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Q63475

- PTPR2_RAT

UniProt

Q63475 - PTPR2_RAT

Protein

Receptor-type tyrosine-protein phosphatase N2

Gene

Ptprn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Implicated in development of nervous system and pancreatic endocrine cells.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei415 – 4162CleavageBy similarity
    Binding sitei902 – 9021SubstrateBy similarity
    Active sitei934 – 9341Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei979 – 9791SubstrateBy similarity

    GO - Molecular functioni

    1. protein binding Source: RGD
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. negative regulation of GTPase activity Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase N2 (EC:3.1.3.48)
    Short name:
    R-PTP-N2
    Alternative name(s):
    PTP NE-6
    Short name:
    PTPNE6
    Phogrin
    Gene namesi
    Name:Ptprn2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi61904. Ptprn2.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicle membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. endoplasmic reticulum lumen Source: RGD
    3. integral component of membrane Source: UniProtKB-KW
    4. secretory granule Source: RGD
    5. terminal bouton Source: RGD
    6. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 1004977Receptor-type tyrosine-protein phosphatase N2PRO_0000025457Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis
    Modified residuei959 – 9591N6-acetyllysineBy similarity

    Post-translational modificationi

    Appears to undergo multiple proteolytic cleavage at consecutive basic residues.By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    PaxDbiQ63475.
    PRIDEiQ63475.

    PTM databases

    PhosphoSiteiQ63475.

    Expressioni

    Tissue specificityi

    Pancreas.

    Gene expression databases

    GenevestigatoriQ63475.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000006942.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63475.
    SMRiQ63475. Positions 713-999.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 603576ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini625 – 1004380CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei604 – 62421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini734 – 994261Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni934 – 9407Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117312.
    HOGENOMiHOG000243992.
    HOVERGENiHBG105788.
    KOiK07817.
    OMAiYRYEVSP.
    OrthoDBiEOG7K9K30.
    PhylomeDBiQ63475.
    TreeFamiTF351976.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR021613. Receptor_IA-2_dom.
    IPR029403. RESP18_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF11548. Receptor_IA-2. 1 hit.
    PF14948. RESP18. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63475-1 [UniParc]FASTAAdd to Basket

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    MGLPLPLLLL LLLPPPLPRA LPAPASARGR QLPGRLGCLF EDGLCGSLET     50
    CVNDGVFGRC QKVPALDTYR YEVSPGALLH LRIILQKLSR TGFTWQDDYT 100
    QRVIAQELSN LPKAYLWHEE ASSPARSLQQ NADNEKWFSL ESEVALAKTL 150
    RRYLPYLELL SQAPTANAHP RIDHETRPVK GEDSSPENIL TYVAHTSALT 200
    YPPATRVKYP DNLLRPLSRL QPDELSPKVD SDIDKQKLIA ALGAYTAQRP 250
    PGENDPEPRY LVHSPMRAPR PFAAPALSQR WPLPPGDSKD SLSMGDDTLL 300
    RSLLKDLQQQ AEVDRLGSLK LEEQADSIAG AIQSDPVEGS QESHGRGAEG 350
    QLREQADAPE EMLQDHRLPE VDDPAAYKEV SRLSFKLGDL LKDHGSPLLP 400
    EAPLLEKSSR AEMKKSEQPE EVLSSEEETA GVEHVKSRTY SKDLLERKPN 450
    SEPQPWRLED QFQNRAPEVW EDEQNLKLAA QGPPSGGLQL EVQPSEEEQQ 500
    GYILTGNNPL SPEKGKQLMD EVAHLLRVPS SFFADVKVLG PAVIFKVSAN 550
    IQNMTTADVT KAAVDNKDEL EKATGLTILQ SGIRPKGKLK LLPHPEEQED 600
    STKFIVLTFL SIACILAVLL ASSLAYCLRH NSHYKLKEKL SGLGADPSAD 650
    ATEAYQELCR QRMAVRPQDH SEGPHTSRIN SVSSQLSDGP MPSPSARSST 700
    SSWSEEPAQS NMDISTGHMI LAYMEDHLKN KNRLEKEWEA LCAYQAEPDS 750
    SLVAQREENA PKNRSLAVLT YDHSRILLKS ENSHSNSDYI NASPIMDHDP 800
    RNPAYIATQG PLPATVADFW QMVWESGCAV IVMLTPLSEN GVRQCHHYWP 850
    DEGSNVYHVY EVNLVSEHIW CQDFLVRSFY LKNLQTNETR TVTQFHFLSW 900
    YDQGVPSSTR SLLDFRRKVN KCYRGRSCPI IVHCSDGAGR SGTYVLIDMV 950
    LNKMAKGAKE IDIAATLEHL RDQRPGMVQT KEQFEFALTA VAEEVNAILK 1000
    ALPQ 1004
    Length:1,004
    Mass (Da):111,863
    Last modified:November 1, 1996 - v1
    Checksum:iA73929E11B486FB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50735 mRNA. Translation: CAA90600.1.
    U73458 mRNA. Translation: AAC08036.1.
    RefSeqiNP_113788.1. NM_031600.1.
    UniGeneiRn.11044.

    Genome annotation databases

    EnsembliENSRNOT00000006942; ENSRNOP00000006942; ENSRNOG00000005003.
    GeneIDi29714.
    KEGGirno:29714.
    UCSCiRGD:61904. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50735 mRNA. Translation: CAA90600.1 .
    U73458 mRNA. Translation: AAC08036.1 .
    RefSeqi NP_113788.1. NM_031600.1.
    UniGenei Rn.11044.

    3D structure databases

    ProteinModelPortali Q63475.
    SMRi Q63475. Positions 713-999.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000006942.

    PTM databases

    PhosphoSitei Q63475.

    Proteomic databases

    PaxDbi Q63475.
    PRIDEi Q63475.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006942 ; ENSRNOP00000006942 ; ENSRNOG00000005003 .
    GeneIDi 29714.
    KEGGi rno:29714.
    UCSCi RGD:61904. rat.

    Organism-specific databases

    CTDi 5799.
    RGDi 61904. Ptprn2.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117312.
    HOGENOMi HOG000243992.
    HOVERGENi HBG105788.
    KOi K07817.
    OMAi YRYEVSP.
    OrthoDBi EOG7K9K30.
    PhylomeDBi Q63475.
    TreeFami TF351976.

    Miscellaneous databases

    NextBioi 610161.
    PROi Q63475.

    Gene expression databases

    Genevestigatori Q63475.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR021613. Receptor_IA-2_dom.
    IPR029403. RESP18_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF11548. Receptor_IA-2. 1 hit.
    PF14948. RESP18. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Wasmeier C., Hutton J.C.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New England Deaconess Hospital.
      Tissue: Insulinoma.
    2. Fitzgerald L.R., Walton K.M., Dixon J.E., Largent B.L.
      Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    3. "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A."
      Hosaka M., Suda M., Sakai Y., Izumi T., Watanabe T., Takeuchi T.
      J. Biol. Chem. 279:3627-3634(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiPTPR2_RAT
    AccessioniPrimary (citable) accession number: Q63475
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3