Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-synuclein

Gene

Sncg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).By similarity

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD

GO - Biological processi

  • aggressive behavior Source: RGD
  • cellular response to hydrostatic pressure Source: RGD
  • peripheral nervous system development Source: RGD
  • response to cocaine Source: RGD
  • response to drug Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-synuclein
Alternative name(s):
Persyn
Sensory neuron synuclein
Gene namesi
Name:Sncg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70996. Sncg.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • microtubule organizing center Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
  • perinuclear region of cytoplasm Source: RGD
  • plasma membrane Source: RGD
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 123123Gamma-synucleinPRO_0000184040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671PhosphoserineCombined sources
Modified residuei72 – 721PhosphoserineCombined sources
Modified residuei120 – 1201Phosphoserine; by BARK1, CaMK2 and CK2By similarity

Post-translational modificationi

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63544.
PRIDEiQ63544.

PTM databases

iPTMnetiQ63544.
PhosphoSiteiQ63544.

Expressioni

Tissue specificityi

Specifically expressed in the peripheral nervous system. High expression in motoneurons of the brainstem. Also found in neurons of many other brain regions including the cerebellar cortex, thalmus, hypothalamus and CA1, CA2, CA3 and CA4 regions of the hippocampus.1 Publication

Interactioni

Subunit structurei

May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation (By similarity).By similarity

GO - Molecular functioni

  • alpha-tubulin binding Source: RGD
  • beta-tubulin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063571.

Structurei

3D structure databases

ProteinModelPortaliQ63544.
SMRiQ63544. Positions 1-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 30111Add
BLAST
Repeati31 – 41112Add
BLAST
Repeati42 – 56153; approximateAdd
BLAST
Repeati57 – 67114Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 67484 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)Add
BLAST

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYGN. Eukaryota.
ENOG4111VY5. LUCA.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ63544.
PhylomeDBiQ63544.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002462. Synuclein_gamma.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01214. GSYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

Q63544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFKKGFSI AREGVVGAVE KTKQGVTEAA EKTKEGVMYV GTKTKGERGT
60 70 80 90 100
SVTSVAEKTK EQANAVSEAV VSSVNTVATK TVEEAENIVV TTGVVRKEDL
110 120
EPPAQDQEAK EQEEGEEAKS GGD
Length:123
Mass (Da):12,976
Last modified:January 9, 2007 - v2
Checksum:iED2B377A37FDEE59
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231K → T in CAA60485 (PubMed:7673161).Curated
Sequence conflicti42 – 421T → A in CAA60485 (PubMed:7673161).Curated
Sequence conflicti80 – 801K → E in CAA60485 (PubMed:7673161).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86789 mRNA. Translation: CAA60485.1.
AY518351 mRNA. Translation: AAR99333.1.
PIRiA57431.
RefSeqiNP_113876.1. NM_031688.1.
UniGeneiRn.2883.

Genome annotation databases

GeneIDi64347.
KEGGirno:64347.
UCSCiRGD:70996. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86789 mRNA. Translation: CAA60485.1.
AY518351 mRNA. Translation: AAR99333.1.
PIRiA57431.
RefSeqiNP_113876.1. NM_031688.1.
UniGeneiRn.2883.

3D structure databases

ProteinModelPortaliQ63544.
SMRiQ63544. Positions 1-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063571.

PTM databases

iPTMnetiQ63544.
PhosphoSiteiQ63544.

Proteomic databases

PaxDbiQ63544.
PRIDEiQ63544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64347.
KEGGirno:64347.
UCSCiRGD:70996. rat.

Organism-specific databases

CTDi6623.
RGDi70996. Sncg.

Phylogenomic databases

eggNOGiENOG410IYGN. Eukaryota.
ENOG4111VY5. LUCA.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiQ63544.
PhylomeDBiQ63544.

Miscellaneous databases

NextBioi613012.
PROiQ63544.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002462. Synuclein_gamma.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01214. GSYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Peripheral nervous system-specific genes identified by subtractive cDNA cloning."
    Akopian A.N., Wood N.
    J. Biol. Chem. 270:21264-21270(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spinal ganglion.
  2. "Gamma synuclein is expressed in the hippocampus of adult rats."
    Klugmann M., Leichtlein C.B., During M.J.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  3. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 81-96, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  4. "Persyn, a member of the synuclein family, has a distinct pattern of expression in the developing nervous system."
    Buchman V.L., Hunter H.J., Pinon L.G., Thompson J., Privalova E.M., Ninkina N.N., Davies A.M.
    J. Neurosci. 18:9335-9341(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67 AND SER-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYUG_RAT
AccessioniPrimary (citable) accession number: Q63544
Secondary accession number(s): Q6R2I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 9, 2007
Last modified: January 20, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.