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Protein

Trefoil factor 1

Gene

Tff1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: RGD
  • maintenance of gastrointestinal epithelium Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • response to immobilization stress Source: RGD
  • response to iron ion Source: RGD
  • response to peptide hormone Source: RGD
  • wound healing Source: RGD

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 1
Alternative name(s):
Protein pS2
Gene namesi
Name:Tff1
Synonyms:Ps2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi620707. Tff1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002345822 – 81Trefoil factor 1Add BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Pyrrolidone carboxylic acidSequence analysis1
Disulfide bondi28 ↔ 54PROSITE-ProRule annotation
Disulfide bondi38 ↔ 53PROSITE-ProRule annotation
Disulfide bondi48 ↔ 65PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ63467.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001164.
GenevisibleiQ63467. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001538.

Structurei

3D structure databases

ProteinModelPortaliQ63467.
SMRiQ63467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 69P-typePROSITE-ProRule annotationAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 78Glu-rich (acidic)3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J868. Eukaryota.
ENOG410Z7FU. LUCA.
GeneTreeiENSGT00840000129881.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ63467.
OMAiPEEECEF.
OrthoDBiEOG091G0XBT.
PhylomeDBiQ63467.
TreeFamiTF336092.

Family and domain databases

CDDicd00111. Trefoil. 1 hit.
InterProiView protein in InterPro
IPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
IPR028824. TFF1.
PANTHERiPTHR13826:SF18. PTHR13826:SF18. 1 hit.
PfamiView protein in Pfam
PF00088. Trefoil. 1 hit.
PRINTSiPR00680. PTREFOIL.
SMARTiView protein in SMART
SM00018. PD. 1 hit.
PROSITEiView protein in PROSITE
PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKVTCVLA MVLMLALSSL AQNQEETCAV IPRERINCGF PGVTAQQCKE
60 70 80
KGCCFDDSVR GFPWCFRPLV IENQQEEECP F
Length:81
Mass (Da):9,155
Last modified:November 1, 1996 - v1
Checksum:i56740550406ECF25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83231 mRNA. Translation: BAA11857.1.
PIRiS71962.
RefSeqiNP_476470.1. NM_057129.1.
UniGeneiRn.10715.

Genome annotation databases

EnsembliENSRNOT00000001538; ENSRNOP00000001538; ENSRNOG00000001164.
GeneIDi117270.
KEGGirno:117270.
UCSCiRGD:620707. rat.

Similar proteinsi

Entry informationi

Entry nameiTFF1_RAT
AccessioniPrimary (citable) accession number: Q63467
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome