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Protein

Receptor-type tyrosine-protein phosphatase N2

Gene

Ptprn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in development of nervous system and pancreatic endocrine cells.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei415 – 4162CleavageBy similarity
Binding sitei902 – 9021SubstrateBy similarity
Active sitei934 – 9341Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei979 – 9791SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. negative regulation of GTPase activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase N2 (EC:3.1.3.48)
Short name:
R-PTP-N2
Alternative name(s):
PTP NE-6
Short name:
PTPNE6
Phogrin
Gene namesi
Name:Ptprn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi61904. Ptprn2.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicle membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 603576ExtracellularSequence AnalysisAdd
BLAST
Transmembranei604 – 62421HelicalSequence AnalysisAdd
BLAST
Topological domaini625 – 1004380CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. endoplasmic reticulum lumen Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. receptor complex Source: Ensembl
  5. secretory granule Source: RGD
  6. terminal bouton Source: RGD
  7. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 1004977Receptor-type tyrosine-protein phosphatase N2PRO_0000025457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis
Modified residuei959 – 9591N6-acetyllysineBy similarity

Post-translational modificationi

Appears to undergo multiple proteolytic cleavage at consecutive basic residues.By similarity

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiQ63475.
PRIDEiQ63475.

PTM databases

PhosphoSiteiQ63475.

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

GenevestigatoriQ63475.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006942.

Structurei

3D structure databases

ProteinModelPortaliQ63475.
SMRiQ63475. Positions 713-999.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini734 – 994261Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni934 – 9407Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00780000121961.
HOGENOMiHOG000243992.
HOVERGENiHBG105788.
InParanoidiQ63475.
KOiK07817.
OMAiHTSALTY.
OrthoDBiEOG7K9K30.
PhylomeDBiQ63475.
TreeFamiTF351976.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR021613. Receptor_IA-2_dom.
IPR029403. RESP18_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF11548. Receptor_IA-2. 1 hit.
PF14948. RESP18. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPLPLLLL LLLPPPLPRA LPAPASARGR QLPGRLGCLF EDGLCGSLET
60 70 80 90 100
CVNDGVFGRC QKVPALDTYR YEVSPGALLH LRIILQKLSR TGFTWQDDYT
110 120 130 140 150
QRVIAQELSN LPKAYLWHEE ASSPARSLQQ NADNEKWFSL ESEVALAKTL
160 170 180 190 200
RRYLPYLELL SQAPTANAHP RIDHETRPVK GEDSSPENIL TYVAHTSALT
210 220 230 240 250
YPPATRVKYP DNLLRPLSRL QPDELSPKVD SDIDKQKLIA ALGAYTAQRP
260 270 280 290 300
PGENDPEPRY LVHSPMRAPR PFAAPALSQR WPLPPGDSKD SLSMGDDTLL
310 320 330 340 350
RSLLKDLQQQ AEVDRLGSLK LEEQADSIAG AIQSDPVEGS QESHGRGAEG
360 370 380 390 400
QLREQADAPE EMLQDHRLPE VDDPAAYKEV SRLSFKLGDL LKDHGSPLLP
410 420 430 440 450
EAPLLEKSSR AEMKKSEQPE EVLSSEEETA GVEHVKSRTY SKDLLERKPN
460 470 480 490 500
SEPQPWRLED QFQNRAPEVW EDEQNLKLAA QGPPSGGLQL EVQPSEEEQQ
510 520 530 540 550
GYILTGNNPL SPEKGKQLMD EVAHLLRVPS SFFADVKVLG PAVIFKVSAN
560 570 580 590 600
IQNMTTADVT KAAVDNKDEL EKATGLTILQ SGIRPKGKLK LLPHPEEQED
610 620 630 640 650
STKFIVLTFL SIACILAVLL ASSLAYCLRH NSHYKLKEKL SGLGADPSAD
660 670 680 690 700
ATEAYQELCR QRMAVRPQDH SEGPHTSRIN SVSSQLSDGP MPSPSARSST
710 720 730 740 750
SSWSEEPAQS NMDISTGHMI LAYMEDHLKN KNRLEKEWEA LCAYQAEPDS
760 770 780 790 800
SLVAQREENA PKNRSLAVLT YDHSRILLKS ENSHSNSDYI NASPIMDHDP
810 820 830 840 850
RNPAYIATQG PLPATVADFW QMVWESGCAV IVMLTPLSEN GVRQCHHYWP
860 870 880 890 900
DEGSNVYHVY EVNLVSEHIW CQDFLVRSFY LKNLQTNETR TVTQFHFLSW
910 920 930 940 950
YDQGVPSSTR SLLDFRRKVN KCYRGRSCPI IVHCSDGAGR SGTYVLIDMV
960 970 980 990 1000
LNKMAKGAKE IDIAATLEHL RDQRPGMVQT KEQFEFALTA VAEEVNAILK

ALPQ
Length:1,004
Mass (Da):111,863
Last modified:November 1, 1996 - v1
Checksum:iA73929E11B486FB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50735 mRNA. Translation: CAA90600.1.
U73458 mRNA. Translation: AAC08036.1.
RefSeqiNP_113788.1. NM_031600.1.
UniGeneiRn.11044.

Genome annotation databases

EnsembliENSRNOT00000006942; ENSRNOP00000006942; ENSRNOG00000005003.
GeneIDi29714.
KEGGirno:29714.
UCSCiRGD:61904. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50735 mRNA. Translation: CAA90600.1.
U73458 mRNA. Translation: AAC08036.1.
RefSeqiNP_113788.1. NM_031600.1.
UniGeneiRn.11044.

3D structure databases

ProteinModelPortaliQ63475.
SMRiQ63475. Positions 713-999.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006942.

PTM databases

PhosphoSiteiQ63475.

Proteomic databases

PaxDbiQ63475.
PRIDEiQ63475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006942; ENSRNOP00000006942; ENSRNOG00000005003.
GeneIDi29714.
KEGGirno:29714.
UCSCiRGD:61904. rat.

Organism-specific databases

CTDi5799.
RGDi61904. Ptprn2.

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00780000121961.
HOGENOMiHOG000243992.
HOVERGENiHBG105788.
InParanoidiQ63475.
KOiK07817.
OMAiHTSALTY.
OrthoDBiEOG7K9K30.
PhylomeDBiQ63475.
TreeFamiTF351976.

Miscellaneous databases

NextBioi610161.
PROiQ63475.

Gene expression databases

GenevestigatoriQ63475.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR021613. Receptor_IA-2_dom.
IPR029403. RESP18_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF11548. Receptor_IA-2. 1 hit.
PF14948. RESP18. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Wasmeier C., Hutton J.C.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New England Deaconess Hospital.
    Tissue: Insulinoma.
  2. Fitzgerald L.R., Walton K.M., Dixon J.E., Largent B.L.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  3. "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A."
    Hosaka M., Suda M., Sakai Y., Izumi T., Watanabe T., Takeuchi T.
    J. Biol. Chem. 279:3627-3634(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPTPR2_RAT
AccessioniPrimary (citable) accession number: Q63475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.