Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C4b-binding protein beta chain

Gene

C4bpb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It interacts also with anticoagulant protein S and with serum amyloid P component.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
C4b-binding protein beta chain
Gene namesi
Name:C4bpb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2236. C4bpb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15By similarityAdd BLAST15
ChainiPRO_000000589316 – 258C4b-binding protein beta chainAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi46 ↔ 73PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi78 ↔ 118PROSITE-ProRule annotation
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 131PROSITE-ProRule annotation
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi136 ↔ 176PROSITE-ProRule annotation
Disulfide bondi162 ↔ 188PROSITE-ProRule annotation
Disulfide bondi217Interchain (with alpha chain)PROSITE-ProRule annotation
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63515.
PRIDEiQ63515.

Interactioni

Subunit structurei

Disulfide-linked complex of alpha and beta chains.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005505.

Structurei

3D structure databases

ProteinModelPortaliQ63515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 75Sushi 1; atypical; lacks a CysPROSITE-ProRule annotationAdd BLAST58
Domaini76 – 133Sushi 2PROSITE-ProRule annotationAdd BLAST58
Domaini134 – 190Sushi 3PROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Contains 3 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000032571.
HOVERGENiHBG004922.
InParanoidiQ63515.
PhylomeDBiQ63515.

Family and domain databases

CDDicd00033. CCP. 3 hits.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 2 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50923. SUSHI. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCLVVCCLI WLISALDGSC SEPPPVNNSV FVGKETEEQI LGIYLCIKGY
60 70 80 90 100
HLVGKKSLVF DPSKEWNSTL PECLLGHCPD PVLENGKINS SGPVNISGKI
110 120 130 140 150
MFECNDGYIL KGSNWSQCLE DHTWAPPLPI CRSRDCEPPE TPVHGYFEGE
160 170 180 190 200
TFTSGSVVTY YCEDGYHLVG TQKVQCSDGE WSPSYPTCES IQEPPKSAEQ
210 220 230 240 250
SALEKAILAF QESKDLCNAT ENFVRQLREG GITMEELKCS LEMKKTKLKS

DILLNYHS
Length:258
Mass (Da):28,642
Last modified:November 1, 1997 - v1
Checksum:i636F99908A85DC1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50052 mRNA. Translation: CAA90392.1.
PIRiS57960.
UniGeneiRn.11151.

Genome annotation databases

UCSCiRGD:2236. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50052 mRNA. Translation: CAA90392.1.
PIRiS57960.
UniGeneiRn.11151.

3D structure databases

ProteinModelPortaliQ63515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005505.

Proteomic databases

PaxDbiQ63515.
PRIDEiQ63515.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2236. rat.

Organism-specific databases

RGDi2236. C4bpb.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000032571.
HOVERGENiHBG004922.
InParanoidiQ63515.
PhylomeDBiQ63515.

Miscellaneous databases

PROiQ63515.

Family and domain databases

CDDicd00033. CCP. 3 hits.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 2 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50923. SUSHI. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC4BPB_RAT
AccessioniPrimary (citable) accession number: Q63515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.