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Q63481

- RAB7L_RAT

UniProt

Q63481 - RAB7L_RAT

Protein

Ras-related protein Rab-7L1

Gene

Rab29

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates also neuronal process morphology in the intact central nervous system (CNS).1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 218GTPBy similarity
    Nucleotide bindingi33 – 397GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi125 – 1284GTPBy similarity
    Nucleotide bindingi156 – 1572GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: RGD
    2. GTP binding Source: RGD
    3. protein binding Source: IntAct

    GO - Biological processi

    1. Golgi organization Source: UniProtKB
    2. GTP catabolic process Source: GOC
    3. positive regulation of intracellular protein transport Source: UniProtKB
    4. protein transport Source: UniProtKB-KW
    5. retrograde transport, plasma membrane to Golgi Source: UniProtKB
    6. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Differentiation, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-7L1
    Alternative name(s):
    Rab-7-like protein 1
    Ras-related protein Rab-29
    Gene namesi
    Name:Rab29
    Synonyms:Rab7l1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi620892. Rab7l1.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Golgi apparatus 1 Publication. Golgi apparatustrans-Golgi network By similarity. Cytoplasmcytoskeleton By similarity
    Note: Colocalizes with GM130 at the Golgi apparatus. Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus. Colocalizes with TGN46 at the trans-Golgi network (TGN) By similarity. Colocalized with LRRK2 along tubular structures emerging from Golgi apparatus.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell
    3. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi21 – 211T → N: Abolishes localization at trans-Golgi network (TGN) and affects the integrity of the TGN. Inhibits retrograde trafficking of M6PR-associated vesicles. 1 Publication
    Mutagenesisi67 – 671Q → L: Localizes predominantly in the cytosol. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Ras-related protein Rab-7L1PRO_0000276770Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi203 – 2031S-geranylgeranyl cysteineBy similarity
    Lipidationi204 – 2041S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    PRIDEiQ63481.

    Expressioni

    Tissue specificityi

    Expressed predominantly in kidney and much less in brain, heart, muscle, fat, liver, spleen, adrenal gland, ovary, thymus and lung. Not expressed in testis and intestine.1 Publication

    Gene expression databases

    GenevestigatoriQ63481.

    Interactioni

    Subunit structurei

    Interacts with LRRK2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LRRK2Q5S0073EBI-6513837,EBI-5323863From a different organism.

    Protein-protein interaction databases

    DIPiDIP-60518N.
    IntActiQ63481. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63481.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 449Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00700000104228.
    HOVERGENiHBG009351.
    KOiK07916.
    OMAiLQTKPSS.
    OrthoDBiEOG78M02X.
    PhylomeDBiQ63481.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q63481-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSRDHLFKV LVVGDAAVGK TSLVQRYSQD SFSKHYKSTV GVDFALKVLQ    50
    WSDSEMVRLQ LWDIAGQERF TSMTRLYYRD ASACVIMFDV TNATTFSNSQ 100
    RWKQDLDSKL TLPSGEPVPC LLLANKSDLS PWAVSRDQID RFSKENGFTG 150
    WTETSVKENK NINEAMRVLV EKMMNNSRED IMSSSTQGNY INLQTKPSPG 200
    WTCC 204
    Length:204
    Mass (Da):23,117
    Last modified:November 1, 1996 - v1
    Checksum:i4CFAE889718F20E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96663 mRNA. Translation: CAA65444.1.
    RefSeqiNP_598274.1. NM_133590.1.
    XP_006249806.1. XM_006249744.1.
    XP_006249807.1. XM_006249745.1.
    UniGeneiRn.4323.

    Genome annotation databases

    EnsembliENSRNOT00000073669; ENSRNOP00000067600; ENSRNOG00000049641.
    GeneIDi171122.
    KEGGirno:171122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96663 mRNA. Translation: CAA65444.1 .
    RefSeqi NP_598274.1. NM_133590.1.
    XP_006249806.1. XM_006249744.1.
    XP_006249807.1. XM_006249745.1.
    UniGenei Rn.4323.

    3D structure databases

    ProteinModelPortali Q63481.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60518N.
    IntActi Q63481. 1 interaction.

    Proteomic databases

    PRIDEi Q63481.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000073669 ; ENSRNOP00000067600 ; ENSRNOG00000049641 .
    GeneIDi 171122.
    KEGGi rno:171122.

    Organism-specific databases

    CTDi 171122.
    RGDi 620892. Rab7l1.

    Phylogenomic databases

    GeneTreei ENSGT00700000104228.
    HOVERGENi HBG009351.
    KOi K07916.
    OMAi LQTKPSS.
    OrthoDBi EOG78M02X.
    PhylomeDBi Q63481.

    Miscellaneous databases

    NextBioi 621866.
    PROi Q63481.

    Gene expression databases

    Genevestigatori Q63481.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of two splicing variants of the novel Ras-related GTPase Rab29 which is predominately expressed in kidney."
      Massmann S., Schuermann A.H., Joost H.-G.
      Biochim. Biophys. Acta 1352:48-55(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."
      MacLeod D.A., Rhinn H., Kuwahara T., Zolin A., Di Paolo G., McCabe B.D., MacCabe B.D., Marder K.S., Honig L.S., Clark L.N., Small S.A., Abeliovich A.
      Neuron 77:425-439(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN RETROGRADE TRANSPORT, INTERACTION WITH LRRK2, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-21 AND GLN-67.

    Entry informationi

    Entry nameiRAB7L_RAT
    AccessioniPrimary (citable) accession number: Q63481
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3