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Protein

Sodium-dependent phosphate transporter 2

Gene

Slc20a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Functions as a retroviral receptor (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processHost-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-RNO-427652 Sodium-coupled phosphate cotransporters

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name:
PiT-2
Receptor for amphotropic viruses 1
Short name:
RAM-1
Solute carrier family 20 member 2
Gene namesi
Name:Slc20a2
Synonyms:Pit2, Ram1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi3699 Slc20a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5ExtracellularSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 46CytoplasmicSequence analysisAdd BLAST20
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 86ExtracellularSequence analysisAdd BLAST19
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 109CytoplasmicSequence analysis2
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 142ExtracellularSequence analysisAdd BLAST12
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 190CytoplasmicSequence analysisAdd BLAST27
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 213ExtracellularSequence analysis2
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 483CytoplasmicSequence analysisAdd BLAST249
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 531ExtracellularSequence analysisAdd BLAST27
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 572CytoplasmicSequence analysisAdd BLAST20
Transmembranei573 – 586HelicalSequence analysisAdd BLAST14
Topological domaini587 – 594ExtracellularSequence analysis8
Transmembranei595 – 610HelicalSequence analysisAdd BLAST16
Topological domaini611 – 622CytoplasmicBy similarityAdd BLAST12
Transmembranei623 – 643HelicalSequence analysisAdd BLAST21
Topological domaini644 – 655ExtracellularSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003412701 – 656Sodium-dependent phosphate transporter 2Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei253PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei268PhosphoserineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63488
PRIDEiQ63488

PTM databases

iPTMnetiQ63488
PhosphoSitePlusiQ63488

Expressioni

Tissue specificityi

Widely expressed with highest levels in liver, heart and brain.1 Publication

Gene expression databases

BgeeiENSRNOG00000019490
ExpressionAtlasiQ63488 baseline and differential
GenevisibleiQ63488 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi248142, 1 interactor
STRINGi10116.ENSRNOP00000026418

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2493 Eukaryota
COG0306 LUCA
GeneTreeiENSGT00390000014879
HOVERGENiHBG053358
InParanoidiQ63488
KOiK14640
OMAiWMRRKIT
OrthoDBiEOG091G07J5
PhylomeDBiQ63488

Family and domain databases

InterProiView protein in InterPro
IPR001204 Phos_transporter
PANTHERiPTHR11101 PTHR11101, 1 hit
PfamiView protein in Pfam
PF01384 PHO4, 1 hit

Sequencei

Sequence statusi: Complete.

Q63488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL
60 70 80 90 100
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV
110 120 130 140 150
WQLIASFLRL PISGTHCIVG STIGFSLVAI GPKGVQWMEL VKIVASWFIS
160 170 180 190 200
PLLSGFMSGV LFILIRMFIL TKEDPVPNGL QALPLFYAAT IAINVFSIMY
210 220 230 240 250
TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR KIAGRLEKES
260 270 280 290 300
ALSRASDESL RKVQEAESPV FKELPGAKAS DDSAVPLTSL AGEAAGASEG
310 320 330 340 350
TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD
360 370 380 390 400
SGLYKDLLHK IHVDKGPEEK PAQENNYRLL RRNNSYTCYT AAICGMPVHA
410 420 430 440 450
TFRASDTSSA PEDSEKLVGD TVSYSKKRLR YDSYSSYCNA VAEAEIEAEE
460 470 480 490 500
GGVEMRLASE LTDPDQPHED PAEDEKEEKD SAEVHLLFHF LQVLTACFGS
510 520 530 540 550
FAHGGNDVSN AIGPLVALWL IYKQGGVTQE AATPVWLLFY GGVGICTGLW
560 570 580 590 600
VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV
610 620 630 640 650
GSVVAVGWIR SRKAVDWRLF RNIFIAWFVT VPVAGLFSAA IMALLMYICG

FVSSSR
Length:656
Mass (Da):70,748
Last modified:November 1, 1996 - v1
Checksum:i448AAB3EC5D64DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19931 mRNA Translation: AAA16532.1
BC070908 mRNA Translation: AAH70908.1
PIRiA49579
RefSeqiNP_058919.1, NM_017223.2
XP_008769573.1, XM_008771351.2
XP_008769574.1, XM_008771352.2
XP_017455543.1, XM_017600054.1
UniGeneiRn.13642
Rn.217359

Genome annotation databases

EnsembliENSRNOT00000026418; ENSRNOP00000026418; ENSRNOG00000019490
GeneIDi29502
KEGGirno:29502
UCSCiRGD:3699 rat

Similar proteinsi

Entry informationi

Entry nameiS20A2_RAT
AccessioniPrimary (citable) accession number: Q63488
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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