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Q63474

- DDR1_RAT

UniProt

Q63474 - DDR1_RAT

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Protein
Epithelial discoidin domain-containing receptor 1
Gene
Ddr1, Eddr1, Ptk3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi212 – 2121Calcium 1; via carbonyl oxygen By similarity
Metal bindingi231 – 2311Calcium 1 By similarity
Metal bindingi231 – 2311Calcium 2; via carbonyl oxygen By similarity
Metal bindingi234 – 2341Calcium 2 By similarity
Metal bindingi236 – 2361Calcium 2; via carbonyl oxygen By similarity
Metal bindingi254 – 2541Calcium 1; via carbonyl oxygen By similarity
Metal bindingi256 – 2561Calcium 1; via carbonyl oxygen By similarity
Metal bindingi361 – 3611Calcium 2; via carbonyl oxygen By similarity
Metal bindingi362 – 3621Calcium 2 By similarity
Binding sitei652 – 6521ATP By similarity
Active sitei763 – 7631Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi613 – 6219ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. collagen binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. protein tyrosine kinase collagen receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. collagen-activated tyrosine kinase receptor signaling pathway Source: UniProtKB
  2. female pregnancy Source: UniProtKB-KW
  3. lactation Source: UniProtKB-KW
  4. organ regeneration Source: RGD
  5. peptidyl-tyrosine autophosphorylation Source: UniProtKB
  6. regulation of extracellular matrix disassembly Source: UniProtKB
  7. skin development Source: RGD
  8. smooth muscle cell migration Source: UniProtKB
  9. smooth muscle cell-matrix adhesion Source: UniProtKB
  10. wound healing, spreading of cells Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Lactation, Pregnancy

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial discoidin domain-containing receptor 1 (EC:2.7.10.1)
Short name:
Epithelial discoidin domain receptor 1
Alternative name(s):
CD167 antigen-like family member A
Cell adhesion kinase
Discoidin receptor tyrosine kinase
Protein-tyrosine kinase 3
Tyrosine kinase DDR
Tyrosine-protein kinase CAK
CD_antigen: CD167a
Gene namesi
Name:Ddr1
Synonyms:Eddr1, Ptk3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2252. Ddr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 414393Extracellular Reviewed prediction
Add
BLAST
Transmembranei415 – 43521Helical; Reviewed prediction
Add
BLAST
Topological domaini436 – 910475Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 910891Epithelial discoidin domain-containing receptor 1
PRO_0000016745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 186 By similarity
Disulfide bondi75 ↔ 178 By similarity
Glycosylationi212 – 2121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi261 – 2611N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi304 ↔ 349 By similarity
Glycosylationi371 – 3711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Modified residuei481 – 4811Phosphotyrosine; by autocatalysis By similarity
Modified residuei510 – 5101Phosphotyrosine; by autocatalysis By similarity
Modified residuei517 – 5171Phosphotyrosine; by autocatalysis By similarity
Modified residuei737 – 7371Phosphotyrosine; by autocatalysis By similarity
Modified residuei789 – 7891Phosphotyrosine; by autocatalysis By similarity
Modified residuei793 – 7931Phosphotyrosine; by autocatalysis By similarity
Modified residuei794 – 7941Phosphotyrosine; by autocatalysis By similarity

Post-translational modificationi

Autophosphorylated in response to fibrillar collagen binding By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63474.

PTM databases

PhosphoSiteiQ63474.

Expressioni

Tissue specificityi

Various embryonic and adult tissues; also proliferative zones of the developing brain; hippocampal neurons.

Gene expression databases

GenevestigatoriQ63474.

