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Protein

C4b-binding protein beta chain

Gene

C4bpb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It interacts also with anticoagulant protein S and with serum amyloid P component.

GO - Biological processi

  1. complement activation, classical pathway Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
C4b-binding protein beta chain
Gene namesi
Name:C4bpb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2236. C4bpb.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515By similarityAdd
BLAST
Chaini16 – 258243C4b-binding protein beta chainPRO_0000005893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi46 ↔ 73PROSITE-ProRule annotation
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi78 ↔ 118PROSITE-ProRule annotation
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 131PROSITE-ProRule annotation
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi136 ↔ 176PROSITE-ProRule annotation
Disulfide bondi162 ↔ 188PROSITE-ProRule annotation
Disulfide bondi217 – 217Interchain (with alpha chain)PROSITE-ProRule annotation
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63515.
PRIDEiQ63515.

Expressioni

Gene expression databases

GenevestigatoriQ63515.

Interactioni

Subunit structurei

Disulfide-linked complex of alpha and beta chains.

Structurei

3D structure databases

ProteinModelPortaliQ63515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 7558Sushi 1; atypical; lacks a CysPROSITE-ProRule annotationAdd
BLAST
Domaini76 – 13358Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 19057Sushi 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG260856.
HOGENOMiHOG000032571.
HOVERGENiHBG004922.
InParanoidiQ63515.
PhylomeDBiQ63515.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 3 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50923. SUSHI. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63515-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLCLVVCCLI WLISALDGSC SEPPPVNNSV FVGKETEEQI LGIYLCIKGY
60 70 80 90 100
HLVGKKSLVF DPSKEWNSTL PECLLGHCPD PVLENGKINS SGPVNISGKI
110 120 130 140 150
MFECNDGYIL KGSNWSQCLE DHTWAPPLPI CRSRDCEPPE TPVHGYFEGE
160 170 180 190 200
TFTSGSVVTY YCEDGYHLVG TQKVQCSDGE WSPSYPTCES IQEPPKSAEQ
210 220 230 240 250
SALEKAILAF QESKDLCNAT ENFVRQLREG GITMEELKCS LEMKKTKLKS

DILLNYHS
Length:258
Mass (Da):28,642
Last modified:November 1, 1997 - v1
Checksum:i636F99908A85DC1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50052 mRNA. Translation: CAA90392.1.
PIRiS57960.
UniGeneiRn.11151.

Genome annotation databases

UCSCiRGD:2236. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50052 mRNA. Translation: CAA90392.1.
PIRiS57960.
UniGeneiRn.11151.

3D structure databases

ProteinModelPortaliQ63515.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ63515.
PRIDEiQ63515.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2236. rat.

Organism-specific databases

RGDi2236. C4bpb.

Phylogenomic databases

eggNOGiNOG260856.
HOGENOMiHOG000032571.
HOVERGENiHBG004922.
InParanoidiQ63515.
PhylomeDBiQ63515.

Miscellaneous databases

PROiQ63515.

Gene expression databases

GenevestigatoriQ63515.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 3 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50923. SUSHI. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of rat C4b binding protein alpha- and beta-chains: structural and functional relationships among human, bovine, rabbit, mouse, and rat proteins."
    Hillarp A., Wiklund H., Thern A., Dahlback B.
    J. Immunol. 158:1315-1323(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiC4BPB_RAT
AccessioniPrimary (citable) accession number: Q63515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.