Q63467 (TFF1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trefoil factor 1

Alternative name(s):
Protein pS2

Gene names

Name:	Tff1
Synonyms:	Ps2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	81 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents By similarity.
Subcellular location	Secreted.
Sequence similarities	Contains 1 P-type (trefoil) domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Disulfide bond Pyrrolidone carboxylic acid
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	maintenance of gastrointestinal epithelium Inferred from expression pattern Ref.1. Source: RGD response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to iron ion Inferred from expression pattern PubMed 16629162. Source: RGD response to peptide hormone stimulus Inferred from expression pattern PubMed 16973727. Source: RGD wound healing Traceable author statement Ref.1. Source: RGD
Cellular_component	cytoplasm Traceable author statement Ref.1. Source: RGD extracellular space Inferred from direct assay PubMed 11903739. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 81	60	Trefoil factor 1		PRO_0000023458
Regions
	Domain	26 – 69	44	P-type
	Compositional bias	76 – 78	3	Glu-rich (acidic)
Amino acid modifications
	Modified residue	22	1	Pyrrolidone carboxylic acid Potential
	Disulfide bond	28 ↔ 54		By similarity
	Disulfide bond	38 ↔ 53		By similarity
	Disulfide bond	48 ↔ 65		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63467 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 56740550406ECF25	FASTA	81	9,155
	10 20 30 40 50 60 MEHKVTCVLA MVLMLALSSL AQNQEETCAV IPRERINCGF PGVTAQQCKE KGCCFDDSVR 70 80 GFPWCFRPLV IENQQEEECP F

References

[1]	"cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis." Itoh H., Tomita M., Uchino H., Kobayashi T., Kataoka H., Sekiya R., Nawa Y. Biochem. J. 318:939-944(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Stomach.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D83231 mRNA. Translation: BAA11857.1.
IPI	IPI00209094.
PIR	S71962.
RefSeq	NP_476470.1. NM_057129.1.
UniGene	Rn.10715.
3D structure databases
ProteinModelPortal	Q63467.
SMR	Q63467. Positions 22-81.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000001538.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000001538; ENSRNOP00000001538; ENSRNOG00000001164.
GeneID	117270.
KEGG	rno:117270.
UCSC	RGD:620707. rat.
Organism-specific databases
CTD	7031.
RGD	620707. Tff1.
Phylogenomic databases
eggNOG	NOG46001.
GeneTree	ENSGT00390000000115.
HOGENOM	HOG000121778.
HOVERGEN	HBG004364.
InParanoid	Q63467.
OMA	PEEECEF.
OrthoDB	EOG4907BN.
Gene expression databases
Genevestigator	Q63467.
GermOnline	ENSRNOG00000001164. Rattus norvegicus.
Family and domain databases
Gene3D	4.10.110.10. 1 hit.
InterPro	IPR000519. P_trefoil. IPR017994. P_trefoil_chordata. IPR017957. P_trefoil_CS. [Graphical view]
Pfam	PF00088. Trefoil. 1 hit. [Graphical view]
PRINTS	PR00680. PTREFOIL.
SMART	SM00018. PD. 1 hit. [Graphical view]
SUPFAM	SSF57492. P_trefoil. 1 hit.
PROSITE	PS00025. P_TREFOIL_1. 1 hit. PS51448. P_TREFOIL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	620187.

Entry information

Entry name

TFF1_RAT

Accession

Primary (citable) accession number: Q63467

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program