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Protein

Phosphotriesterase-related protein

Gene

Pter

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds resiniferotoxin, a vanilloid that desensitizes nociceptive neurons.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261Divalent metal cation 1; via tele nitrogenBy similarity
Metal bindingi28 – 281Divalent metal cation 1; via tele nitrogenBy similarity
Metal bindingi169 – 1691Divalent metal cation 1By similarity
Metal bindingi169 – 1691Divalent metal cation 2By similarity
Metal bindingi201 – 2011Divalent metal cation 2; via pros nitrogenBy similarity
Metal bindingi230 – 2301Divalent metal cation 2; via tele nitrogenBy similarity
Metal bindingi298 – 2981Divalent metal cation 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphotriesterase-related protein (EC:3.1.-.-)
Alternative name(s):
Parathion hydrolase-related protein
Resiniferotoxin-binding phosphotriesterase-related protein
Gene namesi
Name:Pter
Synonyms:Rpr-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi61313. Pter.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Phosphotriesterase-related proteinPRO_0000205366Add
BLAST

Proteomic databases

PaxDbiQ63530.
PRIDEiQ63530.

PTM databases

iPTMnetiQ63530.

Expressioni

Tissue specificityi

Expressed primarily in proximal tubules of the kidney.

Gene expression databases

GenevisibleiQ63530. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023446.

Structurei

3D structure databases

ProteinModelPortaliQ63530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphotriesterase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGM3. Eukaryota.
COG1735. LUCA.
GeneTreeiENSGT00390000006960.
HOGENOMiHOG000081700.
HOVERGENiHBG002463.
InParanoidiQ63530.
KOiK07048.
OMAiETGVHII.
OrthoDBiEOG7J70FS.
PhylomeDBiQ63530.
TreeFamiTF323205.

Family and domain databases

InterProiIPR017947. AryldialkylPase_Zn-BS.
IPR032466. Metal_Hydrolase.
IPR001559. Phosphotriesterase.
[Graphical view]
PANTHERiPTHR10819. PTHR10819. 1 hit.
PfamiPF02126. PTE. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 2 hits.
PROSITEiPS01322. PHOSPHOTRIESTERASE_1. 1 hit.
PS51347. PHOSPHOTRIESTERASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLSGKVQT VLGPVEPSQL GRTLTHEHLT MAFDSFYCPP PPCQEAASRE
60 70 80 90 100
PIMMKNLFWI QKNPYSHQEN LQLNQEVEAV REELLYFKAK GGGAVVENTT
110 120 130 140 150
TGLSRDVRTL KWLAEQTGVH IIAGAGFYVD ATHSAATRAM SVEQLTDVLI
160 170 180 190 200
SEILHGADGT SIKCGVIGEI GCSWPLTDSE RKVLQATAHA QAQLGCPVII
210 220 230 240 250
HPGRNPGAPF QIIRVLQEAG ADISKTVMSH LDRSIFDKKE LLEFAQLGCY
260 270 280 290 300
LEYDLFGTEL LNYQLSPDID MPDDNKRIRR VRFLVNEGYE DRILMAHDIH
310 320 330 340
TKHRLMKYGG HGYSHILTNV VPKMLLRGLT ERVLDKILRE NPKQWLTFK
Length:349
Mass (Da):39,145
Last modified:November 3, 2009 - v2
Checksum:iFAC9749B900D89B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341S → F in CAA67840 (PubMed:9237666).Curated
Sequence conflicti271 – 2711M → L in CAA67840 (PubMed:9237666).Curated
Sequence conflicti277 – 2804RIRR → GLGG in CAA67840 (PubMed:9237666).Curated
Sequence conflicti310 – 3101G → V in CAA67840 (PubMed:9237666).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99477 Genomic DNA. Translation: CAA67840.1.
BC078833 mRNA. Translation: AAH78833.1.
RefSeqiNP_071560.2. NM_022224.2.
XP_006254353.1. XM_006254291.2.
UniGeneiRn.44484.

Genome annotation databases

EnsembliENSRNOT00000023446; ENSRNOP00000023446; ENSRNOG00000017328.
GeneIDi63852.
KEGGirno:63852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99477 Genomic DNA. Translation: CAA67840.1.
BC078833 mRNA. Translation: AAH78833.1.
RefSeqiNP_071560.2. NM_022224.2.
XP_006254353.1. XM_006254291.2.
UniGeneiRn.44484.

3D structure databases

ProteinModelPortaliQ63530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023446.

PTM databases

iPTMnetiQ63530.

Proteomic databases

PaxDbiQ63530.
PRIDEiQ63530.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023446; ENSRNOP00000023446; ENSRNOG00000017328.
GeneIDi63852.
KEGGirno:63852.

Organism-specific databases

CTDi9317.
RGDi61313. Pter.

Phylogenomic databases

eggNOGiENOG410IGM3. Eukaryota.
COG1735. LUCA.
GeneTreeiENSGT00390000006960.
HOGENOMiHOG000081700.
HOVERGENiHBG002463.
InParanoidiQ63530.
KOiK07048.
OMAiETGVHII.
OrthoDBiEOG7J70FS.
PhylomeDBiQ63530.
TreeFamiTF323205.

Miscellaneous databases

NextBioi612468.
PROiQ63530.

Gene expression databases

GenevisibleiQ63530. RN.

Family and domain databases

InterProiIPR017947. AryldialkylPase_Zn-BS.
IPR032466. Metal_Hydrolase.
IPR001559. Phosphotriesterase.
[Graphical view]
PANTHERiPTHR10819. PTHR10819. 1 hit.
PfamiPF02126. PTE. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 2 hits.
PROSITEiPS01322. PHOSPHOTRIESTERASE_1. 1 hit.
PS51347. PHOSPHOTRIESTERASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression pattern of rpr-1, a resiniferatoxin-binding, phosphotriesterase-related protein, expressed in rat kidney tubules."
    Davies J.A., Buchman V., Krylova O., Ninkina N.N.
    FEBS Lett. 410:378-382(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPTER_RAT
AccessioniPrimary (citable) accession number: Q63530
Secondary accession number(s): Q6AYY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 3, 2009
Last modified: January 20, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.