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Protein

Trefoil factor 1

Gene

Tff1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.By similarity

GO - Biological processi

  • cell differentiation Source: Ensembl
  • maintenance of gastrointestinal epithelium Source: RGD
  • negative regulation of cell proliferation Source: Ensembl
  • response to immobilization stress Source: RGD
  • response to iron ion Source: RGD
  • response to peptide hormone Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 1
Alternative name(s):
Protein pS2
Gene namesi
Name:Tff1
Synonyms:Ps2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi620707. Tff1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002345822 – 81Trefoil factor 1Add BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Pyrrolidone carboxylic acidSequence analysis1
Disulfide bondi28 ↔ 54PROSITE-ProRule annotation
Disulfide bondi38 ↔ 53PROSITE-ProRule annotation
Disulfide bondi48 ↔ 65PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ63467.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001164.
GenevisibleiQ63467. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001538.

Structurei

3D structure databases

ProteinModelPortaliQ63467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 69P-typePROSITE-ProRule annotationAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 78Glu-rich (acidic)3

Sequence similaritiesi

Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J868. Eukaryota.
ENOG410Z7FU. LUCA.
GeneTreeiENSGT00840000129881.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ63467.
OMAiPEEECEF.
OrthoDBiEOG091G0XBT.
PhylomeDBiQ63467.
TreeFamiTF336092.

Family and domain databases

CDDicd00111. Trefoil. 1 hit.
Gene3Di4.10.110.10. 1 hit.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKVTCVLA MVLMLALSSL AQNQEETCAV IPRERINCGF PGVTAQQCKE
60 70 80
KGCCFDDSVR GFPWCFRPLV IENQQEEECP F
Length:81
Mass (Da):9,155
Last modified:November 1, 1996 - v1
Checksum:i56740550406ECF25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83231 mRNA. Translation: BAA11857.1.
PIRiS71962.
RefSeqiNP_476470.1. NM_057129.1.
UniGeneiRn.10715.

Genome annotation databases

EnsembliENSRNOT00000001538; ENSRNOP00000001538; ENSRNOG00000001164.
GeneIDi117270.
KEGGirno:117270.
UCSCiRGD:620707. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83231 mRNA. Translation: BAA11857.1.
PIRiS71962.
RefSeqiNP_476470.1. NM_057129.1.
UniGeneiRn.10715.

3D structure databases

ProteinModelPortaliQ63467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001538.

Proteomic databases

PaxDbiQ63467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001538; ENSRNOP00000001538; ENSRNOG00000001164.
GeneIDi117270.
KEGGirno:117270.
UCSCiRGD:620707. rat.

Organism-specific databases

CTDi7031.
RGDi620707. Tff1.

Phylogenomic databases

eggNOGiENOG410J868. Eukaryota.
ENOG410Z7FU. LUCA.
GeneTreeiENSGT00840000129881.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ63467.
OMAiPEEECEF.
OrthoDBiEOG091G0XBT.
PhylomeDBiQ63467.
TreeFamiTF336092.

Miscellaneous databases

PROiQ63467.

Gene expression databases

BgeeiENSRNOG00000001164.
GenevisibleiQ63467. RN.

Family and domain databases

CDDicd00111. Trefoil. 1 hit.
Gene3Di4.10.110.10. 1 hit.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTFF1_RAT
AccessioniPrimary (citable) accession number: Q63467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.