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Q63556

- SPA3M_RAT

UniProt

Q63556 - SPA3M_RAT

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Protein
Serine protease inhibitor A3M
Gene
Serpina3m
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei374 – 3752Reactive bond By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.058.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor A3M
Short name:
Serpin A3M
Alternative name(s):
Serine protease inhibitor 2.4
Short name:
SPI-2.4
Gene namesi
Name:Serpina3m
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi735068. Serpina3m.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: RefGenome
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 20›20 Reviewed prediction
Add
BLAST
Chaini21 – 412392Serine protease inhibitor A3M
PRO_0000032420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi262 – 2621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63556.
PRIDEiQ63556.

Expressioni

Gene expression databases

GenevestigatoriQ63556.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013175.

Structurei

3D structure databases

ProteinModelPortaliQ63556.
SMRiQ63556. Positions 40-409.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni360 – 38627RCL
Add
BLAST

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable By similarity. Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity.

Sequence similaritiesi

Belongs to the serpin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ63556.
PhylomeDBiQ63556.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63556-1 [UniParc]FASTAAdd to Basket

« Hide

FLLMAGICPA VLGFPDGTLG NDTLLHKDQD KGTQLDSLTL ESINTDFAFS    50
LYKMLALKNP DKNVVFSPLS ISAALAIVSL GAKGNTLEEI LEVLRFNLTE 100
SYETDIHQGF GHLLQRLSQP GDQVKIITGN ALFIDKNLQV LAEFQEKTRA 150
LYQVEAFTAS FQQPRVTEKL INDSVRNQTQ GKIQELVSGL KERTSMVLVN 200
ILLFRGKWKV PFDPDYTFES EFYVDEKRSV KVSMMKIEEL TTPYFRDEEL 250
SCSVLELKYT GNSSALFILP DKGRMQQVEA SLQPETLKKW KDSLRPRKID 300
ELYLPRLSIS TDYSLEEVLP ELGIRDVFSQ QADLSRITGA KDLSVSQVVH 350
KVVLDVNETG TEAAAATGAN LVPRSGRPPM IVWFNRPFLI AVSHTHGQHI 400
LFMAKVINPV GA 412
Length:412
Mass (Da):46,095
Last modified:November 1, 1996 - v1
Checksum:iCC6F4DBA7F118CF1
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69834 mRNA. Translation: CAA49488.1.
PIRiS31505.
UniGeneiRn.107050.

Genome annotation databases

UCSCiRGD:735068. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69834 mRNA. Translation: CAA49488.1 .
PIRi S31505.
UniGenei Rn.107050.

3D structure databases

ProteinModelPortali Q63556.
SMRi Q63556. Positions 40-409.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000013175.

Protein family/group databases

MEROPSi I04.058.

Proteomic databases

PaxDbi Q63556.
PRIDEi Q63556.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:735068. rat.

Organism-specific databases

RGDi 735068. Serpina3m.

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238521.
HOVERGENi HBG005957.
InParanoidi Q63556.
PhylomeDBi Q63556.

Gene expression databases

Genevestigatori Q63556.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Inglis J.D.
    Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus."
    Horvath A.J., Forsyth S.L., Coughlin P.B.
    J. Mol. Evol. 59:488-497(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGION RCL.

Entry informationi

Entry nameiSPA3M_RAT
AccessioniPrimary (citable) accession number: Q63556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 6 individual rat paralogs.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi