Reviewed, UniProtKB/Swiss-Prot Q63474 (DDR1_RAT)

Names and origin

Protein names

Recommended name:
    Epithelial discoidin domain-containing receptor 1
      Short name=Epithelial discoidin domain receptor 1
    EC=2.7.10.1
Alternative name(s):
    Tyrosine kinase DDR
    Discoidin receptor tyrosine kinase
    Tyrosine-protein kinase CAK
    Cell adhesion kinase
    Protein-tyrosine kinase PTK-3
    CD167 antigen-like family member A
    CD_antigen=CD167a

Gene names

Name:	Ddr1
Synonyms:	Eddr1, Ptk3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	910 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in cell-cell interactions and recognition By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Various embryonic and adult tissues; also proliferative zones of the developing brain; hippocampal neurons.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 1 F5/8 type C domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: InterPro organ regeneration Inferred from expression pattern. Source: RGD protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro skin development Inferred from expression pattern. Source: RGD transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	basolateral plasma membrane Inferred from direct assay. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 910	891	Epithelial discoidin domain-containing receptor 1		PRO_0000016745
Regions
	Topological domain	20 – 413	394	Extracellular Potential
	Transmembrane	414 – 440	27	Potential
	Topological domain	441 – 910	470	Cytoplasmic Potential
	Domain	32 – 186	155	F5/8 type C
	Domain	607 – 902	296	Protein kinase
	Nucleotide binding	613 – 621	9	ATP By similarity
	Compositional bias	378 – 412	35	Gly/Pro-rich
	Compositional bias	473 – 598	126	Gly/Pro-rich
Sites
	Active site	763	1	Proton acceptor By similarity
	Binding site	652	1	ATP By similarity
Amino acid modifications
	Modified residue	510	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	789	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	793	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	794	1	Phosphotyrosine; by autocatalysis By similarity
	Glycosylation	212	1	N-linked (GlcNAc...) Potential
	Glycosylation	261	1	N-linked (GlcNAc...) Potential
	Glycosylation	371	1	N-linked (GlcNAc...) Potential
	Glycosylation	391	1	N-linked (GlcNAc...) Potential
	Disulfide bond	32 ↔ 186		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63474-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7E7FFA1DCB029806	FASTA	910	101,165
	10 20 30 40 50 60 MGTGTLSSLL LLLLLVTIGD ADMKGHFDPA KCRYALGMQD RTIPDSDISV SSSWSDSTAA 70 80 90 100 110 120 RHSRLESSDG DGAWCPAGPV FPKEEEYLQV DLRRLHLVAL VGTQGRHAGG LGKEFSRSYR 130 140 150 160 170 180 LRYSRDGRRW MDWKDRWGQE VISGNEDPGG VVLKDLGPPM VARLVRFYPR ADRVMSVCLR 190 200 210 220 230 240 VELYGCLWRD GLLSYTAPVG QTMQLSEMVY LNDSTYDGYT AGGLQYGGLG QLADGVVGLD 250 260 270 280 290 300 DFRQSQELRV WPGYDYVGWS NHSFPSGYVE MEFEFDRLRS FQTMQVHCNN MHTLGARLPG 310 320 330 340 350 360 GVECRFKRGP AMAWEGEPVH HALGGSLGDP RARAISVPLG GHVGRFLQCR FLFAGPWLLF 370 380 390 400 410 420 SEISFISDVV NDSSDTFPPA PWWPPGPPPT NFSSLELEPR GQQPVAKAEG SPTAILIGCL 430 440 450 460 470 480 VAIILLLLLI IALMLWRLHW RRLLSKAERR VLEEELTVHL SVPGDTILIN NRPGPREPPP 490 500 510 520 530 540 YQEPRPRGTP THSAPCVPNG SALLLSNPAY RLLLATYARP PRGPGPPTPA WAKPTNTQAC 550 560 570 580 590 600 SGDYMEPEKP GAPLLPPPPQ NSVPHYAEAD IVTLQGVTGG NTYAVPALPP GAVGDGPPRV 610 620 630 640 650 660 DFPRSRLRFK EKLGEGQFGE VHLCEVEDPQ DLVTSDFPIS VQKGHPLLVA VKILRPDATK 670 680 690 700 710 720 NARNDFLKEV KIMSRLKDLN IIRLLGVCVQ DDPLCMITDY MENGDLNQFL SAHQLENKVT 730 740 750 760 770 780 QGLPGDRESD QGPTISYPML LHVGAQIASG MRYLATLNFV HRDLATRNCL VGENFTIKIA 790 800 810 820 830 840 DFGMSRNLYA GDYYRVQGRA VLPIRWMAWE CILMGKFTTA SDVWAFGVTL WEVLMLCRSQ 850 860 870 880 890 900 PFGQLTDEQV IENAGEFFRD QGRQVYLSRP PACPQTLYEL MLRCWSREPE QRPPFSQLHR 910 FLADDALNTV

References

[1]

"Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain." Sanchez M.P., Tapley P., Saini S.S., He B., Pulido D., Barbacid M. Proc. Natl. Acad. Sci. U.S.A. 91:1819-1823(1994) [PubMed: 8127887] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L26525 Genomic DNA. Translation: AAA21089.1.
IPI	IPI00209121.
PIR	A53137.
RefSeq	NP_037269.1.
UniGene	Rn.7807
3D structure databases
HSSP	HSSP built from PDB template 1LUF based on UniProtKB Q62838.
ModBase	Search...
PTM databases
PhosphoSite	Q63474.
Genome annotation databases
Ensembl	ENSRNOG00000000830. Rattus norvegicus. [Contig view]
GeneID	25678.
KEGG	rno:25678.
Organism-specific databases
RGD	2252. Ddr1.
Phylogenomic databases
HOVERGEN	Q63474.
Enzyme and pathway databases
BRENDA	2.7.10.1. 248.
Gene expression databases
ArrayExpress	Q63474.
GermOnline	ENSRNOG00000000830. Rattus norvegicus.
Family and domain databases
InterPro	IPR000421. Coagulation_factor_5/8-type_C. IPR000719. Prot_kinase_core. IPR002011. Recept_tyr_kinase-II_CS. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view]
Pfam	PF00754. F5_F8_type_C. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00231. FA58C. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS01285. FA58C_1. 1 hit. PS01286. FA58C_2. 1 hit. PS50022. FA58C_3. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	607635.

Entry information

Entry name

DDR1_RAT

Accession

Primary (citable) accession number: Q63474

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)