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Q63488

- S20A2_RAT

UniProt

Q63488 - S20A2_RAT

Protein

Sodium-dependent phosphate transporter 2

Gene

Slc20a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Functions as a retroviral receptor By similarity.By similarity

    GO - Molecular functioni

    1. inorganic phosphate transmembrane transporter activity Source: InterPro
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. phosphate ion transport Source: UniProtKB-KW
    2. sodium ion transport Source: UniProtKB-KW
    3. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent phosphate transporter 2
    Alternative name(s):
    Phosphate transporter 2
    Short name:
    PiT-2
    Receptor for amphotropic viruses 1
    Short name:
    RAM-1
    Solute carrier family 20 member 2
    Gene namesi
    Name:Slc20a2
    Synonyms:Pit2, Ram1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3699. Slc20a2.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: RGD
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 656656Sodium-dependent phosphate transporter 2PRO_0000341270Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Modified residuei268 – 2681PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ63488.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in liver, heart and brain.1 Publication

    Gene expression databases

    GenevestigatoriQ63488.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi248142. 1 interaction.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55ExtracellularSequence Analysis
    Topological domaini27 – 4620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 1092CytoplasmicSequence Analysis
    Topological domaini131 – 14212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini164 – 19027CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini212 – 2132ExtracellularSequence Analysis
    Topological domaini235 – 483249CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini505 – 53127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini553 – 57220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini587 – 5948ExtracellularSequence Analysis
    Topological domaini611 – 62212CytoplasmicBy similarityAdd
    BLAST
    Topological domaini644 – 65512ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei532 – 55221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei573 – 58614HelicalSequence AnalysisAdd
    BLAST
    Transmembranei595 – 61016HelicalSequence AnalysisAdd
    BLAST
    Transmembranei623 – 64321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG053358.
    KOiK14640.
    PhylomeDBiQ63488.

    Family and domain databases

    InterProiIPR001204. Phos_transporter.
    [Graphical view]
    PANTHERiPTHR11101. PTHR11101. 1 hit.
    PfamiPF01384. PHO4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63488-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL    50
    ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV 100
    WQLIASFLRL PISGTHCIVG STIGFSLVAI GPKGVQWMEL VKIVASWFIS 150
    PLLSGFMSGV LFILIRMFIL TKEDPVPNGL QALPLFYAAT IAINVFSIMY 200
    TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR KIAGRLEKES 250
    ALSRASDESL RKVQEAESPV FKELPGAKAS DDSAVPLTSL AGEAAGASEG 300
    TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD 350
    SGLYKDLLHK IHVDKGPEEK PAQENNYRLL RRNNSYTCYT AAICGMPVHA 400
    TFRASDTSSA PEDSEKLVGD TVSYSKKRLR YDSYSSYCNA VAEAEIEAEE 450
    GGVEMRLASE LTDPDQPHED PAEDEKEEKD SAEVHLLFHF LQVLTACFGS 500
    FAHGGNDVSN AIGPLVALWL IYKQGGVTQE AATPVWLLFY GGVGICTGLW 550
    VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV 600
    GSVVAVGWIR SRKAVDWRLF RNIFIAWFVT VPVAGLFSAA IMALLMYICG 650
    FVSSSR 656
    Length:656
    Mass (Da):70,748
    Last modified:November 1, 1996 - v1
    Checksum:i448AAB3EC5D64DC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19931 mRNA. Translation: AAA16532.1.
    BC070908 mRNA. Translation: AAH70908.1.
    PIRiA49579.
    RefSeqiNP_058919.1. NM_017223.2.
    UniGeneiRn.13642.
    Rn.217359.

    Genome annotation databases

    GeneIDi29502.
    KEGGirno:29502.
    UCSCiRGD:3699. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19931 mRNA. Translation: AAA16532.1 .
    BC070908 mRNA. Translation: AAH70908.1 .
    PIRi A49579.
    RefSeqi NP_058919.1. NM_017223.2.
    UniGenei Rn.13642.
    Rn.217359.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248142. 1 interaction.

    Proteomic databases

    PRIDEi Q63488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29502.
    KEGGi rno:29502.
    UCSCi RGD:3699. rat.

    Organism-specific databases

    CTDi 6575.
    RGDi 3699. Slc20a2.

    Phylogenomic databases

    HOVERGENi HBG053358.
    KOi K14640.
    PhylomeDBi Q63488.

    Miscellaneous databases

    NextBioi 609408.
    PROi Q63488.

    Gene expression databases

    Genevestigatori Q63488.

    Family and domain databases

    InterProi IPR001204. Phos_transporter.
    [Graphical view ]
    PANTHERi PTHR11101. PTHR11101. 1 hit.
    Pfami PF01384. PHO4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus."
      Miller D.G., Edwards R.H., Miller A.D.
      Proc. Natl. Acad. Sci. U.S.A. 91:78-82(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters."
      Kavanaugh M.P., Miller D.G., Zhang W., Law W., Kozak S.L., Kabat D., Miller A.D.
      Proc. Natl. Acad. Sci. U.S.A. 91:7071-7075(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS20A2_RAT
    AccessioniPrimary (citable) accession number: Q63488
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3