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Q63556

- SPA3M_RAT

UniProt

Q63556 - SPA3M_RAT

Protein

Serine protease inhibitor A3M

Gene

Serpina3m

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei374 – 3752Reactive bondBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.058.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine protease inhibitor A3M
    Short name:
    Serpin A3M
    Alternative name(s):
    Serine protease inhibitor 2.4
    Short name:
    SPI-2.4
    Gene namesi
    Name:Serpina3m
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi735068. Serpina3m.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: RefGenome
    2. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei‹1 – 20›20Sequence AnalysisAdd
    BLAST
    Chaini21 – 412392Serine protease inhibitor A3MPRO_0000032420Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ63556.
    PRIDEiQ63556.

    Expressioni

    Gene expression databases

    GenevestigatoriQ63556.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000013175.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63556.
    SMRiQ63556. Positions 40-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni360 – 38627RCLAdd
    BLAST

    Domaini

    The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable By similarity. Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity.By similarity

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238521.
    HOVERGENiHBG005957.
    InParanoidiQ63556.
    PhylomeDBiQ63556.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63556-1 [UniParc]FASTAAdd to Basket

    « Hide

    FLLMAGICPA VLGFPDGTLG NDTLLHKDQD KGTQLDSLTL ESINTDFAFS    50
    LYKMLALKNP DKNVVFSPLS ISAALAIVSL GAKGNTLEEI LEVLRFNLTE 100
    SYETDIHQGF GHLLQRLSQP GDQVKIITGN ALFIDKNLQV LAEFQEKTRA 150
    LYQVEAFTAS FQQPRVTEKL INDSVRNQTQ GKIQELVSGL KERTSMVLVN 200
    ILLFRGKWKV PFDPDYTFES EFYVDEKRSV KVSMMKIEEL TTPYFRDEEL 250
    SCSVLELKYT GNSSALFILP DKGRMQQVEA SLQPETLKKW KDSLRPRKID 300
    ELYLPRLSIS TDYSLEEVLP ELGIRDVFSQ QADLSRITGA KDLSVSQVVH 350
    KVVLDVNETG TEAAAATGAN LVPRSGRPPM IVWFNRPFLI AVSHTHGQHI 400
    LFMAKVINPV GA 412
    Length:412
    Mass (Da):46,095
    Last modified:November 1, 1996 - v1
    Checksum:iCC6F4DBA7F118CF1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69834 mRNA. Translation: CAA49488.1.
    PIRiS31505.
    UniGeneiRn.107050.

    Genome annotation databases

    UCSCiRGD:735068. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69834 mRNA. Translation: CAA49488.1 .
    PIRi S31505.
    UniGenei Rn.107050.

    3D structure databases

    ProteinModelPortali Q63556.
    SMRi Q63556. Positions 40-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000013175.

    Protein family/group databases

    MEROPSi I04.058.

    Proteomic databases

    PaxDbi Q63556.
    PRIDEi Q63556.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:735068. rat.

    Organism-specific databases

    RGDi 735068. Serpina3m.

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238521.
    HOVERGENi HBG005957.
    InParanoidi Q63556.
    PhylomeDBi Q63556.

    Gene expression databases

    Genevestigatori Q63556.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Inglis J.D.
      Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus."
      Horvath A.J., Forsyth S.L., Coughlin P.B.
      J. Mol. Evol. 59:488-497(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: REGION RCL.

    Entry informationi

    Entry nameiSPA3M_RAT
    AccessioniPrimary (citable) accession number: Q63556
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 6 individual rat paralogs.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3