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Q63563 (ABCC9_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family C member 9
Alternative name(s):
Sulfonylurea receptor 2
Gene names
Name:Abcc9
Synonyms:Sur2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1545 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Subunit structure

Interacts with KCNJ11.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed at high levels in heart, skeletal muscle and ovary. Moderate levels are found in brain, tongue and pancreatic islets. Low levels are found in lung, testis and adrenal gland. Expressed at very low levels in stomach, colon, thyroid and pituitary.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpotassium ion import

Inferred from direct assay Ref.1. Source: BHF-UCL

response to drug

Inferred from expression pattern PubMed 15964031. Source: RGD

signal transduction

Inferred from direct assay Ref.1. Source: GOC

substrate-dependent cell migration, cell contraction

Non-traceable author statement PubMed 11967023. Source: RGD

   Cellular_componentATP-sensitive potassium channel complex

Inferred from direct assay Ref.1. Source: BHF-UCL

T-tubule

Inferred from direct assay PubMed 15647111. Source: RGD

mitochondrion

Inferred from direct assay PubMed 16050978. Source: RGD

plasma membrane

Inferred from direct assay PubMed 14672537. Source: RGD

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity, coupled to transmembrane movement of substances

Inferred from electronic annotation. Source: InterPro

drug binding

Inferred from direct assay PubMed 10347249. Source: RGD

identical protein binding

Inferred from physical interaction PubMed 23253866. Source: IntAct

potassium channel activity

Inferred from mutant phenotype PubMed 10347249. Source: RGD

potassium channel regulator activity

Inferred from direct assay Ref.1. Source: BHF-UCL

sulfonylurea receptor activity

Inferred from direct assay Ref.1. Source: BHF-UCL

syntaxin binding

Inferred from physical interaction PubMed 15339904. Source: RGD

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform SUR2A (identifier: Q63563-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform SUR2B (identifier: Q63563-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1504-1545: SSIMDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15451545ATP-binding cassette sub-family C member 9
PRO_0000093405

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Name=1; Potential
Topological domain52 – 7221Cytoplasmic Potential
Transmembrane73 – 9321Helical; Name=2; Potential
Topological domain94 – 1018Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 13210Cytoplasmic Potential
Transmembrane133 – 15321Helical; Name=4; Potential
Topological domain154 – 16714Extracellular Potential
Transmembrane168 – 18821Helical; Name=5; Potential
Topological domain189 – 301113Cytoplasmic Potential
Transmembrane302 – 32221Helical; Name=6; Potential
Topological domain323 – 34725Extracellular Potential
Transmembrane348 – 36821Helical; Name=7; Potential
Topological domain369 – 42052Cytoplasmic Potential
Transmembrane421 – 44121Helical; Name=8; Potential
Topological domain442 – 45211Extracellular Potential
Transmembrane453 – 47321Helical; Name=9; Potential
Topological domain474 – 52855Cytoplasmic Potential
Transmembrane529 – 54921Helical; Name=10; Potential
Topological domain550 – 56819Extracellular Potential
Transmembrane569 – 58921Helical; Name=11; Potential
Topological domain590 – 986397Cytoplasmic Potential
Transmembrane987 – 100721Helical; Name=12; Potential
Topological domain1008 – 103023Extracellular Potential
Transmembrane1031 – 105121Helical; Name=13; Potential
Topological domain1052 – 112372Cytoplasmic Potential
Transmembrane1124 – 114421Helical; Name=14; Potential
Topological domain1145 – 124197Extracellular Potential
Transmembrane1242 – 126221Helical; Name=15; Potential
Topological domain1263 – 1545283Cytoplasmic Potential
Domain297 – 594298ABC transmembrane type-1 1
Domain668 – 908241ABC transporter 1
Domain990 – 1270281ABC transmembrane type-1 2
Domain1308 – 1542235ABC transporter 2
Nucleotide binding701 – 7088ATP 1 Potential
Nucleotide binding1342 – 13498ATP 2 Potential

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1504 – 154542SSIMD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B.
VSP_000061

Sequences

Sequence LengthMass (Da)Tools
Isoform SUR2A [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 768DA1F58E9945E7

FASTA1,545174,118
        10         20         30         40         50         60 
MSLSFCGNNI SSYNIYHGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG SQSSKVQIHH 

        70         80         90        100        110        120 
NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSQRASR HLHLFMPAVM GFVATTTSIV 

       130        140        150        160        170        180 
YYHNIETSNF PKLLLALFLY WVMAFITKTI KLVKYWQLGW GMSDLRFCIT GVMVILNGLL 

       190        200        210        220        230        240 
MAVEINVIRV RRYVFFMNPQ KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR 

       250        260        270        280        290        300 
KPIDLKAIGK LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS 

       310        320        330        340        350        360 
STFRYLADLL GFAGPLCISG IVQRVNEPKN NTTRFSETLS SKEFLENAHV LAVLLFLALI 

       370        380        390        400        410        420 
LQRTFLQASY YVTIETGINL RGALLAMIYN KILRLSTSNL SMGEMTLGQI NNLVAIETNQ 

       430        440        450        460        470        480 
LMWFLFLCPN LWAMPVQIIM GVILLYNLLG SSALVGAAVI VLLAPIQYFI ATKLAEAQKS 

