G protein-activated inward rectifier potassium channel 3

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Q63511 (IRK9_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 100. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
G protein-activated inward rectifier potassium channel 3
Short name=GIRK-3

Alternative name(s):
Inward rectifier K(+) channel Kir3.3
Potassium channel, inwardly rectifying subfamily J member 9

Gene names

Name:	Kcnj9
Synonyms:	Girk3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium By similarity.
Subunit structure	Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ9 subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Voltage-gated channel
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 14664820. Source: RGD
Molecular_function	G-protein activated inward rectifier potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 393

393

G protein-activated inward rectifier potassium channel 3

PRO_0000154952

Regions

Topological domain

1 – 57

Cytoplasmic By similarity

Transmembrane

58 – 82

Helical; Name=M1; By similarity

Topological domain

83 – 106

Extracellular By similarity

Intramembrane

107 – 118

Helical; Pore-forming; Name=H5; By similarity

Intramembrane

119 – 125

Pore-forming; By similarity

Topological domain

126 – 134

Extracellular By similarity

Transmembrane

135 – 156

Helical; Name=M2; By similarity

Topological domain

157 – 393

237

Cytoplasmic By similarity

Motif

120 – 125

Selectivity filter By similarity

Sites

Site

150

Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

Secondary structure

393

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q63511 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 9CF749672A996608
Show »

FASTA

393

43,965

        10         20         30         40         50         60 
MAQENAAFSP GSEEPPRRRG RQRYVEKDGR CNVQQGNVRE TYRYLTDLFT TLVDLQWRLS 

        70         80         90        100        110        120 
LLFFVLAYAL TWLFFGAIWW LIAYGRGDLE HLEDTAWTPC VNNLNGFVAA FLFSIETETT 

       130        140        150        160        170        180 
IGYGHRVITD QCPEGIVLLL LQAILGSMVN AFMVGCMFVK ISQPNKRAAT LVFSSHAVVS 

       190        200        210        220        230        240 
LRDGRLCLMF RVGDLRSSHI VEASIRAKLI RSRQTLEGEF IPLHQTDLSV GFDTGDDRLF 

       250        260        270        280        290        300 
LVSPLVISHE IDAASPFWEA SRRALERDDF EIVVILEGMV EATGMTCQAR SSYLVDEVLW 

       310        320        330        340        350        360 
GHRFTSVLTL EDGFYEVDYA SFHETFEVPT PSCSARELAE AAARLDAHLY WSIPSRLDEK 

       370        380        390 
VEEEGAGEGA GAGDGADKEQ NGCLPPPESE SKV

« Hide

References

[1]	"Functional expression and cellular mRNA localization of a G protein-activated K+ inward rectifier isolated from rat brain." Dissmann E., Wischmeyer E., Spauschus A., Pfeil D.V., Karschin C., Karschin A. Biochem. Biophys. Res. Commun. 223:474-479(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	Dissmann E., Wischmeyer E., Spauschus A., Pfeil D.V., Karschin C., Karschin A. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L77929 mRNA. Translation: AAB95433.1.

IPI

IPI00209972.

RefSeq

NP_446286.1. NM_053834.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3QDO	X-ray	1.88	A	388-393	[»]
3QE1	X-ray	1.68	A	388-393	[»]
3QGL	X-ray	3.31	F/G/H/I/J	388-393	[»]

ProteinModelPortal

Q63511.

SMR

Q63511. Positions 168-346.

ModBase

Search...

Protein-protein interaction databases

STRING

10116.ENSRNOP00000010113.

PTM databases

PhosphoSite

Q63511.

Proteomic databases

PRIDE

Q63511.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSRNOT00000010113; ENSRNOP00000010113; ENSRNOG00000007645.

GeneID

116560.

KEGG

rno:116560.

Organism-specific databases

CTD

3765.

RGD

621440. Kcnj9.

Phylogenomic databases

eggNOG

NOG72812.

GeneTree

ENSGT00690000101708.

HOGENOM

HOG000237325.

HOVERGEN

HBG006178.

InParanoid

Q63511.

K05002.

OMA

DYASFHQ.

OrthoDB

EOG41C6WD.

Gene expression databases

Genevestigator

Q63511.

GermOnline

ENSRNOG00000007645. Rattus norvegicus.

Family and domain databases

Gene3D

2.60.40.1400. 1 hit.

InterPro

IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003276. K_chnl_inward-rec_Kir3.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]

PANTHER

PTHR11767. PTHR11767. 1 hit.
PTHR11767:SF17. PTHR11767:SF17. 1 hit.

Pfam

PF01007. IRK. 1 hit.
[Graphical view]

PIRSF

PIRSF005465. GIRK_kir. 1 hit.

PRINTS

PR01329. KIR33CHANNEL.
PR01320. KIRCHANNEL.

SUPFAM

SSF81296. Ig_E-set. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q63511.

NextBio

619225.

Entry information

Entry name

IRK9_RAT

Accession

Primary (citable) accession number: Q63511

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 15, 1999
Last modified:	April 3, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents