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Q63467 (TFF1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trefoil factor 1
Alternative name(s):
Protein pS2
Gene names
Name:Tff1
Synonyms:Ps2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length81 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents By similarity.

Subcellular location

Secreted.

Sequence similarities

Contains 1 P-type (trefoil) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 8160Trefoil factor 1
PRO_0000023458

Regions

Domain26 – 6944P-type
Compositional bias76 – 783Glu-rich (acidic)

Amino acid modifications

Modified residue221Pyrrolidone carboxylic acid Potential
Disulfide bond28 ↔ 54 By similarity
Disulfide bond38 ↔ 53 By similarity
Disulfide bond48 ↔ 65 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63467 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 56740550406ECF25

FASTA819,155
        10         20         30         40         50         60 
MEHKVTCVLA MVLMLALSSL AQNQEETCAV IPRERINCGF PGVTAQQCKE KGCCFDDSVR 

        70         80 
GFPWCFRPLV IENQQEEECP F 

« Hide

References

[1]"cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis."
Itoh H., Tomita M., Uchino H., Kobayashi T., Kataoka H., Sekiya R., Nawa Y.
Biochem. J. 318:939-944(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Stomach.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D83231 mRNA. Translation: BAA11857.1.
PIRS71962.
RefSeqNP_476470.1. NM_057129.1.
UniGeneRn.10715.

3D structure databases

ProteinModelPortalQ63467.
SMRQ63467. Positions 22-81.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000001538.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000001538; ENSRNOP00000001538; ENSRNOG00000001164.
GeneID117270.
KEGGrno:117270.
UCSCRGD:620707. rat.

Organism-specific databases

CTD7031.
RGD620707. Tff1.

Phylogenomic databases

eggNOGNOG46001.
GeneTreeENSGT00390000000115.
HOGENOMHOG000121778.
HOVERGENHBG004364.
InParanoidQ63467.
OMAPEEECEF.
OrthoDBEOG70W3GT.
PhylomeDBQ63467.
TreeFamTF336092.

Gene expression databases

GenevestigatorQ63467.

Family and domain databases

Gene3D4.10.110.10. 1 hit.
InterProIPR000519. P_trefoil.
IPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR028824. TFF1.
[Graphical view]
PANTHERPTHR13826:SF3. PTHR13826:SF3. 1 hit.
PfamPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSPR00680. PTREFOIL.
SMARTSM00018. PD. 1 hit.
[Graphical view]
SUPFAMSSF57492. SSF57492. 1 hit.
PROSITEPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio620187.
PROQ63467.

Entry information

Entry nameTFF1_RAT
AccessionPrimary (citable) accession number: Q63467
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families