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Q63548

- SEM3A_RAT

UniProt

Q63548 - SEM3A_RAT

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Protein

Semaphorin-3A

Gene

Sema3a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity).By similarity

GO - Molecular functioni

  1. chemorepellent activity Source: Ensembl
  2. receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: RGD
  2. axonal fasciculation Source: Ensembl
  3. axon extension involved in axon guidance Source: Ensembl
  4. axon guidance Source: MGI
  5. axonogenesis involved in innervation Source: Ensembl
  6. branchiomotor neuron axon guidance Source: Ensembl
  7. dendrite morphogenesis Source: Ensembl
  8. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
  9. facial nerve structural organization Source: Ensembl
  10. gonadotrophin-releasing hormone neuronal migration to the hypothalamus Source: Ensembl
  11. negative regulation of axon extension Source: RGD
  12. negative regulation of axon extension involved in axon guidance Source: Ensembl
  13. negative regulation of epithelial cell migration Source: Ensembl
  14. neural crest cell migration involved in sympathetic nervous system development Source: Ensembl
  15. olfactory bulb development Source: UniProtKB
  16. positive regulation of male gonad development Source: Ensembl
  17. positive regulation of neuron migration Source: Ensembl
  18. regulation of heart rate Source: Ensembl
  19. semaphorin-plexin signaling pathway involved in axon guidance Source: Ensembl
  20. sympathetic ganglion development Source: Ensembl
  21. sympathetic neuron projection extension Source: Ensembl
  22. sympathetic neuron projection guidance Source: Ensembl
  23. trigeminal nerve structural organization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_231436. Sema3A PAK dependent Axon repulsion.
REACT_253285. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_254909. CRMPs in Sema3A signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3A
Alternative name(s):
Semaphorin III
Short name:
Sema III
Gene namesi
Name:Sema3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi3657. Sema3a.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. axon Source: RGD
  2. dendrite Source: RGD
  3. extracellular space Source: RGD
  4. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 772752Semaphorin-3APRO_0000032305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi103 ↔ 114By similarity
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi132 ↔ 141By similarity
Disulfide bondi269 ↔ 381By similarity
Disulfide bondi293 ↔ 341By similarity
Disulfide bondi517 ↔ 535By similarity
Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi650 ↔ 723By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63548.
PRIDEiQ63548.

Expressioni

Developmental stagei

At E11, expression was restricted to the olfactory pit, the basal and rostral surface of the telencephalic vesicle, the eye anlage, the epithelium of Rathke pouch, and somites. At later developmental stages, it was widely distributed in neuronal as well as in mesenchymal and epithelial structures outside the nervous system. After birth, mesenchymal levels decreased rapidly and expression became restricted to specific sets of neurons in the CNS. In the mature CNS, it is detectable in mitral cells, neurons of the accessory bulb and cerebral cortex, cerebellar Purkinje cells, as well as a subset of cranial and spinal motoneurons.

Gene expression databases

GenevestigatoriQ63548.

Interactioni

Subunit structurei

Interacts with PLXND1.By similarity

Protein-protein interaction databases

IntActiQ63548. 1 interaction.
MINTiMINT-1542099.
STRINGi10116.ENSRNOP00000036472.

Structurei

3D structure databases

ProteinModelPortaliQ63548.
SMRiQ63548. Positions 26-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 514484SemaPROSITE-ProRule annotationAdd
BLAST
Domaini577 – 66589Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi728 – 77043Arg/Lys-rich (basic)Add
BLAST

