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Q63515 (C4BPB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C4b-binding protein beta chain
Gene names
Name:C4bpb
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It interacts also with anticoagulant protein S and with serum amyloid P component.

Subunit structure

Disulfide-linked complex of alpha and beta chains.

Subcellular location

Secreted.

Sequence similarities

Contains 3 Sushi (CCP/SCR) domains.

Ontologies

Keywords
   Biological processComplement pathway
Immunity
Innate immunity
   Cellular componentSecreted
   DomainRepeat
Signal
Sushi
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcomplement activation, classical pathway

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 By similarity
Chain16 – 258243C4b-binding protein beta chain
PRO_0000005893

Regions

Domain18 – 7558Sushi 1; atypical; lacks a Cys
Domain76 – 13358Sushi 2
Domain134 – 19057Sushi 3

Amino acid modifications

Glycosylation271N-linked (GlcNAc...) Potential
Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation2181N-linked (GlcNAc...) Potential
Disulfide bond46 ↔ 73 By similarity
Disulfide bond78 ↔ 118 By similarity
Disulfide bond104 ↔ 131 By similarity
Disulfide bond136 ↔ 176 By similarity
Disulfide bond162 ↔ 188 By similarity
Disulfide bond217Interchain (with alpha chain) Potential

Sequences

Sequence LengthMass (Da)Tools
Q63515 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 636F99908A85DC1C

FASTA25828,642
        10         20         30         40         50         60 
MLCLVVCCLI WLISALDGSC SEPPPVNNSV FVGKETEEQI LGIYLCIKGY HLVGKKSLVF 

        70         80         90        100        110        120 
DPSKEWNSTL PECLLGHCPD PVLENGKINS SGPVNISGKI MFECNDGYIL KGSNWSQCLE 

       130        140        150        160        170        180 
DHTWAPPLPI CRSRDCEPPE TPVHGYFEGE TFTSGSVVTY YCEDGYHLVG TQKVQCSDGE 

       190        200        210        220        230        240 
WSPSYPTCES IQEPPKSAEQ SALEKAILAF QESKDLCNAT ENFVRQLREG GITMEELKCS 

       250 
LEMKKTKLKS DILLNYHS 

« Hide

References

[1]"Molecular cloning of rat C4b binding protein alpha- and beta-chains: structural and functional relationships among human, bovine, rabbit, mouse, and rat proteins."
Hillarp A., Wiklund H., Thern A., Dahlback B.
J. Immunol. 158:1315-1323(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z50052 mRNA. Translation: CAA90392.1.
PIRS57960.
UniGeneRn.11151.

3D structure databases

ProteinModelPortalQ63515.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ63515.
PRIDEQ63515.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:2236. rat.

Organism-specific databases

RGD2236. C4bpb.

Phylogenomic databases

eggNOGNOG260856.
HOGENOMHOG000032571.
HOVERGENHBG004922.
InParanoidQ63515.
PhylomeDBQ63515.

Gene expression databases

GenevestigatorQ63515.

Family and domain databases

InterProIPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00084. Sushi. 3 hits.
[Graphical view]
SMARTSM00032. CCP. 3 hits.
[Graphical view]
SUPFAMSSF57535. SSF57535. 3 hits.
PROSITEPS50923. SUSHI. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ63515.

Entry information

Entry nameC4BPB_RAT
AccessionPrimary (citable) accession number: Q63515
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families