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Q63563

- ABCC9_RAT

UniProt

Q63563 - ABCC9_RAT

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Protein

ATP-binding cassette sub-family C member 9

Gene
Abcc9, Sur2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi701 – 7088ATP 1 Reviewed prediction
Nucleotide bindingi1342 – 13498ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. drug binding Source: RGD
  4. identical protein binding Source: IntAct
  5. potassium channel activity Source: RGD
  6. potassium channel regulator activity Source: BHF-UCL
  7. sulfonylurea receptor activity Source: BHF-UCL
  8. syntaxin binding Source: RGD

GO - Biological processi

  1. potassium ion import Source: BHF-UCL
  2. response to drug Source: RGD
  3. signal transduction Source: GOC
  4. substrate-dependent cell migration, cell contraction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 9
Alternative name(s):
Sulfonylurea receptor 2
Gene namesi
Name:Abcc9
Synonyms:Sur2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3787. Abcc9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Extracellular Reviewed predictionAdd
BLAST
Transmembranei31 – 5121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini52 – 7221Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei73 – 9321Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini94 – 1018Extracellular Reviewed prediction
Transmembranei102 – 12221Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini123 – 13210Cytoplasmic Reviewed prediction
Transmembranei133 – 15321Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini154 – 16714Extracellular Reviewed predictionAdd
BLAST
Transmembranei168 – 18821Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini189 – 301113Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei302 – 32221Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini323 – 34725Extracellular Reviewed predictionAdd
BLAST
Transmembranei348 – 36821Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini369 – 42052Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei421 – 44121Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini442 – 45211Extracellular Reviewed predictionAdd
BLAST
Transmembranei453 – 47321Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini474 – 52855Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei529 – 54921Helical; Name=10; Reviewed predictionAdd
BLAST
Topological domaini550 – 56819Extracellular Reviewed predictionAdd
BLAST
Transmembranei569 – 58921Helical; Name=11; Reviewed predictionAdd
BLAST
Topological domaini590 – 986397Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei987 – 100721Helical; Name=12; Reviewed predictionAdd
BLAST
Topological domaini1008 – 103023Extracellular Reviewed predictionAdd
BLAST
Transmembranei1031 – 105121Helical; Name=13; Reviewed predictionAdd
BLAST
Topological domaini1052 – 112372Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1124 – 114421Helical; Name=14; Reviewed predictionAdd
BLAST
Topological domaini1145 – 124197Extracellular Reviewed predictionAdd
BLAST
Transmembranei1242 – 126221Helical; Name=15; Reviewed predictionAdd
BLAST
Topological domaini1263 – 1545283Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. ATP-sensitive potassium channel complex Source: BHF-UCL
  2. mitochondrion Source: RGD
  3. plasma membrane Source: RGD
  4. T-tubule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15451545ATP-binding cassette sub-family C member 9PRO_0000093405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Glycosylationi330 – 3301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ63563.

Expressioni

Tissue specificityi

Expressed at high levels in heart, skeletal muscle and ovary. Moderate levels are found in brain, tongue and pancreatic islets. Low levels are found in lung, testis and adrenal gland. Expressed at very low levels in stomach, colon, thyroid and pituitary.

Gene expression databases

GenevestigatoriQ63563.

Interactioni

Subunit structurei

Interacts with KCNJ11.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063326.

