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Q63472

- KCNH1_RAT

UniProt

Q63472 - KCNH1_RAT

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Protein
Potassium voltage-gated channel subfamily H member 1
Gene
Kcnh1, Eag
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi554 – 671118cNMP
Add
BLAST

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. protein binding Source: IntAct
  3. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calmodulin-binding, Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.20.4. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 1
Alternative name(s):
Ether-a-go-go potassium channel 1
Short name:
EAG channel 1
Short name:
EAG1
Short name:
r-eag
Voltage-gated potassium channel subunit Kv10.1
Gene namesi
Name:Kcnh1
Synonyms:Eag
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi68398. Kcnh1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein. Nucleus inner membrane By similarity; Multi-pass membrane protein
Note: Perinuclear KCNH1 is located to NPC-free islands By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 220220Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini242 – 2487Extracellular Reviewed prediction
Transmembranei249 – 26921Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini270 – 29425Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei295 – 31521Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini316 – 3227Extracellular Reviewed prediction
Transmembranei323 – 34321Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini344 – 3496Cytoplasmic Reviewed prediction
Transmembranei350 – 37021Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Topological domaini371 – 42151Extracellular Reviewed prediction
Add
BLAST
Intramembranei422 – 44221Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Topological domaini443 – 4508Extracellular Reviewed prediction
Transmembranei451 – 47121Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini472 – 962491Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
  2. nuclear inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Potassium voltage-gated channel subfamily H member 1
PRO_0000053996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi388 – 3881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

PTM databases

PhosphoSiteiQ63472.

Expressioni

Tissue specificityi

Detected in brain, but not in the other tissues tested. Expression is highest in granular cells of the dentate gyrus, in hippocampus CA3 pyramidal cells, and in cerebellar granule cells. Found in pituitary.1 Publication

Gene expression databases

GenevestigatoriQ63472.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2 By similarity. Interacts with ALG10B.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Rabep1O355502EBI-7991592,EBI-7991542

Protein-protein interaction databases

IntActiQ63472. 2 interactions.
MINTiMINT-8386100.
STRINGi10116.ENSRNOP00000005209.

Structurei

3D structure databases

ProteinModelPortaliQ63472.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 9481PAS
Add
BLAST
Domaini93 – 14553PAC
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni646 – 74398Calmodulin-binding By similarity
Add
BLAST
Regioni897 – 93741CAD (involved in subunit assembly)
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi436 – 4416Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.1 Publication

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
GeneTreeiENSGT00680000099663.
HOVERGENiHBG101348.
KOiK04904.
OMAiHAKLHAP.
OrthoDBiEOG7QG43V.
PhylomeDBiQ63472.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63472-1 [UniParc]FASTAAdd to Basket

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MTMAGGRRGL VAPQNTFLEN IVRRSNDTNF VLGNAQIVDW PIVYSNDGFC    50
KLSGYHRAEV MQKSSACSFM YGELTDKDTV EKVRQTFENY EMNSFEILMY 100
KKNRTPVWFF VKIAPIRNEQ DKVVLFLCTF SDITAFKQPI EDDSCKGWGK 150
FARLTRALTS SRGVLQQLAP SVQKGENVHK HSRLAEVLQL GSDILPQYKQ 200
EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS FKTRQNNVAW 250
LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL 300
LSCLPYDVIN AFENVDEGIS SLFSSLKVVR LLRLGRVARK LDHYIEYGAA 350
VLVLLVCVFG LAAHWMACIW YSIGDYEIFD EDTKTIRNNS WLYQLALDIG 400
TPYQFNGSGS GKWEGGPSKN SVYISSLYFT MTSLTSVGFG NIAPSTDIEK 450
IFAVAIMMIG SLLYATIFGN VTTIFQQMYA NTNRYHEMLN SVRDFLKLYQ 500
VPKGLSERVM DYIVSTWSMS RGIDTEKVLQ ICPKDMRADI CVHLNRKVFK 550
EHPAFRLASD GCLRALAMEF QTVHCAPGDL IYHAGESVDS LCFVVSGSLE 600
VIQDDEVVAI LGKGDVFGDV FWKEATLAQS CANVRALTYC DLHVIKRDAL 650
QKVLEFYTAF SHSFSRNLIL TYNLRKRIVF RKISDVKREE EERMKRKNEA 700
PLILPPDHPV RRLFQRFRQQ KEARLAAERG GRDLDDLDVE KGNALTDHTS 750
ANHSLVKASV VTVRESPATP VSFQAASTST VSDHAKLHAP GSECLGPKAG 800
GGDPAKRKGW ARFKDACGKG EDWNKVSKAE SMETLPERTK ASGEATLKKT 850
DSCDSGITKS DLRLDNVGEA RSPQDRSPIL AEVKHSFYPI PEQTLQATVL 900
EVKHELKEDI KALNAKMTSI EKQLSEILRI LMSRGSSQSP QDTCEVSRPQ 950
SPESDRDIFG AS 962
Length:962
Mass (Da):108,291
Last modified:November 1, 1996 - v1
Checksum:i69DF4CE2DC435608
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z34264 mRNA. Translation: CAA84018.1.
PIRiI53197.
RefSeqiNP_113930.1. NM_031742.1.
XP_006250553.1. XM_006250491.1.
UniGeneiRn.11071.

Genome annotation databases

EnsembliENSRNOT00000005209; ENSRNOP00000005209; ENSRNOG00000003841.
GeneIDi65198.
KEGGirno:65198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z34264 mRNA. Translation: CAA84018.1 .
PIRi I53197.
RefSeqi NP_113930.1. NM_031742.1.
XP_006250553.1. XM_006250491.1.
UniGenei Rn.11071.

3D structure databases

ProteinModelPortali Q63472.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q63472. 2 interactions.
MINTi MINT-8386100.
STRINGi 10116.ENSRNOP00000005209.

Chemistry

GuidetoPHARMACOLOGYi 570.

Protein family/group databases

TCDBi 1.A.1.20.4. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q63472.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005209 ; ENSRNOP00000005209 ; ENSRNOG00000003841 .
GeneIDi 65198.
KEGGi rno:65198.

Organism-specific databases

CTDi 3756.
RGDi 68398. Kcnh1.

Phylogenomic databases

eggNOGi COG2202.
GeneTreei ENSGT00680000099663.
HOVERGENi HBG101348.
KOi K04904.
OMAi HAKLHAP.
OrthoDBi EOG7QG43V.
PhylomeDBi Q63472.

Enzyme and pathway databases

Reactomei REACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 614144.
PROi Q63472.

Gene expression databases

Genevestigatori Q63472.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003949. K_chnl_volt-dep_EAG.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01464. EAGCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional expression of a rat homologue of the voltage gated ether a go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart."
    Ludwig J., Terlau H., Wunder F., Brueggemann A., Pardo L.A., Marquardt A., Stuehmer W., Pongs O.
    EMBO J. 13:4451-4458(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cerebellum.
  2. "Carboxy-terminal domain mediates assembly of the voltage-gated rat ether-a-go-go potassium channel."
    Ludwig J., Owen D., Pongs O.
    EMBO J. 16:6337-6345(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN CAD.
  3. "KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels."
    Hoshi N., Takahashi H., Shahidullah M., Yokoyama S., Higashida H.
    J. Biol. Chem. 273:23080-23085(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALG10B.
    Strain: Wistar.
    Tissue: Cerebellum.
  4. "Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary."
    Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.
    J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCNH1_RAT
AccessioniPrimary (citable) accession number: Q63472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi