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Protein

Serine protease inhibitor A3M

Gene

Serpina3m

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei374 – 3752Reactive bondBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.058.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor A3M
Short name:
Serpin A3M
Alternative name(s):
Serine protease inhibitor 2.4
Short name:
SPI-2.4
Gene namesi
Name:Serpina3m
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735068. Serpina3m.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 20›20Sequence AnalysisAdd
BLAST
Chaini21 – 412392Serine protease inhibitor A3MPRO_0000032420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63556.
PRIDEiQ63556.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013175.

Structurei

3D structure databases

ProteinModelPortaliQ63556.
SMRiQ63556. Positions 40-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni360 – 38627RCLAdd
BLAST

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ63556.
PhylomeDBiQ63556.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FLLMAGICPA VLGFPDGTLG NDTLLHKDQD KGTQLDSLTL ESINTDFAFS
60 70 80 90 100
LYKMLALKNP DKNVVFSPLS ISAALAIVSL GAKGNTLEEI LEVLRFNLTE
110 120 130 140 150
SYETDIHQGF GHLLQRLSQP GDQVKIITGN ALFIDKNLQV LAEFQEKTRA
160 170 180 190 200
LYQVEAFTAS FQQPRVTEKL INDSVRNQTQ GKIQELVSGL KERTSMVLVN
210 220 230 240 250
ILLFRGKWKV PFDPDYTFES EFYVDEKRSV KVSMMKIEEL TTPYFRDEEL
260 270 280 290 300
SCSVLELKYT GNSSALFILP DKGRMQQVEA SLQPETLKKW KDSLRPRKID
310 320 330 340 350
ELYLPRLSIS TDYSLEEVLP ELGIRDVFSQ QADLSRITGA KDLSVSQVVH
360 370 380 390 400
KVVLDVNETG TEAAAATGAN LVPRSGRPPM IVWFNRPFLI AVSHTHGQHI
410
LFMAKVINPV GA
Length:412
Mass (Da):46,095
Last modified:November 1, 1996 - v1
Checksum:iCC6F4DBA7F118CF1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69834 mRNA. Translation: CAA49488.1.
PIRiS31505.
UniGeneiRn.107050.

Genome annotation databases

UCSCiRGD:735068. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69834 mRNA. Translation: CAA49488.1.
PIRiS31505.
UniGeneiRn.107050.

3D structure databases

ProteinModelPortaliQ63556.
SMRiQ63556. Positions 40-409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013175.

Protein family/group databases

MEROPSiI04.058.

Proteomic databases

PaxDbiQ63556.
PRIDEiQ63556.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:735068. rat.

Organism-specific databases

RGDi735068. Serpina3m.

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ63556.
PhylomeDBiQ63556.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Inglis J.D.
    Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus."
    Horvath A.J., Forsyth S.L., Coughlin P.B.
    J. Mol. Evol. 59:488-497(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGION RCL.

Entry informationi

Entry nameiSPA3M_RAT
AccessioniPrimary (citable) accession number: Q63556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 6 individual rat paralogs.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.