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Q63474

- DDR1_RAT

UniProt

Q63474 - DDR1_RAT

Protein

Epithelial discoidin domain-containing receptor 1

Gene

Ddr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi212 – 2121Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi231 – 2311Calcium 1By similarity
    Metal bindingi231 – 2311Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi234 – 2341Calcium 2By similarity
    Metal bindingi236 – 2361Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi254 – 2541Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi256 – 2561Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi361 – 3611Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi362 – 3621Calcium 2By similarity
    Binding sitei652 – 6521ATPPROSITE-ProRule annotation
    Active sitei763 – 7631Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi613 – 6219ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. collagen binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. protein tyrosine kinase collagen receptor activity Source: UniProtKB

    GO - Biological processi

    1. collagen-activated tyrosine kinase receptor signaling pathway Source: UniProtKB
    2. female pregnancy Source: UniProtKB-KW
    3. lactation Source: UniProtKB-KW
    4. organ regeneration Source: RGD
    5. peptidyl-tyrosine autophosphorylation Source: UniProtKB
    6. regulation of extracellular matrix disassembly Source: UniProtKB
    7. skin development Source: RGD
    8. smooth muscle cell-matrix adhesion Source: UniProtKB
    9. smooth muscle cell migration Source: UniProtKB
    10. wound healing, spreading of cells Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Lactation, Pregnancy

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epithelial discoidin domain-containing receptor 1 (EC:2.7.10.1)
    Short name:
    Epithelial discoidin domain receptor 1
    Alternative name(s):
    CD167 antigen-like family member A
    Cell adhesion kinase
    Discoidin receptor tyrosine kinase
    Protein-tyrosine kinase 3
    Tyrosine kinase DDR
    Tyrosine-protein kinase CAK
    CD_antigen: CD167a
    Gene namesi
    Name:Ddr1
    Synonyms:Eddr1, Ptk3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2252. Ddr1.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: RGD
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 910891Epithelial discoidin domain-containing receptor 1PRO_0000016745Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 186PROSITE-ProRule annotation
    Disulfide bondi75 ↔ 178PROSITE-ProRule annotation
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi304 ↔ 349PROSITE-ProRule annotation
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Modified residuei481 – 4811Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei510 – 5101Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei517 – 5171Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei737 – 7371Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei789 – 7891Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei793 – 7931Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei794 – 7941Phosphotyrosine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated in response to fibrillar collagen binding.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ63474.

    PTM databases

    PhosphoSiteiQ63474.

    Expressioni

    Tissue specificityi

    Various embryonic and adult tissues; also proliferative zones of the developing brain; hippocampal neurons.

    Gene expression databases

    GenevestigatoriQ63474.

    Interactioni

    Subunit structurei

    Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ63474.
    SMRiQ63474. Positions 28-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 414393ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini436 – 910475CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei415 – 43521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 186155F5/8 type CPROSITE-ProRule annotationAdd
    BLAST
    Domaini607 – 902296Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni193 – 368176DS-like domainBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi478 – 4814PPxY motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi378 – 41235Gly/Pro-richAdd
    BLAST
    Compositional biasi473 – 598126Gly/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000043102.
    HOVERGENiHBG005461.
    InParanoidiQ63474.
    PhylomeDBiQ63474.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR029566. DDR1.
    IPR008979. Galactose-bd-like.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view]
    PANTHERiPTHR24416:SF65. PTHR24416:SF65. 1 hit.
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00231. FA58C. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63474-1 [UniParc]FASTAAdd to Basket

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    MGTGTLSSLL LLLLLVTIGD ADMKGHFDPA KCRYALGMQD RTIPDSDISV    50
    SSSWSDSTAA RHSRLESSDG DGAWCPAGPV FPKEEEYLQV DLRRLHLVAL 100
    VGTQGRHAGG LGKEFSRSYR LRYSRDGRRW MDWKDRWGQE VISGNEDPGG 150
    VVLKDLGPPM VARLVRFYPR ADRVMSVCLR VELYGCLWRD GLLSYTAPVG 200
    QTMQLSEMVY LNDSTYDGYT AGGLQYGGLG QLADGVVGLD DFRQSQELRV 250
    WPGYDYVGWS NHSFPSGYVE MEFEFDRLRS FQTMQVHCNN MHTLGARLPG 300
    GVECRFKRGP AMAWEGEPVH HALGGSLGDP RARAISVPLG GHVGRFLQCR 350
    FLFAGPWLLF SEISFISDVV NDSSDTFPPA PWWPPGPPPT NFSSLELEPR 400
    GQQPVAKAEG SPTAILIGCL VAIILLLLLI IALMLWRLHW RRLLSKAERR 450
    VLEEELTVHL SVPGDTILIN NRPGPREPPP YQEPRPRGTP THSAPCVPNG 500
    SALLLSNPAY RLLLATYARP PRGPGPPTPA WAKPTNTQAC SGDYMEPEKP 550
    GAPLLPPPPQ NSVPHYAEAD IVTLQGVTGG NTYAVPALPP GAVGDGPPRV 600
    DFPRSRLRFK EKLGEGQFGE VHLCEVEDPQ DLVTSDFPIS VQKGHPLLVA 650
    VKILRPDATK NARNDFLKEV KIMSRLKDLN IIRLLGVCVQ DDPLCMITDY 700
    MENGDLNQFL SAHQLENKVT QGLPGDRESD QGPTISYPML LHVGAQIASG 750
    MRYLATLNFV HRDLATRNCL VGENFTIKIA DFGMSRNLYA GDYYRVQGRA 800
    VLPIRWMAWE CILMGKFTTA SDVWAFGVTL WEVLMLCRSQ PFGQLTDEQV 850
    IENAGEFFRD QGRQVYLSRP PACPQTLYEL MLRCWSREPE QRPPFSQLHR 900
    FLADDALNTV 910
    Length:910
    Mass (Da):101,165
    Last modified:November 1, 1996 - v1
    Checksum:i7E7FFA1DCB029806
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26525 Genomic DNA. Translation: AAA21089.1.
    PIRiA53137.
    UniGeneiRn.7807.

    Genome annotation databases

    UCSCiRGD:2252. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26525 Genomic DNA. Translation: AAA21089.1 .
    PIRi A53137.
    UniGenei Rn.7807.

    3D structure databases

    ProteinModelPortali Q63474.
    SMRi Q63474. Positions 28-187.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q63474.

    Proteomic databases

    PaxDbi Q63474.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2252. rat.

    Organism-specific databases

    RGDi 2252. Ddr1.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000043102.
    HOVERGENi HBG005461.
    InParanoidi Q63474.
    PhylomeDBi Q63474.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 5301.

    Miscellaneous databases

    PROi Q63474.

    Gene expression databases

    Genevestigatori Q63474.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR029566. DDR1.
    IPR008979. Galactose-bd-like.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view ]
    PANTHERi PTHR24416:SF65. PTHR24416:SF65. 1 hit.
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00231. FA58C. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain."
      Sanchez M.P., Tapley P., Saini S.S., He B., Pulido D., Barbacid M.
      Proc. Natl. Acad. Sci. U.S.A. 91:1819-1823(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiDDR1_RAT
    AccessioniPrimary (citable) accession number: Q63474
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3