       490        500        510        520        530        540 
TLDYSTERLK KTNEILKGIK LLKLYAWEHI FCKSVEETRM KELSSLKTFA LYTSLSIFMN 

       550        560        570        580        590        600 
AAIPIAAVLA TFVTHAYASG NNLKPAEAFA SLSLFHILVT PLFLLSTVVR FAVKAIISVQ 

       610        620        630        640        650        660 
KLNEFLLSDE IGEDSWRTGE GTLPFESCKK HTGVQSKPIN RKQPGRYHLD NYEQARRLRP 

       670        680        690        700        710        720 
AETEDVAIKV TNGYFSWGSG LATLSNIDIR IPTGQLTMIV GQVGCGKSSL LLAILGEMQT 

       730        740        750        760        770        780 
LEGKVYWNNV NESEPSFEAT RSRSRYSVAY AAQKPWLLNA TVEENITFGS SFNRQRYKAV 

       790        800        810        820        830        840 
TDACSLQPDI DLLPFGDQTE IGERGINLSG GQRQRICVAR ALYQNTNIVF LDDPFSALDI 

       850        860        870        880        890        900 
HLSDHLMQEG ILKFLQDDKR TVVLVTHKLQ YLTHADWIIA MKDGSVLREG TLKDIQTKDV 

       910        920        930        940        950        960 
ELYEHWKTLM NRQDQELEKD MEADQTTLER KTLRRAMYSR EAKAQMEDED EEEEEEEDED 

       970        980        990       1000       1010       1020 
DNMSTVMRLR TKMPWKTCWW YLTSGGFFLL FLMIFSKLLK HSVIVAIDYW LATWTSEYSI 

      1030       1040       1050       1060       1070       1080 
NDPGKADQTF YVAGFSILCG AGIFLCLVTS LTVEWMGLTA AKNLHHNLLN KIILGPIRFF 

      1090       1100       1110       1120       1130       1140 
DTTPLGLILN RFSADTNIID QHIPPTLESL TRSTLLCLSA IGMISYATPV FLIALAPLGV 

      1150       1160       1170       1180       1190       1200 
AFYFIQKYFR VASKDLQELD DSTQLPLLCH FSETAEGLTT IRAFRHETRF KQRMLELTDT 

      1210       1220       1230       1240       1250       1260 
NNIAYLFLSA ANRWLEVRTD YLGACIVLTA SIASISGSSN SGLVGLGLLY ALTITNYLNW 

      1270       1280       1290       1300       1310       1320 
VVRNLADLEV QMGAVKKVNS FLTMESENYE GTMDPSQVPE HWPQEGEIKI HDLCVRYENN 

      1330       1340       1350       1360       1370       1380 
LKPVLKHVKA YIKPGQKVGI CGRTGSGKSS LSLAFFRMVD IFDGKIVIDG IDISKLPLHT 

      1390       1400       1410       1420       1430       1440 
LRSRLSIILQ DPILFSGSIR FNLDPECKCT DDRLWEALEI AQLKNMVKSL PGGLDATVTE 

      1450       1460       1470       1480       1490       1500 
GGENFSVGQR QLFCLARAFV RKSSILIMDE ATASIDMATE NILQKVVMTA FADRTVVTIA 

      1510       1520       1530       1540 
HRVSSIMDAG LVLVFSEGIL VECDTGPNLL QHKNGLFSTL VMTNK 

« Hide

Isoform SUR2B [UniParc].

Checksum: 8666453CED33154D
Show »

FASTA1,545174,306

References

[1]"A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels."
Inagaki N., Gonoi T., Clement G., Wang C., Aguilar-Bryan L., Bryan J., Seino S.
Neuron 16:1011-1017(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2A).
Tissue: Brain.
[2]"Rat sulfonylurea receptor 2B, alternatively spliced product."
Furuta H., Inagaki N., Gonoi T., Chien E., Seino S., Bell G.I.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2B).
Strain: Sprague-Dawley.
[3]Tanemoto M., Abe T., Hebert S.C.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2B).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D83598 mRNA. Translation: BAA12020.1.
AF087838 mRNA. Translation: AAC36347.1.
AF019628 mRNA. Translation: AAC24758.1.
PIRT42751.
T46645.
RefSeqNP_037172.2. NM_013040.2.
UniGeneRn.10528.
Rn.164431.

3D structure databases

ProteinModelPortalQ63563.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000063326.

Chemistry

BindingDBQ63563.
ChEMBLCHEMBL3244.

Proteomic databases

PRIDEQ63563.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25560.
KEGGrno:25560.

Organism-specific databases

CTD10060.
RGD3787. Abcc9.

Phylogenomic databases

eggNOGCOG1132.
HOGENOMHOG000168680.
HOVERGENHBG101342.
InParanoidQ63563.
KOK05033.
PhylomeDBQ63563.

Gene expression databases

GenevestigatorQ63563.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR001475. Sulphonylurea_rcpt-2.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSPR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio607143.
PROQ63563.

Entry information

Entry nameABCC9_RAT
AccessionPrimary (citable) accession number: Q63563
Secondary accession number(s): O89115
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families