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Q63515

- C4BPB_RAT

UniProt

Q63515 - C4BPB_RAT

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Protein
C4b-binding protein beta chain
Gene
C4bpb
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It interacts also with anticoagulant protein S and with serum amyloid P component.

GO - Biological processi

  1. complement activation, classical pathway Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
C4b-binding protein beta chain
Gene namesi
Name:C4bpb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2236. C4bpb.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 By similarity
Add
BLAST
Chaini16 – 258243C4b-binding protein beta chain
PRO_0000005893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi46 ↔ 73 By similarity
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi78 ↔ 118 By similarity
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi104 ↔ 131 By similarity
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi136 ↔ 176 By similarity
Disulfide bondi162 ↔ 188 By similarity
Disulfide bondi217 – 217Interchain (with alpha chain) Reviewed prediction
Glycosylationi218 – 2181N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63515.
PRIDEiQ63515.

Expressioni

Gene expression databases

GenevestigatoriQ63515.

Interactioni

Subunit structurei

Disulfide-linked complex of alpha and beta chains.

Structurei

3D structure databases

ProteinModelPortaliQ63515.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 7558Sushi 1; atypical; lacks a Cys
Add
BLAST
Domaini76 – 13358Sushi 2
Add
BLAST
Domaini134 – 19057Sushi 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG260856.
HOGENOMiHOG000032571.
HOVERGENiHBG004922.
InParanoidiQ63515.
PhylomeDBiQ63515.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00084. Sushi. 3 hits.
[Graphical view]
SMARTiSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 3 hits.
PROSITEiPS50923. SUSHI. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63515-1 [UniParc]FASTAAdd to Basket

« Hide

MLCLVVCCLI WLISALDGSC SEPPPVNNSV FVGKETEEQI LGIYLCIKGY    50
HLVGKKSLVF DPSKEWNSTL PECLLGHCPD PVLENGKINS SGPVNISGKI 100
MFECNDGYIL KGSNWSQCLE DHTWAPPLPI CRSRDCEPPE TPVHGYFEGE 150
TFTSGSVVTY YCEDGYHLVG TQKVQCSDGE WSPSYPTCES IQEPPKSAEQ 200
SALEKAILAF QESKDLCNAT ENFVRQLREG GITMEELKCS LEMKKTKLKS 250
DILLNYHS 258
Length:258
Mass (Da):28,642
Last modified:November 1, 1997 - v1
Checksum:i636F99908A85DC1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50052 mRNA. Translation: CAA90392.1.
PIRiS57960.
UniGeneiRn.11151.

Genome annotation databases

UCSCiRGD:2236. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50052 mRNA. Translation: CAA90392.1 .
PIRi S57960.
UniGenei Rn.11151.

3D structure databases

ProteinModelPortali Q63515.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q63515.
PRIDEi Q63515.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2236. rat.

Organism-specific databases

RGDi 2236. C4bpb.

Phylogenomic databases

eggNOGi NOG260856.
HOGENOMi HOG000032571.
HOVERGENi HBG004922.
InParanoidi Q63515.
PhylomeDBi Q63515.

Miscellaneous databases

PROi Q63515.

Gene expression databases

Genevestigatori Q63515.

Family and domain databases

InterProi IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00084. Sushi. 3 hits.
[Graphical view ]
SMARTi SM00032. CCP. 3 hits.
[Graphical view ]
SUPFAMi SSF57535. SSF57535. 3 hits.
PROSITEi PS50923. SUSHI. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of rat C4b binding protein alpha- and beta-chains: structural and functional relationships among human, bovine, rabbit, mouse, and rat proteins."
    Hillarp A., Wiklund H., Thern A., Dahlback B.
    J. Immunol. 158:1315-1323(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiC4BPB_RAT
AccessioniPrimary (citable) accession number: Q63515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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