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Q63481 (RAB7L_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-7L1
Alternative name(s):
Rab-7-like protein 1
Ras-related protein Rab-29
Gene names
Name:Rab7l1
Synonyms:Rab29
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Expressed predominantly in kidney and much less in brain, heart, muscle, fat, liver, spleen, adrenal gland, ovary, thymus and lung. Not expressed in testis and intestine. Ref.1

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LRRK2Q5S0073EBI-6513837,EBI-5323863From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Ras-related protein Rab-7L1
PRO_0000276770

Regions

Nucleotide binding14 – 218GTP By similarity
Nucleotide binding33 – 397GTP By similarity
Nucleotide binding63 – 675GTP By similarity
Nucleotide binding125 – 1284GTP By similarity
Nucleotide binding156 – 1572GTP By similarity
Motif36 – 449Effector region By similarity

Amino acid modifications

Lipidation2031S-geranylgeranyl cysteine By similarity
Lipidation2041S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63481 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4CFAE889718F20E5

FASTA20423,117
        10         20         30         40         50         60 
MGSRDHLFKV LVVGDAAVGK TSLVQRYSQD SFSKHYKSTV GVDFALKVLQ WSDSEMVRLQ 

        70         80         90        100        110        120 
LWDIAGQERF TSMTRLYYRD ASACVIMFDV TNATTFSNSQ RWKQDLDSKL TLPSGEPVPC 

       130        140        150        160        170        180 
LLLANKSDLS PWAVSRDQID RFSKENGFTG WTETSVKENK NINEAMRVLV EKMMNNSRED 

       190        200 
IMSSSTQGNY INLQTKPSPG WTCC 

« Hide

References

[1]"Cloning of two splicing variants of the novel Ras-related GTPase Rab29 which is predominately expressed in kidney."
Massmann S., Schuermann A.H., Joost H.-G.
Biochim. Biophys. Acta 1352:48-55(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X96663 mRNA. Translation: CAA65444.1.
RefSeqNP_598274.1. NM_133590.1.
XP_006249806.1. XM_006249744.1.
XP_006249807.1. XM_006249745.1.
UniGeneRn.4323.

3D structure databases

ProteinModelPortalQ63481.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60518N.
IntActQ63481. 1 interaction.

Proteomic databases

PRIDEQ63481.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000073669; ENSRNOP00000067600; ENSRNOG00000049641.
GeneID171122.
KEGGrno:171122.

Organism-specific databases

CTD226422.
RGD620892. Rab7l1.

Phylogenomic databases

GeneTreeENSGT00700000104228.
HOVERGENHBG009351.
KOK07916.
OMALQTKPSS.
OrthoDBEOG78M02X.
PhylomeDBQ63481.

Gene expression databases

GenevestigatorQ63481.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio621866.
PROQ63481.

Entry information

Entry nameRAB7L_RAT
AccessionPrimary (citable) accession number: Q63481
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families