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Protein

Gamma-synuclein

Gene

Sncg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).By similarity

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD

GO - Biological processi

  • adult locomotory behavior Source: RGD
  • aggressive behavior Source: RGD
  • cellular response to hydrostatic pressure Source: RGD
  • chemical synaptic transmission Source: RGD
  • peripheral nervous system development Source: RGD
  • protein secretion Source: RGD
  • regulation of dopamine secretion Source: RGD
  • regulation of neurotransmitter secretion Source: RGD
  • response to cocaine Source: RGD
  • response to drug Source: RGD
  • synapse organization Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-synuclein
Alternative name(s):
Persyn
Sensory neuron synuclein
Gene namesi
Name:Sncg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70996. Sncg.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840401 – 123Gamma-synucleinAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei120Phosphoserine; by BARK1, CaMK2 and CK2By similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63544.
PRIDEiQ63544.

PTM databases

iPTMnetiQ63544.
PhosphoSitePlusiQ63544.

Expressioni

Tissue specificityi

Specifically expressed in the peripheral nervous system. High expression in motoneurons of the brainstem. Also found in neurons of many other brain regions including the cerebellar cortex, thalmus, hypothalamus and CA1, CA2, CA3 and CA4 regions of the hippocampus.1 Publication

Interactioni

Subunit structurei

May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation (By similarity).By similarity

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063571.

Structurei

3D structure databases

ProteinModelPortaliQ63544.
SMRiQ63544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 674 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYGN. Eukaryota.
ENOG4111VY5. LUCA.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ63544.
PhylomeDBiQ63544.

Family and domain databases

InterProiView protein in InterPro
IPR001058. Synuclein.
IPR002462. Synuclein_gamma.
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiView protein in Pfam
PF01387. Synuclein. 1 hit.
PRINTSiPR01214. GSYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

Q63544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFKKGFSI AREGVVGAVE KTKQGVTEAA EKTKEGVMYV GTKTKGERGT
60 70 80 90 100
SVTSVAEKTK EQANAVSEAV VSSVNTVATK TVEEAENIVV TTGVVRKEDL
110 120
EPPAQDQEAK EQEEGEEAKS GGD
Length:123
Mass (Da):12,976
Last modified:January 9, 2007 - v2
Checksum:iED2B377A37FDEE59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23K → T in CAA60485 (PubMed:7673161).Curated1
Sequence conflicti42T → A in CAA60485 (PubMed:7673161).Curated1
Sequence conflicti80K → E in CAA60485 (PubMed:7673161).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86789 mRNA. Translation: CAA60485.1.
AY518351 mRNA. Translation: AAR99333.1.
PIRiA57431.
RefSeqiNP_113876.1. NM_031688.1.
UniGeneiRn.2883.

Genome annotation databases

GeneIDi64347.
KEGGirno:64347.
UCSCiRGD:70996. rat.

Similar proteinsi

Entry informationi

Entry nameiSYUG_RAT
AccessioniPrimary (citable) accession number: Q63544
Secondary accession number(s): Q6R2I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 9, 2007
Last modified: November 22, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families