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Q63481

- RAB7L_RAT

UniProt

Q63481 - RAB7L_RAT

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Protein

Ras-related protein Rab-7L1

Gene
Rab29, Rab7l1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates also neuronal process morphology in the intact central nervous system (CNS).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218GTP By similarity
Nucleotide bindingi33 – 397GTP By similarity
Nucleotide bindingi63 – 675GTP By similarity
Nucleotide bindingi125 – 1284GTP By similarity
Nucleotide bindingi156 – 1572GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: RGD
  2. GTP binding Source: RGD
  3. protein binding Source: IntAct

GO - Biological processi

  1. Golgi organization Source: UniProtKB
  2. GTP catabolic process Source: GOC
  3. positive regulation of intracellular protein transport Source: UniProtKB
  4. protein transport Source: UniProtKB-KW
  5. retrograde transport, plasma membrane to Golgi Source: UniProtKB
  6. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Differentiation, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-7L1
Alternative name(s):
Rab-7-like protein 1
Ras-related protein Rab-29
Gene namesi
Name:Rab29
Synonyms:Rab7l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi620892. Rab7l1.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side Reviewed prediction. Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Golgi apparatus. Golgi apparatustrans-Golgi network By similarity. Cytoplasmcytoskeleton By similarity
Note: Colocalizes with GM130 at the Golgi apparatus. Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus. Colocalizes with TGN46 at the trans-Golgi network (TGN) By similarity. Colocalized with LRRK2 along tubular structures emerging from Golgi apparatus.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
  3. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi21 – 211T → N: Abolishes localization at trans-Golgi network (TGN) and affects the integrity of the TGN. Inhibits retrograde trafficking of M6PR-associated vesicles.
Mutagenesisi67 – 671Q → L: Localizes predominantly in the cytosol.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Ras-related protein Rab-7L1PRO_0000276770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi203 – 2031S-geranylgeranyl cysteine By similarity
Lipidationi204 – 2041S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PRIDEiQ63481.

Expressioni

Tissue specificityi

Expressed predominantly in kidney and much less in brain, heart, muscle, fat, liver, spleen, adrenal gland, ovary, thymus and lung. Not expressed in testis and intestine.1 Publication

Gene expression databases

GenevestigatoriQ63481.

Interactioni

Subunit structurei

Interacts with LRRK2.

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0073EBI-6513837,EBI-5323863From a different organism.

Protein-protein interaction databases

DIPiDIP-60518N.
IntActiQ63481. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ63481.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 449Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00700000104228.
HOVERGENiHBG009351.
KOiK07916.
OMAiLQTKPSS.
OrthoDBiEOG78M02X.
PhylomeDBiQ63481.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63481-1 [UniParc]FASTAAdd to Basket

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MGSRDHLFKV LVVGDAAVGK TSLVQRYSQD SFSKHYKSTV GVDFALKVLQ    50
WSDSEMVRLQ LWDIAGQERF TSMTRLYYRD ASACVIMFDV TNATTFSNSQ 100
RWKQDLDSKL TLPSGEPVPC LLLANKSDLS PWAVSRDQID RFSKENGFTG 150
WTETSVKENK NINEAMRVLV EKMMNNSRED IMSSSTQGNY INLQTKPSPG 200
WTCC 204
Length:204
Mass (Da):23,117
Last modified:November 1, 1996 - v1
Checksum:i4CFAE889718F20E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96663 mRNA. Translation: CAA65444.1.
RefSeqiNP_598274.1. NM_133590.1.
XP_006249806.1. XM_006249744.1.
XP_006249807.1. XM_006249745.1.
UniGeneiRn.4323.

Genome annotation databases

EnsembliENSRNOT00000073669; ENSRNOP00000067600; ENSRNOG00000049641.
GeneIDi171122.
KEGGirno:171122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96663 mRNA. Translation: CAA65444.1 .
RefSeqi NP_598274.1. NM_133590.1.
XP_006249806.1. XM_006249744.1.
XP_006249807.1. XM_006249745.1.
UniGenei Rn.4323.

3D structure databases

ProteinModelPortali Q63481.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60518N.
IntActi Q63481. 1 interaction.

Proteomic databases

PRIDEi Q63481.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000073669 ; ENSRNOP00000067600 ; ENSRNOG00000049641 .
GeneIDi 171122.
KEGGi rno:171122.

Organism-specific databases

CTDi 226422.
RGDi 620892. Rab7l1.

Phylogenomic databases

GeneTreei ENSGT00700000104228.
HOVERGENi HBG009351.
KOi K07916.
OMAi LQTKPSS.
OrthoDBi EOG78M02X.
PhylomeDBi Q63481.

Miscellaneous databases

NextBioi 621866.
PROi Q63481.

Gene expression databases

Genevestigatori Q63481.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of two splicing variants of the novel Ras-related GTPase Rab29 which is predominately expressed in kidney."
    Massmann S., Schuermann A.H., Joost H.-G.
    Biochim. Biophys. Acta 1352:48-55(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."
    MacLeod D.A., Rhinn H., Kuwahara T., Zolin A., Di Paolo G., McCabe B.D., MacCabe B.D., Marder K.S., Honig L.S., Clark L.N., Small S.A., Abeliovich A.
    Neuron 77:425-439(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN RETROGRADE TRANSPORT, INTERACTION WITH LRRK2, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-21 AND GLN-67.

Entry informationi

Entry nameiRAB7L_RAT
AccessioniPrimary (citable) accession number: Q63481
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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