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Protein

BPI fold-containing family A member 2

Gene

Bpifa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has strong antibacterial activity against P. aeruginosa.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Enzyme and pathway databases

ReactomeiR-RNO-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family A member 2
Alternative name(s):
Neonatal submandibular gland protein
Parotid secretory protein
Short name:
PSP
Gene namesi
Name:Bpifa2
Synonyms:Psp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3431. Bpifa2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001718621 – 235BPI fold-containing family A member 2Add BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi161 ↔ 204By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ63471.
PRIDEiQ63471.

Expressioni

Tissue specificityi

Expressed in parotid, submandibular and sublingual glands.1 Publication

Developmental stagei

Detected in neonatal submandibular and parotid gland secretion but not in sublingual gland secretion (at protein level). In submandibular gland, expressed at high levels in the first postnatal week, with expression diminishing thereafter.1 Publication

Gene expression databases

GenevisibleiQ63471. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018226.

Structurei

3D structure databases

ProteinModelPortaliQ63471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQB. Eukaryota.
ENOG4111BIC. LUCA.
GeneTreeiENSGT00390000014788.
HOGENOMiHOG000231511.
HOVERGENiHBG004495.
InParanoidiQ63471.
OMAiQRECISD.
OrthoDBiEOG091G0RXE.
PhylomeDBiQ63471.
TreeFamiTF337052.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQLGSLVVL CGLLIGTSES LLGDVANAVN NLDILNSPSE AVAQNLNLDV
60 70 80 90 100
GSLQQATTWP SAKDSILETL NKVELGNSNG FTPLNGLLLR VNKFRVLDLQ
110 120 130 140 150
AGLSSNGKDI DLKLPLVFEI SFSLPVIGPT LDVAVSLDLL NSVSVQTNAQ
160 170 180 190 200
TGLPGVTLGK CSGNTDKISI SLLGRRLPFV NRILDGVSGL LTGAVSILLQ
210 220 230
NILCPVLQYL LSTMSGSAIQ GLLSNVLTGQ LAVPL
Length:235
Mass (Da):24,529
Last modified:November 1, 1996 - v1
Checksum:i0B36EC779025986E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83209 mRNA. Translation: AAC06334.1.
PIRiB42337.
RefSeqiNP_434695.1. NM_052808.1.
UniGeneiRn.9766.

Genome annotation databases

EnsembliENSRNOT00000018226; ENSRNOP00000018226; ENSRNOG00000013540.
GeneIDi50585.
KEGGirno:50585.
UCSCiRGD:3431. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83209 mRNA. Translation: AAC06334.1.
PIRiB42337.
RefSeqiNP_434695.1. NM_052808.1.
UniGeneiRn.9766.

3D structure databases

ProteinModelPortaliQ63471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018226.

Proteomic databases

PaxDbiQ63471.
PRIDEiQ63471.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018226; ENSRNOP00000018226; ENSRNOG00000013540.
GeneIDi50585.
KEGGirno:50585.
UCSCiRGD:3431. rat.

Organism-specific databases

CTDi140683.
RGDi3431. Bpifa2.

Phylogenomic databases

eggNOGiENOG410IXQB. Eukaryota.
ENOG4111BIC. LUCA.
GeneTreeiENSGT00390000014788.
HOGENOMiHOG000231511.
HOVERGENiHBG004495.
InParanoidiQ63471.
OMAiQRECISD.
OrthoDBiEOG091G0RXE.
PhylomeDBiQ63471.
TreeFamiTF337052.

Enzyme and pathway databases

ReactomeiR-RNO-6803157. Antimicrobial peptides.

Miscellaneous databases

PROiQ63471.

Gene expression databases

GenevisibleiQ63471. RN.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBPIA2_RAT
AccessioniPrimary (citable) accession number: Q63471
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.