Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q63472

- KCNH1_RAT

UniProt

Q63472 - KCNH1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Potassium voltage-gated channel subfamily H member 1

Gene

Kcnh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi554 – 671118cNMPAdd
BLAST

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calmodulin-binding, Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.20.4. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 1
Alternative name(s):
Ether-a-go-go potassium channel 1
Short name:
EAG channel 1
Short name:
EAG1
Short name:
r-eag
Voltage-gated potassium channel subunit Kv10.1
Gene namesi
Name:Kcnh1
Synonyms:Eag
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi68398. Kcnh1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein. Nucleus inner membrane By similarity; Multi-pass membrane protein
Note: Perinuclear KCNH1 is located to NPC-free islands.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 220220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Topological domaini242 – 2487ExtracellularSequence Analysis
Transmembranei249 – 26921Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini270 – 29425CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Topological domaini316 – 3227ExtracellularSequence Analysis
Transmembranei323 – 34321Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini344 – 3496CytoplasmicSequence Analysis
Transmembranei350 – 37021Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Topological domaini371 – 42151ExtracellularSequence AnalysisAdd
BLAST
Intramembranei422 – 44221Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Topological domaini443 – 4508ExtracellularSequence Analysis
Transmembranei451 – 47121Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini472 – 962491CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Potassium voltage-gated channel subfamily H member 1PRO_0000053996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

PTM databases

PhosphoSiteiQ63472.

Expressioni

Tissue specificityi

Detected in brain, but not in the other tissues tested. Expression is highest in granular cells of the dentate gyrus, in hippocampus CA3 pyramidal cells, and in cerebellar granule cells. Found in pituitary.1 Publication

Gene expression databases

GenevestigatoriQ63472.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2 (By similarity). Interacts with ALG10B.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Rabep1O355502EBI-7991592,EBI-7991542

Protein-protein interaction databases

IntActiQ63472. 2 interactions.
MINTiMINT-8386100.
STRINGi10116.ENSRNOP00000005209.

Structurei

3D structure databases

ProteinModelPortaliQ63472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 9481PASPROSITE-ProRule annotationAdd
BLAST
Domaini93 – 14553PACPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni646 – 74398Calmodulin-bindingBy similarityAdd
BLAST
Regioni897 – 93741CAD (involved in subunit assembly)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi436 – 4416Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.1 Publication

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
GeneTreeiENSGT00760000118772.
HOVERGENiHBG101348.
InParanoidiQ63472.
KOiK04904.
OMAiHAKLHAP.
OrthoDBiEOG7QG43V.
PhylomeDBiQ63472.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63472-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMAGGRRGL VAPQNTFLEN IVRRSNDTNF VLGNAQIVDW PIVYSNDGFC
60 70 80 90 100
KLSGYHRAEV MQKSSACSFM YGELTDKDTV EKVRQTFENY EMNSFEILMY
110 120 130 140 150
KKNRTPVWFF VKIAPIRNEQ DKVVLFLCTF SDITAFKQPI EDDSCKGWGK
160 170 180 190 200
FARLTRALTS SRGVLQQLAP SVQKGENVHK HSRLAEVLQL GSDILPQYKQ
210 220 230 240 250
EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS FKTRQNNVAW
260 270 280 290 300
LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL
310 320 330 340 350
LSCLPYDVIN AFENVDEGIS SLFSSLKVVR LLRLGRVARK LDHYIEYGAA
360 370 380 390 400
VLVLLVCVFG LAAHWMACIW YSIGDYEIFD EDTKTIRNNS WLYQLALDIG
410 420 430 440 450
TPYQFNGSGS GKWEGGPSKN SVYISSLYFT MTSLTSVGFG NIAPSTDIEK
460 470 480 490 500
IFAVAIMMIG SLLYATIFGN VTTIFQQMYA NTNRYHEMLN SVRDFLKLYQ
510 520 530 540 550
VPKGLSERVM DYIVSTWSMS RGIDTEKVLQ ICPKDMRADI CVHLNRKVFK
560 570 580 590 600
EHPAFRLASD GCLRALAMEF QTVHCAPGDL IYHAGESVDS LCFVVSGSLE
610 620 630 640 650
VIQDDEVVAI LGKGDVFGDV FWKEATLAQS CANVRALTYC DLHVIKRDAL
660 670 680 690 700
QKVLEFYTAF SHSFSRNLIL TYNLRKRIVF RKISDVKREE EERMKRKNEA
710 720 730 740 750
PLILPPDHPV RRLFQRFRQQ KEARLAAERG GRDLDDLDVE KGNALTDHTS
760 770 780 790 800
ANHSLVKASV VTVRESPATP VSFQAASTST VSDHAKLHAP GSECLGPKAG
810 820 830 840 850
GGDPAKRKGW ARFKDACGKG EDWNKVSKAE SMETLPERTK ASGEATLKKT
860 870 880 890 900
DSCDSGITKS DLRLDNVGEA RSPQDRSPIL AEVKHSFYPI PEQTLQATVL
910 920 930 940 950
EVKHELKEDI KALNAKMTSI EKQLSEILRI LMSRGSSQSP QDTCEVSRPQ
960
SPESDRDIFG AS
Length:962
Mass (Da):108,291
Last modified:November 1, 1996 - v1
Checksum:i69DF4CE2DC435608
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34264 mRNA. Translation: CAA84018.1.
PIRiI53197.
RefSeqiNP_113930.1. NM_031742.1.
XP_006250553.1. XM_006250491.2.
UniGeneiRn.11071.

