEFLLSDE IGEDSWRTGE GTLPFESCKK HTGVQSKPIN RKQPGRYHLD 650
    NYEQARRLRP AETEDVAIKV TNGYFSWGSG LATLSNIDIR IPTGQLTMIV 700
    GQVGCGKSSL LLAILGEMQT LEGKVYWNNV NESEPSFEAT RSRSRYSVAY 750
    AAQKPWLLNA TVEENITFGS SFNRQRYKAV TDACSLQPDI DLLPFGDQTE 800
    IGERGINLSG GQRQRICVAR ALYQNTNIVF LDDPFSALDI HLSDHLMQEG 850
    ILKFLQDDKR TVVLVTHKLQ YLTHADWIIA MKDGSVLREG TLKDIQTKDV 900
    ELYEHWKTLM NRQDQELEKD MEADQTTLER KTLRRAMYSR EAKAQMEDED 950
    EEEEEEEDED DNMSTVMRLR TKMPWKTCWW YLTSGGFFLL FLMIFSKLLK 1000
    HSVIVAIDYW LATWTSEYSI NDPGKADQTF YVAGFSILCG AGIFLCLVTS 1050
    LTVEWMGLTA AKNLHHNLLN KIILGPIRFF DTTPLGLILN RFSADTNIID 1100
    QHIPPTLESL TRSTLLCLSA IGMISYATPV FLIALAPLGV AFYFIQKYFR 1150
    VASKDLQELD DSTQLPLLCH FSETAEGLTT IRAFRHETRF KQRMLELTDT 1200
    NNIAYLFLSA ANRWLEVRTD YLGACIVLTA SIASISGSSN SGLVGLGLLY 1250
    ALTITNYLNW VVRNLADLEV QMGAVKKVNS FLTMESENYE GTMDPSQVPE 1300
    HWPQEGEIKI HDLCVRYENN LKPVLKHVKA YIKPGQKVGI CGRTGSGKSS 1350
    LSLAFFRMVD IFDGKIVIDG IDISKLPLHT LRSRLSIILQ DPILFSGSIR 1400
    FNLDPECKCT DDRLWEALEI AQLKNMVKSL PGGLDATVTE GGENFSVGQR 1450
    QLFCLARAFV RKSSILIMDE ATASIDMATE NILQKVVMTA FADRTVVTIA 1500
    HRVSSIMDAG LVLVFSEGIL VECDTGPNLL QHKNGLFSTL VMTNK 1545
    Length:1,545
    Mass (Da):174,118
    Last modified:November 1, 1996 - v1
    Checksum:i768DA1F58E9945E7
    GO
    Isoform SUR2B (identifier: Q63563-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1504-1545: SSIMDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM

    Show »
    Length:1,545
    Mass (Da):174,306
    Checksum:i8666453CED33154D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1504 – 154542SSIMD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B. 2 PublicationsVSP_000061Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83598 mRNA. Translation: BAA12020.1.
    AF087838 mRNA. Translation: AAC36347.1.
    AF019628 mRNA. Translation: AAC24758.1.
    PIRiT42751.
    T46645.
    RefSeqiNP_037172.2. NM_013040.2. [Q63563-2]
    UniGeneiRn.10528.
    Rn.164431.

    Genome annotation databases

    GeneIDi25560.
    KEGGirno:25560.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83598 mRNA. Translation: BAA12020.1 .
    AF087838 mRNA. Translation: AAC36347.1 .
    AF019628 mRNA. Translation: AAC24758.1 .
    PIRi T42751.
    T46645.
    RefSeqi NP_037172.2. NM_013040.2. [Q63563-2 ]
    UniGenei Rn.10528.
    Rn.164431.

    3D structure databases

    ProteinModelPortali Q63563.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000063326.

    Chemistry

    BindingDBi Q63563.
    ChEMBLi CHEMBL3244.

    Proteomic databases

    PRIDEi Q63563.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25560.
    KEGGi rno:25560.

    Organism-specific databases

    CTDi 10060.
    RGDi 3787. Abcc9.

    Phylogenomic databases

    eggNOGi COG1132.
    HOGENOMi HOG000168680.
    HOVERGENi HBG101342.
    InParanoidi Q63563.
    KOi K05033.
    PhylomeDBi Q63563.

    Miscellaneous databases

    NextBioi 607143.
    PROi Q63563.

    Gene expression databases

    Genevestigatori Q63563.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    IPR001475. Sulphonylurea_rcpt-2.
    IPR000388. Sulphorea_rcpt.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    PRINTSi PR01094. SULFNYLUR2.
    PR01092. SULFNYLUREAR.
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels."
      Inagaki N., Gonoi T., Clement G., Wang C., Aguilar-Bryan L., Bryan J., Seino S.
      Neuron 16:1011-1017(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2A).
      Tissue: Brain.
    2. "Rat sulfonylurea receptor 2B, alternatively spliced product."
      Furuta H., Inagaki N., Gonoi T., Chien E., Seino S., Bell G.I.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2B).
      Strain: Sprague-Dawley.
    3. Tanemoto M., Abe T., Hebert S.C.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2B).

    Entry informationi

    Entry nameiABCC9_RAT
    AccessioniPrimary (citable) accession number: Q63563
    Secondary accession number(s): O89115
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3