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Q63548

- SEM3A_RAT

UniProt

Q63548 - SEM3A_RAT

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Protein
Semaphorin-3A
Gene
Sema3a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty By similarity.

GO - Molecular functioni

  1. chemorepellent activity Source: Ensembl
  2. receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: RGD
  2. axon extension involved in axon guidance Source: Ensembl
  3. axon guidance Source: MGI
  4. axonal fasciculation Source: Ensembl
  5. axonogenesis involved in innervation Source: Ensembl
  6. dendrite morphogenesis Source: Ensembl
  7. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
  8. negative regulation of axon extension Source: RGD
  9. negative regulation of axon extension involved in axon guidance Source: Ensembl
  10. negative regulation of epithelial cell migration Source: Ensembl
  11. neuron migration Source: Ensembl
  12. olfactory bulb development Source: UniProtKB
  13. positive regulation of neuron migration Source: Ensembl
  14. regulation of heart rate Source: Ensembl
  15. semaphorin-plexin signaling pathway involved in neuron projection guidance Source: Ensembl
  16. sympathetic ganglion development Source: Ensembl
  17. sympathetic neuron projection extension Source: Ensembl
  18. sympathetic neuron projection guidance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3A
Alternative name(s):
Semaphorin III
Short name:
Sema III
Gene namesi
Name:Sema3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi3657. Sema3a.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. axon Source: RGD
  2. dendrite Source: RGD
  3. extracellular space Source: RGD
  4. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 772752Semaphorin-3A
PRO_0000032305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi103 ↔ 114 By similarity
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi132 ↔ 141 By similarity
Disulfide bondi269 ↔ 381 By similarity
Disulfide bondi293 ↔ 341 By similarity
Disulfide bondi517 ↔ 535 By similarity
Glycosylationi591 – 5911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi650 ↔ 723 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63548.
PRIDEiQ63548.

Expressioni

Developmental stagei

At E11, expression was restricted to the olfactory pit, the basal and rostral surface of the telencephalic vesicle, the eye anlage, the epithelium of Rathke pouch, and somites. At later developmental stages, it was widely distributed in neuronal as well as in mesenchymal and epithelial structures outside the nervous system. After birth, mesenchymal levels decreased rapidly and expression became restricted to specific sets of neurons in the CNS. In the mature CNS, it is detectable in mitral cells, neurons of the accessory bulb and cerebral cortex, cerebellar Purkinje cells, as well as a subset of cranial and spinal motoneurons.

Gene expression databases

GenevestigatoriQ63548.

Interactioni

Subunit structurei

Interacts with PLXND1 By similarity.

Protein-protein interaction databases

IntActiQ63548. 1 interaction.
MINTiMINT-1542099.
STRINGi10116.ENSRNOP00000036472.

Structurei

3D structure databases

ProteinModelPortaliQ63548.
SMRiQ63548. Positions 26-520.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 514484Sema
Add
BLAST
Domaini577 – 66589Ig-like C2-type
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi728 – 77043Arg/Lys-rich (basic)
Add
BLAST

Domaini

Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similaritiesi

Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG305380.
GeneTreeiENSGT00560000076660.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ63548.
KOiK06840.
OMAiREPTTIS.
OrthoDBiEOG7VMP4F.
PhylomeDBiQ63548.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63548-1 [UniParc]FASTAAdd to Basket

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MGWFTGIACL FWGILLTARA NYANGKNNVP RLKLSYKEML ESNNVITFNG    50
LANSSSYHTF LLDEERSRLY VGAKDHIFSF NLVNIKDFQK IVWPVSYTRR 100
DECKWAGKDI LKECANFIKV LKAYNQTHLY ACGTGAFHPI CTYIEVGHHP 150
EDNIFKLQDS HFENGRGKSP YDPKLLTASL LIDGELYSGT AADFMGRDFA 200
IFRTLGHHHP IRTEQHDSRW LNDPRFISAH LIPESDNPED DKVYFFFREN 250
AIDGEHSGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG 300
IDTHFDELQD VFLMNSKDPK NPIVYGVFTT SSNIFKGSAV CMYSMSDVRR 350
VFLGPYAHRD GPNYQWVPYQ GRVPYPRPGT CPSKTFGGFD STKDLPDDVI 400
TFARSHPAMY NPVFPINNRP IMIKTDVNYQ FTQIVVDRVD AEDGQYDVMF 450
IGTDVGTVLK VVSVPKETWH DLEEVLLEEM TVFREPTTIS AMELSTKQQQ 500
LYIGSTAGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS SCSRYFPTAK 550
RRTRRQDIRN GDPLTHCSDL QHHDNHHGHS LEERIIYGVE NSSTFLECSP 600
KSQRALVYWQ FQRRNEDRKE EIRVGDHIIR TEQGLLLRSL QKKDSGNYLC 650
HAVEHGFMQT LLKVTLEVID TEHLEELLHK DDDGDGSKTK EMSSSMTPSQ 700
KVWYRDFMQL INHPNLNTMD EFCEQVWKRD RKQRRQRPGH SQGSSNKWKH 750
MQESKKGRNR RTHEFERAPR SV 772
Length:772
Mass (Da):88,808
Last modified:November 1, 1996 - v1
Checksum:i240907812FF9F2D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95286 mRNA. Translation: CAA64607.1.
RefSeqiNP_059006.1. NM_017310.1.
XP_006236051.1. XM_006235989.1.
XP_006236052.1. XM_006235990.1.
UniGeneiRn.44410.

Genome annotation databases

EnsembliENSRNOT00000034692; ENSRNOP00000036472; ENSRNOG00000023337.
GeneIDi29751.
KEGGirno:29751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95286 mRNA. Translation: CAA64607.1 .
RefSeqi NP_059006.1. NM_017310.1.
XP_006236051.1. XM_006235989.1.
XP_006236052.1. XM_006235990.1.
UniGenei Rn.44410.

3D structure databases

ProteinModelPortali Q63548.
SMRi Q63548. Positions 26-520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q63548. 1 interaction.
MINTi MINT-1542099.
STRINGi 10116.ENSRNOP00000036472.

Proteomic databases

PaxDbi Q63548.
PRIDEi Q63548.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000034692 ; ENSRNOP00000036472 ; ENSRNOG00000023337 .
GeneIDi 29751.
KEGGi rno:29751.

Organism-specific databases

CTDi 10371.
RGDi 3657. Sema3a.

Phylogenomic databases

eggNOGi NOG305380.
GeneTreei ENSGT00560000076660.
HOGENOMi HOG000039964.
HOVERGENi HBG055071.
InParanoidi Q63548.
KOi K06840.
OMAi REPTTIS.
OrthoDBi EOG7VMP4F.
PhylomeDBi Q63548.
TreeFami TF316102.

Miscellaneous databases

NextBioi 610281.
PROi Q63548.

Gene expression databases

Genevestigatori Q63548.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Anatomy of rat semaphorin III/collapsin-1 mRNA expression and relationship to developing nerve tracts during neuroembryogenesis."
    Giger R.J., Wolfer D.P., De Wit G.M.J., Verhaagen J.
    J. Comp. Neurol. 375:378-392(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiSEM3A_RAT
AccessioniPrimary (citable) accession number: Q63548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi