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Q63488

- S20A2_RAT

UniProt

Q63488 - S20A2_RAT

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Protein

Sodium-dependent phosphate transporter 2

Gene
Slc20a2, Pit2, Ram1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Functions as a retroviral receptor By similarity.1 Publication

GO - Molecular functioni

  1. inorganic phosphate transmembrane transporter activity Source: InterPro
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. phosphate ion transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
  3. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction, Ion transport, Phosphate transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name:
PiT-2
Receptor for amphotropic viruses 1
Short name:
RAM-1
Solute carrier family 20 member 2
Gene namesi
Name:Slc20a2
Synonyms:Pit2, Ram1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3699. Slc20a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55Extracellular Reviewed prediction
Transmembranei6 – 2621Helical; Reviewed predictionAdd
BLAST
Topological domaini27 – 4620Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei47 – 6721Helical; Reviewed predictionAdd
BLAST
Topological domaini68 – 8619Extracellular Reviewed predictionAdd
BLAST
Transmembranei87 – 10721Helical; Reviewed predictionAdd
BLAST
Topological domaini108 – 1092Cytoplasmic Reviewed prediction
Transmembranei110 – 13021Helical; Reviewed predictionAdd
BLAST
Topological domaini131 – 14212Extracellular Reviewed predictionAdd
BLAST
Transmembranei143 – 16321Helical; Reviewed predictionAdd
BLAST
Topological domaini164 – 19027Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei191 – 21121Helical; Reviewed predictionAdd
BLAST
Topological domaini212 – 2132Extracellular Reviewed prediction
Transmembranei214 – 23421Helical; Reviewed predictionAdd
BLAST
Topological domaini235 – 483249Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei484 – 50421Helical; Reviewed predictionAdd
BLAST
Topological domaini505 – 53127Extracellular Reviewed predictionAdd
BLAST
Transmembranei532 – 55221Helical; Reviewed predictionAdd
BLAST
Topological domaini553 – 57220Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei573 – 58614Helical; Reviewed predictionAdd
BLAST
Topological domaini587 – 5948Extracellular Reviewed prediction
Transmembranei595 – 61016Helical; Reviewed predictionAdd
BLAST
Topological domaini611 – 62212Cytoplasmic By similarityAdd
BLAST
Transmembranei623 – 64321Helical; Reviewed predictionAdd
BLAST
Topological domaini644 – 65512Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: RGD
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Sodium-dependent phosphate transporter 2PRO_0000341270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Modified residuei268 – 2681Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ63488.

Expressioni

Tissue specificityi

Widely expressed with highest levels in liver, heart and brain.1 Publication

Gene expression databases

GenevestigatoriQ63488.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

BioGridi248142. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053358.
KOiK14640.
PhylomeDBiQ63488.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63488-1 [UniParc]FASTAAdd to Basket

« Hide

MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL    50
ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV 100
WQLIASFLRL PISGTHCIVG STIGFSLVAI GPKGVQWMEL VKIVASWFIS 150
PLLSGFMSGV LFILIRMFIL TKEDPVPNGL QALPLFYAAT IAINVFSIMY 200
TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR KIAGRLEKES 250
ALSRASDESL RKVQEAESPV FKELPGAKAS DDSAVPLTSL AGEAAGASEG 300
TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD 350
SGLYKDLLHK IHVDKGPEEK PAQENNYRLL RRNNSYTCYT AAICGMPVHA 400
TFRASDTSSA PEDSEKLVGD TVSYSKKRLR YDSYSSYCNA VAEAEIEAEE 450
GGVEMRLASE LTDPDQPHED PAEDEKEEKD SAEVHLLFHF LQVLTACFGS 500
FAHGGNDVSN AIGPLVALWL IYKQGGVTQE AATPVWLLFY GGVGICTGLW 550
VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV 600
GSVVAVGWIR SRKAVDWRLF RNIFIAWFVT VPVAGLFSAA IMALLMYICG 650
FVSSSR 656
Length:656
Mass (Da):70,748
Last modified:November 1, 1996 - v1
Checksum:i448AAB3EC5D64DC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19931 mRNA. Translation: AAA16532.1.
BC070908 mRNA. Translation: AAH70908.1.
PIRiA49579.
RefSeqiNP_058919.1. NM_017223.2.
UniGeneiRn.13642.
Rn.217359.

Genome annotation databases

GeneIDi29502.
KEGGirno:29502.
UCSCiRGD:3699. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19931 mRNA. Translation: AAA16532.1 .
BC070908 mRNA. Translation: AAH70908.1 .
PIRi A49579.
RefSeqi NP_058919.1. NM_017223.2.
UniGenei Rn.13642.
Rn.217359.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248142. 1 interaction.

Proteomic databases

PRIDEi Q63488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29502.
KEGGi rno:29502.
UCSCi RGD:3699. rat.

Organism-specific databases

CTDi 6575.
RGDi 3699. Slc20a2.

Phylogenomic databases

HOVERGENi HBG053358.
KOi K14640.
PhylomeDBi Q63488.

Miscellaneous databases

NextBioi 609408.
PROi Q63488.

Gene expression databases

Genevestigatori Q63488.

Family and domain databases

InterProi IPR001204. Phos_transporter.
[Graphical view ]
PANTHERi PTHR11101. PTHR11101. 1 hit.
Pfami PF01384. PHO4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus."
    Miller D.G., Edwards R.H., Miller A.D.
    Proc. Natl. Acad. Sci. U.S.A. 91:78-82(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters."
    Kavanaugh M.P., Miller D.G., Zhang W., Law W., Kozak S.L., Kabat D., Miller A.D.
    Proc. Natl. Acad. Sci. U.S.A. 91:7071-7075(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS20A2_RAT
AccessioniPrimary (citable) accession number: Q63488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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