Domaini

Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG305380.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ63548.
KOiK06840.
OMAiREPTTIS.
OrthoDBiEOG7VMP4F.
PhylomeDBiQ63548.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63548-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGWFTGIACL FWGILLTARA NYANGKNNVP RLKLSYKEML ESNNVITFNG
60 70 80 90 100
LANSSSYHTF LLDEERSRLY VGAKDHIFSF NLVNIKDFQK IVWPVSYTRR
110 120 130 140 150
DECKWAGKDI LKECANFIKV LKAYNQTHLY ACGTGAFHPI CTYIEVGHHP
160 170 180 190 200
EDNIFKLQDS HFENGRGKSP YDPKLLTASL LIDGELYSGT AADFMGRDFA
210 220 230 240 250
IFRTLGHHHP IRTEQHDSRW LNDPRFISAH LIPESDNPED DKVYFFFREN
260 270 280 290 300
AIDGEHSGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG
310 320 330 340 350
IDTHFDELQD VFLMNSKDPK NPIVYGVFTT SSNIFKGSAV CMYSMSDVRR
360 370 380 390 400
VFLGPYAHRD GPNYQWVPYQ GRVPYPRPGT CPSKTFGGFD STKDLPDDVI
410 420 430 440 450
TFARSHPAMY NPVFPINNRP IMIKTDVNYQ FTQIVVDRVD AEDGQYDVMF
460 470 480 490 500
IGTDVGTVLK VVSVPKETWH DLEEVLLEEM TVFREPTTIS AMELSTKQQQ
510 520 530 540 550
LYIGSTAGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS SCSRYFPTAK
560 570 580 590 600
RRTRRQDIRN GDPLTHCSDL QHHDNHHGHS LEERIIYGVE NSSTFLECSP
610 620 630 640 650
KSQRALVYWQ FQRRNEDRKE EIRVGDHIIR TEQGLLLRSL QKKDSGNYLC
660 670 680 690 700
HAVEHGFMQT LLKVTLEVID TEHLEELLHK DDDGDGSKTK EMSSSMTPSQ
710 720 730 740 750
KVWYRDFMQL INHPNLNTMD EFCEQVWKRD RKQRRQRPGH SQGSSNKWKH
760 770
MQESKKGRNR RTHEFERAPR SV
Length:772
Mass (Da):88,808
Last modified:November 1, 1996 - v1
Checksum:i240907812FF9F2D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95286 mRNA. Translation: CAA64607.1.
RefSeqiNP_059006.1. NM_017310.1.
XP_006236051.1. XM_006235989.2.
XP_006236052.1. XM_006235990.2.
XP_008760924.1. XM_008762702.1.
UniGeneiRn.44410.

Genome annotation databases

EnsembliENSRNOT00000034692; ENSRNOP00000036472; ENSRNOG00000023337.
GeneIDi29751.
KEGGirno:29751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95286 mRNA. Translation: CAA64607.1 .
RefSeqi NP_059006.1. NM_017310.1.
XP_006236051.1. XM_006235989.2.
XP_006236052.1. XM_006235990.2.
XP_008760924.1. XM_008762702.1.
UniGenei Rn.44410.

3D structure databases

ProteinModelPortali Q63548.
SMRi Q63548. Positions 26-520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q63548. 1 interaction.
MINTi MINT-1542099.
STRINGi 10116.ENSRNOP00000036472.

Proteomic databases

PaxDbi Q63548.
PRIDEi Q63548.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000034692 ; ENSRNOP00000036472 ; ENSRNOG00000023337 .
GeneIDi 29751.
KEGGi rno:29751.

Organism-specific databases

CTDi 10371.
RGDi 3657. Sema3a.

Phylogenomic databases

eggNOGi NOG305380.
GeneTreei ENSGT00760000118854.
HOGENOMi HOG000039964.
HOVERGENi HBG055071.
InParanoidi Q63548.
KOi K06840.
OMAi REPTTIS.
OrthoDBi EOG7VMP4F.
PhylomeDBi Q63548.
TreeFami TF316102.

Enzyme and pathway databases

Reactomei REACT_231436. Sema3A PAK dependent Axon repulsion.
REACT_253285. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_254909. CRMPs in Sema3A signaling.

Miscellaneous databases

NextBioi 610281.
PROi Q63548.

Gene expression databases

Genevestigatori Q63548.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Anatomy of rat semaphorin III/collapsin-1 mRNA expression and relationship to developing nerve tracts during neuroembryogenesis."
    Giger R.J., Wolfer D.P., De Wit G.M.J., Verhaagen J.
    J. Comp. Neurol. 375:378-392(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiSEM3A_RAT
AccessioniPrimary (citable) accession number: Q63548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3