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Protein

Sodium-dependent phosphate transporter 2

Gene

Slc20a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Functions as a retroviral receptor (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-427652. Sodium-coupled phosphate cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name:
PiT-2
Receptor for amphotropic viruses 1
Short name:
RAM-1
Solute carrier family 20 member 2
Gene namesi
Name:Slc20a2
Synonyms:Pit2, Ram1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi3699. Slc20a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5ExtracellularSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 46CytoplasmicSequence analysisAdd BLAST20
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 86ExtracellularSequence analysisAdd BLAST19
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 109CytoplasmicSequence analysis2
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 142ExtracellularSequence analysisAdd BLAST12
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 190CytoplasmicSequence analysisAdd BLAST27
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 213ExtracellularSequence analysis2
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 483CytoplasmicSequence analysisAdd BLAST249
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 531ExtracellularSequence analysisAdd BLAST27
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 572CytoplasmicSequence analysisAdd BLAST20
Transmembranei573 – 586HelicalSequence analysisAdd BLAST14
Topological domaini587 – 594ExtracellularSequence analysis8
Transmembranei595 – 610HelicalSequence analysisAdd BLAST16
Topological domaini611 – 622CytoplasmicBy similarityAdd BLAST12
Transmembranei623 – 643HelicalSequence analysisAdd BLAST21
Topological domaini644 – 655ExtracellularSequence analysisAdd BLAST12

GO - Cellular componenti

  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003412701 – 656Sodium-dependent phosphate transporter 2Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Modified residuei253PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei268PhosphoserineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63488.
PRIDEiQ63488.

PTM databases

iPTMnetiQ63488.
PhosphoSitePlusiQ63488.

Expressioni

Tissue specificityi

Widely expressed with highest levels in liver, heart and brain.1 Publication

Gene expression databases

BgeeiENSRNOG00000019490.
ExpressionAtlasiQ63488. baseline and differential.
GenevisibleiQ63488. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi248142. 1 interactor.
STRINGi10116.ENSRNOP00000026418.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2493. Eukaryota.
COG0306. LUCA.
GeneTreeiENSGT00390000014879.
HOVERGENiHBG053358.
InParanoidiQ63488.
KOiK14640.
OMAiSWFVTPV.
OrthoDBiEOG091G07J5.
PhylomeDBiQ63488.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL
60 70 80 90 100
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV
110 120 130 140 150
WQLIASFLRL PISGTHCIVG STIGFSLVAI GPKGVQWMEL VKIVASWFIS
160 170 180 190 200
PLLSGFMSGV LFILIRMFIL TKEDPVPNGL QALPLFYAAT IAINVFSIMY
210 220 230 240 250
TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR KIAGRLEKES
260 270 280 290 300
ALSRASDESL RKVQEAESPV FKELPGAKAS DDSAVPLTSL AGEAAGASEG
310 320 330 340 350
TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD
360 370 380 390 400
SGLYKDLLHK IHVDKGPEEK PAQENNYRLL RRNNSYTCYT AAICGMPVHA
410 420 430 440 450
TFRASDTSSA PEDSEKLVGD TVSYSKKRLR YDSYSSYCNA VAEAEIEAEE
460 470 480 490 500
GGVEMRLASE LTDPDQPHED PAEDEKEEKD SAEVHLLFHF LQVLTACFGS
510 520 530 540 550
FAHGGNDVSN AIGPLVALWL IYKQGGVTQE AATPVWLLFY GGVGICTGLW
560 570 580 590 600
VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV
610 620 630 640 650
GSVVAVGWIR SRKAVDWRLF RNIFIAWFVT VPVAGLFSAA IMALLMYICG

FVSSSR
Length:656
Mass (Da):70,748
Last modified:November 1, 1996 - v1
Checksum:i448AAB3EC5D64DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19931 mRNA. Translation: AAA16532.1.
BC070908 mRNA. Translation: AAH70908.1.
PIRiA49579.
RefSeqiNP_058919.1. NM_017223.2.
XP_008769573.1. XM_008771351.2.
XP_008769574.1. XM_008771352.2.
XP_017455543.1. XM_017600054.1.
UniGeneiRn.13642.
Rn.217359.

Genome annotation databases

EnsembliENSRNOT00000026418; ENSRNOP00000026418; ENSRNOG00000019490.
GeneIDi29502.
KEGGirno:29502.
UCSCiRGD:3699. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19931 mRNA. Translation: AAA16532.1.
BC070908 mRNA. Translation: AAH70908.1.
PIRiA49579.
RefSeqiNP_058919.1. NM_017223.2.
XP_008769573.1. XM_008771351.2.
XP_008769574.1. XM_008771352.2.
XP_017455543.1. XM_017600054.1.
UniGeneiRn.13642.
Rn.217359.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248142. 1 interactor.
STRINGi10116.ENSRNOP00000026418.

PTM databases

iPTMnetiQ63488.
PhosphoSitePlusiQ63488.

Proteomic databases

PaxDbiQ63488.
PRIDEiQ63488.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026418; ENSRNOP00000026418; ENSRNOG00000019490.
GeneIDi29502.
KEGGirno:29502.
UCSCiRGD:3699. rat.

Organism-specific databases

CTDi6575.
RGDi3699. Slc20a2.

Phylogenomic databases

eggNOGiKOG2493. Eukaryota.
COG0306. LUCA.
GeneTreeiENSGT00390000014879.
HOVERGENiHBG053358.
InParanoidiQ63488.
KOiK14640.
OMAiSWFVTPV.
OrthoDBiEOG091G07J5.
PhylomeDBiQ63488.

Enzyme and pathway databases

ReactomeiR-RNO-427652. Sodium-coupled phosphate cotransporters.

Miscellaneous databases

PROiQ63488.

Gene expression databases

BgeeiENSRNOG00000019490.
ExpressionAtlasiQ63488. baseline and differential.
GenevisibleiQ63488. RN.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS20A2_RAT
AccessioniPrimary (citable) accession number: Q63488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.