Q63515 (C4BPB_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C4b-binding protein beta chain

Gene names

Name:

C4bpb

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It interacts also with anticoagulant protein S and with serum amyloid P component.
Subunit structure	Disulfide-linked complex of alpha and beta chains.
Subcellular location	Secreted.
Sequence similarities	Contains 3 Sushi (CCP/SCR) domains.

Ontologies

Keywords
Biological process	Complement pathway Immunity Innate immunity
Cellular component	Secreted
Domain	Repeat Signal Sushi
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	complement activation, classical pathway Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	By similarity
	Chain	16 – 258	243	C4b-binding protein beta chain		PRO_0000005893
Regions
	Domain	18 – 75	58	Sushi 1; atypical; lacks a Cys
	Domain	76 – 133	58	Sushi 2
	Domain	134 – 190	57	Sushi 3
Amino acid modifications
	Glycosylation	27	1	N-linked (GlcNAc...) Potential
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	89	1	N-linked (GlcNAc...) Potential
	Glycosylation	95	1	N-linked (GlcNAc...) Potential
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
	Glycosylation	218	1	N-linked (GlcNAc...) Potential
	Disulfide bond	46 ↔ 73		By similarity
	Disulfide bond	78 ↔ 118		By similarity
	Disulfide bond	104 ↔ 131		By similarity
	Disulfide bond	136 ↔ 176		By similarity
	Disulfide bond	162 ↔ 188		By similarity
	Disulfide bond	217		Interchain (with alpha chain) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q63515 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 636F99908A85DC1C	FASTA	258	28,642
	10 20 30 40 50 60 MLCLVVCCLI WLISALDGSC SEPPPVNNSV FVGKETEEQI LGIYLCIKGY HLVGKKSLVF 70 80 90 100 110 120 DPSKEWNSTL PECLLGHCPD PVLENGKINS SGPVNISGKI MFECNDGYIL KGSNWSQCLE 130 140 150 160 170 180 DHTWAPPLPI CRSRDCEPPE TPVHGYFEGE TFTSGSVVTY YCEDGYHLVG TQKVQCSDGE 190 200 210 220 230 240 WSPSYPTCES IQEPPKSAEQ SALEKAILAF QESKDLCNAT ENFVRQLREG GITMEELKCS 250 LEMKKTKLKS DILLNYHS

References

[1]	"Molecular cloning of rat C4b binding protein alpha- and beta-chains: structural and functional relationships among human, bovine, rabbit, mouse, and rat proteins." Hillarp A., Wiklund H., Thern A., Dahlback B. J. Immunol. 158:1315-1323(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z50052 mRNA. Translation: CAA90392.1.
IPI	IPI00209975.
PIR	S57960.
UniGene	Rn.11151.
3D structure databases
ProteinModelPortal	Q63515.
ModBase	Search...
Proteomic databases
PaxDb	Q63515.
PRIDE	Q63515.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:2236. rat.
Organism-specific databases
RGD	2236. C4bpb.
Phylogenomic databases
eggNOG	NOG260856.
HOGENOM	HOG000032571.
HOVERGEN	HBG004922.
InParanoid	Q63515.
OrthoDB	EOG4RBQK9.
Gene expression databases
ArrayExpress	Q63515.
Genevestigator	Q63515.
GermOnline	ENSRNOG00000004125. Rattus norvegicus.
Family and domain databases
InterPro	IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF00084. Sushi. 3 hits. [Graphical view]
SMART	SM00032. CCP. 3 hits. [Graphical view]
SUPFAM	SSF57535. Complement_control_module. 3 hits.
PROSITE	PS50923. SUSHI. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C4BPB_RAT

Accession

Primary (citable) accession number: Q63515

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program