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Q63556 (SPA3M_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine protease inhibitor A3M

Short name=Serpin A3M
Alternative name(s):
Serine protease inhibitor 2.4
Short name=SPI-2.4
Gene names
Name:Serpina3m
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length412 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Domain

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable By similarity. Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity.

Miscellaneous

The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 6 individual rat paralogs.

Sequence similarities

Belongs to the serpin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide‹1 – 20›20 Potential
Chain21 – 412392Serine protease inhibitor A3M
PRO_0000032420

Regions

Region360 – 38627RCL

Sites

Site374 – 3752Reactive bond By similarity

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q63556 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CC6F4DBA7F118CF1

FASTA41246,095
        10         20         30         40         50         60 
FLLMAGICPA VLGFPDGTLG NDTLLHKDQD KGTQLDSLTL ESINTDFAFS LYKMLALKNP 

        70         80         90        100        110        120 
DKNVVFSPLS ISAALAIVSL GAKGNTLEEI LEVLRFNLTE SYETDIHQGF GHLLQRLSQP 

       130        140        150        160        170        180 
GDQVKIITGN ALFIDKNLQV LAEFQEKTRA LYQVEAFTAS FQQPRVTEKL INDSVRNQTQ 

       190        200        210        220        230        240 
GKIQELVSGL KERTSMVLVN ILLFRGKWKV PFDPDYTFES EFYVDEKRSV KVSMMKIEEL 

       250        260        270        280        290        300 
TTPYFRDEEL SCSVLELKYT GNSSALFILP DKGRMQQVEA SLQPETLKKW KDSLRPRKID 

       310        320        330        340        350        360 
ELYLPRLSIS TDYSLEEVLP ELGIRDVFSQ QADLSRITGA KDLSVSQVVH KVVLDVNETG 

       370        380        390        400        410 
TEAAAATGAN LVPRSGRPPM IVWFNRPFLI AVSHTHGQHI LFMAKVINPV GA 

« Hide

References

[1]Inglis J.D.
Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus."
Horvath A.J., Forsyth S.L., Coughlin P.B.
J. Mol. Evol. 59:488-497(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: REGION RCL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69834 mRNA. Translation: CAA49488.1.
PIRS31505.
UniGeneRn.107050.

3D structure databases

ProteinModelPortalQ63556.
SMRQ63556. Positions 40-409.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000013175.

Protein family/group databases

MEROPSI04.058.

Proteomic databases

PaxDbQ63556.
PRIDEQ63556.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:735068. rat.

Organism-specific databases

RGD735068. Serpina3m.

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238521.
HOVERGENHBG005957.
InParanoidQ63556.
PhylomeDBQ63556.

Gene expression databases

GenevestigatorQ63556.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPA3M_RAT
AccessionPrimary (citable) accession number: Q63556
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families