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Q63467

- TFF1_RAT

UniProt

Q63467 - TFF1_RAT

Protein

Trefoil factor 1

Gene

Tff1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.By similarity

    GO - Biological processi

    1. cell differentiation Source: Ensembl
    2. maintenance of gastrointestinal epithelium Source: RGD
    3. negative regulation of cell proliferation Source: Ensembl
    4. response to estradiol Source: Ensembl
    5. response to immobilization stress Source: RGD
    6. response to iron ion Source: RGD
    7. response to peptide hormone Source: RGD
    8. wound healing Source: RGD

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trefoil factor 1
    Alternative name(s):
    Protein pS2
    Gene namesi
    Name:Tff1
    Synonyms:Ps2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi620707. Tff1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 8160Trefoil factor 1PRO_0000023458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221Pyrrolidone carboxylic acidSequence Analysis
    Disulfide bondi28 ↔ 54PROSITE-ProRule annotation
    Disulfide bondi38 ↔ 53PROSITE-ProRule annotation
    Disulfide bondi48 ↔ 65PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Expressioni

    Gene expression databases

    GenevestigatoriQ63467.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000001538.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63467.
    SMRiQ63467. Positions 22-81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 6944P-typePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi76 – 783Glu-rich (acidic)

    Sequence similaritiesi

    Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46001.
    GeneTreeiENSGT00390000000115.
    HOGENOMiHOG000121778.
    HOVERGENiHBG004364.
    InParanoidiQ63467.
    OMAiPEEECEF.
    OrthoDBiEOG70W3GT.
    PhylomeDBiQ63467.
    TreeFamiTF336092.

    Family and domain databases

    Gene3Di4.10.110.10. 1 hit.
    InterProiIPR000519. P_trefoil.
    IPR017994. P_trefoil_chordata.
    IPR017957. P_trefoil_CS.
    IPR028824. TFF1.
    [Graphical view]
    PANTHERiPTHR13826:SF15. PTHR13826:SF15. 1 hit.
    PfamiPF00088. Trefoil. 1 hit.
    [Graphical view]
    PRINTSiPR00680. PTREFOIL.
    SMARTiSM00018. PD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57492. SSF57492. 1 hit.
    PROSITEiPS00025. P_TREFOIL_1. 1 hit.
    PS51448. P_TREFOIL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63467-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHKVTCVLA MVLMLALSSL AQNQEETCAV IPRERINCGF PGVTAQQCKE   50
    KGCCFDDSVR GFPWCFRPLV IENQQEEECP F 81
    Length:81
    Mass (Da):9,155
    Last modified:November 1, 1996 - v1
    Checksum:i56740550406ECF25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83231 mRNA. Translation: BAA11857.1.
    PIRiS71962.
    RefSeqiNP_476470.1. NM_057129.1.
    UniGeneiRn.10715.

    Genome annotation databases

    EnsembliENSRNOT00000001538; ENSRNOP00000001538; ENSRNOG00000001164.
    GeneIDi117270.
    KEGGirno:117270.
    UCSCiRGD:620707. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83231 mRNA. Translation: BAA11857.1 .
    PIRi S71962.
    RefSeqi NP_476470.1. NM_057129.1.
    UniGenei Rn.10715.

    3D structure databases

    ProteinModelPortali Q63467.
    SMRi Q63467. Positions 22-81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000001538.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000001538 ; ENSRNOP00000001538 ; ENSRNOG00000001164 .
    GeneIDi 117270.
    KEGGi rno:117270.
    UCSCi RGD:620707. rat.

    Organism-specific databases

    CTDi 7031.
    RGDi 620707. Tff1.

    Phylogenomic databases

    eggNOGi NOG46001.
    GeneTreei ENSGT00390000000115.
    HOGENOMi HOG000121778.
    HOVERGENi HBG004364.
    InParanoidi Q63467.
    OMAi PEEECEF.
    OrthoDBi EOG70W3GT.
    PhylomeDBi Q63467.
    TreeFami TF336092.

    Miscellaneous databases

    NextBioi 620187.
    PROi Q63467.

    Gene expression databases

    Genevestigatori Q63467.

    Family and domain databases

    Gene3Di 4.10.110.10. 1 hit.
    InterProi IPR000519. P_trefoil.
    IPR017994. P_trefoil_chordata.
    IPR017957. P_trefoil_CS.
    IPR028824. TFF1.
    [Graphical view ]
    PANTHERi PTHR13826:SF15. PTHR13826:SF15. 1 hit.
    Pfami PF00088. Trefoil. 1 hit.
    [Graphical view ]
    PRINTSi PR00680. PTREFOIL.
    SMARTi SM00018. PD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57492. SSF57492. 1 hit.
    PROSITEi PS00025. P_TREFOIL_1. 1 hit.
    PS51448. P_TREFOIL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis."
      Itoh H., Tomita M., Uchino H., Kobayashi T., Kataoka H., Sekiya R., Nawa Y.
      Biochem. J. 318:939-944(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Stomach.

    Entry informationi

    Entry nameiTFF1_RAT
    AccessioniPrimary (citable) accession number: Q63467
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3