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Protein

Voltage-gated potassium channel subunit beta-3

Gene

Kcnab3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.4 but not Kv1.1 or Kv1.5.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-RNO-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-3
Alternative name(s):
K(+) channel subunit beta-3
Kv-beta-3
RCK beta3
Gene namesi
Name:Kcnab3
Synonyms:Ckbeta3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61830 Kcnab3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001487521 – 404Voltage-gated potassium channel subunit beta-3Add BLAST404

Proteomic databases

PaxDbiQ63494
PRIDEiQ63494

PTM databases

iPTMnetiQ63494
PhosphoSitePlusiQ63494

Expressioni

Tissue specificityi

Predominantly expressed in brain. Strongest expression in olfactory bulb and thalamic nuclei. Not detected in heart, spleen, lung, liver, skeletal muscle, kidney and testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000008480
GenevisibleiQ63494 RN

Interactioni

Subunit structurei

Forms heteromultimeric complex with alpha subunits.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011523

Structurei

3D structure databases

ProteinModelPortaliQ63494
SMRiQ63494
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
HOGENOMiHOG000250283
HOVERGENiHBG052216
InParanoidiQ63494
KOiK04884
OMAiQMALAWT
OrthoDBiEOG091G0KDN
PhylomeDBiQ63494
TreeFamiTF324563

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR005402 K_chnl_volt-dep_bsu_KCNAB3
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01580 KCNAB3CHANEL
PR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit

Sequencei

Sequence statusi: Complete.

Q63494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPVGGGH GNPPGGGGLG
60 70 80 90 100
SKSRTAVVPR PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT
110 120 130 140 150
FGSQISDETA EDLLTVAYEH GVNLFDTAEV YAAGKAERTL GNILKSKGWR
160 170 180 190 200
RSSYVITTKI FWGGQAETER GLSRKHIIEG LQGSLDRLQL EYVDIVFANR
210 220 230 240 250
SDPSSPMEEI VRAMTYVINQ GLALYWGTSR WSAAEIMEAY SMARQFNLIP
260 270 280 290 300
PVCEQAENHF FQREKVEMQL PELYHKIGVG SVTWSPLACS LITSKYDGQV
310 320 330 340 350
PDACKATVKG YQWLKEKVQS EDGKKQQARV TDLLPIAHQL GCTVAQLAIA
360 370 380 390 400
WCLRSEGVSS VLLGVSSAEQ LMEHLGSLQV LGQLTPQTVM EIDALLGNKS

HSKK
Length:404
Mass (Da):43,690
Last modified:November 1, 1996 - v1
Checksum:i7F39B80D15E71A03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76723 mRNA Translation: CAA54141.1
AY903239 Genomic DNA Translation: AAX85369.1
AY903240 Genomic DNA Translation: AAX85370.1
AY903241 Genomic DNA Translation: AAX85371.1
PIRiS68409
RefSeqiNP_113840.1, NM_031652.1
UniGeneiRn.11260

Genome annotation databases

EnsembliENSRNOT00000011523; ENSRNOP00000011523; ENSRNOG00000008480
GeneIDi58981
KEGGirno:58981
UCSCiRGD:61830 rat

Similar proteinsi

Entry informationi

Entry nameiKCAB3_RAT
AccessioniPrimary (citable) accession number: Q63494
Secondary accession number(s): Q2KML7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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