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Q63467

- TFF1_RAT

UniProt

Q63467 - TFF1_RAT

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Protein

Trefoil factor 1

Gene

Tff1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.By similarity

GO - Biological processi

  1. cell differentiation Source: Ensembl
  2. maintenance of gastrointestinal epithelium Source: RGD
  3. negative regulation of cell proliferation Source: Ensembl
  4. response to estradiol Source: Ensembl
  5. response to immobilization stress Source: RGD
  6. response to iron ion Source: RGD
  7. response to peptide hormone Source: RGD
  8. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 1
Alternative name(s):
Protein pS2
Gene namesi
Name:Tff1
Synonyms:Ps2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi620707. Tff1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 8160Trefoil factor 1PRO_0000023458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Pyrrolidone carboxylic acidSequence Analysis
Disulfide bondi28 ↔ 54PROSITE-ProRule annotation
Disulfide bondi38 ↔ 53PROSITE-ProRule annotation
Disulfide bondi48 ↔ 65PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Gene expression databases

GenevestigatoriQ63467.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001538.

Structurei

3D structure databases

ProteinModelPortaliQ63467.
SMRiQ63467. Positions 22-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6944P-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi76 – 783Glu-rich (acidic)

Sequence similaritiesi

Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46001.
GeneTreeiENSGT00390000000115.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ63467.
OMAiPEEECEF.
OrthoDBiEOG70W3GT.
PhylomeDBiQ63467.
TreeFamiTF336092.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR000519. P_trefoil.
IPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR028824. TFF1.
[Graphical view]
PANTHERiPTHR13826:SF15. PTHR13826:SF15. 1 hit.
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63467-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHKVTCVLA MVLMLALSSL AQNQEETCAV IPRERINCGF PGVTAQQCKE
60 70 80
KGCCFDDSVR GFPWCFRPLV IENQQEEECP F
Length:81
Mass (Da):9,155
Last modified:November 1, 1996 - v1
Checksum:i56740550406ECF25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83231 mRNA. Translation: BAA11857.1.
PIRiS71962.
RefSeqiNP_476470.1. NM_057129.1.
UniGeneiRn.10715.

Genome annotation databases

EnsembliENSRNOT00000001538; ENSRNOP00000001538; ENSRNOG00000001164.
GeneIDi117270.
KEGGirno:117270.
UCSCiRGD:620707. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83231 mRNA. Translation: BAA11857.1 .
PIRi S71962.
RefSeqi NP_476470.1. NM_057129.1.
UniGenei Rn.10715.

3D structure databases

ProteinModelPortali Q63467.
SMRi Q63467. Positions 22-81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000001538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000001538 ; ENSRNOP00000001538 ; ENSRNOG00000001164 .
GeneIDi 117270.
KEGGi rno:117270.
UCSCi RGD:620707. rat.

Organism-specific databases

CTDi 7031.
RGDi 620707. Tff1.

Phylogenomic databases

eggNOGi NOG46001.
GeneTreei ENSGT00390000000115.
HOGENOMi HOG000121778.
HOVERGENi HBG004364.
InParanoidi Q63467.
OMAi PEEECEF.
OrthoDBi EOG70W3GT.
PhylomeDBi Q63467.
TreeFami TF336092.

Miscellaneous databases

NextBioi 620187.
PROi Q63467.

Gene expression databases

Genevestigatori Q63467.

Family and domain databases

Gene3Di 4.10.110.10. 1 hit.
InterProi IPR000519. P_trefoil.
IPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR028824. TFF1.
[Graphical view ]
PANTHERi PTHR13826:SF15. PTHR13826:SF15. 1 hit.
Pfami PF00088. Trefoil. 1 hit.
[Graphical view ]
PRINTSi PR00680. PTREFOIL.
SMARTi SM00018. PD. 1 hit.
[Graphical view ]
SUPFAMi SSF57492. SSF57492. 1 hit.
PROSITEi PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis."
    Itoh H., Tomita M., Uchino H., Kobayashi T., Kataoka H., Sekiya R., Nawa Y.
    Biochem. J. 318:939-944(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Stomach.

Entry informationi

Entry nameiTFF1_RAT
AccessioniPrimary (citable) accession number: Q63467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3