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Q63515

- C4BPB_RAT

UniProt

Q63515 - C4BPB_RAT

Protein

C4b-binding protein beta chain

Gene

C4bpb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It interacts also with anticoagulant protein S and with serum amyloid P component.

    GO - Biological processi

    1. complement activation, classical pathway Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Complement pathway, Immunity, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C4b-binding protein beta chain
    Gene namesi
    Name:C4bpb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2236. C4bpb.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515By similarityAdd
    BLAST
    Chaini16 – 258243C4b-binding protein beta chainPRO_0000005893Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi46 ↔ 73PROSITE-ProRule annotation
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi78 ↔ 118PROSITE-ProRule annotation
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 131PROSITE-ProRule annotation
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi136 ↔ 176PROSITE-ProRule annotation
    Disulfide bondi162 ↔ 188PROSITE-ProRule annotation
    Disulfide bondi217 – 217Interchain (with alpha chain)PROSITE-ProRule annotation
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ63515.
    PRIDEiQ63515.

    Expressioni

    Gene expression databases

    GenevestigatoriQ63515.

    Interactioni

    Subunit structurei

    Disulfide-linked complex of alpha and beta chains.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 7558Sushi 1; atypical; lacks a CysPROSITE-ProRule annotationAdd
    BLAST
    Domaini76 – 13358Sushi 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 19057Sushi 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Sushi

    Phylogenomic databases

    eggNOGiNOG260856.
    HOGENOMiHOG000032571.
    HOVERGENiHBG004922.
    InParanoidiQ63515.
    PhylomeDBiQ63515.

    Family and domain databases

    InterProiIPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF00084. Sushi. 3 hits.
    [Graphical view]
    SMARTiSM00032. CCP. 3 hits.
    [Graphical view]
    SUPFAMiSSF57535. SSF57535. 3 hits.
    PROSITEiPS50923. SUSHI. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63515-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLCLVVCCLI WLISALDGSC SEPPPVNNSV FVGKETEEQI LGIYLCIKGY    50
    HLVGKKSLVF DPSKEWNSTL PECLLGHCPD PVLENGKINS SGPVNISGKI 100
    MFECNDGYIL KGSNWSQCLE DHTWAPPLPI CRSRDCEPPE TPVHGYFEGE 150
    TFTSGSVVTY YCEDGYHLVG TQKVQCSDGE WSPSYPTCES IQEPPKSAEQ 200
    SALEKAILAF QESKDLCNAT ENFVRQLREG GITMEELKCS LEMKKTKLKS 250
    DILLNYHS 258
    Length:258
    Mass (Da):28,642
    Last modified:November 1, 1997 - v1
    Checksum:i636F99908A85DC1C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50052 mRNA. Translation: CAA90392.1.
    PIRiS57960.
    UniGeneiRn.11151.

    Genome annotation databases

    UCSCiRGD:2236. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50052 mRNA. Translation: CAA90392.1 .
    PIRi S57960.
    UniGenei Rn.11151.

    3D structure databases

    ProteinModelPortali Q63515.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q63515.
    PRIDEi Q63515.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2236. rat.

    Organism-specific databases

    RGDi 2236. C4bpb.

    Phylogenomic databases

    eggNOGi NOG260856.
    HOGENOMi HOG000032571.
    HOVERGENi HBG004922.
    InParanoidi Q63515.
    PhylomeDBi Q63515.

    Miscellaneous databases

    PROi Q63515.

    Gene expression databases

    Genevestigatori Q63515.

    Family and domain databases

    InterProi IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF00084. Sushi. 3 hits.
    [Graphical view ]
    SMARTi SM00032. CCP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF57535. SSF57535. 3 hits.
    PROSITEi PS50923. SUSHI. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of rat C4b binding protein alpha- and beta-chains: structural and functional relationships among human, bovine, rabbit, mouse, and rat proteins."
      Hillarp A., Wiklund H., Thern A., Dahlback B.
      J. Immunol. 158:1315-1323(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiC4BPB_RAT
    AccessioniPrimary (citable) accession number: Q63515
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3