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Protein

Trefoil factor 1

Gene

Tff1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.By similarity

GO - Biological processi

  • cell differentiation Source: Ensembl
  • maintenance of gastrointestinal epithelium Source: RGD
  • negative regulation of cell proliferation Source: Ensembl
  • response to estradiol Source: Ensembl
  • response to immobilization stress Source: RGD
  • response to iron ion Source: RGD
  • response to peptide hormone Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 1
Alternative name(s):
Protein pS2
Gene namesi
Name:Tff1
Synonyms:Ps2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi620707. Tff1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 8160Trefoil factor 1PRO_0000023458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Pyrrolidone carboxylic acidSequence Analysis
Disulfide bondi28 ↔ 54PROSITE-ProRule annotation
Disulfide bondi38 ↔ 53PROSITE-ProRule annotation
Disulfide bondi48 ↔ 65PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Gene expression databases

GenevisibleiQ63467. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001538.

Structurei

3D structure databases

ProteinModelPortaliQ63467.
SMRiQ63467. Positions 22-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6944P-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi76 – 783Glu-rich (acidic)

Sequence similaritiesi

Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46001.
GeneTreeiENSGT00390000000115.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ63467.
OMAiPEEECEF.
OrthoDBiEOG70W3GT.
PhylomeDBiQ63467.
TreeFamiTF336092.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR000519. P_trefoil.
IPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR028824. TFF1.
[Graphical view]
PANTHERiPTHR13826:SF15. PTHR13826:SF15. 1 hit.
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKVTCVLA MVLMLALSSL AQNQEETCAV IPRERINCGF PGVTAQQCKE
60 70 80
KGCCFDDSVR GFPWCFRPLV IENQQEEECP F
Length:81
Mass (Da):9,155
Last modified:November 1, 1996 - v1
Checksum:i56740550406ECF25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83231 mRNA. Translation: BAA11857.1.
PIRiS71962.
RefSeqiNP_476470.1. NM_057129.1.
UniGeneiRn.10715.

Genome annotation databases

EnsembliENSRNOT00000001538; ENSRNOP00000001538; ENSRNOG00000001164.
GeneIDi117270.
KEGGirno:117270.
UCSCiRGD:620707. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83231 mRNA. Translation: BAA11857.1.
PIRiS71962.
RefSeqiNP_476470.1. NM_057129.1.
UniGeneiRn.10715.

3D structure databases

ProteinModelPortaliQ63467.
SMRiQ63467. Positions 22-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001538.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001538; ENSRNOP00000001538; ENSRNOG00000001164.
GeneIDi117270.
KEGGirno:117270.
UCSCiRGD:620707. rat.

Organism-specific databases

CTDi7031.
RGDi620707. Tff1.

Phylogenomic databases

eggNOGiNOG46001.
GeneTreeiENSGT00390000000115.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ63467.
OMAiPEEECEF.
OrthoDBiEOG70W3GT.
PhylomeDBiQ63467.
TreeFamiTF336092.

Miscellaneous databases

NextBioi620187.
PROiQ63467.

Gene expression databases

GenevisibleiQ63467. RN.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR000519. P_trefoil.
IPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR028824. TFF1.
[Graphical view]
PANTHERiPTHR13826:SF15. PTHR13826:SF15. 1 hit.
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis."
    Itoh H., Tomita M., Uchino H., Kobayashi T., Kataoka H., Sekiya R., Nawa Y.
    Biochem. J. 318:939-944(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Stomach.

Entry informationi

Entry nameiTFF1_RAT
AccessioniPrimary (citable) accession number: Q63467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.