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Protein

Synaptonemal complex protein 3

Gene

Sycp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:8289794, PubMed:9933407). Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex protein 3
Short name:
SCP-3
Gene namesi
Name:Sycp3
Synonyms:Scp31 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3795. Sycp3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002230451 – 257Synaptonemal complex protein 3Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei221PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63520.
PRIDEiQ63520.

PTM databases

iPTMnetiQ63520.
PhosphoSitePlusiQ63520.

Expressioni

Tissue specificityi

Detected in spermatocytes and testis (at protein level) (PubMed:8289794, PubMed:9933407). Testis-specific (PubMed:8289794).1 Publication

Gene expression databases

BgeeiENSRNOG00000005270.
GenevisibleiQ63520. RN.

Interactioni

Subunit structurei

Component of the lateral elements of synaptonemal complexes (PubMed:8289794, PubMed:9933407). Homotetramer; the tetrameric helix bundles assemble end to end into long homopolimeric fibers (in vitro) (By similarity). Homooligomer that assembles into fibers; the fibers exhibit a transversal striation with a periodicity of about 20 nm (in vitro) (PubMed:9679134, PubMed:18391527). Interacts with SYCP2 (PubMed:10652260).By similarity4 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007088.

Structurei

3D structure databases

SMRiQ63520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 79Interaction with DNABy similarity6
Regioni90 – 95Important for oligomerization and fiber formationBy similarity6
Regioni109 – 112Interaction with DNABy similarity4
Regioni252 – 257Important for oligomerization and fiber formationBy similarity6

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 244Sequence analysisBy similarityAdd BLAST158

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi109 – 112Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi126 – 253Gln-richAdd BLAST128

Domaini

Composed of a long central coiled coil domain. The N-terminal and C-terminal regions interact with DNA.By similarity

Sequence similaritiesi

Belongs to the XLR/SYCP3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ2Y. Eukaryota.
ENOG4111MZD. LUCA.
GeneTreeiENSGT00390000000062.
HOGENOMiHOG000236293.
HOVERGENiHBG100390.
InParanoidiQ63520.
KOiK19528.
OMAiVFQQSRI.
OrthoDBiEOG091G0L3F.
PhylomeDBiQ63520.

Family and domain databases

InterProiView protein in InterPro
IPR006888. XLR/SYCP3/FAM9_dom.
PfamiView protein in Pfam
PF04803. Cor1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGCGEVGA VDCSPEQLNK HLKMVPGGRK HSGKSGKPPL IDQPKKAFDF
60 70 80 90 100
EKEDKDLSGS EEDAVDEKTQ VFDKHGKKRS AGIIEDVGGE VQNMLEKFGA
110 120 130 140 150
DINKALLAKK KRIEMYTKAS FKASNQKIEQ IWKTQQEEIQ KLNNEYSQQF
160 170 180 190 200
LSVLQQWELD MQKFEEQGEK LTNLFRQQQK IFQQTRIVQS QRMKAIKQLH
210 220 230 240 250
EQFIKSLEDV EKNNDNLFTG TQSELKKEMA MLQKKVMMET QQQEMANVRK

SLQSMLF
Length:257
Mass (Da):29,733
Last modified:November 1, 1996 - v1
Checksum:i97C709F56918AF32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75785 mRNA. Translation: CAA53430.1.
PIRiA55925.
RefSeqiNP_037173.1. NM_013041.1.
UniGeneiRn.34889.

Genome annotation databases

EnsembliENSRNOT00000007088; ENSRNOP00000007088; ENSRNOG00000005270.
GeneIDi25561.
KEGGirno:25561.

Similar proteinsi

Entry informationi

Entry nameiSYCP3_RAT
AccessioniPrimary (citable) accession number: Q63520
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families