Interactioni

Subunit structurei

Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ63474.
SMRiQ63474. Positions 28-187.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 186155F5/8 type C
Add
BLAST
Domaini607 – 902296Protein kinase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni193 – 368176DS-like domain By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi478 – 4814PPxY motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi378 – 41235Gly/Pro-rich
Add
BLAST
Compositional biasi473 – 598126Gly/Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 F5/8 type C domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000043102.
HOVERGENiHBG005461.
InParanoidiQ63474.
PhylomeDBiQ63474.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR029566. DDR1.
IPR008979. Galactose-bd-like.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PANTHERiPTHR24416:SF65. PTHR24416:SF65. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00231. FA58C. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63474-1 [UniParc]FASTAAdd to Basket

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MGTGTLSSLL LLLLLVTIGD ADMKGHFDPA KCRYALGMQD RTIPDSDISV    50
SSSWSDSTAA RHSRLESSDG DGAWCPAGPV FPKEEEYLQV DLRRLHLVAL 100
VGTQGRHAGG LGKEFSRSYR LRYSRDGRRW MDWKDRWGQE VISGNEDPGG 150
VVLKDLGPPM VARLVRFYPR ADRVMSVCLR VELYGCLWRD GLLSYTAPVG 200
QTMQLSEMVY LNDSTYDGYT AGGLQYGGLG QLADGVVGLD DFRQSQELRV 250
WPGYDYVGWS NHSFPSGYVE MEFEFDRLRS FQTMQVHCNN MHTLGARLPG 300
GVECRFKRGP AMAWEGEPVH HALGGSLGDP RARAISVPLG GHVGRFLQCR 350
FLFAGPWLLF SEISFISDVV NDSSDTFPPA PWWPPGPPPT NFSSLELEPR 400
GQQPVAKAEG SPTAILIGCL VAIILLLLLI IALMLWRLHW RRLLSKAERR 450
VLEEELTVHL SVPGDTILIN NRPGPREPPP YQEPRPRGTP THSAPCVPNG 500
SALLLSNPAY RLLLATYARP PRGPGPPTPA WAKPTNTQAC SGDYMEPEKP 550
GAPLLPPPPQ NSVPHYAEAD IVTLQGVTGG NTYAVPALPP GAVGDGPPRV 600
DFPRSRLRFK EKLGEGQFGE VHLCEVEDPQ DLVTSDFPIS VQKGHPLLVA 650
VKILRPDATK NARNDFLKEV KIMSRLKDLN IIRLLGVCVQ DDPLCMITDY 700
MENGDLNQFL SAHQLENKVT QGLPGDRESD QGPTISYPML LHVGAQIASG 750
MRYLATLNFV HRDLATRNCL VGENFTIKIA DFGMSRNLYA GDYYRVQGRA 800
VLPIRWMAWE CILMGKFTTA SDVWAFGVTL WEVLMLCRSQ PFGQLTDEQV 850
IENAGEFFRD QGRQVYLSRP PACPQTLYEL MLRCWSREPE QRPPFSQLHR 900
FLADDALNTV 910
Length:910
Mass (Da):101,165
Last modified:November 1, 1996 - v1
Checksum:i7E7FFA1DCB029806
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26525 Genomic DNA. Translation: AAA21089.1.
PIRiA53137.
UniGeneiRn.7807.

Genome annotation databases

UCSCiRGD:2252. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26525 Genomic DNA. Translation: AAA21089.1 .
PIRi A53137.
UniGenei Rn.7807.

3D structure databases

ProteinModelPortali Q63474.
SMRi Q63474. Positions 28-187.
ModBasei Search...

PTM databases

PhosphoSitei Q63474.

Proteomic databases

PaxDbi Q63474.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2252. rat.

Organism-specific databases

RGDi 2252. Ddr1.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000043102.
HOVERGENi HBG005461.
InParanoidi Q63474.
PhylomeDBi Q63474.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 5301.

Miscellaneous databases

PROi Q63474.

Gene expression databases

Genevestigatori Q63474.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR029566. DDR1.
IPR008979. Galactose-bd-like.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view ]
PANTHERi PTHR24416:SF65. PTHR24416:SF65. 1 hit.
Pfami PF00754. F5_F8_type_C. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00231. FA58C. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain."
    Sanchez M.P., Tapley P., Saini S.S., He B., Pulido D., Barbacid M.
    Proc. Natl. Acad. Sci. U.S.A. 91:1819-1823(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiDDR1_RAT
AccessioniPrimary (citable) accession number: Q63474
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi