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Reviewed, UniProtKB/Swiss-Prot Q63474 (DDR1_RAT)

Last modified June 16, 2009. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Epithelial discoidin domain-containing receptor 1
      Short name=Epithelial discoidin domain receptor 1
    EC=2.7.10.1
Alternative name(s):
    Tyrosine kinase DDR
    Discoidin receptor tyrosine kinase
    Tyrosine-protein kinase CAK
    Cell adhesion kinase
    Protein-tyrosine kinase PTK-3
    CD167 antigen-like family member A
    CD_antigen=CD167a
Gene names
Name: Ddr1
Synonyms: Eddr1, Ptk3
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

May be involved in cell-cell interactions and recognition By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Various embryonic and adult tissues; also proliferative zones of the developing brain; hippocampal neurons.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Contains 1 F5/8 type C domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 910891Epithelial discoidin domain-containing receptor 1
PRO_0000016745

Regions

Topological domain20 – 413394Extracellular Potential
Transmembrane414 – 44027 Potential
Topological domain441 – 910470Cytoplasmic Potential
Domain32 – 186155F5/8 type C
Domain607 – 902296Protein kinase
Nucleotide binding613 – 6219ATP By similarity
Compositional bias378 – 41235Gly/Pro-rich
Compositional bias473 – 598126Gly/Pro-rich

Sites

Active site7631Proton acceptor By similarity
Binding site6521ATP By similarity

Amino acid modifications

Modified residue5101Phosphotyrosine; by autocatalysis By similarity
Modified residue7891Phosphotyrosine; by autocatalysis By similarity
Modified residue7931Phosphotyrosine; by autocatalysis By similarity
Modified residue7941Phosphotyrosine; by autocatalysis By similarity
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation3711N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Disulfide bond32 ↔ 186 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63474-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7E7FFA1DCB029806

FASTA910101,165
        10         20         30         40         50         60 
MGTGTLSSLL LLLLLVTIGD ADMKGHFDPA KCRYALGMQD RTIPDSDISV SSSWSDSTAA 

        70         80         90        100        110        120 
RHSRLESSDG DGAWCPAGPV FPKEEEYLQV DLRRLHLVAL VGTQGRHAGG LGKEFSRSYR 

       130        140        150        160        170        180 
LRYSRDGRRW MDWKDRWGQE VISGNEDPGG VVLKDLGPPM VARLVRFYPR ADRVMSVCLR 

       190        200        210        220        230        240 
VELYGCLWRD GLLSYTAPVG QTMQLSEMVY LNDSTYDGYT AGGLQYGGLG QLADGVVGLD 

       250        260        270        280        290        300 
DFRQSQELRV WPGYDYVGWS NHSFPSGYVE MEFEFDRLRS FQTMQVHCNN MHTLGARLPG 

       310        320        330        340        350        360 
GVECRFKRGP AMAWEGEPVH HALGGSLGDP RARAISVPLG GHVGRFLQCR FLFAGPWLLF 

       370        380        390        400        410        420 
SEISFISDVV NDSSDTFPPA PWWPPGPPPT NFSSLELEPR GQQPVAKAEG SPTAILIGCL 

       430        440        450        460        470        480 
VAIILLLLLI IALMLWRLHW RRLLSKAERR VLEEELTVHL SVPGDTILIN NRPGPREPPP 

       490        500        510        520        530        540 
YQEPRPRGTP THSAPCVPNG SALLLSNPAY RLLLATYARP PRGPGPPTPA WAKPTNTQAC 

       550        560        570        580        590        600 
SGDYMEPEKP GAPLLPPPPQ NSVPHYAEAD IVTLQGVTGG NTYAVPALPP GAVGDGPPRV 

       610        620        630        640        650        660 
DFPRSRLRFK EKLGEGQFGE VHLCEVEDPQ DLVTSDFPIS VQKGHPLLVA VKILRPDATK 

       670        680        690        700        710        720 
NARNDFLKEV KIMSRLKDLN IIRLLGVCVQ DDPLCMITDY MENGDLNQFL SAHQLENKVT 

       730        740        750        760        770        780 
QGLPGDRESD QGPTISYPML LHVGAQIASG MRYLATLNFV HRDLATRNCL VGENFTIKIA 

       790        800        810        820        830        840 
DFGMSRNLYA GDYYRVQGRA VLPIRWMAWE CILMGKFTTA SDVWAFGVTL WEVLMLCRSQ 

       850        860        870        880        890        900 
PFGQLTDEQV IENAGEFFRD QGRQVYLSRP PACPQTLYEL MLRCWSREPE QRPPFSQLHR 

       910 
FLADDALNTV 

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References

[1]"Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain."
Sanchez M.P., Tapley P., Saini S.S., He B., Pulido D., Barbacid M.
Proc. Natl. Acad. Sci. U.S.A. 91:1819-1823(1994) [PubMed: 8127887] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
Tissue: Brain.

Cross-references

Sequence databases

L26525 Genomic DNA. Translation: AAA21089.1.
IPIIPI00209121.
PIRA53137.
RefSeqNP_037269.1.
UniGeneRn.7807

3D structure databases

HSSPHSSP built from PDB template 1LUF based on UniProtKB Q62838.
ModBaseSearch...

PTM databases

PhosphoSiteQ63474.

Genome annotation databases

EnsemblENSRNOG00000000830. Rattus norvegicus. [Contig view]
GeneID25678.
KEGGrno:25678.

Organism-specific databases

RGD2252. Ddr1.

Phylogenomic databases

HOVERGENQ63474.

Enzyme and pathway databases

BRENDA2.7.10.1. 248.

Gene expression databases

ArrayExpressQ63474.
GermOnlineENSRNOG00000000830. Rattus norvegicus.

Family and domain databases

InterProIPR000421. Coagulation_factor_5/8-type_C.
IPR000719. Prot_kinase_core.
IPR002011. Recept_tyr_kinase-II_CS.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
[Graphical view]
PfamPF00754. F5_F8_type_C. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00231. FA58C. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio607635.

Entry information

Entry nameDDR1_RAT
AccessionPrimary (citable) accession number: Q63474
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents