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Protein

Sodium-dependent phosphate transporter 2

Gene

Slc20a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Functions as a retroviral receptor (By similarity).By similarity

GO - Molecular functioni

  1. inorganic phosphate transmembrane transporter activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. phosphate ion transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
  3. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_299818. Sodium-coupled phosphate cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name:
PiT-2
Receptor for amphotropic viruses 1
Short name:
RAM-1
Solute carrier family 20 member 2
Gene namesi
Name:Slc20a2
Synonyms:Pit2, Ram1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3699. Slc20a2.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55ExtracellularSequence Analysis
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST
Topological domaini27 – 4620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence AnalysisAdd
BLAST
Topological domaini68 – 8619ExtracellularSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Topological domaini108 – 1092CytoplasmicSequence Analysis
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Topological domaini131 – 14212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 19027CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence AnalysisAdd
BLAST
Topological domaini212 – 2132ExtracellularSequence Analysis
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Topological domaini235 – 483249CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST
Topological domaini505 – 53127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence AnalysisAdd
BLAST
Topological domaini553 – 57220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei573 – 58614HelicalSequence AnalysisAdd
BLAST
Topological domaini587 – 5948ExtracellularSequence Analysis
Transmembranei595 – 61016HelicalSequence AnalysisAdd
BLAST
Topological domaini611 – 62212CytoplasmicBy similarityAdd
BLAST
Transmembranei623 – 64321HelicalSequence AnalysisAdd
BLAST
Topological domaini644 – 65512ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: RGD
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Sodium-dependent phosphate transporter 2PRO_0000341270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Modified residuei259 – 2591PhosphoserineBy similarity
Modified residuei268 – 2681PhosphoserineBy similarity
Modified residuei316 – 3161PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ63488.

Expressioni

Tissue specificityi

Widely expressed with highest levels in liver, heart and brain.1 Publication

Gene expression databases

ExpressionAtlasiQ63488. baseline and differential.
GenevestigatoriQ63488.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi248142. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053358.
InParanoidiQ63488.
KOiK14640.
PhylomeDBiQ63488.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL
60 70 80 90 100
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV
110 120 130 140 150
WQLIASFLRL PISGTHCIVG STIGFSLVAI GPKGVQWMEL VKIVASWFIS
160 170 180 190 200
PLLSGFMSGV LFILIRMFIL TKEDPVPNGL QALPLFYAAT IAINVFSIMY
210 220 230 240 250
TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR KIAGRLEKES
260 270 280 290 300
ALSRASDESL RKVQEAESPV FKELPGAKAS DDSAVPLTSL AGEAAGASEG
310 320 330 340 350
TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD
360 370 380 390 400
SGLYKDLLHK IHVDKGPEEK PAQENNYRLL RRNNSYTCYT AAICGMPVHA
410 420 430 440 450
TFRASDTSSA PEDSEKLVGD TVSYSKKRLR YDSYSSYCNA VAEAEIEAEE
460 470 480 490 500
GGVEMRLASE LTDPDQPHED PAEDEKEEKD SAEVHLLFHF LQVLTACFGS
510 520 530 540 550
FAHGGNDVSN AIGPLVALWL IYKQGGVTQE AATPVWLLFY GGVGICTGLW
560 570 580 590 600
VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV
610 620 630 640 650
GSVVAVGWIR SRKAVDWRLF RNIFIAWFVT VPVAGLFSAA IMALLMYICG

FVSSSR
Length:656
Mass (Da):70,748
Last modified:October 31, 1996 - v1
Checksum:i448AAB3EC5D64DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19931 mRNA. Translation: AAA16532.1.
BC070908 mRNA. Translation: AAH70908.1.
PIRiA49579.
RefSeqiNP_058919.1. NM_017223.2.
XP_008769573.1. XM_008771351.1.
XP_008769574.1. XM_008771352.1.
UniGeneiRn.13642.
Rn.217359.

Genome annotation databases

GeneIDi29502.
KEGGirno:29502.
UCSCiRGD:3699. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19931 mRNA. Translation: AAA16532.1.
BC070908 mRNA. Translation: AAH70908.1.
PIRiA49579.
RefSeqiNP_058919.1. NM_017223.2.
XP_008769573.1. XM_008771351.1.
XP_008769574.1. XM_008771352.1.
UniGeneiRn.13642.
Rn.217359.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248142. 1 interaction.

Proteomic databases

PRIDEiQ63488.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29502.
KEGGirno:29502.
UCSCiRGD:3699. rat.

Organism-specific databases

CTDi6575.
RGDi3699. Slc20a2.

Phylogenomic databases

HOVERGENiHBG053358.
InParanoidiQ63488.
KOiK14640.
PhylomeDBiQ63488.

Enzyme and pathway databases

ReactomeiREACT_299818. Sodium-coupled phosphate cotransporters.

Miscellaneous databases

NextBioi609408.
PROiQ63488.

Gene expression databases

ExpressionAtlasiQ63488. baseline and differential.
GenevestigatoriQ63488.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus."
    Miller D.G., Edwards R.H., Miller A.D.
    Proc. Natl. Acad. Sci. U.S.A. 91:78-82(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters."
    Kavanaugh M.P., Miller D.G., Zhang W., Law W., Kozak S.L., Kabat D., Miller A.D.
    Proc. Natl. Acad. Sci. U.S.A. 91:7071-7075(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS20A2_RAT
AccessioniPrimary (citable) accession number: Q63488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 9, 2008
Last sequence update: October 31, 1996
Last modified: March 31, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.