Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Semaphorin-3A

Gene

Sema3a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-RNO-399954 Sema3A PAK dependent Axon repulsion
R-RNO-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-RNO-399956 CRMPs in Sema3A signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3A
Alternative name(s):
Semaphorin III
Short name:
Sema III
Gene namesi
Name:Sema3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3657 Sema3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003230521 – 772Semaphorin-3AAdd BLAST752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 114By similarity
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 141By similarity
Disulfide bondi269 ↔ 381By similarity
Disulfide bondi293 ↔ 341By similarity
Disulfide bondi517 ↔ 535By similarity
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi650 ↔ 723By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63548
PRIDEiQ63548

PTM databases

iPTMnetiQ63548
PhosphoSitePlusiQ63548

Expressioni

Developmental stagei

At E11, expression was restricted to the olfactory pit, the basal and rostral surface of the telencephalic vesicle, the eye anlage, the epithelium of Rathke pouch, and somites. At later developmental stages, it was widely distributed in neuronal as well as in mesenchymal and epithelial structures outside the nervous system. After birth, mesenchymal levels decreased rapidly and expression became restricted to specific sets of neurons in the CNS. In the mature CNS, it is detectable in mitral cells, neurons of the accessory bulb and cerebral cortex, cerebellar Purkinje cells, as well as a subset of cranial and spinal motoneurons.

Gene expression databases

BgeeiENSRNOG00000023337
GenevisibleiQ63548 RN

Interactioni

Subunit structurei

Interacts with PLXND1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ63548, 1 interactor
MINTiQ63548
STRINGi10116.ENSRNOP00000036472

Structurei

3D structure databases

ProteinModelPortaliQ63548
SMRiQ63548
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 514SemaPROSITE-ProRule annotationAdd BLAST484
Domaini577 – 665Ig-like C2-typeAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi728 – 770Arg/Lys-rich (basic)Add BLAST43

Domaini

Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000039964
HOVERGENiHBG055071
InParanoidiQ63548
KOiK06840
OMAiREPTTIS
OrthoDBiEOG091G01W0
PhylomeDBiQ63548
TreeFamiTF316102

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWFTGIACL FWGILLTARA NYANGKNNVP RLKLSYKEML ESNNVITFNG
60 70 80 90 100
LANSSSYHTF LLDEERSRLY VGAKDHIFSF NLVNIKDFQK IVWPVSYTRR
110 120 130 140 150
DECKWAGKDI LKECANFIKV LKAYNQTHLY ACGTGAFHPI CTYIEVGHHP
160 170 180 190 200
EDNIFKLQDS HFENGRGKSP YDPKLLTASL LIDGELYSGT AADFMGRDFA
210 220 230 240 250
IFRTLGHHHP IRTEQHDSRW LNDPRFISAH LIPESDNPED DKVYFFFREN
260 270 280 290 300
AIDGEHSGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG
310 320 330 340 350
IDTHFDELQD VFLMNSKDPK NPIVYGVFTT SSNIFKGSAV CMYSMSDVRR
360 370 380 390 400
VFLGPYAHRD GPNYQWVPYQ GRVPYPRPGT CPSKTFGGFD STKDLPDDVI
410 420 430 440 450
TFARSHPAMY NPVFPINNRP IMIKTDVNYQ FTQIVVDRVD AEDGQYDVMF
460 470 480 490 500
IGTDVGTVLK VVSVPKETWH DLEEVLLEEM TVFREPTTIS AMELSTKQQQ
510 520 530 540 550
LYIGSTAGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS SCSRYFPTAK
560 570 580 590 600
RRTRRQDIRN GDPLTHCSDL QHHDNHHGHS LEERIIYGVE NSSTFLECSP
610 620 630 640 650
KSQRALVYWQ FQRRNEDRKE EIRVGDHIIR TEQGLLLRSL QKKDSGNYLC
660 670 680 690 700
HAVEHGFMQT LLKVTLEVID TEHLEELLHK DDDGDGSKTK EMSSSMTPSQ
710 720 730 740 750
KVWYRDFMQL INHPNLNTMD EFCEQVWKRD RKQRRQRPGH SQGSSNKWKH
760 770
MQESKKGRNR RTHEFERAPR SV
Length:772
Mass (Da):88,808
Last modified:November 1, 1996 - v1
Checksum:i240907812FF9F2D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95286 mRNA Translation: CAA64607.1
RefSeqiNP_059006.1, NM_017310.1
XP_006236051.1, XM_006235989.3
XP_006236052.1, XM_006235990.3
XP_008760924.1, XM_008762702.1
XP_017448057.1, XM_017592568.1
UniGeneiRn.44410

Genome annotation databases

EnsembliENSRNOT00000034692; ENSRNOP00000036472; ENSRNOG00000023337
GeneIDi29751
KEGGirno:29751

Similar proteinsi

Entry informationi

Entry nameiSEM3A_RAT
AccessioniPrimary (citable) accession number: Q63548
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health