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Q63475 (PTPR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase N2
Short name=R-PTP-N2
EC=3.1.3.48
Alternative name(s):
PTP NE-6
Short name=PTPNE6
Phogrin
Gene names
Name:Ptprn2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length1004 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Implicated in development of nervous system and pancreatic endocrine cells.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasmic vesicle › secretory vesicle membrane; Single-pass type I membrane protein Ref.3.

Tissue specificity

Pancreas.

Post-translational modification

Appears to undergo multiple proteolytic cleavage at consecutive basic residues By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 1004977Receptor-type tyrosine-protein phosphatase N2
PRO_0000025457

Regions

Topological domain28 – 603576Extracellular Potential
Transmembrane604 – 62421Helical; Potential
Topological domain625 – 1004380Cytoplasmic Potential
Domain734 – 994261Tyrosine-protein phosphatase
Region934 – 9407Substrate binding By similarity

Sites

Active site9341Phosphocysteine intermediate Potential
Binding site9021Substrate By similarity
Binding site9791Substrate By similarity
Site415 – 4162Cleavage By similarity

Amino acid modifications

Modified residue6811Phosphoserine By similarity
Modified residue9591N6-acetyllysine By similarity
Glycosylation5531N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q63475 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A73929E11B486FB2

FASTA1,004111,863
        10         20         30         40         50         60 
MGLPLPLLLL LLLPPPLPRA LPAPASARGR QLPGRLGCLF EDGLCGSLET CVNDGVFGRC 

        70         80         90        100        110        120 
QKVPALDTYR YEVSPGALLH LRIILQKLSR TGFTWQDDYT QRVIAQELSN LPKAYLWHEE 

       130        140        150        160        170        180 
ASSPARSLQQ NADNEKWFSL ESEVALAKTL RRYLPYLELL SQAPTANAHP RIDHETRPVK 

       190        200        210        220        230        240 
GEDSSPENIL TYVAHTSALT YPPATRVKYP DNLLRPLSRL QPDELSPKVD SDIDKQKLIA 

       250        260        270        280        290        300 
ALGAYTAQRP PGENDPEPRY LVHSPMRAPR PFAAPALSQR WPLPPGDSKD SLSMGDDTLL 

       310        320        330        340        350        360 
RSLLKDLQQQ AEVDRLGSLK LEEQADSIAG AIQSDPVEGS QESHGRGAEG QLREQADAPE 

       370        380        390        400        410        420 
EMLQDHRLPE VDDPAAYKEV SRLSFKLGDL LKDHGSPLLP EAPLLEKSSR AEMKKSEQPE 

       430        440        450        460        470        480 
EVLSSEEETA GVEHVKSRTY SKDLLERKPN SEPQPWRLED QFQNRAPEVW EDEQNLKLAA 

       490        500        510        520        530        540 
QGPPSGGLQL EVQPSEEEQQ GYILTGNNPL SPEKGKQLMD EVAHLLRVPS SFFADVKVLG 

       550        560        570        580        590        600 
PAVIFKVSAN IQNMTTADVT KAAVDNKDEL EKATGLTILQ SGIRPKGKLK LLPHPEEQED 

       610        620        630        640        650        660 
STKFIVLTFL SIACILAVLL ASSLAYCLRH NSHYKLKEKL SGLGADPSAD ATEAYQELCR 

       670        680        690        700        710        720 
QRMAVRPQDH SEGPHTSRIN SVSSQLSDGP MPSPSARSST SSWSEEPAQS NMDISTGHMI 

       730        740        750        760        770        780 
LAYMEDHLKN KNRLEKEWEA LCAYQAEPDS SLVAQREENA PKNRSLAVLT YDHSRILLKS 

       790        800        810        820        830        840 
ENSHSNSDYI NASPIMDHDP RNPAYIATQG PLPATVADFW QMVWESGCAV IVMLTPLSEN 

       850        860        870        880        890        900 
GVRQCHHYWP DEGSNVYHVY EVNLVSEHIW CQDFLVRSFY LKNLQTNETR TVTQFHFLSW 

       910        920        930        940        950        960 
YDQGVPSSTR SLLDFRRKVN KCYRGRSCPI IVHCSDGAGR SGTYVLIDMV LNKMAKGAKE 

       970        980        990       1000 
IDIAATLEHL RDQRPGMVQT KEQFEFALTA VAEEVNAILK ALPQ

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References

[1]Wasmeier C., Hutton J.C.
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New England Deaconess Hospital.
Tissue: Insulinoma.
[2]Fitzgerald L.R., Walton K.M., Dixon J.E., Largent B.L.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[3]"Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A."
Hosaka M., Suda M., Sakai Y., Izumi T., Watanabe T., Takeuchi T.
J. Biol. Chem. 279:3627-3634(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z50735 mRNA. Translation: CAA90600.1.
U73458 mRNA. Translation: AAC08036.1.
IPIIPI00231945.
RefSeqNP_113788.1. NM_031600.1.
UniGeneRn.11044.

3D structure databases

ProteinModelPortalQ63475.
SMRQ63475. Positions 713-999.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000006942.

PTM databases

PhosphoSiteQ63475.

Proteomic databases

PaxDbQ63475.
PRIDEQ63475.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006942; ENSRNOP00000006942; ENSRNOG00000005003.
GeneID29714.
KEGGrno:29714.
UCSCRGD:61904. rat.

Organism-specific databases

CTD5799.
RGD61904. Ptprn2.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00690000102184.
HOGENOMHOG000243992.
HOVERGENHBG105788.
KOK07817.
OrthoDBEOG4J6RQ4.

Gene expression databases

GenevestigatorQ63475.

Family and domain databases

InterProIPR021613. Receptor_IA-2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF11548. Receptor_IA-2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610161.

Entry information

Entry namePTPR2_RAT
AccessionPrimary (citable) accession number: Q63475
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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