Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q63548

- SEM3A_RAT

UniProt

Q63548 - SEM3A_RAT

Protein

Semaphorin-3A

Gene

Sema3a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty By similarity.By similarity

    GO - Molecular functioni

    1. chemorepellent activity Source: Ensembl
    2. receptor activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: RGD
    2. axonal fasciculation Source: Ensembl
    3. axon extension involved in axon guidance Source: Ensembl
    4. axon guidance Source: MGI
    5. axonogenesis involved in innervation Source: Ensembl
    6. dendrite morphogenesis Source: Ensembl
    7. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
    8. negative regulation of axon extension Source: RGD
    9. negative regulation of axon extension involved in axon guidance Source: Ensembl
    10. negative regulation of epithelial cell migration Source: Ensembl
    11. neuron migration Source: Ensembl
    12. olfactory bulb development Source: UniProtKB
    13. positive regulation of neuron migration Source: Ensembl
    14. regulation of heart rate Source: Ensembl
    15. semaphorin-plexin signaling pathway involved in neuron projection guidance Source: Ensembl
    16. sympathetic ganglion development Source: Ensembl
    17. sympathetic neuron projection extension Source: Ensembl
    18. sympathetic neuron projection guidance Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-3A
    Alternative name(s):
    Semaphorin III
    Short name:
    Sema III
    Gene namesi
    Name:Sema3a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi3657. Sema3a.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. axon Source: RGD
    2. dendrite Source: RGD
    3. extracellular space Source: RGD
    4. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 772752Semaphorin-3APRO_0000032305Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi103 ↔ 114By similarity
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi132 ↔ 141By similarity
    Disulfide bondi269 ↔ 381By similarity
    Disulfide bondi293 ↔ 341By similarity
    Disulfide bondi517 ↔ 535By similarity
    Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi650 ↔ 723By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ63548.
    PRIDEiQ63548.

    Expressioni

    Developmental stagei

    At E11, expression was restricted to the olfactory pit, the basal and rostral surface of the telencephalic vesicle, the eye anlage, the epithelium of Rathke pouch, and somites. At later developmental stages, it was widely distributed in neuronal as well as in mesenchymal and epithelial structures outside the nervous system. After birth, mesenchymal levels decreased rapidly and expression became restricted to specific sets of neurons in the CNS. In the mature CNS, it is detectable in mitral cells, neurons of the accessory bulb and cerebral cortex, cerebellar Purkinje cells, as well as a subset of cranial and spinal motoneurons.

    Gene expression databases

    GenevestigatoriQ63548.

    Interactioni

    Subunit structurei

    Interacts with PLXND1.By similarity

    Protein-protein interaction databases

    IntActiQ63548. 1 interaction.
    MINTiMINT-1542099.
    STRINGi10116.ENSRNOP00000036472.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63548.
    SMRiQ63548. Positions 26-520.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 514484SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini577 – 66589Ig-like C2-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi728 – 77043Arg/Lys-rich (basic)Add
    BLAST

    Domaini

    Strong binding to neuropilin is mediated by the carboxy third of the protein.

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG305380.
    GeneTreeiENSGT00560000076660.
    HOGENOMiHOG000039964.
    HOVERGENiHBG055071.
    InParanoidiQ63548.
    KOiK06840.
    OMAiREPTTIS.
    OrthoDBiEOG7VMP4F.
    PhylomeDBiQ63548.
    TreeFamiTF316102.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PfamiPF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63548-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWFTGIACL FWGILLTARA NYANGKNNVP RLKLSYKEML ESNNVITFNG    50
    LANSSSYHTF LLDEERSRLY VGAKDHIFSF NLVNIKDFQK IVWPVSYTRR 100
    DECKWAGKDI LKECANFIKV LKAYNQTHLY ACGTGAFHPI CTYIEVGHHP 150
    EDNIFKLQDS HFENGRGKSP YDPKLLTASL LIDGELYSGT AADFMGRDFA 200
    IFRTLGHHHP IRTEQHDSRW LNDPRFISAH LIPESDNPED DKVYFFFREN 250
    AIDGEHSGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG 300
    IDTHFDELQD VFLMNSKDPK NPIVYGVFTT SSNIFKGSAV CMYSMSDVRR 350
    VFLGPYAHRD GPNYQWVPYQ GRVPYPRPGT CPSKTFGGFD STKDLPDDVI 400
    TFARSHPAMY NPVFPINNRP IMIKTDVNYQ FTQIVVDRVD AEDGQYDVMF 450
    IGTDVGTVLK VVSVPKETWH DLEEVLLEEM TVFREPTTIS AMELSTKQQQ 500
    LYIGSTAGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS SCSRYFPTAK 550
    RRTRRQDIRN GDPLTHCSDL QHHDNHHGHS LEERIIYGVE NSSTFLECSP 600
    KSQRALVYWQ FQRRNEDRKE EIRVGDHIIR TEQGLLLRSL QKKDSGNYLC 650
    HAVEHGFMQT LLKVTLEVID TEHLEELLHK DDDGDGSKTK EMSSSMTPSQ 700
    KVWYRDFMQL INHPNLNTMD EFCEQVWKRD RKQRRQRPGH SQGSSNKWKH 750
    MQESKKGRNR RTHEFERAPR SV 772
    Length:772
    Mass (Da):88,808
    Last modified:November 1, 1996 - v1
    Checksum:i240907812FF9F2D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95286 mRNA. Translation: CAA64607.1.
    RefSeqiNP_059006.1. NM_017310.1.
    XP_006236051.1. XM_006235989.1.
    XP_006236052.1. XM_006235990.1.
    UniGeneiRn.44410.

    Genome annotation databases

    EnsembliENSRNOT00000034692; ENSRNOP00000036472; ENSRNOG00000023337.
    GeneIDi29751.
    KEGGirno:29751.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95286 mRNA. Translation: CAA64607.1 .
    RefSeqi NP_059006.1. NM_017310.1.
    XP_006236051.1. XM_006235989.1.
    XP_006236052.1. XM_006235990.1.
    UniGenei Rn.44410.

    3D structure databases

    ProteinModelPortali Q63548.
    SMRi Q63548. Positions 26-520.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q63548. 1 interaction.
    MINTi MINT-1542099.
    STRINGi 10116.ENSRNOP00000036472.

    Proteomic databases

    PaxDbi Q63548.
    PRIDEi Q63548.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000034692 ; ENSRNOP00000036472 ; ENSRNOG00000023337 .
    GeneIDi 29751.
    KEGGi rno:29751.

    Organism-specific databases

    CTDi 10371.
    RGDi 3657. Sema3a.

    Phylogenomic databases

    eggNOGi NOG305380.
    GeneTreei ENSGT00560000076660.
    HOGENOMi HOG000039964.
    HOVERGENi HBG055071.
    InParanoidi Q63548.
    KOi K06840.
    OMAi REPTTIS.
    OrthoDBi EOG7VMP4F.
    PhylomeDBi Q63548.
    TreeFami TF316102.

    Miscellaneous databases

    NextBioi 610281.
    PROi Q63548.

    Gene expression databases

    Genevestigatori Q63548.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    Pfami PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Anatomy of rat semaphorin III/collapsin-1 mRNA expression and relationship to developing nerve tracts during neuroembryogenesis."
      Giger R.J., Wolfer D.P., De Wit G.M.J., Verhaagen J.
      J. Comp. Neurol. 375:378-392(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.

    Entry informationi

    Entry nameiSEM3A_RAT
    AccessioniPrimary (citable) accession number: Q63548
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3