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Q63563

- ABCC9_RAT

UniProt

Q63563 - ABCC9_RAT

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Protein

ATP-binding cassette sub-family C member 9

Gene

Abcc9

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi701 – 7088ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1342 – 13498ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. drug binding Source: RGD
  4. identical protein binding Source: IntAct
  5. potassium channel activity Source: RGD
  6. potassium channel regulator activity Source: BHF-UCL
  7. sulfonylurea receptor activity Source: BHF-UCL
  8. syntaxin binding Source: RGD

GO - Biological processi

  1. potassium ion import Source: BHF-UCL
  2. response to drug Source: RGD
  3. signal transduction Source: GOC
  4. substrate-dependent cell migration, cell contraction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 9
Alternative name(s):
Sulfonylurea receptor 2
Gene namesi
Name:Abcc9
Synonyms:Sur2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3787. Abcc9.

Subcellular locationi

Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Topological domaini52 – 7221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei73 – 9321Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Topological domaini94 – 1018ExtracellularSequence Analysis
Transmembranei102 – 12221Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Topological domaini123 – 13210CytoplasmicSequence Analysis
Transmembranei133 – 15321Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Topological domaini154 – 16714ExtracellularSequence AnalysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Topological domaini189 – 301113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Topological domaini323 – 34725ExtracellularSequence AnalysisAdd
BLAST
Transmembranei348 – 36821Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Topological domaini369 – 42052CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei421 – 44121Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Topological domaini442 – 45211ExtracellularSequence AnalysisAdd
BLAST
Transmembranei453 – 47321Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Topological domaini474 – 52855CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei529 – 54921Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Topological domaini550 – 56819ExtracellularSequence AnalysisAdd
BLAST
Transmembranei569 – 58921Helical; Name=11PROSITE-ProRule annotationAdd
BLAST
Topological domaini590 – 986397CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei987 – 100721Helical; Name=12PROSITE-ProRule annotationAdd
BLAST
Topological domaini1008 – 103023ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1031 – 105121Helical; Name=13PROSITE-ProRule annotationAdd
BLAST
Topological domaini1052 – 112372CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1124 – 114421Helical; Name=14PROSITE-ProRule annotationAdd
BLAST
Topological domaini1145 – 124197ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1242 – 126221Helical; Name=15PROSITE-ProRule annotationAdd
BLAST
Topological domaini1263 – 1545283CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. ATP-sensitive potassium channel complex Source: BHF-UCL
  2. mitochondrion Source: RGD
  3. plasma membrane Source: RGD
  4. T-tubule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15451545ATP-binding cassette sub-family C member 9PRO_0000093405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ63563.

Expressioni

Tissue specificityi

Expressed at high levels in heart, skeletal muscle and ovary. Moderate levels are found in brain, tongue and pancreatic islets. Low levels are found in lung, testis and adrenal gland. Expressed at very low levels in stomach, colon, thyroid and pituitary.

Gene expression databases

GenevestigatoriQ63563.

Interactioni

Subunit structurei

Interacts with KCNJ11.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063326.

