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Q63537 (SYN2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Synapsin-2
Alternative name(s):
Synapsin II
Gene names
Name:Syn2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release By similarity.

Subunit structure

Interacts with CAPON. Ref.3

Subcellular location

Cell junction › synapse.

Sequence similarities

Belongs to the synapsin family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform IIa (identifier: Q63537-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform IIb (identifier: Q63537-2)

The sequence of this isoform differs from the canonical sequence as follows:
     459-479: GPGQPQGMQPPGKVLPPRRLP → CLQYILNCNGIAVGPKQVQAS
     480-586: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 586586Synapsin-2
PRO_0000183023

Regions

Region1 – 2929A
Region33 – 11381B; linker
Region114 – 421308C; actin-binding and synaptic-vesicle binding
Region422 – 45837G; Pro-rich linker
Region459 – 53779H; Pro/Ser-rich linker
Region538 – 58649E
Compositional bias487 – 49913Poly-Ser
Compositional bias515 – 5206Poly-Ser

Amino acid modifications

Modified residue4221Phosphothreonine By similarity
Modified residue4261Phosphoserine By similarity

Natural variations

Alternative sequence459 – 47921GPGQP…PRRLP → CLQYILNCNGIAVGPKQVQA S in isoform IIb.
VSP_006322
Alternative sequence480 – 586107Missing in isoform IIb.
VSP_006323

Secondary structure

1 ........................................................ 586
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform IIa [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 630B7071B2F38857

FASTA58663,457
        10         20         30         40         50         60 
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPAPGP GTATASAATS AASPGPERRP 

        70         80         90        100        110        120 
PPAQAPAPQP APQPAPTPSV GSSFFSSLSQ AVKQTAASAG LVDAPAPSAA SRKAKVLLVV 

       130        140        150        160        170        180 
DEPHTDWAKC FRGKKILGDY DIKVEQAEFS ELNLVAHADG TYAVDMQVLR NGTKVVRSFR 

       190        200        210        220        230        240 
PDFVLIRQHA FGMAENEDFR HLVIGMQYAG LPSINSLESI YNFCDKPWVF AQMVAIFKTL 

       250        260        270        280        290        300 
GGEKFPLIEQ TYYPNHREML TLPTFPVVVK IGHAHSGMGK VKVENHYDFQ DIASVVALTQ 

       310        320        330        340        350        360 
TYATAEPFID AKYDIRVQKI GNNYKAYMRT SISGNWKTNT GSAMLEQIAM SDRYKLWVDA 

       370        380        390        400        410        420 
CSEMFGGLDI CAVKAVHGKD GKDYIFEVMD CSMPLIGEHQ VEDRQLITDL VISKMNQLLS 

       430        440        450        460        470        480 
RTPALSPQRP LTTQQPQSGT LKEPDSSKTP PQRPAPQGGP GQPQGMQPPG KVLPPRRLPS 

       490        500        510        520        530        540 
GPSLPPSSSS SSSSSSSSSA PQRPGGPTST QVNASSSSNS LAEPQAPQAA PPQKPQPHPQ 

       550        560        570        580 
LNKSQSLTNA FSFSESSFFR SSANEDEAKA ETIRSLRKSF ASLFSD

« Hide

Isoform IIb [UniParc].

Checksum: 9A495D706EA65614
Show »

FASTA47952,455

References

[1]"Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins."
Suedhof T.C., Czernik A.J., Kao H.-T., Takei K., Johnston P.A., Horiuchi A., Kanazir S.D., Wagner M.A., Perin M.S., de Camilli P., Greengard P.
Science 245:1474-1480(1989) [PubMed: 2506642] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIA AND IIB).
Tissue: Brain.
[2]Lubec G., Chen W.-Q.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 136-143; 178-200; 245-257; 405-414 AND 544-560, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Hippocampus.
[3]"Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON."
Jaffrey S.R., Benfenati F., Snowman A.M., Czernik A.J., Snyder S.H.
Proc. Natl. Acad. Sci. U.S.A. 99:3199-3204(2002) [PubMed: 11867766] [Abstract]
Cited for: INTERACTION WITH CAPON.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M27925 mRNA. Translation: AAA42100.1.
M27926 mRNA. Translation: AAA42101.1.
IPIIPI00210036.
IPI00231408.
PIRC30411.
RefSeqNP_001029192.1. NM_001034020.1.
NP_062032.1. NM_019159.1.
UniGeneRn.506.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1I7LX-ray2.35A/B113-421[»]
1I7NX-ray1.90A/B113-421[»]
ProteinModelPortalQ63537.
SMRQ63537. Positions 113-421.
ModBaseSearch...

Protein-protein interaction databases

IntActQ63537. 1 interaction.
MINTMINT-233013.
STRINGQ63537.

PTM databases

PhosphoSiteQ63537.

2D gel databases

World-2DPAGE0004:Q63537.

Proteomic databases

PRIDEQ63537.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29179.
KEGGrno:29179.
UCSCNM_001034020. rat.

Organism-specific databases

CTD6854.
RGD3798. Syn2.

Phylogenomic databases

eggNOGroNOG09210.
GeneTreeENSGT00530000063319.
HOVERGENHBG016354.
InParanoidQ63537.
OrthoDBEOG4KPTB4.

Gene expression databases

ArrayExpressQ63537.
GenevestigatorQ63537.
GermOnlineENSRNOG00000008157. Rattus norvegicus.

Family and domain databases

InterProIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR013817. Pre-ATP_grasp.
IPR016185. PreATP-grasp-like.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
Gene3DG3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit.
G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 2 hits.
G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
PfamPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSPR01368. SYNAPSIN.
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
PROSITEPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608259.
PMAP-CutDBQ63537.

Entry information

Entry nameSYN2_RAT
AccessionPrimary (citable) accession number: Q63537
Secondary accession number(s): Q9Z1H0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 21, 2011
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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