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Protein

SNF-related serine/threonine-protein kinase

Gene

Snrk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Enzyme regulationi

Activated by phosphorylation on Thr-173.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATPPROSITE-ProRule annotationBy similarity
Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 309ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • protein phosphorylation Source: UniProtKB
  • regulation of neuron apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SNF-related serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
SNF1-related kinase
Gene namesi
Name:SnrkImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi69653. Snrk.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746SNF-related serine/threonine-protein kinaseCuratedPRO_0000225607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei162 – 1621PhosphoserineBy similarity
Modified residuei173 – 1731Phosphothreonine; by LKB1By similarity
Modified residuei362 – 3621PhosphoserineCombined sources
Modified residuei390 – 3901PhosphoserineBy similarity
Modified residuei482 – 4821PhosphoserineBy similarity
Modified residuei495 – 4951PhosphoserineCombined sources
Modified residuei518 – 5181PhosphoserineCombined sources

Post-translational modificationi

Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63553.
PRIDEiQ63553.

PTM databases

iPTMnetiQ63553.
PhosphoSiteiQ63553.

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined with highest levels in the brain and testis. Strongly expressed in the pyramidal and granule neurons of the hippocampus and also in the cerebellum.2 Publications

Developmental stagei

Weakly expressed in the cerebellum by E20, levels increase until 28 days after birth.1 Publication

Gene expression databases

GenevisibleiQ63553. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005422.

Structurei

3D structure databases

ProteinModelPortaliQ63553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 269254Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini291 – 33444UBAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4717. Eukaryota.
ENOG410XR6N. LUCA.
GeneTreeiENSGT00840000129774.
HOGENOMiHOG000059616.
HOVERGENiHBG093970.
InParanoidiQ63553.
KOiK08802.
OMAiTTSGRKC.
OrthoDBiEOG7CZK55.
PhylomeDBiQ63553.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFKRGYDG KIAGLYDLDK TLGRGHFAVV KLARHVFTGE KVAVKVIDKT
60 70 80 90 100
KLDTLATGHL FQEVRCMKLV QHPNIVRLYE VIDTQTKLYL ILELGDGGDM
110 120 130 140 150
FDYIMKHEEG LNEDLAKKYF AQIVHAISYC HKLHVVHRDL KPENVVFFEK
160 170 180 190 200
QGLVKLTDFG FSNKFQPGKK LTTSCGSLAY SAPEILLGDE YDAPAVDIWS
210 220 230 240 250
LGVILFMLVC GQPPFQEAND SETLTMIMDC KYTVPPRVSA GCRDLITRML
260 270 280 290 300
QRDPKRRASL EEIESHPWLQ GVDPSPATKY NIPLVSYKNL SEEEHNSIIQ
310 320 330 340 350
RMVLGDIADR DAIVEALETN RYNHITATYF LLAERILREK QEKEIQTRSA
360 370 380 390 400
SPSNIKAQFR QSWPTKIDVP QDLEDDLTAT PLSHATVPQS PARAGDSVLN
410 420 430 440 450
GHRSKGLCDP AKKDELPELA GPALSTVPPA SLKPAASGRK CLFRVEEDEE
460 470 480 490 500
EDEEDKKPVS LSTQVVLRRK PSVTNRLTSR KSAPVLNQIF EEGESDDEFD
510 520 530 540 550
MDENLPPKLS RLKMNIASPG TVHKRYHRRK SQGRGSSCSS SETSDDDSES
560 570 580 590 600
RRRLDKDSGL AYSWHRRDSS EGPPGSEGDG GGQSKPSGGG GVDKASPGEQ
610 620 630 640 650
GTGGSGQGGS GGTPSGTAGS SRRCAGPDSS SSSPASAAPR GAELVQSLKL
660 670 680 690 700
VSLCLGSQLH GAKYILDPQK ALLSSVKVQE RSTWKMCISA PGPGPSADLD
710 720 730 740
PVRTKKLRNN VLQLPLCEKT ISVNIQRSRK EGLLCASSPA SCCHVI
Length:746
Mass (Da):81,627
Last modified:November 1, 1996 - v1
Checksum:i57F6A8FC2704BBEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89383 mRNA. Translation: CAA61563.1.
PIRiS62365.
RefSeqiNP_620188.1. NM_138833.1.
XP_006244119.1. XM_006244057.2.
XP_006244120.1. XM_006244058.2.
XP_006244121.1. XM_006244059.1.
XP_006244122.1. XM_006244060.2.
XP_006244123.1. XM_006244061.1.
XP_006244124.1. XM_006244062.2.
XP_008764888.1. XM_008766666.1.
XP_008764889.1. XM_008766667.1.
UniGeneiRn.10245.

Genome annotation databases

EnsembliENSRNOT00000005422; ENSRNOP00000005422; ENSRNOG00000004050.
ENSRNOT00000079273; ENSRNOP00000071648; ENSRNOG00000004050.
GeneIDi170837.
KEGGirno:170837.
UCSCiRGD:69653. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89383 mRNA. Translation: CAA61563.1.
PIRiS62365.
RefSeqiNP_620188.1. NM_138833.1.
XP_006244119.1. XM_006244057.2.
XP_006244120.1. XM_006244058.2.
XP_006244121.1. XM_006244059.1.
XP_006244122.1. XM_006244060.2.
XP_006244123.1. XM_006244061.1.
XP_006244124.1. XM_006244062.2.
XP_008764888.1. XM_008766666.1.
XP_008764889.1. XM_008766667.1.
UniGeneiRn.10245.

3D structure databases

ProteinModelPortaliQ63553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005422.

PTM databases

iPTMnetiQ63553.
PhosphoSiteiQ63553.

Proteomic databases

PaxDbiQ63553.
PRIDEiQ63553.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005422; ENSRNOP00000005422; ENSRNOG00000004050.
ENSRNOT00000079273; ENSRNOP00000071648; ENSRNOG00000004050.
GeneIDi170837.
KEGGirno:170837.
UCSCiRGD:69653. rat.

Organism-specific databases

CTDi54861.
RGDi69653. Snrk.

Phylogenomic databases

eggNOGiKOG4717. Eukaryota.
ENOG410XR6N. LUCA.
GeneTreeiENSGT00840000129774.
HOGENOMiHOG000059616.
HOVERGENiHBG093970.
InParanoidiQ63553.
KOiK08802.
OMAiTTSGRKC.
OrthoDBiEOG7CZK55.
PhylomeDBiQ63553.

Miscellaneous databases

PROiQ63553.

Gene expression databases

GenevisibleiQ63553. RN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases."
    Becker W., Heukelbach J., Kentrup H., Joost H.G.
    Eur. J. Biochem. 235:736-743(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AUTOPHOSPHORYLATION, TISSUE SPECIFICITY.
    Strain: Sprague-DawleyImported.
    Tissue: EpendymocyteImported.
  2. "SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons."
    Yoshida K., Yamada M., Nishio C., Konishi A., Hatanaka H.
    Brain Res. 873:274-282(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362; SER-495 AND SER-518, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNRK_RAT
AccessioniPrimary (citable) accession number: Q63553
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.