Structurei

3D structure databases

ProteinModelPortaliQ63563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini297 – 594298ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini668 – 908241ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini990 – 1270281ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1308 – 1542235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
HOGENOMiHOG000168680.
HOVERGENiHBG101342.
InParanoidiQ63563.
KOiK05033.
PhylomeDBiQ63563.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR001475. Sulphonylurea_rcpt-2.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform SUR2A (identifier: Q63563-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSFCGNNI SSYNIYHGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG
60 70 80 90 100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSQRASR
110 120 130 140 150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI
160 170 180 190 200
KLVKYWQLGW GMSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ
210 220 230 240 250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK
260 270 280 290 300
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS
310 320 330 340 350
STFRYLADLL GFAGPLCISG IVQRVNEPKN NTTRFSETLS SKEFLENAHV
360 370 380 390 400
LAVLLFLALI LQRTFLQASY YVTIETGINL RGALLAMIYN KILRLSTSNL
410 420 430 440 450
SMGEMTLGQI NNLVAIETNQ LMWFLFLCPN LWAMPVQIIM GVILLYNLLG
460 470 480 490 500
SSALVGAAVI VLLAPIQYFI ATKLAEAQKS TLDYSTERLK KTNEILKGIK
510 520 530 540 550
LLKLYAWEHI FCKSVEETRM KELSSLKTFA LYTSLSIFMN AAIPIAAVLA
560 570 580 590 600
TFVTHAYASG NNLKPAEAFA SLSLFHILVT PLFLLSTVVR FAVKAIISVQ
610 620 630 640 650
KLNEFLLSDE IGEDSWRTGE GTLPFESCKK HTGVQSKPIN RKQPGRYHLD
660 670 680 690 700
NYEQARRLRP AETEDVAIKV TNGYFSWGSG LATLSNIDIR IPTGQLTMIV
710 720 730 740 750
GQVGCGKSSL LLAILGEMQT LEGKVYWNNV NESEPSFEAT RSRSRYSVAY
760 770 780 790 800
AAQKPWLLNA TVEENITFGS SFNRQRYKAV TDACSLQPDI DLLPFGDQTE
810 820 830 840 850
IGERGINLSG GQRQRICVAR ALYQNTNIVF LDDPFSALDI HLSDHLMQEG
860 870 880 890 900
ILKFLQDDKR TVVLVTHKLQ YLTHADWIIA MKDGSVLREG TLKDIQTKDV
910 920 930 940 950
ELYEHWKTLM NRQDQELEKD MEADQTTLER KTLRRAMYSR EAKAQMEDED
960 970 980 990 1000
EEEEEEEDED DNMSTVMRLR TKMPWKTCWW YLTSGGFFLL FLMIFSKLLK
1010 1020 1030 1040 1050
HSVIVAIDYW LATWTSEYSI NDPGKADQTF YVAGFSILCG AGIFLCLVTS
1060 1070 1080 1090 1100
LTVEWMGLTA AKNLHHNLLN KIILGPIRFF DTTPLGLILN RFSADTNIID
1110 1120 1130 1140 1150
QHIPPTLESL TRSTLLCLSA IGMISYATPV FLIALAPLGV AFYFIQKYFR
1160 1170 1180 1190 1200
VASKDLQELD DSTQLPLLCH FSETAEGLTT IRAFRHETRF KQRMLELTDT
1210 1220 1230 1240 1250
NNIAYLFLSA ANRWLEVRTD YLGACIVLTA SIASISGSSN SGLVGLGLLY
1260 1270 1280 1290 1300
ALTITNYLNW VVRNLADLEV QMGAVKKVNS FLTMESENYE GTMDPSQVPE
1310 1320 1330 1340 1350
HWPQEGEIKI HDLCVRYENN LKPVLKHVKA YIKPGQKVGI CGRTGSGKSS
1360 1370 1380 1390 1400
LSLAFFRMVD IFDGKIVIDG IDISKLPLHT LRSRLSIILQ DPILFSGSIR
1410 1420 1430 1440 1450
FNLDPECKCT DDRLWEALEI AQLKNMVKSL PGGLDATVTE GGENFSVGQR
1460 1470 1480 1490 1500
QLFCLARAFV RKSSILIMDE ATASIDMATE NILQKVVMTA FADRTVVTIA
1510 1520 1530 1540
HRVSSIMDAG LVLVFSEGIL VECDTGPNLL QHKNGLFSTL VMTNK
Length:1,545
Mass (Da):174,118
Last modified:November 1, 1996 - v1
Checksum:i768DA1F58E9945E7
GO
Isoform SUR2B (identifier: Q63563-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1504-1545: SSIMDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM

Show »
Length:1,545
Mass (Da):174,306
Checksum:i8666453CED33154D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1504 – 154542SSIMD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B. 2 PublicationsVSP_000061Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83598 mRNA. Translation: BAA12020.1.
AF087838 mRNA. Translation: AAC36347.1.
AF019628 mRNA. Translation: AAC24758.1.
PIRiT42751.
T46645.
RefSeqiNP_037172.2. NM_013040.2. [Q63563-2]
UniGeneiRn.10528.
Rn.164431.

Genome annotation databases

GeneIDi25560.
KEGGirno:25560.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83598 mRNA. Translation: BAA12020.1 .
AF087838 mRNA. Translation: AAC36347.1 .
AF019628 mRNA. Translation: AAC24758.1 .
PIRi T42751.
T46645.
RefSeqi NP_037172.2. NM_013040.2. [Q63563-2 ]
UniGenei Rn.10528.
Rn.164431.

3D structure databases

ProteinModelPortali Q63563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000063326.

Chemistry

ChEMBLi CHEMBL3244.

Proteomic databases

PRIDEi Q63563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25560.
KEGGi rno:25560.

Organism-specific databases

CTDi 10060.
RGDi 3787. Abcc9.

Phylogenomic databases

eggNOGi COG1132.
HOGENOMi HOG000168680.
HOVERGENi HBG101342.
InParanoidi Q63563.
KOi K05033.
PhylomeDBi Q63563.

Miscellaneous databases

NextBioi 607143.
PROi Q63563.

Gene expression databases

Genevestigatori Q63563.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR001475. Sulphonylurea_rcpt-2.
IPR000388. Sulphorea_rcpt.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
PRINTSi PR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels."
    Inagaki N., Gonoi T., Clement G., Wang C., Aguilar-Bryan L., Bryan J., Seino S.
    Neuron 16:1011-1017(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2A).
    Tissue: Brain.
  2. "Rat sulfonylurea receptor 2B, alternatively spliced product."
    Furuta H., Inagaki N., Gonoi T., Chien E., Seino S., Bell G.I.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2B).
    Strain: Sprague-Dawley.
  3. Tanemoto M., Abe T., Hebert S.C.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SUR2B).

Entry informationi

Entry nameiABCC9_RAT
AccessioniPrimary (citable) accession number: Q63563
Secondary accession number(s): O89115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3