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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2

Gene

murG2

Organism
Bacillus cereus (strain ZK / E33L)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBCER288681:G1G3U-4441-MONOMER
UniPathwayiUPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2UniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 2UniRule annotation
Gene namesi
Name:murG2UniRule annotation
Ordered Locus Names:BCE33L4004
OrganismiBacillus cereus (strain ZK / E33L)
Taxonomic identifieri288681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002612 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002250241 – 352UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2Add BLAST352

Proteomic databases

PRIDEiQ634T3

Structurei

3D structure databases

ProteinModelPortaliQ634T3
SMRiQ634T3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

KOiK02563
OMAiNSIFEFL

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

Q634T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIVFTGGG SAGHVTPNLA IIPYLKEDNW DISYIGSHQG IEKTIIEKED
60 70 80 90 100
ILYYSIASGK LRRYFDLKNI KDPFLVMKGV MDAYVRIRKL KPDVIFSKGG
110 120 130 140 150
FVSVPVVIGG WLNRVPVLLH ESDMTPGLAN KIALRFASKI FVTFEEAAKH
160 170 180 190 200
LPKEKVIYTG SPVREEVLKG NREKALAFLG FSRKKPVITI MGGSLGAKKI
210 220 230 240 250
NETVREALPE LLRKYQIVHL CGRGNLDDSL QNKEGYRQFE YVHGELPDIL
260 270 280 290 300
AITDFVISRA GSNAIFEFLT LQKPMLLIPL SKFASRGDQI LNAESFERQG
310 320 330 340 350
YASVLYEEDV TVNSLIKHVE ELSHNNEAYK TALKKYNGKE AIQTIIHHIS

EA
Length:352
Mass (Da):39,551
Last modified:October 25, 2004 - v1
Checksum:i1BB9CA11D864A035
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000001 Genomic DNA Translation: AAU16265.1
RefSeqiWP_000724759.1, NZ_CP009968.1

Genome annotation databases

EnsemblBacteriaiAAU16265; AAU16265; BCE33L4004
KEGGibcz:BCE33L4004
PATRICifig|288681.22.peg.1390

Similar proteinsi

Entry informationi

Entry nameiMURG2_BACCZ
AccessioniPrimary (citable) accession number: Q634T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health