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Q63475

- PTPR2_RAT

UniProt

Q63475 - PTPR2_RAT

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Protein

Receptor-type tyrosine-protein phosphatase N2

Gene
Ptprn2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Implicated in development of nervous system and pancreatic endocrine cells.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei415 – 4162Cleavage By similarity
Binding sitei902 – 9021Substrate By similarity
Active sitei934 – 9341Phosphocysteine intermediate Reviewed prediction
Binding sitei979 – 9791Substrate By similarity

GO - Molecular functioni

  1. protein binding Source: RGD
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. negative regulation of GTPase activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase N2 (EC:3.1.3.48)
Short name:
R-PTP-N2
Alternative name(s):
PTP NE-6
Short name:
PTPNE6
Phogrin
Gene namesi
Name:Ptprn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi61904. Ptprn2.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicle membrane; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 603576Extracellular Reviewed predictionAdd
BLAST
Transmembranei604 – 62421Helical; Reviewed predictionAdd
BLAST
Topological domaini625 – 1004380Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. endoplasmic reticulum lumen Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. secretory granule Source: RGD
  5. terminal bouton Source: RGD
  6. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 1004977Receptor-type tyrosine-protein phosphatase N2PRO_0000025457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi553 – 5531N-linked (GlcNAc...) Reviewed prediction
Modified residuei959 – 9591N6-acetyllysine By similarity

Post-translational modificationi

Appears to undergo multiple proteolytic cleavage at consecutive basic residues By similarity.

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiQ63475.
PRIDEiQ63475.

PTM databases

PhosphoSiteiQ63475.

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

GenevestigatoriQ63475.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006942.

Structurei

3D structure databases

ProteinModelPortaliQ63475.
SMRiQ63475. Positions 713-999.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini734 – 994261Tyrosine-protein phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni934 – 9407Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117312.
HOGENOMiHOG000243992.
HOVERGENiHBG105788.
KOiK07817.
OMAiYRYEVSP.
OrthoDBiEOG7K9K30.
PhylomeDBiQ63475.
TreeFamiTF351976.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR021613. Receptor_IA-2_dom.
IPR029403. RESP18_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF11548. Receptor_IA-2. 1 hit.
PF14948. RESP18. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63475-1 [UniParc]FASTAAdd to Basket

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MGLPLPLLLL LLLPPPLPRA LPAPASARGR QLPGRLGCLF EDGLCGSLET     50
CVNDGVFGRC QKVPALDTYR YEVSPGALLH LRIILQKLSR TGFTWQDDYT 100
QRVIAQELSN LPKAYLWHEE ASSPARSLQQ NADNEKWFSL ESEVALAKTL 150
RRYLPYLELL SQAPTANAHP RIDHETRPVK GEDSSPENIL TYVAHTSALT 200
YPPATRVKYP DNLLRPLSRL QPDELSPKVD SDIDKQKLIA ALGAYTAQRP 250
PGENDPEPRY LVHSPMRAPR PFAAPALSQR WPLPPGDSKD SLSMGDDTLL 300
RSLLKDLQQQ AEVDRLGSLK LEEQADSIAG AIQSDPVEGS QESHGRGAEG 350
QLREQADAPE EMLQDHRLPE VDDPAAYKEV SRLSFKLGDL LKDHGSPLLP 400
EAPLLEKSSR AEMKKSEQPE EVLSSEEETA GVEHVKSRTY SKDLLERKPN 450
SEPQPWRLED QFQNRAPEVW EDEQNLKLAA QGPPSGGLQL EVQPSEEEQQ 500
GYILTGNNPL SPEKGKQLMD EVAHLLRVPS SFFADVKVLG PAVIFKVSAN 550
IQNMTTADVT KAAVDNKDEL EKATGLTILQ SGIRPKGKLK LLPHPEEQED 600
STKFIVLTFL SIACILAVLL ASSLAYCLRH NSHYKLKEKL SGLGADPSAD 650
ATEAYQELCR QRMAVRPQDH SEGPHTSRIN SVSSQLSDGP MPSPSARSST 700
SSWSEEPAQS NMDISTGHMI LAYMEDHLKN KNRLEKEWEA LCAYQAEPDS 750
SLVAQREENA PKNRSLAVLT YDHSRILLKS ENSHSNSDYI NASPIMDHDP 800
RNPAYIATQG PLPATVADFW QMVWESGCAV IVMLTPLSEN GVRQCHHYWP 850
DEGSNVYHVY EVNLVSEHIW CQDFLVRSFY LKNLQTNETR TVTQFHFLSW 900
YDQGVPSSTR SLLDFRRKVN KCYRGRSCPI IVHCSDGAGR SGTYVLIDMV 950
LNKMAKGAKE IDIAATLEHL RDQRPGMVQT KEQFEFALTA VAEEVNAILK 1000
ALPQ 1004
Length:1,004
Mass (Da):111,863
Last modified:November 1, 1996 - v1
Checksum:iA73929E11B486FB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50735 mRNA. Translation: CAA90600.1.
U73458 mRNA. Translation: AAC08036.1.
RefSeqiNP_113788.1. NM_031600.1.
UniGeneiRn.11044.

Genome annotation databases

EnsembliENSRNOT00000006942; ENSRNOP00000006942; ENSRNOG00000005003.
GeneIDi29714.
KEGGirno:29714.
UCSCiRGD:61904. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50735 mRNA. Translation: CAA90600.1 .
U73458 mRNA. Translation: AAC08036.1 .
RefSeqi NP_113788.1. NM_031600.1.
UniGenei Rn.11044.

3D structure databases

ProteinModelPortali Q63475.
SMRi Q63475. Positions 713-999.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000006942.

PTM databases

PhosphoSitei Q63475.

Proteomic databases

PaxDbi Q63475.
PRIDEi Q63475.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006942 ; ENSRNOP00000006942 ; ENSRNOG00000005003 .
GeneIDi 29714.
KEGGi rno:29714.
UCSCi RGD:61904. rat.

Organism-specific databases

CTDi 5799.
RGDi 61904. Ptprn2.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117312.
HOGENOMi HOG000243992.
HOVERGENi HBG105788.
KOi K07817.
OMAi YRYEVSP.
OrthoDBi EOG7K9K30.
PhylomeDBi Q63475.
TreeFami TF351976.

Miscellaneous databases

NextBioi 610161.
PROi Q63475.

Gene expression databases

Genevestigatori Q63475.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR021613. Receptor_IA-2_dom.
IPR029403. RESP18_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF11548. Receptor_IA-2. 1 hit.
PF14948. RESP18. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Wasmeier C., Hutton J.C.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New England Deaconess Hospital.
    Tissue: Insulinoma.
  2. Fitzgerald L.R., Walton K.M., Dixon J.E., Largent B.L.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  3. "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A."
    Hosaka M., Suda M., Sakai Y., Izumi T., Watanabe T., Takeuchi T.
    J. Biol. Chem. 279:3627-3634(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPTPR2_RAT
AccessioniPrimary (citable) accession number: Q63475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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