Genome annotation databases

EnsembliENSRNOT00000005209; ENSRNOP00000005209; ENSRNOG00000003841.
ENSRNOT00000077014; ENSRNOP00000068394; ENSRNOG00000003841.
GeneIDi65198.
KEGGirno:65198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34264 mRNA. Translation: CAA84018.1 .
PIRi I53197.
RefSeqi NP_113930.1. NM_031742.1.
XP_006250553.1. XM_006250491.2.
UniGenei Rn.11071.

3D structure databases

ProteinModelPortali Q63472.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q63472. 2 interactions.
MINTi MINT-8386100.
STRINGi 10116.ENSRNOP00000005209.

Chemistry

GuidetoPHARMACOLOGYi 570.

Protein family/group databases

TCDBi 1.A.1.20.4. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q63472.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005209 ; ENSRNOP00000005209 ; ENSRNOG00000003841 .
ENSRNOT00000077014 ; ENSRNOP00000068394 ; ENSRNOG00000003841 .
GeneIDi 65198.
KEGGi rno:65198.

Organism-specific databases

CTDi 3756.
RGDi 68398. Kcnh1.

Phylogenomic databases

eggNOGi COG2202.
GeneTreei ENSGT00760000118772.
HOVERGENi HBG101348.
InParanoidi Q63472.
KOi K04904.
OMAi HAKLHAP.
OrthoDBi EOG7QG43V.
PhylomeDBi Q63472.

Enzyme and pathway databases

Reactomei REACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 614144.
PROi Q63472.

Gene expression databases

Genevestigatori Q63472.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional expression of a rat homologue of the voltage gated ether a go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart."
    Ludwig J., Terlau H., Wunder F., Brueggemann A., Pardo L.A., Marquardt A., Stuehmer W., Pongs O.
    EMBO J. 13:4451-4458(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cerebellum.
  2. "Carboxy-terminal domain mediates assembly of the voltage-gated rat ether-a-go-go potassium channel."
    Ludwig J., Owen D., Pongs O.
    EMBO J. 16:6337-6345(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN CAD.
  3. "KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels."
    Hoshi N., Takahashi H., Shahidullah M., Yokoyama S., Higashida H.
    J. Biol. Chem. 273:23080-23085(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALG10B.
    Strain: Wistar.
    Tissue: Cerebellum.
  4. "Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary."
    Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.
    J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCNH1_RAT
AccessioniPrimary (citable) accession number: Q63472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3