Q63481 (RAB7L_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-7L1

Alternative name(s):
Rab-7-like protein 1
Ras-related protein Rab-29

Gene names

Name:	Rab7l1
Synonyms:	Rab29

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Expressed predominantly in kidney and much less in brain, heart, muscle, fat, liver, spleen, adrenal gland, ovary, thymus and lung. Not expressed in testis and intestine. Ref.1
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Traceable author statement Ref.1. Source: RGD GTPase activity Traceable author statement Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Ras-related protein Rab-7L1		PRO_0000276770
Regions
	Nucleotide binding	14 – 21	8	GTP By similarity
	Nucleotide binding	63 – 67	5	GTP By similarity
	Nucleotide binding	125 – 128	4	GTP By similarity
	Motif	36 – 44	9	Effector region By similarity
Amino acid modifications
	Lipidation	203	1	S-geranylgeranyl cysteine By similarity
	Lipidation	204	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63481 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4CFAE889718F20E5	FASTA	204	23,117
	10 20 30 40 50 60 MGSRDHLFKV LVVGDAAVGK TSLVQRYSQD SFSKHYKSTV GVDFALKVLQ WSDSEMVRLQ 70 80 90 100 110 120 LWDIAGQERF TSMTRLYYRD ASACVIMFDV TNATTFSNSQ RWKQDLDSKL TLPSGEPVPC 130 140 150 160 170 180 LLLANKSDLS PWAVSRDQID RFSKENGFTG WTETSVKENK NINEAMRVLV EKMMNNSRED 190 200 IMSSSTQGNY INLQTKPSPG WTCC

References

[1]	"Cloning of two splicing variants of the novel Ras-related GTPase Rab29 which is predominately expressed in kidney." Massmann S., Schuermann A.H., Joost H.-G. Biochim. Biophys. Acta 1352:48-55(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X96663 mRNA. Translation: CAA65444.1.
IPI	IPI00209145.
RefSeq	NP_598274.1. NM_133590.1.
UniGene	Rn.4323.
3D structure databases
HSSP	HSSP built from PDB template 1WMS based on UniProtKB P51151.
ProteinModelPortal	Q63481.
ModBase	Search...
Proteomic databases
PRIDE	Q63481.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000073669; ENSRNOP00000067600; ENSRNOG00000049641.
GeneID	171122.
KEGG	rno:171122.
Organism-specific databases
CTD	8934.
RGD	620892. Rab7l1.
Phylogenomic databases
GeneTree	ENSGT00700000104228.
HOVERGEN	HBG009351.
KO	K07916.
Gene expression databases
Genevestigator	Q63481.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	621866.

Entry information

Entry name

RAB7L_RAT

Accession

Primary (citable) accession number: Q63481

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program