Structurei

3D structure databases

ProteinModelPortaliQ63563.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini297 – 594298ABC transmembrane type-1 1Add
BLAST
Domaini668 – 908241ABC transporter 1Add
BLAST
Domaini990 – 1270281ABC transmembrane type-1 2Add
BLAST
Domaini1308 – 1542235ABC transporter 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
HOGENOMiHOG000168680.
HOVERGENiHBG101342.
InParanoidiQ63563.
KOiK05033.
PhylomeDBiQ63563.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR001475. Sulphonylurea_rcpt-2.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform SUR2A (identifier: Q63563-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLSFCGNNI SSYNIYHGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG     50
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSQRASR 100
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI 150
KLVKYWQLGW GMSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ 200
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK 250
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS 300
STFRYLADLL GFAGPLCISG IVQRVNEPKN NTTRFSETLS SKEFLENAHV 350
LAVLLFLALI LQRTFLQASY YVTIETGINL RGALLAMIYN KILRLSTSNL 400
SMGEMTLGQI NNLVAIETNQ LMWFLFLCPN LWAMPVQIIM GVILLYNLLG 450
SSALVGAAVI VLLAPIQYFI ATKLAEAQKS TLDYSTERLK KTNEILKGIK 500
LLKLYAWEHI FCKSVEETRM KELSSLKTFA LYTSLSIFMN AAIPIAAVLA 550
TFVTHAYASG NNLKPAEAFA SLSLFHILVT PLFLLSTVVR FAVKAIISVQ 600
KLNEFLLSDE IGEDSWRTGE GTLPFESCKK HTGVQSKPIN RKQPGRYHLD 650
NYEQARRLRP AETEDVAIKV TNGYFSWGSG LATLSNIDIR IPTGQLTMIV 700
GQVGCGKSSL LLAILGEMQT LEGKVYWNNV NESEPSFEAT RSRSRYSVAY 750
AAQKPWLLNA TVEENITFGS SFNRQRYKAV TDACSLQPDI DLLPFGDQTE 800
IGERGINLSG GQRQRICVAR ALYQNTNIVF LDDPFSALDI HLSDHLMQEG 850
ILKFLQDDKR TVVLVTHKLQ YLTHADWIIA MKDGSVLREG TLKDIQTKDV 900
ELYEHWKTLM NRQDQELEKD MEADQTTLER KTLRRAMYSR EAKAQMEDED 950
EEEEEEEDED DNMSTVMRLR TKMPWKTCWW YLTSGGFFLL FLMIFSKLLK 1000
HSVIVAIDYW LATWTSEYSI NDPGKADQTF YVAGFSILCG AGIFLCLVTS 1050
LTVEWMGLTA AKNLHHNLLN KIILGPIRFF DTTPLGLILN RFSADTNIID 1100
QHIPPTLESL TRSTLLCLSA IGMISYATPV FLIALAPLGV AFYFIQKYFR 1150
VASKDLQELD DSTQLPLLCH FSETAEGLTT IRAFRHETRF KQRMLELTDT 1200
NNIAYLFLSA ANRWLEVRTD YLGACIVLTA SIASISGSSN SGLVGLGLLY 1250
ALTITNYLNW VVRNLADLEV QMGAVKKVNS FLTMESENYE GTMDPSQVPE 1300
HWPQEGEIKI HDLCVRYENN LKPVLKHVKA YIKPGQKVGI CGRTGSGKSS 1350
LSLAFFRMVD IFDGKIVIDG IDISKLPLHT LRSRLSIILQ DPILFSGSIR 1400
FNLDPECKCT DDRLWEALEI AQLKNMVKSL PGGLDATVTE GGENFSVGQR 1450
QLFCLARAFV RKSSILIMDE ATASIDMATE NILQKVVMTA FADRTVVTIA 1500
HRVSSIMDAG LVLVFSEGIL VECDTGPNLL QHKNGLFSTL VMTNK 1545
Length:1,545
Mass (Da):174,118
Last modified:November 1, 1996 - v1
Checksum:i768DA1F58E9945E7
GO
Isoform SUR2B (identifier: Q63563-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1504-1545: SSIMDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM

Show »
Length:1,545
Mass (Da):174,306
Checksum:i8666453CED33154D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1504 – 154542SSIMD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B. VSP_000061Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83598 mRNA. Translation: BAA12020.1.
AF087838 mRNA. Translation: AAC36347.1.
AF019628 mRNA. Translation: AAC24758.1.
PIRiT42751.
T46645.
RefSeqiNP_037172.2. NM_013040.2. [Q63563-2]
UniGeneiRn.10528.
Rn.164431.

Genome annotation databases

GeneIDi25560.
KEGGirno:25560.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83598 mRNA. Translation: BAA12020.1 .
AF087838 mRNA. Translation: AAC36347.1 .
AF019628 mRNA. Translation: AAC24758.1 .
PIRi T42751.
T46645.
RefSeqi NP_037172.2. NM_013040.2. [Q63563-2 ]
UniGenei Rn.10528.
Rn.164431.

3D structure databases

ProteinModelPortali Q63563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000063326.

Chemistry

BindingDBi Q63563.
ChEMBLi CHEMBL3244.

Proteomic databases

PRIDEi Q63563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25560.
KEGGi rno:25560.

Organism-specific databases

CTDi 10060.
RGDi 3787. Abcc9.

Phylogenomic databases

eggNOGi COG1132.
HOGENOMi HOG000168680.
HOVERGENi HBG101342.
InParanoidi Q63563.
KOi K05033.
PhylomeDBi Q63563.

Miscellaneous databases

NextBioi 607143.
PROi Q63563.

Gene expression databases

Genevestigatori Q63563.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR001475. Sulphonylurea_rcpt-2.
IPR000388. Sulphorea_rcpt.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
PRINTSi PR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels."
    Inagaki N., Gonoi T., Clement G., Wang C., Aguilar-Bryan L., Bryan J., Seino S.
    Neuron 16:1011-1017(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2A).
    Tissue: Brain.
  2. "Rat sulfonylurea receptor 2B, alternatively spliced product."
    Furuta H., Inagaki N., Gonoi T., Chien E., Seino S., Bell G.I.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2B).
    Strain: Sprague-Dawley.
  3. Tanemoto M., Abe T., Hebert S.C.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2B).

Entry informationi

Entry nameiABCC9_RAT
AccessioniPrimary (citable) accession number: Q63563
Secondary accession number(s): O89115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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