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Protein

SNF-related serine/threonine-protein kinase

Gene

Snrk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Enzyme regulationi

Activated by phosphorylation on Thr-173.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotationBy similarity1
Active sitei139Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • protein phosphorylation Source: UniProtKB
  • regulation of neuron apoptotic process Source: UniProtKB

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SNF-related serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
SNF1-related kinase
Gene namesi
Name:SnrkImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi69653. Snrk.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256071 – 746SNF-related serine/threonine-protein kinaseCuratedAdd BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineBy similarity1
Modified residuei173Phosphothreonine; by LKB1By similarity1
Modified residuei362PhosphoserineCombined sources1
Modified residuei390PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei495PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei534Omega-N-methylarginineBy similarity1

Post-translational modificationi

Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ63553.
PRIDEiQ63553.

PTM databases

iPTMnetiQ63553.
PhosphoSitePlusiQ63553.

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined with highest levels in the brain and testis. Strongly expressed in the pyramidal and granule neurons of the hippocampus and also in the cerebellum.2 Publications

Developmental stagei

Weakly expressed in the cerebellum by E20, levels increase until 28 days after birth.1 Publication

Gene expression databases

BgeeiENSRNOG00000004050.
GenevisibleiQ63553. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005422.

Structurei

3D structure databases

ProteinModelPortaliQ63553.
SMRiQ63553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 269Protein kinasePROSITE-ProRule annotationAdd BLAST254
Domaini291 – 334UBAPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4717. Eukaryota.
ENOG410XR6N. LUCA.
GeneTreeiENSGT00900000140806.
HOGENOMiHOG000059616.
HOVERGENiHBG093970.
InParanoidiQ63553.
KOiK08802.
OMAiNVLNGHR.
OrthoDBiEOG091G08XV.
PhylomeDBiQ63553.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFKRGYDG KIAGLYDLDK TLGRGHFAVV KLARHVFTGE KVAVKVIDKT
60 70 80 90 100
KLDTLATGHL FQEVRCMKLV QHPNIVRLYE VIDTQTKLYL ILELGDGGDM
110 120 130 140 150
FDYIMKHEEG LNEDLAKKYF AQIVHAISYC HKLHVVHRDL KPENVVFFEK
160 170 180 190 200
QGLVKLTDFG FSNKFQPGKK LTTSCGSLAY SAPEILLGDE YDAPAVDIWS
210 220 230 240 250
LGVILFMLVC GQPPFQEAND SETLTMIMDC KYTVPPRVSA GCRDLITRML
260 270 280 290 300
QRDPKRRASL EEIESHPWLQ GVDPSPATKY NIPLVSYKNL SEEEHNSIIQ
310 320 330 340 350
RMVLGDIADR DAIVEALETN RYNHITATYF LLAERILREK QEKEIQTRSA
360 370 380 390 400
SPSNIKAQFR QSWPTKIDVP QDLEDDLTAT PLSHATVPQS PARAGDSVLN
410 420 430 440 450
GHRSKGLCDP AKKDELPELA GPALSTVPPA SLKPAASGRK CLFRVEEDEE
460 470 480 490 500
EDEEDKKPVS LSTQVVLRRK PSVTNRLTSR KSAPVLNQIF EEGESDDEFD
510 520 530 540 550
MDENLPPKLS RLKMNIASPG TVHKRYHRRK SQGRGSSCSS SETSDDDSES
560 570 580 590 600
RRRLDKDSGL AYSWHRRDSS EGPPGSEGDG GGQSKPSGGG GVDKASPGEQ
610 620 630 640 650
GTGGSGQGGS GGTPSGTAGS SRRCAGPDSS SSSPASAAPR GAELVQSLKL
660 670 680 690 700
VSLCLGSQLH GAKYILDPQK ALLSSVKVQE RSTWKMCISA PGPGPSADLD
710 720 730 740
PVRTKKLRNN VLQLPLCEKT ISVNIQRSRK EGLLCASSPA SCCHVI
Length:746
Mass (Da):81,627
Last modified:November 1, 1996 - v1
Checksum:i57F6A8FC2704BBEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89383 mRNA. Translation: CAA61563.1.
PIRiS62365.
RefSeqiNP_620188.1. NM_138833.1.
XP_006244119.1. XM_006244057.3.
XP_006244120.1. XM_006244058.3.
XP_006244121.1. XM_006244059.1.
XP_006244122.1. XM_006244060.3.
XP_006244123.1. XM_006244061.2.
XP_006244124.1. XM_006244062.2.
XP_017450914.1. XM_017595425.1.
XP_017450915.1. XM_017595426.1.
UniGeneiRn.10245.

Genome annotation databases

EnsembliENSRNOT00000005422; ENSRNOP00000005422; ENSRNOG00000004050.
ENSRNOT00000079273; ENSRNOP00000071648; ENSRNOG00000004050.
GeneIDi170837.
KEGGirno:170837.
UCSCiRGD:69653. rat.

Similar proteinsi

Entry informationi

Entry nameiSNRK_RAT
AccessioniPrimary (citable) accession number: Q63553
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families