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Q63488 (S20A2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-dependent phosphate transporter 2
Alternative name(s):
Phosphate transporter 2
Short name=PiT-2
Receptor for amphotropic viruses 1
Short name=RAM-1
Solute carrier family 20 member 2
Gene names
Name:Slc20a2
Synonyms:Pit2, Ram1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length656 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Functions as a retroviral receptor By similarity. Ref.3

Subunit structure

Homodimer By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Widely expressed with highest levels in liver, heart and brain. Ref.3

Sequence similarities

Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 656656Sodium-dependent phosphate transporter 2
PRO_0000341270

Regions

Topological domain1 – 55Extracellular Potential
Transmembrane6 – 2621Helical; Potential
Topological domain27 – 4620Cytoplasmic Potential
Transmembrane47 – 6721Helical; Potential
Topological domain68 – 8619Extracellular Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 1092Cytoplasmic Potential
Transmembrane110 – 13021Helical; Potential
Topological domain131 – 14212Extracellular Potential
Transmembrane143 – 16321Helical; Potential
Topological domain164 – 19027Cytoplasmic Potential
Transmembrane191 – 21121Helical; Potential
Topological domain212 – 2132Extracellular Potential
Transmembrane214 – 23421Helical; Potential
Topological domain235 – 483249Cytoplasmic Potential
Transmembrane484 – 50421Helical; Potential
Topological domain505 – 53127Extracellular Potential
Transmembrane532 – 55221Helical; Potential
Topological domain553 – 57220Cytoplasmic Potential
Transmembrane573 – 58614Helical; Potential
Topological domain587 – 5948Extracellular Potential
Transmembrane595 – 61016Helical; Potential
Topological domain611 – 62212Cytoplasmic By similarity
Transmembrane623 – 64321Helical; Potential
Topological domain644 – 65512Extracellular Potential

Amino acid modifications

Modified residue2681Phosphoserine By similarity
Glycosylation811N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q63488 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 448AAB3EC5D64DC1

FASTA65670,748
        10         20         30         40         50         60 
MAMDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETTGSV 

        70         80         90        100        110        120 
LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV WQLIASFLRL PISGTHCIVG 

       130        140        150        160        170        180 
STIGFSLVAI GPKGVQWMEL VKIVASWFIS PLLSGFMSGV LFILIRMFIL TKEDPVPNGL 

       190        200        210        220        230        240 
QALPLFYAAT IAINVFSIMY TGAPVLGLSL PIWAIALISF GVALLFAFFV WLFVCPWMKR 

       250        260        270        280        290        300 
KIAGRLEKES ALSRASDESL RKVQEAESPV FKELPGAKAS DDSAVPLTSL AGEAAGASEG 

       310        320        330        340        350        360 
TSAGNHPRAS YGRALSMTHG SAKSPISNGT FGFEGHMRND GHVYHTVHKD SGLYKDLLHK 

       370        380        390        400        410        420 
IHVDKGPEEK PAQENNYRLL RRNNSYTCYT AAICGMPVHA TFRASDTSSA PEDSEKLVGD 

       430        440        450        460        470        480 
TVSYSKKRLR YDSYSSYCNA VAEAEIEAEE GGVEMRLASE LTDPDQPHED PAEDEKEEKD 

       490        500        510        520        530        540 
SAEVHLLFHF LQVLTACFGS FAHGGNDVSN AIGPLVALWL IYKQGGVTQE AATPVWLLFY 

       550        560        570        580        590        600 
GGVGICTGLW VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNIG LPVSTTHCKV 

       610        620        630        640        650 
GSVVAVGWIR SRKAVDWRLF RNIFIAWFVT VPVAGLFSAA IMALLMYICG FVSSSR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus."
Miller D.G., Edwards R.H., Miller A.D.
Proc. Natl. Acad. Sci. U.S.A. 91:78-82(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]"Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters."
Kavanaugh M.P., Miller D.G., Zhang W., Law W., Kozak S.L., Kabat D., Miller A.D.
Proc. Natl. Acad. Sci. U.S.A. 91:7071-7075(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS SODIUM-PHOSPHATE SYMPORTER, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19931 mRNA. Translation: AAA16532.1.
BC070908 mRNA. Translation: AAH70908.1.
PIRA49579.
RefSeqNP_058919.1. NM_017223.2.
UniGeneRn.13642.
Rn.217359.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248142. 1 interaction.

Proteomic databases

PRIDEQ63488.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29502.
KEGGrno:29502.
UCSCRGD:3699. rat.

Organism-specific databases

CTD6575.
RGD3699. Slc20a2.

Phylogenomic databases

HOVERGENHBG053358.
KOK14640.
PhylomeDBQ63488.

Gene expression databases

GenevestigatorQ63488.

Family and domain databases

InterProIPR001204. Phos_transporter.
[Graphical view]
PANTHERPTHR11101. PTHR11101. 1 hit.
PfamPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609408.
PROQ63488.

Entry information

Entry nameS20A2_RAT
AccessionPrimary (citable) accession number: Q63488
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families