Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Advanced glycosylation end product-specific receptor

Gene

Ager

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.By similarity1 Publication

GO - Molecular functioni

  • advanced glycation end-product receptor activity Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • calcium ion homeostasis Source: RGD
  • cellular response to drug Source: RGD
  • cellular response to fatty acid Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • glycoprotein metabolic process Source: RGD
  • inflammatory response Source: UniProtKB-KW
  • JAK-STAT cascade Source: RGD
  • lung development Source: RGD
  • negative regulation of cell adhesion Source: RGD
  • negative regulation of collagen biosynthetic process Source: RGD
  • negative regulation of endothelial cell migration Source: RGD
  • negative regulation of endothelial cell proliferation Source: RGD
  • negative regulation of osteoblast proliferation Source: RGD
  • negative regulation of protein phosphorylation Source: RGD
  • neuron projection development Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of autophagy Source: RGD
  • positive regulation of cell migration Source: RGD
  • positive regulation of endothelial cell apoptotic process Source: RGD
  • positive regulation of epithelial to mesenchymal transition Source: RGD
  • positive regulation of fibroblast migration Source: RGD
  • positive regulation of fibroblast proliferation Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of inflammatory response Source: RGD
  • positive regulation of neuron apoptotic process Source: RGD
  • positive regulation of neuron death Source: RGD
  • positive regulation of phagocytosis, engulfment Source: RGD
  • positive regulation of potassium ion transmembrane transporter activity Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of reactive oxygen species metabolic process Source: RGD
  • positive regulation of smooth muscle cell migration Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of type B pancreatic cell apoptotic process Source: RGD
  • response to activity Source: RGD
  • response to fructose Source: RGD
  • response to genistein Source: RGD
  • response to hyperoxia Source: RGD
  • response to methylglyoxal Source: RGD
  • response to selenite ion Source: RGD
  • response to vitamin A Source: RGD
  • transdifferentiation Source: RGD

Keywordsi

Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Advanced glycosylation end product-specific receptor
Alternative name(s):
Receptor for advanced glycosylation end products
Gene namesi
Name:Ager
Synonyms:Rage
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi69258 Ager

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 341ExtracellularSequence analysisAdd BLAST319
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 402CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176847

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001492523 – 402Advanced glycosylation end product-specific receptorAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi38 ↔ 98PROSITE-ProRule annotation
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 206PROSITE-ProRule annotation
Disulfide bondi257InterchainPROSITE-ProRule annotation
Disulfide bondi299InterchainPROSITE-ProRule annotation
Modified residuei376PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63495
PRIDEiQ63495

PTM databases

iPTMnetiQ63495
PhosphoSitePlusiQ63495

Expressioni

Tissue specificityi

Endothelial cells and cardiomyocytes.1 Publication

Inductioni

Up-regulated in periinfarct ventricular myocardium.1 Publication

Interactioni

Subunit structurei

Interacts with S100A12, S100A14 and APP. Constitutive homodimer; disulfide-linked (By similarity). Interacts with S100B and S100A1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
S100bP046313EBI-6479195,EBI-2696631

Protein-protein interaction databases

IntActiQ63495, 2 interactors
STRINGi10116.ENSRNOP00000000508

Structurei

3D structure databases

ProteinModelPortaliQ63495
SMRiQ63495
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 109Ig-like V-typeAdd BLAST87
Domaini123 – 219Ig-like C2-type 1Add BLAST97
Domaini233 – 315Ig-like C2-type 2Add BLAST83

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVT2 Eukaryota
ENOG4111C4I LUCA
HOGENOMiHOG000232122
HOVERGENiHBG004350
InParanoidiQ63495
PhylomeDBiQ63495

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTGTVARAW VLVLALWGAV AGGQNITARI GEPLMLSCKG APKKPTQKLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGDP WDSVARILPN GSLLLPAIGI VDEGTFRCRA
110 120 130 140 150
TNRLGKEVKS NYRVRVYQIP GKPEIVNPAS ELTANVPNKV GTCVSEGSYP
160 170 180 190 200
AGTLSWHLDG KPLIPDGKGT VVKEETRRHP ETGLFTLRSE LTVTPAQGGT
210 220 230 240 250
TPTYSCSFSL GLPRRRPLNT APIQPRVREP LPPEGIQLLV EPEGGTVAPG
260 270 280 290 300
GTVTLTCAIS AQPPPQIHWI KDGTPLPLAP SPVLLLPEVG HEDEGIYSCV
310 320 330 340 350
ATHPSHGPQE SPPVNIRVTE TGDEGQAAGS VDGSGLGTLA LALGILGGLG
360 370 380 390 400
IAALLIGAIL WRKRQPRLEE RKAPESQEDE EERAELNQSE EAEMPENGAG

GP
Length:402
Mass (Da):42,664
Last modified:November 1, 1997 - v1
Checksum:i594481BC3A51E94E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33413 mRNA Translation: AAA42027.1
UniGeneiRn.9829

Genome annotation databases

UCSCiRGD:69258 rat

Entry informationi

Entry nameiRAGE_RAT
AccessioniPrimary (citable) accession number: Q63495
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health