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Protein

Myosin-binding protein C, slow-type

Gene

Mybpc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

GO - Molecular functioni

  • myosin binding Source: RGD

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • muscle contraction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein C, slow-type
Short name:
Slow MyBP-C
Alternative name(s):
C-protein, skeletal muscle slow isoform
Gene namesi
Name:Mybpc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735102. Mybpc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›621›621Myosin-binding protein C, slow-typePRO_0000072690Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei28 – 281PhosphothreonineCombined sources
Modified residuei233 – 2331PhosphoserineCombined sources
Modified residuei420 – 4201PhosphothreonineCombined sources
Modified residuei445 – 4451PhosphotyrosineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ63518.

PTM databases

iPTMnetiQ63518.

Interactioni

Subunit structurei

Interacts with USP25 (isoform USP25m only); the interaction prevents proteasomal degradation of MYBPC1.By similarity

GO - Molecular functioni

  • myosin binding Source: RGD

Protein-protein interaction databases

IntActiQ63518. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ63518.
SMRiQ63518. Positions 1-53, 55-144, 345-454, 546-621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 53›53Ig-like C2-type 1Add
BLAST
Domaini54 – 14289Ig-like C2-type 2Add
BLAST
Domaini144 – 24198Ig-like C2-type 3Add
BLAST
Domaini244 – 343100Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini344 – 459116Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini459 – 55395Ig-like C2-type 4Add
BLAST
Domaini556 – 62166Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

HOVERGENiHBG052560.
InParanoidiQ63518.
KOiK12557.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q63518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EEIVPGPKSR YRIKVEGKKH TLIIEGATKA DSAEYSVMTT GGQSSAKLSV
60 70 80 90 100
DLRPLKITTP LTDQTVKLGK EVCLKCEISE NVPGKWTKNG LPVQEGERLK
110 120 130 140 150
VVHKGRIHKL VIANALIEDE GEYVFTPDAI TVPLVCQIHV IDPPKIILDG
160 170 180 190 200
LEADNTVTVI AGSKLRLEIP VTGEPPPKAI WSRADKAIME GSGRIRAESY
210 220 230 240 250
PDSSTLVIDV AERDDSGVYN INLKNEAGEA HASIKLRLWI SLILRLAPNV
260 270 280 290 300
TEVGDDWCIM NWEPPVYDGG SPILGYFIER KKKQSSRWMR LNFDLCKETT
310 320 330 340 350
FEPKKMIEGV AYEVRIFAVN AIGISKPSMP SKPFVPLAVT SPPTLLAVDS
360 370 380 390 400
VTDSSVTMKW RPPDQIGAAG LSGYVLEYCF EGSTSAKQSN ENGEAANDLP
410 420 430 440 450
AEDWSLQTQT GSTRPKFTIT GLPTDAKIFV RVKAINAAGA SETKYYSQPI
460 470 480 490 500
LVKEIIEPPK IRIPRHLKQT YIRRVGEAVN LVIPFQGKPR PELTWKKDGA
510 520 530 540 550
EIDKNQINIR NSETDTIIFI RKAERSHSGK YDLEVKVDKY VENASIDIQI
560 570 580 590 600
VDRPGPPQAV TIEDVWGENV ALTWTPPKDD GNAAITGYTI QKADKKSMEW
610 620
FAVIEHYHRT NATITELVIG N
Length:621
Mass (Da):68,737
Last modified:November 1, 1996 - v1
Checksum:i07B68B1FB8793FEA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei621 – 6211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90475 mRNA. Translation: CAA62085.1.
PIRiB57431.
RefSeqiNP_001094228.2. NM_001100758.2.
UniGeneiRn.9153.

Genome annotation databases

GeneIDi362867.
KEGGirno:362867.
UCSCiRGD:735102. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90475 mRNA. Translation: CAA62085.1.
PIRiB57431.
RefSeqiNP_001094228.2. NM_001100758.2.
UniGeneiRn.9153.

3D structure databases

ProteinModelPortaliQ63518.
SMRiQ63518. Positions 1-53, 55-144, 345-454, 546-621.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ63518. 1 interaction.

PTM databases

iPTMnetiQ63518.

Proteomic databases

PRIDEiQ63518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362867.
KEGGirno:362867.
UCSCiRGD:735102. rat.

Organism-specific databases

CTDi4604.
RGDi735102. Mybpc1.

Phylogenomic databases

HOVERGENiHBG052560.
InParanoidiQ63518.
KOiK12557.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYPC1_RAT
AccessioniPrimary (citable) accession number: Q63518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.